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Neurodegenerative Diseases

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Neurodegenerative diseases are characterized by the gradual loss of selectively vulnerable neuronal populations, in contrast to selected static neuronal loss due to metabolic or toxic diseases. Neurodegenerative diseases can be classified according to major clinical features (such as dementia, Parkinson’s disease, or motor neuron diseases), anatomical distribution of neurodegenerative diseases (such as anterior temporal lobe degeneration, extrapyramidal disease, or spinocerebellar degeneration), or major molecular abnormalities. The common neurodegenerative diseases in adults such as Alzheimer’s disease, frontotemporal lobe degeneration, Parkinson’s disease, and multiple system atrophy are really rare in children. The childhood neurogenerative diseases of as yet unclear pathophysiology are sometimes categorized based on whether they affect the brain homogenously (diffuse encephalopathies) or preferentially affecting the cerebral cortex (poliodystrophies), the cerebral white matter (leukodystrophies), the basal ganglia (corencephalopathies), or the cerebellum, brainstem, and spinal cord (spinocerebellar diseases). In this chapter, we only introduce two relatively common neurodegenerative diseases in children and hope to contribute to a more comprehensive and detailed study of childhood neurogenerative diseases in the future.

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Correspondence to Xiaoan Zhang .

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Shang, H., Zhao, X., Zhang, X. (2022). Neurodegenerative Diseases. In: Liu, H., Zhang, X. (eds) Pediatric Neuroimaging. Springer, Singapore.

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  • Print ISBN: 978-981-16-7927-8

  • Online ISBN: 978-981-16-7928-5

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