Abstract
Neurodegenerative diseases are characterized by the gradual loss of selectively vulnerable neuronal populations, in contrast to selected static neuronal loss due to metabolic or toxic diseases. Neurodegenerative diseases can be classified according to major clinical features (such as dementia, Parkinson’s disease, or motor neuron diseases), anatomical distribution of neurodegenerative diseases (such as anterior temporal lobe degeneration, extrapyramidal disease, or spinocerebellar degeneration), or major molecular abnormalities. The common neurodegenerative diseases in adults such as Alzheimer’s disease, frontotemporal lobe degeneration, Parkinson’s disease, and multiple system atrophy are really rare in children. The childhood neurogenerative diseases of as yet unclear pathophysiology are sometimes categorized based on whether they affect the brain homogenously (diffuse encephalopathies) or preferentially affecting the cerebral cortex (poliodystrophies), the cerebral white matter (leukodystrophies), the basal ganglia (corencephalopathies), or the cerebellum, brainstem, and spinal cord (spinocerebellar diseases). In this chapter, we only introduce two relatively common neurodegenerative diseases in children and hope to contribute to a more comprehensive and detailed study of childhood neurogenerative diseases in the future.
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Dejerine J, Thomas A. L’atrophieolivo-ponto-cèrèbelleuse. NouvIconogr Salpêtrière. 1900;13:330–70.
Duvoisin RC. An apology and an introduction to the olivoponto-cerebellar atrophies. In: Duvoisin RC, Plaitakis A, editors. Olivopontocerebellar atrophies. New York: Raven Press; 1984. p. 13–38.
Jiang J, Wang J, Lin M, et al. Bilateral middle cerebellar peduncle lesions: neuroimaging features and differential diagnoses. Brain Behav. 2020;10(10):e01778.
Gilman S, Koeppe RA, Junck L, et al. Patterns of cerebral glucose metabolism detected with positron emission tomography differ in multiple system atrophy and olivopontocerebellar atrophy. Ann Neurol. 2010;36(2):166–75.
Cagnoli C, Mariotti C, Taroni F, et al. SCA28, a novel form of autosomal dominant cerebellar ataxia on chromosome 18p11.22-q22. Brain. 2006;129:235–42.
Bower PG. Multiple system atrophy: building a global community—30years of advocacy efforts. Auton Neurosci. 2017;211:39–42.
Loos M, Dihné M, Block F. Tumor necrosis factor-alpha expression in areas of remote degeneration following middle cerebral artery occlusion of the rat. Neuroscience. 2003;122(2):373–80.
Yu C, Zhu C, Zhang Y, Chen H, Qin W, Wang M, Li K. A longitudinal diffusion tensor imaging study on Wallerian degeneration of corticospinal tract after motor pathway stroke. NeuroImage. 2009;47:451–8.
Conforti L, Gilley J, Coleman MP. Wallerian degeneration: an emerging axon death pathway linking injury and disease. Nat Rev Neurosci. 2014;15(6):394–409.
Kuhn MJ, Mikulis DJ, Ayoub DM, Kosofsky BE, Davis KR, Taveras JM. Wallerian degeneration after cerebral infarction: evaluation with sequential MR imaging. Radiology. 1989;172(1):179–82.
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© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
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Shang, H., Zhao, X., Zhang, X. (2022). Neurodegenerative Diseases. In: Liu, H., Zhang, X. (eds) Pediatric Neuroimaging. Springer, Singapore. https://doi.org/10.1007/978-981-16-7928-5_8
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DOI: https://doi.org/10.1007/978-981-16-7928-5_8
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