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Influenza Virus

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Diamond Electrodes

Abstract

The rapid diagnosis of patients in clinical practice is important for anti-influenza therapy. However, since the sensitivity of conventional rapid diagnostic test kits is low, false-negative results are often produced. Therefore, simple and convenient test kits with high sensitivity are needed in clinical practice. In this chapter, we describe the construction of a boron-doped diamond (BDD) electrode that terminates with a receptor (sialic acid-containing oligosaccharide chain)-mimicking peptide as well as its performance in the electrochemical detection of human and avian influenza viruses (IFVs).

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References

  1. Paules C, Subbarao K (2017) Influenza. Lancet 390(10095):697–708

    Article  Google Scholar 

  2. Webster RG, Govorkova EA (2014) Continuing challenges in influenza. Ann N Y Acad Sci 1323:115–139

    Article  CAS  Google Scholar 

  3. Gamblin SJ, Skehel JJ (2010) Influenza hemagglutinin and neuraminidase membrane glycoproteins. J Biol Chem 285(37):28403–28409

    Article  CAS  Google Scholar 

  4. Lai S, Qin Y, Cowling BJ, Ren X, Wardrop NA, Gilbert M, Tsang TK, Wu P, Feng L, Jiang H, Peng Z, Zheng J, Liao Q, Li S, Horby PW, Farrar JJ, Gao GF, Tatem AJ, Yu H (2016) Global epidemiology of avian influenza A H5N1 virus infection in humans, 1997–2015: a systematic review of individual case data. Lancet Infect Dis 16(7):e108–e118

    Article  Google Scholar 

  5. Li Q, Zhou L, Zhou M, Chen Z, Li F, Wu H, Xiang N, Chen E, Tang F, Wang D, Meng L, Hong Z, Tu W, Cao Y, Li L, Ding F, Liu B, Wang M, Xie R, Gao R, Li X, Bai T, Zou S, He J, Hu J, Xu Y, Chai C, Wang S, Gao Y, Jin L, Zhang Y, Luo H, Yu H, He J, Li Q, Wang X, Gao L, Pang X, Liu G, Yan Y, Yuan H, Shu Y, Yang W, Wang Y, Wu F, Uyeki TM, Feng Z (2014) Epidemiology of human infections with avian influenza A(H7N9) virus in China. N Engl J Med 370(6):520–532

    Article  CAS  Google Scholar 

  6. Yu K, Luo C, Qin G, Xu Z, Li N, Liu H, Shen X, Ma J, Wang Q, Yang C, Zhu W, Jiang H (2009) Why are oseltamivir and zanamivir effective against the newly emerged influenza a virus (A/H1N1)? Cell Res 19(10):1221–1224

    Article  Google Scholar 

  7. Salomon R, Webster RG (2009) The influenza virus enigma. Cell 136(3):402–410

    Article  CAS  Google Scholar 

  8. von Itzstein M (2007) The war against influenza: discovery and development of sialidase inhibitors. Nat Rev Drug Discovery 6(12):967–974

    Article  Google Scholar 

  9. Ikematsu H, Hayden FG, Kawaguchi K, Kinoshita M, de Jong MD, Lee N, Takashima S, Noshi T, Tsuchiya K, Uehara T (2020) Baloxavir marboxil for prophylaxis against Influenza in household contacts. N Engl J Med 383(4):309–320

    Article  CAS  Google Scholar 

  10. Sakai-Tagawa Y, Ozawa M, Tamura D, Le M, Nidom CA, Sugaya N, Kawaoka Y (2010) Sensitivity of influenza rapid diagnostic tests to H5N1 and 2009 pandemic H1N1 viruses. J Clin Microbiol 48(8):2872–2877

    Article  Google Scholar 

  11. Hayden FG, Osterhaus AD, Treanor JJ, Fleming DM, Aoki FY, Nicholson KG, Bohnen AM, Hirst HM, Keene O, Wightman K (1997) Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenza virus infections. GG167 Influenza Study Group. N Engl J Med 337(13):874–880

    Google Scholar 

  12. Ruest A, Michaud S, Deslandes S, Frost EH (2003) Comparison of the Directigen flu A+B test, the QuickVue influenza test, and clinical case definition to viral culture and reverse transcription-PCR for rapid diagnosis of influenza virus infection. J Clin Microbiol 41(8):3487–3493

    Article  CAS  Google Scholar 

  13. Smith GP, Petrenko VA (1997) Phage display. Chem Rev 97(2):391–410

    Article  CAS  Google Scholar 

  14. Matsubara T, Onishi A, Saito T, Shimada A, Inoue H, Taki T, Nagata K, Okahata Y, Sato T (2010) Sialic acid-mimic peptides as hemagglutinin inhibitors for anti-influenza therapy. J Med Chem 53(11):4441–4449

    Article  CAS  Google Scholar 

  15. Hatano K, Matsubara T, Muramatsu Y, Ezure M, Koyama T, Matsuoka K, Kuriyama R, Kori H, Sato T (2014) Synthesis and influenza virus inhibitory activities of carbosilane dendrimers peripherally functionalized with hemagglutinin-binding peptide. J Med Chem 57(20):8332–8339

    Article  CAS  Google Scholar 

  16. Matsubara T, Onishi A, Yamaguchi D, Sato T (2016) Heptapeptide ligands against receptor-binding sites of influenza hemagglutinin toward anti-influenza therapy. Bioorg Med Chem 24(5):1106–1114

    Article  CAS  Google Scholar 

  17. Luong JH, Male KB, Glennon JD (2009) Boron-doped diamond electrode: synthesis, characterization, functionalization and analytical applications. Analyst 134(10):1965–1979

    Article  CAS  Google Scholar 

  18. Einaga Y (2010) Diamond electrodes for electrochemical analysis. J Appl Electrochem 40(10):1807–1816

    Article  CAS  Google Scholar 

  19. Leroux YR, Fei H, Noel JM, Roux C, Hapiot P (2010) Efficient covalent modification of a carbon surface: use of a silyl protecting group to form an active monolayer. J Am Chem Soc 132(40):14039–14041

    Article  CAS  Google Scholar 

  20. Natsui K, Yamamoto T, Akahori M, Einaga Y (2015) Photochromism-induced amplification of critical current density in superconducting boron-doped diamond with an azobenzene molecular layer. ACS Appl Mater Interfaces 7(1):887–894

    Article  CAS  Google Scholar 

  21. Matsubara T, Ujie M, Yamamoto T, Akahori M, Einaga Y, Sato T (2016) Highly sensitive detection of influenza virus by boron-doped diamond electrode terminated with sialic acid-mimic peptide. Proc Natl Acad Sci USA 113(32):8981–8984

    Article  CAS  Google Scholar 

  22. Matsubara T, Ujie M, Yamamoto T, Einaga Y, Daidoji T, Nakaya T, Sato T (2020) Avian influenza virus detection by optimized peptide termination on a boron-doped diamond electrode. ACS Sens 5(2):431–439

    Article  CAS  Google Scholar 

  23. Kolb HC, Finn MG, Sharpless KB (2001) Click chemistry: diverse chemical function from a few good reactions. Angew Chem Int Ed 40(11):2004–2021

    Google Scholar 

  24. Yamamoto T, Akahori M, Natsui K, Saitoh T, Einaga Y (2018) Controlled decoration of boron-doped diamond electrodes by electrochemical click reaction (e–CLICK). Carbon 130:350–354

    Article  CAS  Google Scholar 

  25. Tam JP (1988) Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide system. Proc Natl Acad Sci USA 85(15):5409–5413

    Article  CAS  Google Scholar 

  26. Kira M, Matsubara T, Shinohara H, Sisido M (1997) Synthesis and redox property of polypeptides containing L-ferrocenylalanine. Chem Lett 1:89–90

    Article  Google Scholar 

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Acknowledgements

The bare BDD materials and guide of electrochemical procedures were provided by Prof. Y. Einaga and Prof. T. Yamamoto (Keio University). Electrochemical measurements were performed by Dr. M. Ujie and Ms. M. Akahori. Avian IFVs were provided by Prof. T. Nakaya and Prof. T. Daidoji (Kyoto Prefectural University of Medicine). We greatly thank all the collaborators.

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Correspondence to Toshinori Sato .

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Matsubara, T., Sato, T. (2022). Influenza Virus. In: Einaga, Y. (eds) Diamond Electrodes. Springer, Singapore. https://doi.org/10.1007/978-981-16-7834-9_15

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