Abstract
This chapter concentrated mainly on the use of stem cells and their products in tissue engineering and regenerative medicine. It showed the promising therapeutic role of stem cells and their products for many chronic debilitating diseases. Combining the suitable stem cells/products with the suitable biomaterial to engineer the therapy of choice for certain diseases that has no cure so far with no or minimum side effects is the ultimate goal of TERM. Researchers all over the world are working in their laboratories and producing results on daily basis regarding the latest in this multidisciplinary field that requires collaboration of basic scientists, physicians, biomedical and software engineers and members of the community to come up with a solution for most/if not all the diseases affecting humanity.
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References
Andreas K, Sittinger M, Ringe J (2014) Toward in situ tissue engineering: chemokine-guided stem cell recruitment. Trends Biotechnol 32(9):483–492. https://doi.org/10.1016/j.tibtech.2014.06.008
Arslan F, Lai RC, Smeets MB, Akeroyd L, Choo A, Aguor EN, Timmers L, van Rijen HV, Doevendans PA, Pasterkamp G, Lim SK, de Kleijn DP (2013) Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury. Stem Cell Res 10(3):301–312. https://doi.org/10.1016/j.scr.2013.01.002
Barreca MM, Cancemi P, Geraci F (2020) Mesenchymal and induced pluripotent stem cells-derived extracellular vesicles: the new frontier for regenerative medicine? Cell 9(5):1163. https://doi.org/10.3390/cells9051163
Bernardo ME, Fibbe WE (2013) Mesenchymal stromal cells: sensors and switchers of inflammation. Cell Stem Cell 13(4):392–402. https://doi.org/10.1016/j.stem.2013.09.006
Bertheuil N, Chaput B, Ménard C, Varin A, Laloze J, Watier E, Tarte K (2019) Adipose mesenchymal stromal cells: definition, immunomodulatory properties, mechanical isolation and interest for plastic surgery. Ann Chir Plast Esthet 64(1):1–10. https://doi.org/10.1016/j.anplas.2018.07.005
Bharadwaj S, Liu G, Shi Y, Wu R, Yang B, He T, Fan Y, Lu X, Zhou X, Liu H, Atala A, Rohozinski J, Zhang Y (2013) Multipotential differentiation of human urine-derived stem cells: potential for therapeutic applications in urology. Stem Cells (Dayton, Ohio) 31(9):1840–1856. https://doi.org/10.1002/stem.1424
Bjorklund LM, Sánchez-Pernaute R, Chung S, Andersson T, Chen IY, McNaught KS, Brownell AL, Jenkins BG, Wahlestedt C, Kim KS, Isacson O (2002) Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci U S A 99(4):2344–2349. https://doi.org/10.1073/pnas.022438099
Bruno S, Tapparo M, Collino F, Chiabotto G, Deregibus MC, Soares Lindoso R, Neri F, Kholia S, Giunti S, Wen S, Quesenberry P, Camussi G (2017) Renal regenerative potential of different extracellular vesicle populations derived from bone marrow mesenchymal stromal cells. Tissue Eng Part A 23(21–22):1262–1273. https://doi.org/10.1089/ten.TEA.2017.0069
Burt RK, Loh Y, Cohen B, Stefoski D, Balabanov R, Katsamakis G, Oyama Y, Russell EJ, Stern J, Muraro P, Rose J, Testori A, Bucha J, Jovanovic B, Milanetti F, Storek J, Voltarelli JC, Burns WH (2009) Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II study. Lancet Neurol 8(3):244–253. https://doi.org/10.1016/S1474-4422(09)70017-1
Caby MP, Lankar D, Vincendeau-Scherrer C, Raposo G, Bonnerot C (2005) Exosomal-like vesicles are present in human blood plasma. Int Immunol 17(7):879–887. https://doi.org/10.1093/intimm/dxh267
Candela ME, Geraci F, Turturici G, Taverna S, Albanese I, Sconzo G (2010) Membrane vesicles containing matrix metalloproteinase-9 and fibroblast growth factor-2 are released into the extracellular space from mouse mesoangioblast stem cells. J Cell Physiol 224:144–151. https://doi.org/10.1002/jcp.22111
Caplan AI (1991) Mesenchymal stem cells. J Orthop Res 9(5):641–650. https://doi.org/10.1002/jor.1100090504
Caplan AI (2017) Mesenchymal stem cells: time to change the name! Stem Cells Transl Med 6(6):1445–1451. https://doi.org/10.1002/sctm.17-0051
Caspi O, Huber I, Kehat I, Habib M, Arbel G, Gepstein A, Yankelson L, Aronson D, Beyar R, Gepstein L (2007) Transplantation of human embryonic stem cell-derived cardiomyocytes improves myocardial performance in infarcted rat hearts. J Am Coll Cardiol 50(19):1884–1893. https://doi.org/10.1016/j.jacc.2007.07.054
Chen X, Song XH, Yin Z, Zou XH, Wang LL, Hu H, Cao T, Zheng M, Ouyang HW (2009) Stepwise differentiation of human embryonic stem cells promotes tendon regeneration by secreting fetal tendon matrix and differentiation factors. Stem Cells (Dayton, Ohio) 27(6):1276–1287. https://doi.org/10.1002/stem.61
Chen JL, Yin Z, Shen WL, Chen X, Heng BC, Zou XH, Ouyang HW (2010) Efficacy of hESC-MSCs in knitted silk-collagen scaffold for tendon tissue engineering and their roles. Biomaterials 31(36):9438–9451. https://doi.org/10.1016/j.biomaterials.2010.08.011
Chen L, Xiang B, Wang X, Xiang C (2017) Exosomes derived from human menstrual blood-derived stem cells alleviate fulminant hepatic failure. Stem Cell Res Ther 8:9. https://doi.org/10.1186/s13287-016-0453-456
Chuang TJ, Lin KC, Chio CC, Wang CC, Chang CP, Kuo JR (2012) Effects of secretome obtained from normoxia-preconditioned human mesenchymal stem cells in traumatic brain injury rats. J Trauma Acute Care Surg 73(5):1161–1167. https://doi.org/10.1097/TA.0b013e318265d128
Collino F, Lopes JA, Tapparo M, Tortelote GG, Kasai-Brunswick TH, Lopes G, Almeida DB, Skovronova R, Wendt C, Miranda KR, Bussolati B, Vieyra A, Lindoso RS (2020) Extracellular vesicles derived from induced pluripotent stem cells promote renoprotection in acute kidney injury model. Cell 9(2):453. https://doi.org/10.3390/cells9020453
Colombo M, Raposo G, Théry C (2014) Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu Rev Cell Dev Biol 30:255–289. https://doi.org/10.1146/annurev-cellbio-101512-122326
Crisan M, Yap S, Casteilla L, Chen CW, Corselli M, Park TS, Andriolo G, Sun B, Zheng B, Zhang L, Norotte C, Teng PN, Traas J, Schugar R, Deasy BM, Badylak S, Buhring HJ, Giacobino JP, Lazzari L, Huard J et al (2008) A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 3(3):301–313. https://doi.org/10.1016/j.stem.2008.07.003
Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, Deans R, Keating A, Prockop D j, Horwitz E (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement. Cytotherapy 8(4):315–317. https://doi.org/10.1080/14653240600855905
Duan H, Ge W, Zhang A, Xi Y, Chen Z, Luo D, Cheng Y, Fan KS, Horvath S, Sofroniew MV, Cheng L, Yang Z, Sun YE, Li X (2015) Transcriptome analyses reveal molecular mechanisms underlying functional recovery after spinal cord injury. Proc Natl Acad Sci U S A 112(43):13360–13365. https://doi.org/10.1073/pnas.1510176112
Feng Y, Huang W, Wani M, Yu X, Ashraf M (2014) Ischemic preconditioning potentiates the protective effect of stem cells through secretion of exosomes by targeting Mecp2 via miR-22. PLoS One 9(2):e88685. https://doi.org/10.1371/journal.pone.0088685
Fontaine MJ, Shih H, Schäfer R, Pittenger MF (2016) Unraveling the mesenchymal stromal cells’ paracrine immunomodulatory effects. Transfus Med Rev 30:37–43. https://doi.org/10.1016/j.tmrv.2015.11.004
Fu JD, Stone NR, Liu L, Spencer CI, Qian L, Hayashi Y, Delgado-Olguin P, Ding S, Bruneau BG, Srivastava D (2013) Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. Stem Cell Rep 1(3):235–247. https://doi.org/10.1016/j.stemcr.2013.07.005
Gatti S, Bruno S, Deregibus MC, Sordi A, Cantaluppi V, Tetta C, Camussi G (2011) Microvesicles derived from human adult mesenchymal stem cells protect against ischaemia-reperfusion-induced acute and chronic kidney injury. Nephrol Dial Transplant Official Publ Eur Dial Transplant Assoc Eur Renal Assoc 26(5):1474–1483. https://doi.org/10.1093/ndt/gfr015
Gazdhar A, Grad I, Tamò L, Gugger M, Feki A, Geiser T (2014) The secretome of induced pluripotent stem cells reduces lung fibrosis in part by hepatocyte growth factor. Stem Cell Res Ther 5(6):123. https://doi.org/10.1186/scrt513
Gimble JM, Katz AJ, Bunnell BA (2007) Adipose-derived stem cells for regenerative medicine. Circ Res 100(9):1249–1260. https://doi.org/10.1161/01.RES.0000265074.83288.09
György B, Szabó TG, Pásztói M, Pál Z, Misják P, Aradi B, László V, Pállinger E, Pap E, Kittel A, Nagy G, Falus A, Buzás EI (2011) Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles. Cell Mol Life Sci CMLS 68(16):2667–2688. https://doi.org/10.1007/s00018-011-0689-3
Hagège AA, Marolleau JP, Vilquin JT, Alhéritière A, Peyrard S, Duboc D, Abergel E, Messas E, Mousseaux E, Schwartz K, Desnos M, Menasché P (2006) Skeletal myoblast transplantation in ischemic heart failure: long-term follow-up of the first phase I cohort of patients. Circulation 114(1 Suppl):I108–I113. https://doi.org/10.1161/CIRCULATIONAHA.105.000521
Han Y, Li X, Zhang Y, Han Y, Chang F, Ding J (2019) Mesenchymal stem cells for regenerative medicine. Cell 8(8):886. https://doi.org/10.3390/cells8080886
Haynesworth SE, Goshima J, Goldberg VM, Caplan AI (1992) Characterization of cells with osteogenic potential from human marrow. Bone 13(1):81–88. https://doi.org/10.1016/8756-3282(92)90364-3
Hutmacher DW (2000) Scaffolds in tissue engineering bone and cartilage. Biomaterials 21(24):2529–2543. https://doi.org/10.1016/s0142-9612(00)00121-6
Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau BG, Srivastava D (2010) Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell 142(3):375–386. https://doi.org/10.1016/j.cell.2010.07.002
Im W, Ban J, Lim J, Lee M, Lee ST, Chu K, Kim M (2013) Extracts of adipose derived stem cells slows progression in the R6/2 model of Huntington's disease. PLoS One 8(4):e59438. https://doi.org/10.1371/journal.pone.0059438
Jiang W, Tan Y, Cai M, Zhao T, Mao F, Zhang X, Xu W, Yan Z, Qian H, Yan Y (2018) Human umbilical cord MSC-derived exosomes suppress the development of CCl4-induced liver injury through antioxidant effect. Stem Cells Int 2018:6079642. https://doi.org/10.1155/2018/6079642
Karp JM, Leng Teo GS (2009) Mesenchymal stem cell homing: the devil is in the details. Cell Stem Cell 4(3):206–216. https://doi.org/10.1016/j.stem.2009.02.001
Kern S, Eichler H, Stoeve J, Klüter H, Bieback K (2006) Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells (Dayton, Ohio) 24(5):1294–1301. https://doi.org/10.1634/stemcells.2005-0342
Kikuchi K, Masuda T, Fujiwara N, Kuji A, Miura H, Jung HS et al (2018) Craniofacial bone regeneration using iPS cell-derived neural crest like cells. J Hard Tissue Biol 27:1–10. https://doi.org/10.2485/jhtb.27.1
Kim DK, Nishida H, An SY, Shetty AK, Bartosh TJ, Prockop DJ (2016) Chromatographically isolated CD63+CD81+ extracellular vesicles from mesenchymal stromal cells rescue cognitive impairments after TBI. Proc Natl Acad Sci U S A 113(1):170–175. https://doi.org/10.1073/pnas.1522297113
Kumamoto M, Nishiwaki T, Matsuo N, Kimura H, Matsushima K (2009) Minimally cultured bone marrow mesenchymal stem cells ameliorate fibrotic lung injury. Eur Respir J 34(3):740–748. https://doi.org/10.1183/09031936.00128508
Kupcova Skalnikova H (2013) Proteomic techniques for characterisation of mesenchymal stem cell secretome. Biochimie 95(12):2196–2211. https://doi.org/10.1016/j.biochi.2013.07.015
Laflamme MA, Chen KY, Naumova AV, Muskheli V, Fugate JA, Dupras SK, Reinecke H, Xu C, Hassanipour M, Police S, O'Sullivan C, Collins L, Chen Y, Minami E, Gill EA, Ueno S, Yuan C, Gold J, Murry CE (2007) Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol 25(9):1015–1024. https://doi.org/10.1038/nbt1327
Lai RC, Arslan F, Lee MM, Sze NS, Choo A, Chen TS, Salto-Tellez M, Timmers L, Lee CN, El Oakley RM, Pasterkamp G, de Kleijn DP, Lim SK (2010) Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res 4(3):214–222. https://doi.org/10.1016/j.scr.2009.12.003
Lataillade JJ, Doucet C, Bey E, Carsin H, Huet C, Clairand I, Bottollier-Depois JF, Chapel A, Ernou I, Gourven M, Boutin L, Hayden A, Carcamo C, Buglova E, Joussemet M, de Revel T, Gourmelon P (2007) New approach to radiation burn treatment by dosimetry-guided surgery combined with autologous mesenchymal stem cell therapy. Regen Med 2(5):785–794. https://doi.org/10.2217/17460751.2.5.785
Leblond AL, Naud P, Forest V, Gourden C, Sagan C, Romefort B, Mathieu E, Delorme B, Collin C, Pagès JC, Sensebé L, Pitard B, Lemarchand P (2009) Developing cell therapy techniques for respiratory disease: intratracheal delivery of genetically engineered stem cells in a murine model of airway injury. Hum Gene Ther 20(11):1329–1343. https://doi.org/10.1089/hum.2009.035
Lee CY, Landreth GE (2010) The role of microglia in amyloid clearance from the AD brain. J Neural Transm (Vienna, Austria: 1996) 117(8):949–960. https://doi.org/10.1007/s00702-010-0433-4
Lee C, Mitsialis SA, Aslam M, Vitali SH, Vergadi E, Konstantinou G, Sdrimas K, Fernandez-Gonzalez A, Kourembanas S (2012a) Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension. Circulation 126(22):2601–2611. https://doi.org/10.1161/CIRCULATIONAHA.112.114173
Lee PY, Chien Y, Chiou GY, Lin CH, Chiou CH, Tarng DC (2012b) Induced pluripotent stem cells without c-Myc attenuate acute kidney injury via downregulating the signaling of oxidative stress and inflammation in ischemia-reperfusion rats. Cell Transplant 21(12):2569–2585. https://doi.org/10.3727/096368912X636902
Lee HJ, Lee JK, Lee H, Carter JE, Chang JW, Oh W, Yang YS, Suh JG, Lee BH, Jin HK, Bae JS (2012c) Human umbilical cord blood-derived mesenchymal stem cells improve neuropathology and cognitive impairment in an Alzheimer's disease mouse model through modulation of neuroinflammation. Neurobiol Aging 33(3):588–602. https://doi.org/10.1016/j.neurobiolaging.2010.03.024
Li X, Yang Z, Zhang A, Wang T, Chen W (2009) Repair of thoracic spinal cord injury by chitosan tube implantation in adult rats. Biomaterials 30(6):1121–1132. https://doi.org/10.1016/j.biomaterials.2008.10.063
Li D, Zhu L, Liu Y, Yin Z, Liu Y, Liu F, He A, Feng S, Zhang Y, Zhang Z, Zhang W, Liu W, Cao Y, Zhou G (2017) Stable subcutaneous cartilage regeneration of bone marrow stromal cells directed by chondrocyte sheet. Acta Biomater 54:321–332. https://doi.org/10.1016/j.actbio.2017.03.031
Li W, Liu Y, Zhang P, Tang Y, Zhou M, Jiang W, Zhang X, Wu G, Zhou Y (2018) Tissue-engineered bone immobilized with human adipose stem cells-derived exosomes promotes bone regeneration. ACS Appl Mater Interfaces 10(6):5240–5254. https://doi.org/10.1021/acsami.7b17620
Lim KS, Baptista M, Moon S, Woodfield TBF, Rnjak-Kovacina J (2019) Microchannels in development, survival, and vascularisation of tissue analogues for regenerative medicine. Trends Biotechnol 37(11):1189–1201. https://doi.org/10.1016/j.tibtech.2019.04.004
Linard C, Brachet M, L'homme B, Strup-Perrot C, Busson E, Bonneau M, Lataillade JJ, Bey E, Benderitter M (2018) Long-term effectiveness of local BM-MSCs for skeletal muscle regeneration: a proof of concept obtained on a pig model of severe radiation burn. Stem Cell Res Ther 9(1):299. https://doi.org/10.1186/s13287-018-1051-6
Lindroos B, Suuronen R, Miettinen S (2011) The potential of adipose stem cells in regenerative medicine. Stem Cell Rev 7:269–291. https://doi.org/10.1007/s12015-010-9193-9197
Lindvall O, Kokaia Z (2006) Stem cells for the treatment of neurological disorders. Nature 441(7097):1094–1096. https://doi.org/10.1038/nature04960
Liu S, Jiang L, Li H, Shi H, Luo H, Zhang Y, Yu C, Jin Y (2014) Mesenchymal stem cells prevent hypertrophic scar formation via inflammatory regulation when undergoing apoptosis. J Invest Dermatol 134(10):2648–2657. https://doi.org/10.1038/jid.2014.169
Liu W, Yin L, Yan X, Cui J, Liu W, Rao Y, Sun M, Wei Q, Chen F (2017) Directing the differentiation of parthenogenetic stem cells into tenocytes for tissue-engineered tendon regeneration. Stem Cells Transl Med 6(1):196–208. https://doi.org/10.5966/sctm.2015-0334
Liu B, Lee BW, Nakanishi K, Villasante A, Williamson R, Metz J, Kim J, Kanai M, Bi L, Brown K, Di Paolo G, Homma S, Sims PA, Topkara VK, Vunjak-Novakovic G (2018) Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells. Nature Biomed Eng 2(5):293–303. https://doi.org/10.1038/s41551-018-0229-7
Lu W, Yu J, Zhang Y, Ji K, Zhou Y, Li Y, Deng Z, Jin Y (2012) Mixture of fibroblasts and adipose tissue-derived stem cells can improve epidermal morphogenesis of tissue-engineered skin. Cells Tissues Organs 195(3):197–206. https://doi.org/10.1159/000324921
Lysaght MJ, Crager J (2009) Origins. Tissue Eng Part A 15:1449–1450. https://doi.org/10.1089/ten.tea.2007.0412
Mahla RS (2016) Stem cells applications in regenerative medicine and disease therapeutics. Int J Cell Biol 2016:6940283. https://doi.org/10.1155/2016/6940283
Malik N, Rao MS (2013) A review of the methods for human iPSC derivation. Methods Mol Biol (Clifton, N.J.) 997:23–33. https://doi.org/10.1007/978-1-62703-348-0_3
Mansilla E, MarÃn GH, Drago H, Sturla F, Salas E, Gardiner C, Bossi S, Lamonega R, Guzmán A, Nuñez A, Gil MA, Piccinelli G, Ibar R, Soratti C (2006) Bloodstream cells phenotypically identical to human mesenchymal bone marrow stem cells circulate in large amounts under the influence of acute large skin damage: new evidence for their use in regenerative medicine. Transplant Proc 38(3):967–969. https://doi.org/10.1016/j.transproceed.2006.02.053
Mao Q, Nguyen PD, Shanti RM, Shi S, Shakoori P, Zhang Q, Le AD (2019) Gingiva-derived mesenchymal stem cell-extracellular vesicles activate Schwann cell repair phenotype and promote nerve regeneration. Tissue Eng Part A 25(11–12):887–900. https://doi.org/10.1089/ten.TEA.2018.0176
Marquez-Curtis LA, Janowska-Wieczorek A, McGann LE, Elliott JA (2015) Mesenchymal stromal cells derived from various tissues: biological, clinical and cryopreservation aspects. Cryobiology 71(2):181–197. https://doi.org/10.1016/j.cryobiol.2015.07.003
Mazini L, Rochette L, Amine M, Malka G (2019) Regenerative capacity of adipose derived stem cells (ADSCs), comparison with mesenchymal stem cells (MSCs). Int J Mol Sci 20(10):2523. https://doi.org/10.3390/ijms20102523
Menasché P, Alfieri O, Janssens S, McKenna W, Reichenspurner H, Trinquart L, Vilquin JT, Marolleau JP, Seymour B, Larghero J, Lake S, Chatellier G, Solomon S, Desnos M, Hagège AA (2008) The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation. Circulation 117(9):1189–1200. https://doi.org/10.1161/CIRCULATIONAHA.107.734103
Mizuno H (2010) Adipose-derived stem and stromal cells for cell-based therapy: current status of preclinical studies and clinical trials. Curr Opin Mol Ther 12(4):442–449
Moodley Y, Atienza D, Manuelpillai U, Samuel CS, Tchongue J, Ilancheran S, Boyd R, Trounson A (2009) Human umbilical cord mesenchymal stem cells reduce fibrosis of bleomycin-induced lung injury. Am J Pathol 175(1):303–313. https://doi.org/10.2353/ajpath.2009.080629
Moon GJ, Sung JH, Kim DH, Kim EH, Cho YH, Son JP, Cha JM, Bang OY (2019) Application of mesenchymal stem cell-derived extracellular vesicles for stroke: biodistribution and MicroRNA study. Transl Stroke Res 10(5):509–521. https://doi.org/10.1007/s12975-018-0668-1
Morel O, Toti F, Hugel B, Freyssinet JM (2004) Cellular microparticles: a disseminated storage pool of bioactive vascular effectors. Curr Opin Hematol 11(3):156–164. https://doi.org/10.1097/01.moh.0000131441.10020.87
Mousa NA, Abou-Taleb HA, Orabi H (2015) Stem cell applications for pathologies of the urinary bladder. World J Stem Cells 7(5):815–822. https://doi.org/10.4252/wjsc.v7.i5.815
Nasef A, Ashammakhi N, Fouillard L (2008) Immunomodulatory effect of mesenchymal stromal cells: possible mechanisms. Regen Med 3(4):531–546. https://doi.org/10.2217/17460751.3.4.531
Oh M, Lee J, Kim YJ, Rhee WJ, Park JH (2018) Exosomes derived from human induced pluripotent stem cells ameliorate the aging of skin fibroblasts. Int J Mol Sci 19(6):1715. https://doi.org/10.3390/ijms19061715
Omole AE, Fakoya A (2018) Ten years of progress and promise of induced pluripotent stem cells: historical origins, characteristics, mechanisms, limitations, and potential applications. PeerJ 6:e4370. https://doi.org/10.7717/peerj.4370
Ouyang HW, Toh SL, Goh J, Tay TE, Moe K (2005) Assembly of bone marrow stromal cell sheets with knitted poly (L-lactide) scaffold for engineering ligament analogs. J Biomed Mater Res Part B Appl Biomater 75B:264–271. https://doi.org/10.1002/jbm.b.30281
Pan W, Zhu Y, Meng X, Zhang C, Yang Y, Bei Y (2019) Immunomodulation by exosomes in myocardial infarction. J Cardiovasc Transl Res 12(1):28–36. https://doi.org/10.1007/s12265-018-9836-7
Park YB, Ha CW, Lee CH, Yoon YC, Park YG (2017) Cartilage regeneration in osteoarthritic patients by a composite of allogeneic umbilical cord blood-derived mesenchymal stem cells and hyaluronate hydrogel: results from a clinical trial for safety and proof-of-concept with 7 years of extended follow-up. Stem Cells Transl Med 6:613–621. https://doi.org/10.5966/sctm.2016-2157
Park YB, Ha CW, Kim JA, Kim S, Park YG (2019) Comparison of undifferentiated versus chondrogenic predifferentiated mesenchymal stem cells derived from human umbilical cord blood for cartilage repair in a rat model. Am J Sports Med 47:451–461. https://doi.org/10.1177/0363546518815151
Patel NA, Moss LD, Lee JY, Tajiri N, Acosta S, Hudson C, Parag S, Cooper DR, Borlongan CV, Bickford PC (2018) Long noncoding RNA MALAT1 in exosomes drives regenerative function and modulates inflammation-linked networks following traumatic brain injury. J Neuroinflammation 15(1):204. https://doi.org/10.1186/s12974-018-1240-3
Phinney DG, Pittenger MF (2017) Concise review: MSC-derived exosomes for cell-free therapy. Stem Cells (Dayton, Ohio) 35(4):851–858. https://doi.org/10.1002/stem.2575
Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR (1999) Multilineage potential of adult human mesenchymal stem cells. Science (New York, NY) 284(5411):143–147. https://doi.org/10.1126/science.284.5411.143
Porada CD, Atala AJ, Almeida-Porada G (2016) The hematopoietic system in the context of regenerative medicine. Methods 99:44–61. https://doi.org/10.1016/j.ymeth.2015.08.015
Potter DR, Miyazawa BY, Gibb SL, Deng X, Togaratti PP, Croze RH, Srivastava AK, Trivedi A, Matthay M, Holcomb JB, Schreiber MA, Pati S (2018) Mesenchymal stem cell-derived extracellular vesicles attenuate pulmonary vascular permeability and lung injury induced by hemorrhagic shock and trauma. J Trauma Acute Care Surg 84(2):245–256. https://doi.org/10.1097/TA.0000000000001744
Ratajczak J, Wysoczynski M, Hayek F, Janowska-Wieczorek A, Ratajczak MZ (2006) Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication. Leukemia 20(9):1487–1495. https://doi.org/10.1038/sj.leu.2404296
Ren ML, Peng W, Yang ZL, Sun XJ, Zhang SC, Wang ZG, Zhang B (2012) Allogeneic adipose-derived stem cells with low immunogenicity constructing tissue-engineered bone for repairing bone defects in pigs. Cell Transplant 21(12):2711–2721. https://doi.org/10.3727/096368912X654966
Rodeheffer MS, Birsoy K, Friedman JM (2008) Identification of white adipocyte progenitor cells in vivo. Cell 135:240–249. https://doi.org/10.1016/j.cell.2008.09.036
Rodriguez AM, Elabd C, Amri EZ, Ailhaud G, Dani C (2005) The human adipose tissue is a source of multipotent stem cells. Biochimie 87:125–128. https://doi.org/10.1016/j.biochi.2004.11.007
Romanov YA, Svintsitskaya VA, Smirnov VN (2003) Searching for alternative sources of postnatal human mesenchymal stem cells: candidate MSC-like cells from umbilical cord. Stem Cells 21:105–110. https://doi.org/10.1634/stemcells.21-1-105
Ruetze M, Richter W (2014) Adipose-derived stromal cells for osteoarticular repair: trophic function versus stem cell activity. Expert Rev Mol Med 16:e9. https://doi.org/10.1017/erm.2014.9
Sacchetti B, Funari A, Michienzi S, Di Cesare S, Piersanti S, Saggio I, Tagliafico E, Ferrari S, Robey PG, Riminucci M, Bianco P (2007) Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell 131(2):324–336. https://doi.org/10.1016/j.cell.2007.08.025
Sadahiro T, Yamanaka S, Ieda M (2015) Direct cardiac reprogramming: progress and challenges in basic biology and clinical applications. Circ Res 116:1378–1391. https://doi.org/10.1161/CIRCRESAHA.116.305374
Salgado AJ, Oliveira JM, Martins A, Teixeira FG, Silva NA, Neves NM, Sousa N, Reis RL (2013) Tissue engineering and regenerative medicine: past, present, and future. Int Rev Neurobiol 108:1–33. https://doi.org/10.1016/B978-0-12-410499-0.00001-0
Schäfer R, Spohn G, Baer PC (2016) Mesenchymal stem/stromal cells in regenerative medicine: can preconditioning strategies improve therapeutic efficacy? Transfus Med Hemother 43:256–267. https://doi.org/10.1159/000447458
Shao L, Zhang Y, Lan B, Wang J, Zhang Z, Zhang L, Xiao P, Meng Q, Geng YJ, Yu XY, Li Y (2017) MiRNA-sequence indicates that mesenchymal stem cells and exosomes have similar mechanism to enhance cardiac repair. Biomed Res Int 2017:4150705. https://doi.org/10.1155/2017/4150705
Shi Q, Qian Z, Liu D, Sun J, Wang X, Liu H, Xu J, Guo X (2017) GMSC-derived exosomes combined with a chitosan/silk hydrogel sponge accelerates wound healing in a diabetic rat skin defect model. Front Physiol 8:904. https://doi.org/10.3389/fphys.2017.00904
Shiba Y, Fernandes S, Zhu WZ, Filice D, Muskheli V, Kim J, Palpant NJ, Gantz J, Moyes KW, Reinecke H, Van Biber B, Dardas T, Mignone JL, Izawa A, Hanna R, Viswanathan M, Gold JD, Kotlikoff MI, Sarvazyan N, Kay MW et al (2012) Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts. Nature 489(7415):322–325. https://doi.org/10.1038/nature11317
Sionkowska A, Płanecka A (2013) Preparation and characterization of silk fibroin/chitosan composite sponges for tissue engineering. J Mol Liq 178:5–14. https://doi.org/10.1016/j.molliq.2012.10.042
Skop NB, Calderon F, Cho CH, Gandhi CD, Levison SW (2014) Improvements in biomaterial matrices for neural precursor cell transplantation. Mol Cell Ther 2:19. https://doi.org/10.1186/2052-8426-2-19
Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663–676. https://doi.org/10.1016/j.cell.2006.07.024
Tang XD, Shi L, Monsel A, Li XY, Zhu HL, Zhu YG, Qu JM (2017) Mesenchymal stem cell microvesicles attenuate acute lung injury in mice partly mediated by Ang-1 mRNA. Stem Cells (Dayton, Ohio) 35(7):1849–1859. https://doi.org/10.1002/stem.2619
Théry C, Amigorena S, Raposo G, Clayton A (2006) Isolation and characterization of exosomes from cell culture supernatants and biological fluids. In: Current protocols in cell biology, Chapter 3. https://doi.org/10.1002/0471143030.cb0322s30
Théry C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, Ayre DC, Bach JM, Bachurski D, Baharvand H, Balaj L, Baldacchino S, Bauer NN, Baxter AA, Bebawy M, Beckham C et al (2018) Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracellular Vesicles 7(1):1535750. https://doi.org/10.1080/20013078.2018.1535750
Tsuji O, Sugai K, Yamaguchi R, Tashiro S, Nagoshi N, Kohyama J, Iida T, Ohkubo T, Itakura G, Isoda M, Shinozaki M, Fujiyoshi K, Kanemura Y, Yamanaka S, Nakamura M, Okano H (2019) Concise review: laying the groundwork for a first-in-human study of an induced pluripotent stem cell-based intervention for spinal cord injury. Stem Cells (Dayton, Ohio) 37(1):6–13. https://doi.org/10.1002/stem.2926
Turturici G, Tinnirello R, Sconzo G, Geraci F (2014) Extracellular membrane vesicles as a mechanism of cell-to-cell communication: advantages and disadvantages. Am J Physiol Cell Physiol 306(7):C621–C633. https://doi.org/10.1152/ajpcell.00228.2013
Ullah I, Subbarao RB, Rho GJ (2015) Human mesenchymal stem cells - Current trends and future prospective. Biosci Rep 35(2):e00191. https://doi.org/10.1042/BSR20150025
van Laake LW, Passier R, Monshouwer-Kloots J, Verkleij AJ, Lips DJ, Freund C, den Ouden K, Ward-van Oostwaard D, Korving J, Tertoolen LG, van Echteld CJ, Doevendans PA, Mummery CL (2007) Human embryonic stem cell-derived cardiomyocytes survive and mature in the mouse heart and transiently improve function after myocardial infarction. Stem Cell Res 1(1):9–24. https://doi.org/10.1016/j.scr.2007.06.001
Wada R, Muraoka N, Inagawa K, Yamakawa H, Miyamoto K, Sadahiro T, Umei T, Kaneda R, Suzuki T, Kamiya K, Tohyama S, Yuasa S, Kokaji K, Aeba R, Yozu R, Yamagishi H, Kitamura T, Fukuda K, Ieda M (2013) Induction of human cardiomyocyte-like cells from fibroblasts by defined factors. Proc Natl Acad Sci U S A 110(31):12667–12672. https://doi.org/10.1073/pnas.1304053110
Wang Y, Zhang L, Li Y, Chen L, Wang X, Guo W, Zhang X, Qin G, He SH, Zimmerman A, Liu Y, Kim IM, Weintraub NL, Tang Y (2015) Exosomes/microvesicles from induced pluripotent stem cells deliver cardioprotective miRNAs and prevent cardiomyocyte apoptosis in the ischemic myocardium. Int J Cardiol 192:61–69. https://doi.org/10.1016/j.ijcard.2015.05.020
Wang Y, Tan H, Hui X (2018) Biomaterial scaffolds in regenerative therapy of the central nervous system. Biomed Res Int. https://doi.org/10.1155/2018/7848901
Wei Y, Wu Y, Zhao R, Zhang K, Midgley AC, Kong D, Li Z, Zhao Q (2019) MSC-derived sEVs enhance patency and inhibit calcification of synthetic vascular grafts by immunomodulation in a rat model of hyperlipidemia. Biomaterials 204:13–24. https://doi.org/10.1016/j.biomaterials.2019.01.049
Willerth SM, Sakiyama-Elbert SE (2008) Combining stem cells and biomaterial scaffolds for constructing tissues and cell delivery. In: StemBook (ed) The stem cell research community. https://doi.org/10.3824/stembook.1.1.1
Williams DF (2008) On the mechanisms of biocompatibility. Biomaterials 29(20):2941–2953. https://doi.org/10.1016/j.biomaterials.2008.04.023
Williams AR, Hare JM, Dimmeler S, Losordo D (2011) Mesenchymal stem cells: biology, pathophysiology, translational findings, and therapeutic implications for cardiac disease. Circ Res 109:923–940. https://doi.org/10.1161/CIRCRESAHA.111.243147
Wong WH, Mooney DJ (1997) Synthesis and properties of biodegradable polymers used as synthetic matrices for tissue engineering. In: Atala A, Mooney DJ (eds) Synthetic biodegradable polymer scaffolds. Birkhäuser, Boston. https://doi.org/10.1007/978-1-4612-4154-6_4
Wu Z, Zhou Q, Duan H, Wang X, Xiao J, Duan H, Li N, Li C, Wan P, Liu Y, Song Y, Zhou C, Huang Z, Wang Z (2014) Reconstruction of auto-tissue-engineered lamellar cornea by dynamic culture for transplantation: a rabbit model. PLoS One 9(4):e93012. https://doi.org/10.1371/journal.pone.0093012
Wu R, Huang C, Wu Q, Jia X, Liu M, Xue Z, Qiu Y, Niu X, Wang Y (2019) Exosomes secreted by urine-derived stem cells improve stress urinary incontinence by promoting repair of pubococcygeus muscle injury in rats. Stem Cell Res Ther 10(1):80. https://doi.org/10.1186/s13287-019-1182-4
Xiang B, Chen L, Wang X, Zhao Y, Wang Y, Xiang C (2017) Transplantation of menstrual blood-derived mesenchymal stem cells promotes the repair of LPS-induced acute lung injury. Int J Mol Sci 18(4):689. https://doi.org/10.3390/ijms18040689
Xie H, Wang Z, Zhang L, Lei Q, Zhao A, Wang H, Li Q, Cao Y, Jie Zhang W, Chen Z (2017) Extracellular vesicle-functionalized decalcified bone matrix scaffolds with enhanced pro-angiogenic and pro-bone regeneration activities. Sci Rep 7:45622. https://doi.org/10.1038/srep45622
Xuan W, Wang L, Xu M, Weintraub NL, Ashraf M (2019) miRNAs in extracellular vesicles from iPS-derived cardiac progenitor cells effectively reduce fibrosis and promote angiogenesis in infarcted heart. Stem Cells Int 2019:3726392. https://doi.org/10.1155/2019/3726392
Yamashita K, Inagaki E, Hatou S, Higa K, Ogawa A, Miyashita H, Tsubota K, Shimmura S (2018) Corneal endothelial regeneration using mesenchymal stem cells derived from human umbilical cord. Stem Cells Dev 27(16):1097–1108. https://doi.org/10.1089/scd.2017.0297
Yarlagadda PK, Chandrasekharan M, Shyan JY (2005) Recent advances and current developments in tissue scaffolding. Biomed Mater Eng 15(3):159–177
Zeng X, Zeng YS, Ma YH, Lu LY, Du BL, Zhang W, Li Y, Chan WY (2011) Bone marrow mesenchymal stem cells in a three-dimensional gelatin sponge scaffold attenuate inflammation, promote angiogenesis, and reduce cavity formation in experimental spinal cord injury. Cell Transplant 20(11–12):1881–1899. https://doi.org/10.3727/096368911X566181
Zeng X, Ma YH, Chen YF, Qiu XC, Wu JL, Ling EA, Zeng YS (2016) Autocrine fibronectin from differentiating mesenchymal stem cells induces the neurite elongation in vitro and promotes nerve fiber regeneration in transected spinal cord injury. J Biomed Mater Res Part A 104(8):1902–1911. https://doi.org/10.1002/jbm.a.35720
Zhang D, Wei G, Li P, Zhou X, Zhang Y (2014a) Urine-derived stem cells: a novel and versatile progenitor source for cell-based therapy and regenerative medicine. Genes Dis 1:8–17. https://doi.org/10.1016/j.gendis.2014.07.001
Zhang L, He A, Yin Z, Yu Z, Luo X, Liu W, Zhang W, Cao Y, Liu Y, Zhou G (2014b) Regeneration of human-ear-shaped cartilage by co-culturing human microtia chondrocytes with BMSCs. Biomaterials 35(18):4878–4887. https://doi.org/10.1016/j.biomaterials.2014.02.043
Zhao Y, Chen X, Wu Y, Wang Y, Li Y, Xiang C (2018) Transplantation of human menstrual blood-derived mesenchymal stem cells alleviates Alzheimer’s disease-like pathology in APP/PS1 transgenic mice. Front Mol Neurosci 11:140. https://doi.org/10.3389/fnmol.2018.00140
Zheng B, Cao B, Crisan M, Sun B, Li G, Logar A, Yap S, Pollett JB, Drowley L, Cassino T, Gharaibeh B, Deasy BM, Huard J, Péault B (2007) Prospective identification of myogenic endothelial cells in human skeletal muscle. Nat Biotechnol 25(9):1025–1034. https://doi.org/10.1038/nbt1334
Zhou C, Yang B, Tian Y, Jiao H, Zheng W, Wang J, Guan F (2011) Immunomodulatory effect of human umbilical cord Wharton’s jelly-derived mesenchymal stem cells on lymphocytes. Cell Immunol 272(1):33–38. https://doi.org/10.1016/j.cellimm.2011.09.010
Zou X, Gu D, Xing X, Cheng Z, Gong D, Zhang G, Zhu Y (2016) Human mesenchymal stromal cell-derived extracellular vesicles alleviate renal ischemic reperfusion injury and enhance angiogenesis in rats. Am J Transl Res 8(10):4289–4299
Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H, Alfonso ZC, Fraser JK, Benhaim P, Hedrick MH (2002) Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 13(12):4279–4295. https://doi.org/10.1091/mbc.e02-02-0105
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Al Ghamdi, K. (2022). Stem Cell Therapy: Significance and Applications of Stem Cell Products in Tissue Engineering and Regenerative Medicine. In: Khan, F.A. (eds) Stem Cell Production. Springer, Singapore. https://doi.org/10.1007/978-981-16-7589-8_1
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