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Chromosomal Organization of DNA

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Abstract

In this chapter, we will understand how the ginormous amount of genetic information is packaged in a cell to not only be accommodated in a limited space but be functionally efficient as well. We will take a close look at DNA packaging in both bacterial and eukaryotic cells. In the eukaryotic cell, each DNA molecule undergoes structured levels of compaction, starting from the nucleosome assembly, to a solenoid and finally to a highly compacted chromosome with heterochromatic and euchromatin regions. Each eukaryotic chromosome has a distinct karyotype with its individual banding pattern. We will close with a discussion on key structural features of a chromosome and specialized chromosomes.

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Gupta, P. (2022). Chromosomal Organization of DNA. In: Kar, D., Sarkar, S. (eds) Genetics Fundamentals Notes. Springer, Singapore. https://doi.org/10.1007/978-981-16-7041-1_8

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