Homocysteine Metabolism as a Biomarker for Cancer

Kathpalia, Meghavi; Kumar, Prashant; Mohapatra, Swati

doi:10.1007/978-981-16-6867-8_8

Meghavi Kathpalia⁵^na1,
Prashant Kumar⁶^na1 &
Swati Mohapatra^7,8^na1

319 Accesses

Abstract

Changes in methyl group metabolism and homocysteine balance have been implicated in various clinical disorders in recent decades. Elevated circulating homocysteine concentrations are linked to various dietary, hormonal, and genetic variables, cancer development, and autoimmunity. Here in this chapter, we have explained detailed links about homocysteine and cancer. Homocysteine is a sulfur-containing amino acid that is metabolized via one of the two pathways: remethylation or transsulfuration. It is produced from the metabolism of methionine, an essential amino acid. Abnormalities cause hyperhomocysteinemia in this mechanism. It is linked to a higher risk of vascular and neurological illnesses, auto immunological disorders, birth abnormalities, diabetes, renal disease, osteoporosis, neuropsychiatric disorders, and cancer. Hcy appears to be a vital predictor of overall health condition, according to a wealth of evidence. Recent research has begun to uncover the cellular and molecular pathways through which folate prevents age-related illness. Even though much remains to be learned, our understanding of the relationship between disease, methyl balance, and epigenetic control of gene expression has continuously progressed. However, the role of homocysteine balance in health and disease seems to be well known.

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Meghavi Kathpalia and Prashant Kumar contributed equally with all other contributors.

Authors and Affiliations

Department of Centre for Clinical and Translational Research, Jamia Hamdard, Delhi, India
Meghavi Kathpalia
Department of Biotechnology, Motilal Nehru National Institute of Technology, Allahabad, India
Prashant Kumar
Department of Infection Biology, School of Medicine, Wonkwang University, Iksan, South Korea
Swati Mohapatra
School of Science, Gujarat State Fertilizers and Chemicals University (GSFCU), Vadodara, Gujarat, India
Swati Mohapatra

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Meghavi Kathpalia
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Prashant Kumar
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Swati Mohapatra
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Editors and Affiliations

Kriya Sharira and Kaya Chikitsa, Banaras Hindu University, Varanasi, Uttar Pradesh, India
Govind Prasad Dubey
Department of Applied Sciences, Indian Institute of Information Technology (IIITA), Prayagraj, Uttar Pradesh, India
Krishna Misra
Department of Computer Application, Nehru Gram Bharati (Deemed to be University), Prayagraj, Uttar Pradesh, India
Rajesh K. Kesharwani
Department of Zoology, Nehru Gram Bharati (Deemed to be University), Prayagraj, Uttar Pradesh, India
Rudra P. Ojha

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Kathpalia, M., Kumar, P., Mohapatra, S. (2022). Homocysteine Metabolism as a Biomarker for Cancer. In: Dubey, G.P., Misra, K., Kesharwani, R.K., Ojha, R.P. (eds) Homocysteine Metabolism in Health and Disease. Springer, Singapore. https://doi.org/10.1007/978-981-16-6867-8_8

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DOI: https://doi.org/10.1007/978-981-16-6867-8_8
Published: 13 May 2022
Publisher Name: Springer, Singapore
Print ISBN: 978-981-16-6866-1
Online ISBN: 978-981-16-6867-8
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)

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