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Diagnostic Special Stains, Immunohistochemical Markers, and Special Techniques Used in Gastrointestinal Tract Pathology

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Surgical Pathology of the Gastrointestinal System

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Abstract

The gastrointestinal pathology laboratory services involve an appreciable amount of workload predominantly comprising of luminal endoscopic biopsies and resection specimens. Along with samples soliciting histological diagnoses, many follow-up biopsies are also received for assessment of response to treatment and to look for residual or active disease or secondary tumor deposit. Although usual morphological interpretation on hematoxylin and eosin (H&E) by a team of experienced and skilled gastrointestinal pathologists is usually sufficient in most cases and plays the pivotal role in patient management, at times confirmation by use of few special histochemical stains aids in the diagnostic workup. These stains could be relatively economical but useful adjuncts in confirmation of diagnosis. Application of further ancillary techniques like immunohistochemical panels, in addition to offering specific diagnostic categorization, has also come up with therapeutic and prognostic implications in the era of targeted therapy. With the advent of these theranostic markers, further supplementation by molecular and ultrastructural workup, which are labor-intensive and demand high-end expensive infrastructure, may be rarely required.

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The authors agree to the fact that all biopsy procedures and surgical resections were performed after taking informed consent from respective patients as per the individual Institutional policies, which also includes consent for publishing the unidentified clinical images for publication or research purposes. The authors also declare no conflict of interest.

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Authors and Affiliations

  1. Department of Pathology, Al Sabah Hospital, Kuwait City, Kuwait

    Kaushik Majumdar

  2. Department of Pathology, Govind Ballabh Pant Institute of Postgraduate Medical Education & Research, New Delhi, India

    Puja Sakhuja

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  1. Kaushik Majumdar
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  2. Puja Sakhuja
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Correspondence to Puja Sakhuja .

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Editors and Affiliations

  1. Department of Pathology, All India Institute of Medical Sciences, New Delhi, India

    Prasenjit Das

  2. Department of Pathology, Al Sabah Hospital, Kuwait City, Kuwait

    Kaushik Majumdar

  3. Department of Pathology, All India Institute of Medical Sciences, New Delhi, India

    Siddhartha Datta Gupta

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Majumdar, K., Sakhuja, P. (2022). Diagnostic Special Stains, Immunohistochemical Markers, and Special Techniques Used in Gastrointestinal Tract Pathology. In: Das, P., Majumdar, K., Datta Gupta, S. (eds) Surgical Pathology of the Gastrointestinal System. Springer, Singapore. https://doi.org/10.1007/978-981-16-6395-6_6

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  • DOI: https://doi.org/10.1007/978-981-16-6395-6_6

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