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Lymphoma of the Gastrointestinal Tract

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Surgical Pathology of the Gastrointestinal System

Abstract

A comprehensive description of the common B-cell and T-cell lymphomas seen in the GIT. This chapter describes all the entity in short with their diagnostic tips, immunophenotype, histological grading and staging systems, and pathogenesis where relevant. High-quality images have been provided to help readers understand the entities well.

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References

B-Cell Lymphomas of the GIT

  1. Bellesi G, Alterini R, Messori A, Bosi A, Bernardi F, di Lollo S, et al. Combined surgery and chemotherapy for the treatment of primary gastrointestinal intermediate- or high-grade non-Hodgkin's lymphomas. Br J Cancer. 1989;60:244–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  2. Jain S, Lone MR, Goswami A, Mandal T, Panda AK, Ramteke P, Srivastav T, Sharma MC, Gogia A, Sharma A, Bakhshi S. Lymphoma subtypes in India: a tertiary care center review. Clinical and Experimental Medicine. 2021;21(2):315–21.

    Google Scholar 

  3. Swerdlow SH, Campo E, Pileri SA, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016;127(20):2375–90.

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Dawson IM, Cornes JS, Morson BC. Primary malignant tumors of the intestinal tract. Br J Surg. 1961;49:80–9.

    CAS  PubMed  Google Scholar 

  5. Herrmann R, Panahon AM, Barcos MP, et al. Gastrointestinal involvement in non-Hodgkin’s lymphoma. Cancer. 1980;46(1):215–22.

    CAS  PubMed  Google Scholar 

  6. Shirsat HS, Vaiphei K. Primary gastrointestinal lymphomas – a study of 81 cases from a tertiary healthcare Centre. Indian J Cancer. 2014;51(3):290–2.

    CAS  PubMed  Google Scholar 

  7. Arora N, Manipadam MT, Pulimood A, Ramakrishna BS, Chacko A, Kurian SS, Nair S. Gastrointestinal lymphomas: pattern of distribution and histological subtypes: 10 years experience in a tertiary centre in South India. Indian J Pathol Microbiol. 2011;54(4):712–9.

    PubMed  Google Scholar 

  8. Srikumaran R, Nair RA, Jacob PM, Vasudevan JA, Narayanan G, Kumar TP. Anatomic distribution and histologic subtypes of primary gastrointestinal lymphomas: a retrospective analysis of 152 cases. Clin Cancer Investig J. 2017;6:15–20.

    Google Scholar 

  9. Koch P, del Valle F, Berdel WE, Willich NA, Reers B, Hiddemann W, et al. Primary gastrointestinal non-Hodgkin’s lymphoma: I. Anatomic and histologic distribution, clinical features, and survival data of 371 patients registered in the German Multicenter Study GIT NHL 01/92. J Clin Oncol. 2001;19:3861–73.

    CAS  PubMed  Google Scholar 

  10. Radaszkiewicz T, Dragosics B, Bauer P. Gastrointestinal malignant lymphomas of the mucosa-associated lymphoid tissue: factors relevant to prognosis. Gastroenterology. 1992;102:1628–38.

    CAS  PubMed  Google Scholar 

  11. Morton JE, Leyland MJ, Vaughan Hudson G, Vaughan Hudson B, Anderson L, Bennett MH, et al. Primary gastrointestinal non-Hodgkin’s lymphoma: a review of 175 British National Lymphoma Investigation cases. Br J Cancer. 1993;67:776–82.

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Warrick J, Luo J, Robirds D, et al. Gastrointestinal lymphomas in a North American population: clinicopathologic features from one major Central-Midwestern United States tertiary care medical center. Diagn Pathol. 2012;7:76.

    PubMed  PubMed Central  Google Scholar 

  13. Howell JM, Auer-Grzesiak I, Zhang J, Andrews CN, Stewart D, Urbanski SJ. Increasing incidence rates, distribution and histological characteristics of primary gastrointestinal non-Hodgkin lymphoma in a North American population. Can J Gastroenterol. 2012;26(7):452–6.

    PubMed  PubMed Central  Google Scholar 

  14. Müller AM, Ihorst G, Mertelsmann R, Engelhardt M. Epidemiology of non-Hodgkin’s lymphoma (NHL): trends, geographic distribution, and etiology. Ann Hematol. 2005;84:1–12.

    PubMed  Google Scholar 

  15. Nakamura S, Matsumoto T, Iida M, Yao T, Tsuneyoshi M. Primary gastrointestinal lymphoma in Japan: a clinicopathologic analysis of 455 patients with special reference to its time trends. Cancer. 2003;97:2462–73.

    PubMed  Google Scholar 

  16. Rohatiner A, d’Amore F, Coiffier B, et al. Report on a workshop convened to discuss the pathological and staging classifications of gastrointestinal tract lymphoma. Ann Oncol. 1994;5(5):397–400.

    CAS  PubMed  Google Scholar 

  17. Hatano B, et al. Clinicopathological features of gastric B-cell lymphoma: a series of 317 cases. Pathol Int. 2002;52:677–82.

    PubMed  Google Scholar 

  18. Isaacson PG. Gastrointestinal lymphoma. Hum Pathol. 1994;25:10201029.

    Google Scholar 

  19. Zullo A, Hassan C, Ridola L, Repici A, Manta R, Andriani A. Gastric MALT lymphoma: old and new insights. Ann Gastroenterol. 2014;27(1):27–33.

    PubMed  PubMed Central  Google Scholar 

  20. Lecuit M, Abachin E, Martin A, Poyart C, et al. Immunoproliferative small intestinal disease associated with campylobacter jejuni. N Engl J Med. 2004;350:239–48.

    CAS  PubMed  Google Scholar 

  21. Planelles L, Medema JP, Hahne M, Hardenberg G. The expanding role of APRIL in cancer and immunity. Curr Mol Med. 2008;8(8):829–44.

    CAS  PubMed  Google Scholar 

  22. Lin WC, Tsai HF, Kuo SH, Wu MS, Lin CW, Hsu PI, et al. Translocation of helicobacter pylori CagA into human B lymphocytes, the origin of mucosa-associated lymphoid tissue lymphoma. Cancer Res. 2010;70:5740–8.

    CAS  PubMed  Google Scholar 

  23. Bacon CM, Du MQ, Dogan A. Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologists. J Clin Pathol. 2007;60(4):361–72.

    CAS  PubMed  Google Scholar 

  24. Chan J. Gastrointestinal lymphomas: an overview with emphasis on new findings and diagnostic problems. Semin Diagn Pathol. 1996;13:260–96.

    CAS  PubMed  Google Scholar 

  25. Yoshino T, et al. Clinicopathological features of gastric mucosa associated lymphoid tissue (MALT) lymphoma: high grade transformation and comparison with diffuse large B-cell lymphomas without MALT lymphoma features. Clin Pathol. 2000;53:187–90.

    CAS  Google Scholar 

  26. Wotherspoon AC, Doglioni C, Diss TC, et al. Regression of primary lowgrade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet. 1993;342(8871):575–7.

    CAS  PubMed  Google Scholar 

  27. Falini B, Agostinelli C, Bigerna B, et al. IRTA1 is selectively expressed in nodal and extranodal marginal zone lymphomas. Histopathology. 2012;61(5):930–41.

    PubMed  Google Scholar 

  28. Evans PAS, Pott C, Groenen PJTA, et al. Significantly improved PCR-based clonality testing in B-cell malignancies by use of multiple immunoglobulin gene targets: report of the BIOMED-2 concerted action BHM4-CT98-3936. Leukemia. 2007;21(2):207–14.

    CAS  PubMed  Google Scholar 

  29. Wundisch T, Neubauer A, Stolte M, Ritter M, Thiede C. B-cell monoclonality is associated with lymphoid follicles in gastritis. Am J Surg Pathol. 2003;27(7):882–7.

    PubMed  Google Scholar 

  30. Liu H, Ruskon-Fourmestraux A, Lavergne-Slove A, et al. Resistance of t(11; 18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy. Lancet. 2001;357(9249):39–40.

    CAS  PubMed  Google Scholar 

  31. Raderer M, Streubel B, Woehrer S, et al. High relapse rate in patients with MALT lymphoma warrants lifelong follow-up. Clin Cancer Res. 2005;11:3349–52. PMID:15867234.

    Google Scholar 

  32. Opie-Bergman C, Gaulard P, Lavergne-Slove A, et al. Proposal for a new histological grading system for post-treatment evaluation of gastric MALT lymphoma. Gut. 2003;52(11):1656.

    Google Scholar 

  33. Thieblemont C, Bertoni F, Gopie-Bergman C, et al. Chronic inflammation and extra-nodal marginal-zone lymphomas of MALT-type. Semin Cancer Biol. 2014;24:33–42.

    CAS  PubMed  Google Scholar 

  34. Schmatz AL, Streubel B, Kretschmer-Chott E, et al. Primary follicular lymphoma of the duodenum is a distinct mucosal submucosal variant of follicular lymphoma: a retrospective study of 63 cases. J C lin Oncol. 2011;29:1445–51. PMID:21383289

    Google Scholar 

  35. lwamuro M, Okada H, Kawano S, et al. A multicenter survey of enteroscopy for the diagnosis of intestinal follicular lymphoma. Oncol Lett. 2015;10:131-B. PMID:26170988.

    Google Scholar 

  36. Mamessier E, Song JY, Eberle FC, et al. Early lesions of follicular lymphoma: a genetic perspective. Haematologica. 2014;99:481–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  37. Misdraji J, Harris NL, Hasserjian RP, Lauwers GY, Ferry JA. Primary follicular lymphoma of the gastrointestinal tract. Am J Surg Pathol. 2011;35(9):1255–63. https://doi.org/10.1097/PAS.0b013e318224e661.

    Article  PubMed  Google Scholar 

  38. Takata K, Sato Y, Nakamura N, et al. Duodenal and nodal follicular lymphomas are distinct: the former lacks activation-induced cytidine deaminase and follicular dendritic cells despite ongoing somatic hypermutations. Mod Pathol. 2009;22(7):940–9.

    CAS  PubMed  Google Scholar 

  39. Kodama T, et al. Lymphomatous polyposis of the gastrointestinal tract, including mantle cell lymphoma, follicular lymphoma and mucosa-associated lymphoid tissue lymphoma. Histopathology. 2005;47:467–78.

    CAS  PubMed  Google Scholar 

  40. Iwamuro M, et al. Endoscopic features and prognoses of mantle cell lymphoma with gastrointestinal involvement. World J Gastroenterol. 2010;16:4661–9.

    PubMed  PubMed Central  Google Scholar 

  41. Zeng W, Fu K, Quintanilla-Fend L, Lim M, Ondrejka S, Hsi ED. Cyclin D1negative blastoid mantle cell lymphoma identified by SOX11 expression. Am J Surg Pathol. 2012;36(2):214–9.

    PubMed  Google Scholar 

  42. Geissmann F, et al. Homing receptor α4β7 integrin expression predicts digestive tract involvement in mantle cell lymphoma. Am J Pathol. 1998;153:1701–5.

    CAS  PubMed  PubMed Central  Google Scholar 

  43. Lal A, Bhurgri Y, Vaziri I, et al. Extranodal non-Hodgkin’s lymphomas – a retrospective review of clinico-pathologic features and outcomes in comparison with nodal non-Hodgkin’s lymphomas. Asian Pac J Cancer Prev. 2008;9:453–7.

    PubMed  Google Scholar 

  44. Ferreri AJ, Montalbán C. Primary diffuse large B-cell lymphoma of the stomach. Crit Rev Oncol Hematol. 2007;63:65–71.

    PubMed  Google Scholar 

  45. Salcedo LMJ, Sokol L, Chavez JC, Dalia S. Primary gastric lymphoma, epidemiology, clinical diagnosis, and treatment. Cancer Control. 2018;25:1–12.

    Google Scholar 

  46. Gascoyne R.D. Campo E. Jaffe E.S. Chan J.K.C. Rosenwald A. Stein H. Swerdlow SH. Diffuse large B cell lymphoma NOS. WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th ed, Lyon: International Agency for Research on Cancer; 2016; p. 291–7.

    Google Scholar 

  47. He M, Chen K, Li S, et al. Clinical significance of “double-hit” and “double-protein” expression in primary gastric B-cell lymphomas. J Cancer. 2016;7(10):1215–25.

    CAS  PubMed  PubMed Central  Google Scholar 

  48. Cogliatti SB, Griesser H, Peng H, et al. Significantly different BCL-2 expression profiles in gastric and nongastric primary extranodal high-grade B-cell lymphomas. J Pathol. 2000;192(4):470–8.

    CAS  PubMed  Google Scholar 

  49. Bautista-Quach MA, Ake CD, Chen M, Wang J. Gastrointestinal lymphomas: morphology, immunophenotype and molecular features. J Gastrointest Oncol. 2012;3(3):209–25.

    PubMed  PubMed Central  Google Scholar 

  50. Ishikawa E, et al. Clinicopathological analysis of primary intestinal diffuse large B-cell lymphoma: prognostic evaluation of CD5, PD-L1, and Epstein-Barr virus on tumor cells. Cancer Med. 2018;7(12):6051–63.

    CAS  PubMed  PubMed Central  Google Scholar 

  51. Chen LT, Lin JT, Tai JJ, Chen GH, Yeh HZ, Yang SS, Wang HP, Kuo SH, Sheu BS, Jan CM, Wang WM, Wang TE, Wu CW, Chen CL, Su IJ, Whang-Peng J, Cheng AL. Long- term results of anti-Helicobacter pylori therapy in early-stage gastric high-grade transformed MALT lymphoma. J Natl Cancer Inst. 2005;97:1345–53.

    CAS  PubMed  Google Scholar 

  52. Kuo SH, Yeh KH, Wu MS, Lin CW, Hsu PN, Wang HP, Chen LT, Cheng AL. Helicobacter pylori eradication therapy is effective in the treatment of early-stage H. pylori-positive gastric diffuse large B-cell lymphomas. Blood. 2012;119:4838–44.

    CAS  PubMed  Google Scholar 

  53. Leoncini L, Campo E, Stein H, Harris NL, Jaffe ES, Kluin PM. Burkitt lymphoma. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, editors. WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th ed. Lyon: International Agency for Research on Cancer; 2017. p. 330.

    Google Scholar 

  54. Wright DH. Burkitt’s lymphoma: a review of the pathology, immunology, and possible etiologic factors. Pathol Annu. 1971;6:337–63.

    CAS  PubMed  Google Scholar 

  55. Magrath I. Epidemiology: clues to the pathogenesis of Burkitt lymphoma. Br J Haematol. 2012;156:744–56.

    CAS  PubMed  Google Scholar 

  56. Roithmann S, Toledano M, Tourani JM, et al. HIV-associated non-Hodgkin’s lymphomas: clinical characteristics and outcome. The experience of the French registry of HIV-associated tumors. Ann Oncol. 1991;2:289–95.

    CAS  PubMed  Google Scholar 

  57. Kim SJ, et al. Multicenter retrospective analysis of 581 patients with primary intestinal non-hodgkin lymphoma from the consortium for improving survival of lymphoma (CISL). BMC Cancer. 2011;11:321.

    PubMed  PubMed Central  Google Scholar 

  58. Domizio P, et al. Primary lymphoma of the small intestine: a clinicopathologic study of 119 cases. Am J Surg Pathol. 1993;17:429–42.

    CAS  PubMed  Google Scholar 

  59. Banks PM. Gastro-intestinal lymphoproliferative disorders. Histopathology. 2007;50:42.

    CAS  PubMed  Google Scholar 

  60. Toujani S, Dessen P, lthzar N, et al. High resolution genome-wide analysis of chromosomal alterations in Burkitt’s lymphoma. PLoS One. 2009;4:e7089. PMID:19759907

    PubMed  PubMed Central  Google Scholar 

  61. Love C, Sun Z, Jima D, et al. The genetic landscape of mutations in Burkitt lymphoma. Nat Genet. 2012;44:1321–5. PMID:23143597

    CAS  PubMed  PubMed Central  Google Scholar 

  62. Cook JR, Harris NL, Isaacson PG, Jaffe ES. Havy chain disease. In: Swerdlow SH, Campo E, Harris NL, et al., editors. World Health Organization classification of tumors of haematopoietic and lymphoid tissues. 4th ed. Lyon, France: IARC; 2017. p. 240.

    Google Scholar 

  63. Alpha-chain disease and related small-intestinal lymphoma: a memorandum. Bull WHO. 1976;54:615–24.

    Google Scholar 

  64. Seijffers MJ, Levy M, Hermann G. Intractable watery diarrhea, hypokalemia, and malabsorption in a patient with mediterranean type of abdominal lymphoma. Gastroenterology. 1968;55:118–24.

    CAS  PubMed  Google Scholar 

  65. Seligmann M, Mihaesco E, Hurez D, et al. Immunochemical studies in four cases of alpha chain disease. J Clin Invest. 1969;48:2374–89.

    CAS  PubMed  PubMed Central  Google Scholar 

  66. Al-Saleem T, Al-Mondhiry H. Immunoproliferative small intestinal disease (IPSID): a model for mature B-cell neoplasms. Blood. 2005;105(6):2274–80.

    CAS  PubMed  Google Scholar 

  67. Al-Saleem T, Zardawi IM. Primary lymphomas of the small intestine in Iraq: a pathological study of 145 cases. Histopathology. 1979;3:89–106.

    CAS  PubMed  Google Scholar 

  68. Biswas B, Sharma A, Makharia GK, et al. Immunoproliferative small intestinal disease: a report of 6 cases. Trop Gastroenterol. 2014;35(4):269–72.

    PubMed  Google Scholar 

  69. Ramos L, Marcos J, Illanas M, et al. Radiological characteristics of primary intestinal lymphoma of the “Mediterranean” type: observations on twelve cases. Radiology. 1978;126:379–85.

    CAS  PubMed  Google Scholar 

  70. Fine KD, Stone MJ. Alpha-heavy chain disease, Mediterranean lymphoma, and immunoproliferative small intestinal disease: a review of clinicopathological features, pathogenesis, and differential diagnosis. Am J Gastroenterol. 1999;94(5):1139–52.

    CAS  PubMed  Google Scholar 

  71. Rambaud JC. Small intestinal lymphomas and alpha-chain disease. Clin Gastroenterol. 1983;12:743–66.

    CAS  PubMed  Google Scholar 

  72. Al-Mondhiry H. Primary lymphomas of the small intestine: East–West contrast. Am J Hematol. 1986;22:89–105.

    CAS  PubMed  Google Scholar 

  73. Seligmann M. Immunochemical, clinical, and pathological features of a-chain disease. Arch Intern Med. 1975;135:78–82.

    CAS  PubMed  Google Scholar 

  74. Pellet P, Tsapis A, Brouet JC. Alpha heavy chain disease of patient MAL: structure of the non-functional rearranged alpha gene translocated on chromosome 9. Eur J Immunol. 1990;20(12):2731–5.

    CAS  PubMed  Google Scholar 

  75. Seligmann M, Mihaesco E, Preud’homme JL, Danon F, Brouet JC. Heavy chain diseases: current findings and concepts. Immunol Rev. 1979;48:145–67.

    CAS  PubMed  Google Scholar 

  76. Ye H, Liu H, Attygalle A, et al. Variable frequencies of t(11;18)(q21;q21) in MALT lymphomas of different sites: significant association with CagA strains of H pylori in gastric MALT lymphoma. Blood. 2003;102:1012–8.

    CAS  PubMed  Google Scholar 

  77. Pellet P, Berger R, Bernheim A, Brouet JC, Tsapis A. Molecular analysis of a t(9;14)(p11;q32) translocation occurring in a case of human alpha heavy chain disease. Oncogene. 1989;4:653–7.

    CAS  PubMed  Google Scholar 

  78. Chang CS, Lin SF, Chen TP, et al. Leukemic manifestation in a case of alpha-chain disease with multiple polypoid intestinal lymphocytic lymphoma. Am J Hematol. 1992;41:209–14.

    CAS  PubMed  Google Scholar 

  79. Nikbin B, Banisadre M, Ala F, Mojtabai A. HLA AW19, B12 in immunoproliferative small intestinal disease. Gut. 1979;20:226–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  80. Galian A, Lecestre MJ, Scotto J, Bognel C, Matuchansky C, Rambaud JC. Pathological study of alpha-chain disease, with special emphasis on evolution. Cancer. 1977;39:2081–101.

    CAS  PubMed  Google Scholar 

  81. Campo E, Stein H, Harris NL. Plasmablastic lymphoma. In: Swerdlow SH, Campo E, Harris NL, editors. WHO classification of tumors of hematopoietic and lymphoid tissues. Lyon, France: IARC Press; 2017. p. 321–2. Lopez A, Abrisqueta P. Plasmablastic lymphoma: current perspectives. Blood Lymphat Cancer 2018;8:63–70.

    Google Scholar 

  82. Carbone A, Gloghini A. Plasmablastic lymphoma: one or more entities? Am J Hematol. 2008;83:763–4.

    PubMed  Google Scholar 

  83. Rafaniello Raviele P, Pruneri G, Maiorano E. Plasmablastic lymphoma: a review. Oral Dis. 2009;15:38–45. 5.

    Google Scholar 

  84. Tchernonog E, Faurie P, Coppo P, et al. Clinical characteristics and prognostic factors of plasmablastic lymphoma patients: analysis of 135 patients from the LYSA group. Ann Oncol. 2017;28(4):843–8.

    CAS  PubMed  Google Scholar 

  85. Qunaj L, Castillo JJ, Olszewski AJ. Survival of patients with CD20- negative variants of large B-cell lymphoma: an analysis of the National Cancer Data Base. Leuk Lymphoma. 2018;59(6):1–9.

    Google Scholar 

  86. Morscio J, Dierickx D, Nijs J, et al. Clinicopathologic comparison of plasmablastic lymphoma in HIV-positive, immunocompetent, and posttransplant patients: single-center series of 25 cases and meta-analysis of 277 reported cases. Am J Surg Pathol. 2014;38(7):875–86.

    PubMed  Google Scholar 

  87. Lopez A, Abrisqueta P. Plasmablastic lymphoma: current perspectives. Blood Lymphat Cancer. 2018;8:63–70.

    CAS  PubMed  PubMed Central  Google Scholar 

  88. Vega F, Chang CC, Medeiros LJ, Udden MM, Cho-Vega JH, Lau CC, Finch CJ, Vilchez RA, McGregor D, Jorgensen JL. Plasmablastic lymphomas and plasmablastic plasma cell myelomas have nearly identical immunophenotypic profiles. Mod Pathol. 2005;18:806–15.

    PubMed  Google Scholar 

  89. Archives of Pathology and Laboratory Medicine.

    Google Scholar 

  90. Castillo JJ, Reagan JL. Plasmablastic lymphoma: a systematic review. Sci World J. 2011;11:687–96.

    Google Scholar 

  91. Harris NL, Jaffe ES, Diebold J, et al. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the clinical advisory committee meeting-Airlie House, Virginia, November 1997. J Clin Oncol. 1999;17(12):3835–49.

    CAS  PubMed  Google Scholar 

  92. Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD, Jaffe ES. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016;127(20):2375–90.

    CAS  PubMed  PubMed Central  Google Scholar 

  93. Hoeller S, Tzankov A, Pileri SA, Went P, Dirnhofer S. Epstein-Barr virus-positive diffuse large B-cell lymphoma in elderly patients is rare in Western populations. Hum Pathol. 2010;41(3):352–7.

    PubMed  Google Scholar 

  94. Hofscheier A, Ponciano A, Bonzheim I, et al. Geographic variation in the prevalence of Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly: a comparative analysis of a Mexican and a German population. Mod Pathol. 2011;24(8):1046–54.

    PubMed  Google Scholar 

  95. Oyama T, Ichimura K, Suzuki R, et al. Senile EBV1 B-cell lymphoproliferative disorders: a clinicopathologic study of 22 patients. Am J Surg Pathol. 2003;27(1):16–26.

    PubMed  Google Scholar 

  96. Castillo JJ, Beltran BE, Miranda RN, Young KH, Chavez JC, Sotomayor EM. EBV-positive diffuse large B-cell lymphoma, not otherwise specified: 2018 update on diagnosis, risk-stratification and management. Am J Hematol. 2018 Jul;93(7):953–62.

    CAS  PubMed  Google Scholar 

  97. Ok CY, Papathomas TG, Medeiros LJ, Young KH. EBV-positive diffuse large B-cell lymphoma of the elderly. Blood. 2013;122(3):328–40.

    CAS  PubMed  PubMed Central  Google Scholar 

  98. Castillo JJ, Beltran BE, Miranda RN, Paydas S, Winer ES, Butera JN. Epstein-Barr virus–positive diffuse large B-cell lymphoma of the elderly: what we know so far. Oncologist. 2011;16(1):87–96.

    PubMed  PubMed Central  Google Scholar 

  99. Lu TX, Liang JH, Miao Y, Fan L, Wang L, Qu XY, Cao L, Gong QX, Wang Z, Zhang ZH, Xu W, Li JY. Epstein-Barr virus positive diff use large B-cell lymphoma predicts poor outcome, regardless of the age. Sci Rep. 2015;5(1):12168.

    CAS  PubMed  PubMed Central  Google Scholar 

  100. Song CG, Huang JJ, Li YJ, Xia Y, Wang Y, Bi XW, Jiang WQ, Huang HQ, Lin TY, Li ZM. Epstein-Barr virus–positive diff use large B-cell lymphoma in the elderly: a matched case-control analysis. PLoS One. 2015;10(7):e0133973.

    PubMed  PubMed Central  Google Scholar 

  101. Gaulard P, Swerdlow SH, Harris NL, Sundstrom C, Jaffe ES. EBV-positive mucocutaneous ulcer. In: Swerdlow SH, Campo E, Harris NL, et al., editors. WHO classification of tumours of haematopoietic and lymphoid tissues. Revised 4th ed. Lyon: International Agency for Research on Cancer; 2016. p. 307–8.

    Google Scholar 

  102. Dojcinov SD, Venkataraman G, Raffeld M, Pittaluga S, Jaffe ES. EBV positive mucocutaneous ulcer-a study of 26 cases associated with various sources of immunosuppression. Am J Surg Pathol. 2010;34:405–17.

    PubMed  PubMed Central  Google Scholar 

  103. Juan A, Lobatón T, Tapia G, et al. Epstein-Barr virus-positive mucocutaneous ulcer in Crohn’s disease. A condition to consider in immunosuppressed IBD patients. Dig Liver Dis. 2017;49:934–7.

    PubMed  Google Scholar 

  104. Ikeda T, Gion Y, Yoshino T, Sato Y. A review of EBV-positive mucocutaneous ulcers focusing on clinical and pathological aspects. J Clin Exp Hematop. 2019;59(2):64–71.

    PubMed  PubMed Central  Google Scholar 

T-Cell Lymphomas of the GIT

  1. Ferreri AJM, Zinzani PL, Govi S, Pileri SA. Enteropathy-associated T-cell lymphoma. Crit Rev Oncol Hematol. 2011;79:84–90.

    PubMed  Google Scholar 

  2. Delabie J, Holte H, Julie M, et al. Enteropathy-associated T-cell lymphoma: clinical and histological findings from the International Peripheral T-Cell Lymphoma Project. Blood. 2011;118(1):148–55.

    Google Scholar 

  3. Zanelli M, Zizzo M, Sanguedolce F, Martino G, Soriano A, Ricci S, Ruiz CC, Annessi V, Ascani S. Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract: a tricky diagnosis of a gastric case. BMC Gastroenterol. 2020;20(1):1–5.

    Google Scholar 

  4. Swerdlow SH, Jaffe ES, Brousset P, et al. Cytotoxic T-cell and NK-cell lymphomas -current questions and controversies. Am J Surg Pathol. 2014;38:e60–71.

    PubMed  PubMed Central  Google Scholar 

  5. Sun ZH, Zhou HM, Song GX, Zhou ZX, Bai L. Intestinal T-cell lymphomas: a retrospective analysis of 68 cases in China. World J Gastroenterol: WJG. 2014;20(1):296.

    PubMed  PubMed Central  Google Scholar 

  6. Horie R, Yatomi Y, Wakabayashi T, Ohno Y, Eriguchi M, Higashihara M, Nakahara K, Watanabe T. Primary gastric T-cell lymphomas: report of two cases and a review of the literature. Jpn J Clin Oncol. 1999;29(3):171–8.

    CAS  PubMed  Google Scholar 

  7. Makar R, Maklad M, Fayad JM. A rare case of primary anaplastic large cell lymphoma of the colon, anaplastic lymphoma kinase negative: 1607. Off J Am Coll Gastroenterol ACG. 2018;113:S923–4.

    Google Scholar 

  8. Sadiya N, Ghosh M. Primary ALK positive anaplastic large cell lymphoma of T-cell type of jejunum: report of a rare extranodal entity with review of literature. Arch Int Surg. 2014;4(1):50.

    Google Scholar 

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The authors agree to the fact that all biopsy procedures and surgical resections were performed after taking informed consent from respective patients as per the individual Institutional policies, which also includes consent for publishing the unidentified clinical images for publication or research purposes. The authors also declare no conflict of interest.

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Mallick, S., Ramteke, P., Gujral, S., Das, A. (2022). Lymphoma of the Gastrointestinal Tract. In: Das, P., Majumdar, K., Datta Gupta, S. (eds) Surgical Pathology of the Gastrointestinal System. Springer, Singapore. https://doi.org/10.1007/978-981-16-6395-6_18

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