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Pathology of Malignant Lesions of the Gastrointestinal Tract

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Surgical Pathology of the Gastrointestinal System

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Abstract

Malignant epithelial tumors of the gastrointestinal tract are especially common worldwide, including in Asia. This chapter carefully brings out the differences of demography of various epithelial malignancies between Asian and western countries. With globalization, the incidence and prevalence of malignant gastrointestinal tract carcinomas are changing rapidly and currently the incidences of most malignant gastrointestinal tract carcinomas are showing an upwards trend. If we take the example of colorectal adenocarcinomas, its incidence and age-adjusted death rates are increasing both in western countries and Asia in patients less than 50-years old; while, the incidence in patients aged more than 50-years is increasing in Asia, but decreasing in America and European countries. Also, the classifications of these malignant epithelial tumors are changing, especially in stomach, and their pathogenetic mechanisms are undergoing rapid updation, especially owing to availability of molecular data. Nowadays, all histologically similar malignant epithelial tumors of the gastrointestinal tract, as adenocarcinomas of the esophagus, stomach, small bowel, right colon and left colon are appearing as distinct entities. This chapter, along will chap. 21 will give the readers an comprehensive view of the current epidemiology, classifications, clinical and histological details, prognostic factors, pathogenesis and molecular classifications and recommended work up. The chapter has been supplemented with numerous images, tables, diagrams, learning tips and case studies.

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The authors agree to the fact that all biopsy procedures and surgical resections were performed after taking informed consent from respective patients as per the individual Institutional policies, which also includes consent for publishing the unidentified clinical images for publication or research purposes. The authors also declare no conflict of interest.

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Authors and Affiliations

  1. Asian Institute of Gastroenterology, Hyderabad, India

    Anuradha Sekaran

  2. Tata Medical Center, Kolkata, India

    Debdeep Dey & Angad Singh

  3. Department of Pathology, All India Institute of Medical Sciences, New Delhi, India

    Prasenjit Das

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  1. Anuradha Sekaran
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  2. Debdeep Dey
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  4. Prasenjit Das
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Correspondence to Prasenjit Das .

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Editors and Affiliations

  1. Department of Pathology, All India Institute of Medical Sciences, New Delhi, India

    Prasenjit Das

  2. Department of Pathology, Al Sabah Hospital, Kuwait City, Kuwait

    Kaushik Majumdar

  3. Department of Pathology, All India Institute of Medical Sciences, New Delhi, India

    Siddhartha Datta Gupta

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Sekaran, A., Dey, D., Singh, A., Das, P. (2022). Pathology of Malignant Lesions of the Gastrointestinal Tract. In: Das, P., Majumdar, K., Datta Gupta, S. (eds) Surgical Pathology of the Gastrointestinal System. Springer, Singapore. https://doi.org/10.1007/978-981-16-6395-6_17

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