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Immune Boosting Activity of Nutraceuticals and Functional Foods

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Immunomodulators and Human Health

Abstract

The key to good health is to have a functional and strong immune system. A strong immune system is characterized by the ability to protect the body from infection and any form of invasion by foreign objects. The strength of an immune system is also exhibited by the ability to prevent allergy and autoimmune diseases. The two major components of immune responses are innate and acquired immune responses which work together in synergy. Recent advances in medicine use diverse immunomodulators of natural origin, which can evoke biological reactions and reinforce body’s natural defense mechanisms. A lot of studies in dietary and food biotechnology are ongoing about new alternatives for disease prevention. The need to improve health and quality of life has led to the discovery of certain food substances, which have nutritional value as well as biological activities. These are classified as either nutraceuticals or functional foods. Extensive studies, which have established that there is a relationship between gut microbiome and immunity, have spurred many research and studies on functional foods. Majority of the nutraceuticals and functional foods have been known to possess multiple therapeutic benefits against a variety of disease conditions. Their biological activities include antioxidant, anti-inflammatory, antimicrobial, anti-tumor, hepatoprotective, immunomodulatory, and many more. This chapter aims to discuss immune boosting activities of functional foods and nutraceuticals as well as narrate the mechanism of the immune modulation.

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References

  • Abuelsaad AS (2014) Supplementation with Astragalus polysaccharides alters Aeromonas-induced tissue-specific cellular immune response. Microb Pathog 66:48–56

    Article  CAS  PubMed  Google Scholar 

  • Aguilar JC, Rodriguez EG (2007) Vaccine adjuvants revisited. Vaccine 25:3752–3762

    Article  CAS  PubMed  Google Scholar 

  • Albuquerque PBS, de Oliveira WF, dos Santos Silva PM, dos Santos Correia MT, Kennedy JF, Coelho LCBB (2020) Epiphanies of well-known and newly discovered macromolecular carbohydrates–a review. Int J Biol Macromol 156:51–66

    Article  CAS  PubMed  Google Scholar 

  • Aronson JK (2017) Defining ‘nutraceuticals’: neither nutritious nor pharmaceutical. Br J Clin Pharmacol 83:8–19

    Article  PubMed  Google Scholar 

  • Ashaolu TJ (2020) Antioxidative peptides derived from plants for human nutrition: their production, mechanisms and applications. Eur Food Res. Technol:1–13

    Google Scholar 

  • Atarashi K, Umesaki Y, Honda K (2011) Microbiotal influence on T cell subset development. In: Seminars in immunology (Vol. 23, no. 2). Academic Press, pp 146–153

    Google Scholar 

  • Bahramzadeh S, Tabarsa M, You S, Li C, Bita S (2019) Purification, structural analysis and mechanism of murine macrophage cell activation by sulfated polysaccharides from Cystoseira indica. Carbohydr Polym 205:261–270

    Article  CAS  PubMed  Google Scholar 

  • Baradaran A, Madihi Y, Merrikhi A, Rafieian-Kopaei M, Nasri H (2013) Serum lipoprotein (a) in diabetic patients with various renal function not yet on dialysis. Pak J Med Sci 29(Suppl):354–357

    Google Scholar 

  • Barsanti L, Passarelli V, Evangelista V, Frassanito AM, Gualtieri P (2011) Chemistry, physico-chemistry and applications linked to biological activities of beta-glucans. Nat Prod Rep 28(3):457–466

    Article  CAS  PubMed  Google Scholar 

  • Bermudez-Brito M, Faas MM, de Vos P (2016) Modulation of dendritic-epithelial cell responses against sphingomonas paucimobilis by dietary fibers. Sci Rep 6(1):1–8

    Article  CAS  Google Scholar 

  • Bhakta M, Kumar P (2013) Mushroom polysaccharides as a potential prebiotics. Int J Health Sci Res 3:77–84

    Google Scholar 

  • Borchers AT, Krishnamurthy A, Keen CL, Meyers FJ, Gershwin ME (2008) The immunobiology of mushrooms. Exp Biol Med (Maywood) 233:259–276

    Article  CAS  Google Scholar 

  • Bouhnik Y, Raskine L, Simoneau G, Paineau D, Bornet F (2006) The capacity of short-chain fructo-oligosaccharides to stimulate faecal bifidobacteria: a dose-response relationship study in healthy humans. Nutr J 5:8

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bradley JR (2008) TNF-mediated inflammatory disease. J Pathol 214(2):149–160

    Article  CAS  PubMed  Google Scholar 

  • Byrne KA, Loving CL, McGill JL (2020) Innate immunomodulation in food animals: evidence for trained immunity. Front Immunol 11(1099):1–15

    Google Scholar 

  • Calder PC (2005) Polyunsaturated fatty acids and inflammation. Biochem Soc Trans 33(2):423–427

    Article  CAS  PubMed  Google Scholar 

  • Carroll IM, Ringel-Kulka T, Siddle JP, Ringel Y (2012) Alterations in composition and diversity of the intestinal microbiota in patients with diarrhea-predominant irritable bowel syndrome. Neurogastroenterol Motil 24:521.e248–530.e248

    Article  PubMed Central  Google Scholar 

  • Carvalho S, Levi-Schaffer F, Sela M, Yarden Y (2016) Immunotherapy of cancer: from monoclonal to oligoclonal cocktails of anti-cancer antibodies: IUPHAR review 18. Br J Pharmacol 173(9):1407–1424

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chandua S, Kailash H (2011) Studies on immunomodulatory activity of Aloe vera (Linn). Int J Appl Biol Pharm Technol 2:19–22

    Google Scholar 

  • Chen X, Murakami T, Oppenheim JJ, Howard OMZ (2005) Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking. Blood 106:2409–2416

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen Q, Ren Y, Lu J, Bartlett M, Chen L, Zhang Y, Guo X, Liu CA (2017) Novel prebiotic blend product prevents irritable bowel syndrome in mice by improving gut microbiota and modulating immune response. Nutrients 9:1341

    Article  PubMed Central  CAS  Google Scholar 

  • Childs CE, Calder PC, Miles EA (2019) Diet and immune function. Nutrients 11(1933):1–9

    Google Scholar 

  • Corzo L, Fernández-Novoa L, Carrera I, Martínez O, Rodríguez S, Alejo R, Cacabelos R (2020) Nutrition, health, and disease: role of selected marine and vegetal nutraceuticals. Nutrients 12(3):747

    Article  CAS  PubMed Central  Google Scholar 

  • Costantini L, Molinari R, Farinon B, Merendino N (2017) Impact of Omega-3 fatty acids on the gut microbiota. Int J Mol Sci 18:2645

    Article  PubMed Central  CAS  Google Scholar 

  • Das AK, Nanda PK, Madane P, Biswas S, Das A, Zhang W, Lorenzo JM (2020) A comprehensive review on antioxidant dietary fibre enriched meat-based functional foods. Trends Food Sci Technol 99:323–326

    Article  CAS  Google Scholar 

  • Davinelli S, Melvang HM, Andersen LP, Scapagnini G, Nielsen ME (2019) Astaxanthin from shrimp cephalothorax stimulates the immune response by enhancing IFN-γ, IL-10, and IL-2 secretion in splenocytes of Helicobacter pylori-infected mice. Mar Drugs 17(7):382

    Article  CAS  PubMed Central  Google Scholar 

  • De Keersmaecker SC, Verhoeven TL, Desair J, Marchal K, Vanderleyden J, Nagy I (2006) Strong antimicrobial activity of Lactobacillus rhamnosus GG against Salmonella typhimurium is due to accumulation of lactic acid. FEMS Microbiol Lett 259(1):89–96

    Article  PubMed  CAS  Google Scholar 

  • De Sousa VMC, Dos Santos EF, Sgarbieri VC (2011) The importance of prebiotics in functional foods and clinical practice. Food Nutr Sci 2:4

    Google Scholar 

  • Di Sotto A, Vitalone A, Di Giacomo S (2020) Plant-derived nutraceuticals and immune system modulation: an evidence-based overview. Vaccines 8(3):468

    Article  PubMed Central  CAS  Google Scholar 

  • El Enshasy H (2010) Immunomodulators. In: The mycota: industrial applications, vol 10. Springer, Berlin, Germany, pp 165–194

    Google Scholar 

  • Fan Y, Hu Y, Wang D, Liu J, Zhang J, Zhao X, Liu X, Liu C, Yuan J, Ruan S (2012) Effects of Astragalus polysaccharide liposome on lymphocyte proliferation in vitro and adjuvanticity in vivo. Carbohydr Polym 88:68–74

    Article  CAS  Google Scholar 

  • Farias GA, Guzman-Martinez L, Delgado C, Maccioni RB (2014) Nutraceuticals: a novel concept in prevention and treatment of Alzheimer's disease and related disorders. J Alzheimers Dis 42(2):357–367

    Article  CAS  PubMed  Google Scholar 

  • Feng W, Ao H, Peng C (2018) Gut microbiota, short-chain fatty acids, and herbal medicines. Front Pharmacol 9:1354

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Feng K, Wei YS, Hu TG, Linhardt RJ, Zong MH, Wu H (2020) Colon-targeted delivery systems for nutraceuticals: a review of current vehicles, evaluation methods and future prospects. Trends Food Sci Technol 102:203–222

    Article  CAS  Google Scholar 

  • Ferreira SS, Passos CP, Madureira P, Vilanova M, Coimbra MA (2015) Structure-function relationships of immunostimulatory polysaccharides: a review. Carbohydr Polym 132:378–396

    Article  CAS  PubMed  Google Scholar 

  • Ford AC, Harris LA, Lacy BE, Quigley EM, Moayyedi P (2018) Systematic review with meta-analysis: the efficacy of prebiotics, probiotics, synbiotics and antibiotics in irritable bowel syndrome. Aliment Pharmacol Ther 48(10):1044–1060

    Article  PubMed  Google Scholar 

  • Friedman M (2016) Mushroom polysaccharides: chemistry and antiobesity, antidiabetes, anticancer, and antibiotic properties in cells, rodents, and humans. Foods 5(4):80

    Article  PubMed Central  CAS  Google Scholar 

  • Geurts L, Neyrinck AM, Delzenne NM (2014) Gut microbiota controls adipose tissue expansion, gut barrier and glucose metabolism: novel insights into molecular targets and interventions using prebiotics. Benef Microbes 5:3–17

    Article  CAS  PubMed  Google Scholar 

  • Gibson GR, Hutkins R, Sanders ME, Prescott SL, Reimer RA, Salminen SJ, Scott K, Stanton C, Swanson KS, Cani PD, Verbeke K (2017) Expert consensus document: the international scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol 14(8):491

    Article  PubMed  Google Scholar 

  • Green M, Arora K, Prakash S (2020) Microbial medicine: prebiotic and probiotic functional foods to target obesity and metabolic syndrome. Int J Mol Sci 21(8):2890

    Article  CAS  PubMed Central  Google Scholar 

  • Guimarães JT, Balthazar CF, Silva R, Rocha RS, Graça JS, Esmerino EA, Silva MC, Sant’Ana AS, Duarte MCK, Freitas MQ, Cruz AG (2020) Impact of probiotics and prebiotics on food texture. Curr Opin Food Sci 33:38–44

    Article  Google Scholar 

  • Hachimura S, Totsuka M, Hosono A (2018) Immunomodulation by food: impact on gut immunity and immune cell function. Biosci Biotechnol Biochem 82(4):584–599

    Article  CAS  PubMed  Google Scholar 

  • Hassan M, Kjos M, Nes IF, Diep DB, Lotfipour F (2012) Natural antimicrobial peptides from bacteria: characteristics and potential applications to fight against antibiotic resistance. J Appl Microbiol 113(4):723–736

    Article  CAS  PubMed  Google Scholar 

  • Hemalatha R, Ouwehand AC, Saarinen MT, Prasad UV, Swetha K, Bhaskar V (2017) Effect of probiotic supplementation on total lactobacilli, bifidobacteria and short chain fatty acids in 2–5-year-old children. Microb Ecol Health Dis 10:1298340

    Google Scholar 

  • Hill BF, Guarner G, Reid GR, Gibson DJ, Merenstein B (2014) Expert consensus document: the international scientific Association for Probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 11(8):506–514

    Article  PubMed  Google Scholar 

  • Ho CY, Lau CB, Kim CF, Leung KN, Fung KP, Tse TF, Chan HH, Chow MS (2004) Differential effect of Coriolus versicolor (Yunzhi) extract on cytokine production by murine lymphocytes in vitro. Int Immunopharmacol 4(12):1549–1557

    Article  CAS  PubMed  Google Scholar 

  • Hollmig ST, Ariizumi K, Cruz PD Jr (2009) Recognition of non - self- polysaccharides by C-type lectin receptors dectin-1 and dectin-2. Glycobiol 19(6):568–575

    Article  CAS  Google Scholar 

  • Hong H, Kim J, Lim T, Song Y, Cho C, Jang M (2018) Mixing ratio optimization for functional complex extracts of Rhodiola crenulata, Panax quinquefolius, and Astragalus membranaceus using mixture design and verification of immune functional efficacy in animal models. J Funct Foods 40:447–454

    Article  CAS  PubMed  Google Scholar 

  • Hui DS, Lee N, Chan PK, Beigel JH (2018) The role of adjuvant immunomodulatory agents for treatment of severe influenza. Antivir Res 150:202–216

    Article  CAS  PubMed  Google Scholar 

  • Jantan I, Ahmad W, Bukhari SNA (2015) Plant-derived Immunomodulators: an insight on their preclinical evaluation and clinical trials. Front Plant Sci 6(655):1–18

    Google Scholar 

  • Jeffery NM, Cortina M, Newsholme EA, Calder PC (1997) Effects of variations in the proportions of saturated, monounsaturated and polyunsaturated fatty acids in the rat diet on spleen lymphocyte functions. Br J Nutr 77:805–823

    Article  CAS  PubMed  Google Scholar 

  • Jeurink PV, Knippin K, Wiens F, Barańska K, Stahl B, Garssen J, Krolak-Olejni B (2019) Importance of maternal diet in the training of the infant's immune system during gestation and lactation. Crit Rev Food Sci Nutr 59(8):1311–1319

    Article  CAS  PubMed  Google Scholar 

  • John GK, Wang L, Nanavati J, Twose C, Singh R, Mullin G (2018) Dietary alteration of the gut microbiome and its impact on weight and fat mass: a systematic review and meta-analysis. Genes 9(3):167

    Article  CAS  Google Scholar 

  • Joossens M, Huys G, Van Steen K, Cnockaert M, Vermeire S, Rutgeerts P, Verbele K, Vandamme P, De Preter V (2011) High-throughput method for comparative analysis of denaturing gradient gel electrophoresis profiles from human fecal samples reveals significant increases in two bifidobacterial species after inulin-type prebiotic intake. FEMS Microbiol Ecol 75(2):343–349

    Article  CAS  PubMed  Google Scholar 

  • Kaminogawa S, Nanno M (2004) Modulation of immune functions by foods. Evid Based Complement Alternat Med 1:241–250

    Article  PubMed  PubMed Central  Google Scholar 

  • Kang SC, Koo HJ, Park S, Lim JD, Kim YJ, Kim T, Sohn EH (2013) Effects of β-glucans from Coriolus versicolor on macrophage phagocytosis are related to the Akt and CK2/Ikaros. Int J Biol Macromol 57:9–16

    Article  CAS  PubMed  Google Scholar 

  • Keservani RK, Kesharwani RK, Vyas N, Jain S, Raghuvanshi R, Sharma AK (2010a) Nutraceutical and functional food as future food: a review. Pharm Lett 2(1):106–116

    Google Scholar 

  • Keservani RK, Kesharwani RK, Sharma AK, Vyas N, Chadokar A (2010b) Nutritional supplements: an overview. J Curr Pharm Rev Res 1(1):59–75

    Google Scholar 

  • Keservani RK, Kesharwani RK, Sharma AK, Jarouliya U (2015) Dietary supplements, nutraceutical, and functional foods in immune response (immunomodulators). In: Bagchi D, Swaroop A, Preuss HG (eds) Nutraceutical and functional foods in human life and disease prevention. CRC Press, Taylor and Francis, Boca Raton, FL, pp 343–360

    Google Scholar 

  • Keservani RK, Sharma AK, Kesharwani RK, 2017. An overview and therapeutic applications of nutraceutical and functional foods. In Recent advances in drug delivery technology, pp 160–201

    Google Scholar 

  • Khosravi-Boroujeni H, Mohammadifard N, Sarrafzadegan N, Sajjadi F, Maghroun M, Khosravi A, Alikhasi H, Rafieian M, Azadbakht L (2012) Potato consumption and cardiovascular disease risk factors among Iranian population. Int J Food Sci Nutr 63(8):913–920

    Article  PubMed  Google Scholar 

  • Khozin-Goldberg I, Leu S, Boussiba S (2016) Microalgae as a source for VLC-PUFA production. Lipids in plant and algae development. Subcell Biochem 86:471–510

    Article  CAS  PubMed  Google Scholar 

  • Kim SJ, Kim HM (2017) Dynamic lipopolysaccharide transfer cascade to TLR4/MD2 complex via LBP and CD14. BMB Rep 50(2):55

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kim GY, Lee JY, Lee JO, Ryu CH, Choi BT, Jeong YK, Lee KW, Jeong SC, Choi YH (2006) Partial characterization and immunostimulatory effect of a novel polysaccharide–protein complex extracted from Phellinus linteus. Biosci Biotechnol Biochem 70(5):1218–1226

    Article  CAS  PubMed  Google Scholar 

  • Kim MH, Kang SG, Park JH, Yanagisawa M, Kim CH (2013) Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice. Gastroenterology 145(2):396–406

    Article  CAS  PubMed  Google Scholar 

  • Kim DH, Cho YM, Lee KH, Jeong SW, Kwon OJ (2017) Oleate protects macrophages from palmitate-induced apoptosis through the downregulation of CD36 expression. Biochem Biophys Res Commun 488(3):477–482

    Article  CAS  PubMed  Google Scholar 

  • Kim DE, Shang X, Assefa AD, Keum YS, Saini RK (2018) Metabolite profiling of green, green/red, and red lettuce cultivars: variation in health beneficial compounds and antioxidant potential. Food Res Int 105:361–370

    Article  CAS  PubMed  Google Scholar 

  • Koh A, De Vadder F, Kovatcheva-Datchary P, Backhed F (2016) From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell 165:1332–1345

    Article  CAS  PubMed  Google Scholar 

  • Kong ZL, Kao NJ, Hu JY, Wu CS (2016) Fucoxanthin-rich Brown algae extract decreases inflammation and attenuates colitis-associated colon cancer in mice. J Food Nutr Res 4:137–147

    CAS  Google Scholar 

  • Kotsafti A, Scarpa M, Castagliuolo I, Scarpa M (2020) Reactive oxygen species and anti-tumor immunity—from surveillance to evasion. Cancers 12(7):1748

    Article  CAS  PubMed Central  Google Scholar 

  • Krishnamoorthy D, Sankaran M (2016) Modulatory effect of Pleurotus ostreatus on oxidant/antioxidant status in 7, 12-dimethylbenz (a) anthracene induced mammary carcinoma in experimental rats—a dose-response study. J. Cancer Res Ther 12:1–10

    Google Scholar 

  • Kumar D, Romero Y, Schuck KN, Smalley H, Subedi B, Fleming SD (2020) Drivers and regulators of humoral innate immune responses to infection and cancer. Mol Immunol 121:99–110

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kure C, Timmer J, Stough C (2017) The immunomodulatory effects of plant extracts and plant secondary metabolites on chronic neuroinflammation and cognitive aging: a mechanistic and empirical review. Front Pharmacol 8:117

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kwak JH, Baek SH, Woo Y, Han JK, Kim BG, Kim OY, Lee JH (2012) Beneficial immunostimulatory effect of short-term chlorella supplementation: enhancement of natural killer cell activity and early inflammatory response (randomized, double-blinded, placebo-controlled trial). Nutr J 11(1):1–8

    Article  CAS  Google Scholar 

  • Kwon HK, Lee CG, So JS, Chae CS, Hwang JS, Sahoo A, Nam JH, Rhee JH, Hwang KC, Im SH (2010) Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders. Proc Natl Acad Sci U S A 107:2159–2164

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lee CL, Yang X, Wan J (2006) The culture duration affects the immunomodulatory and anticancer effect of polysaccharopeptide derived from Coriolus versicolor. Enzym Microb Technol 38(1 & 2):14–21

    Article  CAS  Google Scholar 

  • Li R, Chen W, Wang W, Tian W, Zhang X (2009) Extraction, characterization of Astragalus polysaccharides and its immune modulating activities in rats with gastric cancer. Carbohydr Polym 78:738–742

    Article  CAS  Google Scholar 

  • Li J, Zhong Y, Li H, Zhang N, Ma W, Cheng G, Liu F, Liu F, Xu J (2011) Enhancement of Astragalus polysaccharide on the immune responses in pigs inoculated with foot-and-mouth disease virus vaccine. Int J Biol Macromol 49:362–368

    Article  CAS  PubMed  Google Scholar 

  • Li Q, Guo G, Meng F, Wang HH, Niu Y, Zhang Q, Zhang J, Wang Y, Dong L, Wang C (2016) A naturally derived, growth factor-binding polysaccharide for therapeutic angiogenesis. ACS Macro Lett 5(5):617–621

    Article  CAS  PubMed  Google Scholar 

  • Li Q, Feng Y, He W, Wang L, Wang R, Dong L, Wang C (2017) Post-screening characterization and in vivo evaluation of an anti-inflammatory polysaccharide fraction from Eucommia ulmoides. Carbohydr Polym 169:304–314

    Article  CAS  PubMed  Google Scholar 

  • Llado V, Gutierrez A, Martínez J, Casas J, Terés S, Higuera M, Galmés A, Saus C, Besalduch J, Busquets X, Escribá PV (2010) Minerval induces apoptosis in Jurkat and other cancer cells. J Cell Mol Med 14(3):659–670

    CAS  PubMed  Google Scholar 

  • Lu B, Zhao Y (2017) Photooxidation of phytochemicals in food and control: a review. Ann N Y Acad Sci 1398(1):72–82

    Article  CAS  PubMed  Google Scholar 

  • Luu M, Visekruna A (2019) Short-chain fatty acids: bacterial messengers modulating the immunometabolism of T cells. Eur J Immunol 9:842–848

    Article  CAS  Google Scholar 

  • Madihi Y, Merrikhi A, Baradaran A, Rafieian-kopaei M, Shahinfard N, Ansari R (2013) Impact of sumac on postprandial high-fat oxidative stress. Pak J Med Sci 29:340–345

    Article  Google Scholar 

  • Manu KA, Kuttan G (2009) Immunomodulatory activities of Punarnavine, an alkaloid from Boerhaavia diffusa. Immunopharmacol Immunotoxicol 31:377–387

    Article  CAS  PubMed  Google Scholar 

  • Manzo E, Cutignano A, Pagano D, Gallo C, Barra G, Nuzzo G, Sansone C, Ianora A, Urbanek K, Fenoglio D, Ferrera F (2017) A new marine-derived sulfoglycolipid triggers dendritic cell activation and immune adjuvant response. Sci Rep 7(1):1–10

    Article  CAS  Google Scholar 

  • Martirosyan D, Singh J (2015) A new definition of functional by FFC: what makes a new definition unique? Funct Foods Health Dis 5:209–223

    Article  Google Scholar 

  • Michel J, Mezouar S, Sereme Y, Chanez P, Vitte J, Dubus JC, Chantran Y, Leone M, Mège JL, Fabre A (2018) Microbiome and the immune system: from a healthy steady-state to allergy associated disruption. Hum Microb J 10:11–20

    Article  Google Scholar 

  • Mimouni V, Ulmann L, Pasquet V, Mathieu M, Picot L, Bougaran G, Cadoret JP, Morant-Manceau A, Schoefs B (2012) The potential of microalgae for the production of bioactive molecules of pharmaceutical interest. Curr Pharm Biotechnol 13(15):2733–2750

    Article  CAS  PubMed  Google Scholar 

  • Mohamed SIA, Jantan I, Haque MA (2017) Naturally occurring immunomodulators with antitumor activity: an insight on their mechanisms of action. Int Immunopharmacol 50:291–304

    Article  CAS  PubMed  Google Scholar 

  • Moreno-Mendieta S, Guillen D, Hernandez-Pando R, Sanchez S, Rodriguez-Sanoja R (2017) Potential of glucans as vaccine adjuvants: a review of the α-glucans case. Carbohydr Polym 165:103–114

    Article  CAS  PubMed  Google Scholar 

  • Moser M, Leo O (2010) Key concepts in immunology. Vaccine 28:C2–C13

    Article  CAS  PubMed  Google Scholar 

  • Niu Y, Li Q, Xie R, Liu S, Wang R, Xing P, Shi Y, Wang Y, Dong L, Wang C (2017) Modulating the phenotype of host macrophages to enhance osteogenesis in MSC-laden hydrogels: design of a glucomannan coating material. Biomaterials 139:39–55

    Article  CAS  PubMed  Google Scholar 

  • Novak M, Vetvicka V (2008) β-Glucans, history, and the present: immunomodulatory aspects and mechanisms of action. J Immunotoxicol 5(1):47–57

    Article  CAS  PubMed  Google Scholar 

  • Olaiya CO, Soetan KO, Esan AM (2016) The role of nutraceuticals, functional foods and value added food products in the prevention and treatment of chronic diseases. Afr J Food Sci 10(10):185–193

    Article  CAS  Google Scholar 

  • Oyedepo TA, Kayode AAA (2020) Bioactive carbohydrates, biological activities, and sources. In: Egbuna C, Tupas GD (eds) Functional foods and nutraceuticals. Springer Nature, Cham, Switzerland, pp 39–74

    Chapter  Google Scholar 

  • Oyedepo TA, Morakinyo AE (2020) Medicinal mushrooms. In: Sharma AK, Keservani RK, Gautam MSP (eds) Herbal product development formulation and applications. Apple Academic Press, Palm Bay, FL. Hard ISBN: 9781771888776; E-Book ISBN: 9781003003182

    Google Scholar 

  • Pancer Z, Cooper MD (2006) The evolution of adaptive immunity. Annu Rev Immunol 24:497–518

    Article  CAS  PubMed  Google Scholar 

  • Pandey KR, Naik SR, Vakil BV (2015) Probiotics, prebiotics and synbiotics-a review. J Food Sci Technol 52:7577–7587

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Panico S, Mattiello A, Panico C, Chiodini P (2014) Mediterranean dietary pattern and chronic diseases. Cancer Treat Res 159:69–81

    Article  CAS  PubMed  Google Scholar 

  • Parascandolo A, Rappa F, Cappello F, Kim J, Cantu DA, Chen H, Mazzoccoli G, Hematti P, Castellone MD, Salvatore M, Laukkanen MO (2017) Extracellular superoxide dismutase expression in papillary thyroid cancer mesenchymal stem/stromal cells modulates cancer cell growth and migration. Sci Rep 7:41,416

    Article  CAS  Google Scholar 

  • Park JS, Chyun JH, Kim YK, Line LL, Chew BP (2010) Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. Nutr Metab 7:18

    Article  CAS  Google Scholar 

  • Patil PS, Patil KN, Dudhgaonkar TD, Mohite Ks MC (2016) A review on phytochemicals as nutraceuticals. Int J Innov Res Sci Technol 2:254–260

    Google Scholar 

  • Pawelec G, Gupta S (2019) Editorial: immunology of aging. Front Immunol 10:1614

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Plaza M, Herrero M, Cifuentes A, Ibanez E (2009) Innovative natural functional ingredients from microalgae. J Agric Food Chem 57:7159–7170

    Article  CAS  PubMed  Google Scholar 

  • Prakash D, Dhakarey R, Mishra A (2004) Carotenoids: the phytochemicals of nutraceutical importance. Ind J Agric Biochem 17:1–8

    CAS  Google Scholar 

  • Radzikowska U, Rinaldi AO, Çelebi Sözener Z, Karaguzel D, Wojcik M, Cypryk K, Akdis M, Akdis CA, Sokolowska M (2019) The influence of dietary fatty acids on immune responses. Nutrients 11:2990

    Article  CAS  PubMed Central  Google Scholar 

  • Ramesh CK, Jamuna KS (2012) Concepts and trends of functional foods: a review. Int J Pharm Res Dev 4(06):273–290

    Google Scholar 

  • Riccio G, Lauritano C (2020) Microalgae with immunomodulatory activities. Mar Drugs 18(1):2

    Article  CAS  Google Scholar 

  • Rodríguez JM, Murphy K, Stanton C, Ross RP, Kober OI, Juge N, Avershina E, Rudi K, Narbad A, Jenmalm MC, Marchesi JR (2015) The composition of the gut microbiota throughout life, with an emphasis on early life. Microb Ecol Health Dis 26(1):26050

    PubMed  Google Scholar 

  • Roohafza H, Sarrafzadegan N, Sadeghi M, Rafieian-Kopaei M, Sajjadi F, Khosravi-Boroujeni H (2013) The association between stress levels and food consumption among Iranian population. Arch Iran Med 16:145–148

    PubMed  Google Scholar 

  • Sahasrabudhe NM, Beukema M, Tian L, Troost B, Scholte J, Bruininx E, Bruggeman G, van den Berg M, Scheurink A, Schols HA, Faas MM (2018) Dietary fiber pectin directly blocks toll-like receptor 2–1 and prevents doxorubicin-induced ileitis. Front Immunol 9:383

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Saini RK, Keum YS (2018) Omega-3 and omega-6 polyunsaturated fatty acids: dietary sources, metabolism, and significance—a review. Life Sci 203:255–267

    Article  CAS  PubMed  Google Scholar 

  • Saleh MH, Rashedi I, Keating A (2017) Immunomodulatory properties of Coriolus versicolor: the role of polysaccharopeptide. Front Immunol 8:1087

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Saman P, Chaiongkarn A, Moonmangmee S, Sukcharoen J, Kuancha C, Fungsin B (2016) Evaluation of prebiotic property in edible mushrooms. Biol Chem Res 3:75–85

    Google Scholar 

  • Sanders ME, Merenstein DJ, Reid G, Gibson GR, Rastall RA (2019) Probiotics and prebiotics in intestinal health and disease: from biology to the clinic. Nat Rev Gastroenterol Hepatol 16(10):605–616

    Article  PubMed  Google Scholar 

  • Schorey JS, Lawrence C (2008) The pattern recognition receptor Dectin-1: from fungi to mycobacteria. Curr Drug Targets 9:123–129

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sekhon BK, Sze DMY, Chan WK, Fan K, Li GQ, Moore DE, Roubin RH (2013) PSP activates monocytes in resting human peripheral blood mononuclear cells: immunomodulatory implications for cancer treatment. Food Chem 138(4):2201–2209

    Article  CAS  PubMed  Google Scholar 

  • Servili M, Sordini B, Esposto S, Urbani S, Veneziani G, Di Maio I, Selvaggini R, Taticchi A (2013) Biological activities of phenolic compounds of extra virgin olive oil. Antioxidants 3:1–23

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Seyed MA (2019) A comprehensive review on Phyllanthus derived natural products as potential chemotherapeutic and immunomodulators for a wide range of human diseases. Biocatal Agric Biotechnol 17:529–537

    Article  Google Scholar 

  • Shantilal S, Vaghela JS, Sisodia SS (2018) Review on immunomodulation and immunomodulatory activity of some medicinal plant. Eur J Biomed 5(8):163–174

    Google Scholar 

  • Shirzad M, Kordyazdi R, Shahinfard N, Nikokar M (2013) Does Royal Jelly affect tumor cells? J Herb Med Pharmacol 2:45–48

    Google Scholar 

  • Silva NA, Albuquerque TG, Alves RC, Oliveira MPB, Costa HS (2020) Melon (Cucumis melo L.) by- products: potential food ingredients for novel functional foods? Trends Food Sci Technol 98:181–189

    Article  CAS  Google Scholar 

  • Singdevsachan SK, Auroshree P, Mishra J, Baliyarsingh B, Tayung K, Thatoi H (2016) Mushroom polysaccharides as potential prebiotics with their anti-tumor and immunomodulating properties: a review. Bioact Carbohydr Diet Fibre 7(1):1–4

    Article  CAS  Google Scholar 

  • Spelman K, Burns J, Nichols D, Winters N, Ottersberg S, Tenborg M (2006) Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Altern Med Rev 11:128–150

    PubMed  Google Scholar 

  • Sze DM, Chan GC (2009) Supplements for immune enhancement in hematologic malignancies. Hematology. Am Soc Hematol Educ Program 2009(1):313–319

    Article  Google Scholar 

  • Temizoz B, Kuroda E, Ishii KJ (2016) Vaccine adjuvants as potential cancer immunotherapeutics. Int Immunol 28:329–338

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tian J, Ma J, Ma K, Guo H, Baidoo SE, Zhang Y, Yan J, Lu L, Xu H, Wang S (2013) β-Glucan enhances anti-tumor immune responses by regulating differentiation and function of monocytic myeloid-derived suppressor cells. Eur J Immunol 43(5):1220–1230

    Article  CAS  PubMed  Google Scholar 

  • Van der Beek CM, Dejong CHC, Troost FJ, Masclee AAM, Lenaerts K (2017) Role of short-chain fatty acids in colonic inflammation, carcinogenesis, and mucosal protection and healing. Nutr Rev 75:286–305

    Article  PubMed  Google Scholar 

  • Varshney J, Ooi JH, Jayarao BM (2013) White button mushrooms increase microbial diversity and accelerate the resolution of Citrobacter rodentium infection in mice. J Nutr 143:526–532

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vulevic J, Juric A, Walton GE, Claus SP, Tzortzis G, Toward RE, Gibson GR (2015) Influence of galactooligosaccharide mixture (B-GOS) on gut microbiota, immune parameters and metabolomics in elderly persons. Br J Nutr 114:586–595

    Article  CAS  PubMed  Google Scholar 

  • Wan MLY, Forsythe SJ, El-Nezami H (2019) Probiotics interaction with food borne pathogens: a potential alternative to antibiotics and future challenges. Crit Rev Food Sci Nutr 59(20):3320–3333

    Article  CAS  PubMed  Google Scholar 

  • Wang J, Dong B, Tan Y, Yu S, Bao YX (2013) A study on the immunomodulation of polysaccharopeptide through the TLR4-TIRAP/MAL-MyD88 signaling pathway in PBMCs from breast cancer patients. Immunopharmacol Immunotoxicol 35(4):497–504

    Article  CAS  PubMed  Google Scholar 

  • Wang H, Gao K, Wen K, Allen IC, Li G, Zhang W, Kocher J, Yang X, Giri-Rachman E, Li GH, Clark-Deener S (2016) Lactobacillus rhamnosus GG modulates innate signaling pathway and cytokine responses to rotavirus vaccine in intestinal mononuclear cells of gnotobiotic pigs transplanted with human gut microbiota. BMC Microbiol 16(1):1–14

    Article  CAS  Google Scholar 

  • Wangchuk P, Apte SH, Smout MJ, Groves PL, Loukas A, Doolan DL (2018) Defined small molecules produced by Himalayan medicinal plants display immunomodulatory properties. Int J Mol Sci 19(11):3490

    Article  PubMed Central  CAS  Google Scholar 

  • Wells JM (2011) Immunomodulatory mechanisms of lactobacilli. Microb Cell Factories 10:S17

    Article  Google Scholar 

  • Wen CC, Chen HM, Yang NS (2012) Developing Phytocompounds from medicinal plants as Immunomodulators. Adv Bot Res 62:197–272

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • West CE, Jenmalm MC, Prescott SL (2015) The gut microbiota and its role in the development of allergic disease: a wider perspective. Clin Exp Allergy 45:43–53

    Article  CAS  PubMed  Google Scholar 

  • Wu D, Lewis ED, Pae M, Meydani SN (2019) Nutritional modulation of immune function: analysis of evidence, mechanisms, and clinical relevance. Front Immunol 9:3160

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Yang SF, Zhuang TF, Si YM, Qi KY, Zhao J (2015) Coriolus versicolor mushroom polysaccharides exert immunoregulatory effects on mouse B cells via membrane Ig and TLR-4 to activate the MAPK and NF-kappaB signaling pathways. Mol Immunol 64(1):144–151

    Article  CAS  PubMed  Google Scholar 

  • Yaqoob P (2002) Monounsaturated fatty acids and immune function. Eur J Clin Nutr 56:S9–S13

    Article  CAS  PubMed  Google Scholar 

  • Yin M, Zhang Y, Li H (2019) Advances in research on immunoregulation of macrophages by plant polysaccharides. Front. Immunol 10:145

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yoshida N, Yamashita T, Hirata KI (2018) Gut microbiome and cardiovascular diseases. Diseases 6(3):56

    Article  CAS  PubMed Central  Google Scholar 

  • Zhao J (2007) Nutraceuticals, nutritional therapy, phytonutrients, and phytotherapy for improvement of human health: a perspective on plant biotechnology application. Recent Pat Biotechnol 1(1):75–97

    Article  CAS  PubMed  Google Scholar 

  • Zhao Y, Wang C (2018) Effect of ω-3 polyunsaturated fatty acid-supplemented parenteral nutrition on inflammatory and immune function in postoperative patients with gastrointestinal malignancy: a meta-analysis of randomized control trials in China. Medicine 97(16):e0472

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhao M, Chen Z, Xia G, Cui FY, Zhang JJ, Jia MS, Jia SH, Jia L (2015a) Enzymatic and acidic degradation effect on intracellular polysaccharide of Flammulina velutipes SF-08. Int J Biol Macromol 73:236–244

    Article  CAS  Google Scholar 

  • Zhao W, Liu W, Li J, Lin X, Wang Y (2015b) Preparation of animal polysaccharides nanofibers by electrospinning and their potential biomedical applications. J Biomed Mater Res Part A 103(2):807–818

    Article  CAS  Google Scholar 

  • Zheng D, Liwinski T, Elinav E (2020) Interaction between microbiota and immunity in health and disease. Cell Res 30:492–506

    Article  PubMed  PubMed Central  Google Scholar 

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Oyedepo, T.A., Morakinyo, A.E., Babarinde, S.O. (2022). Immune Boosting Activity of Nutraceuticals and Functional Foods. In: Kesharwani, R.K., Keservani, R.K., Sharma, A.K. (eds) Immunomodulators and Human Health. Springer, Singapore. https://doi.org/10.1007/978-981-16-6379-6_3

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