Skip to main content
SpringerLink
Log in

Anti-Aging Properties of Medicinal Mushrooms in Systemic Aesthetic Medicine

  • Chapter
  • First Online:
Biology, Cultivation and Applications of Mushrooms

Abstract

Medicinal mushrooms are a rich source of bioactive molecules, nutraceutic products, as well as natural co-formulants and excipients. The fungal cell wall is rich in branched polysaccharides (mainly β-glucans), peptidic residues, and chitin or chitosan. A plethora of secondary metabolites with current or potential application includes e.g. terpenoids, polyketides, ceramides, polyphenolics, l-ergothioneine and others.

Mushroom application in cosmetics has been explored for a few decades only, but the increasing demand for bio-based products has stimulated this research field. Strategies against skin aging are the main target of cosmetic and cosmeceutic applications. Based on an integrated approach that pursues psycho-physical wellness, Systemic Aesthetic Medicine focuses on both external (creams, lotions) and internal (food supplements) uses of fungal molecules and extracts, besides the introduction in the diet of bulk fungal biomass (nutritional strategy). Far beyond the pure cosmetology, Systemic Aesthetic Medicine in fact focuses on prevention and treatment of skin diseases and cutaneous symptoms. Main properties reported from mushrooms at this concern include: hydration, anti-oxidant, acceleration of skin cells turnover, stimulation of skin bio-reparation, antiseptic, and immunomodulant.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  • Agrawal S, Adholeya A, Barrow CJ et al (2018) Marine fungi: an untapped bioresource for future cosmeceuticals. Phytochem Lett 23:15–20

    Article  CAS  Google Scholar 

  • Angeli JP, Ribeiro LR, Bellini MF et al (2009) β-Glucan extracted from the medicinal mushroom Agaricus blazei prevents the genotoxic effects of benzo[a]pyrene in the human hepatoma cell line HepG2. Arch Toxicol 83:81–86

    Article  CAS  PubMed  Google Scholar 

  • Angelini P, Tirillini B, Bistocchi G et al (2018) Overview of the biological activities of the methanolic extract from wild Fomitopsis pinicola fruiting body from Central Italy. Int J Med Mushrooms 20(11):1047–1063

    Article  PubMed  Google Scholar 

  • Angelini P, Girometta C, Tirillini B et al (2019) A comparative study of the antimicrobial and antioxidant activities of Inonotus hispidus fruit and their mycelia extracts. Int J Food Prop 22(1):768–783

    Article  CAS  Google Scholar 

  • Angelini P, Venanzoni R, Angeles Flores G et al (2020) Evaluation of antioxidant, antimicrobial and tyrosinase inhibitory activities of extracts from Tricholosporum goniospermum, an edible wild mushroom. Antibiotics 9:513

    Article  CAS  PubMed Central  Google Scholar 

  • Anunciato TP, da Rocha Filho PA (2012) Carotenoids and polyphenols in nutricosmetics, nutraceuticals, and cosmeceuticals. J Cosmet Dermatol 11:51–54

    Article  PubMed  Google Scholar 

  • Anuradha SN, Vilashene G, Lalithambigai J et al (2015) Cosmeceuticals: an opinion in the direction of pharmaceuticals. Asian J Pharm Clin Res 8:64–69

    Google Scholar 

  • Aranaz I, Acosta N, Civera C et al (2018) Cosmetics and cosmeceutical applications of chitin, chitosan and their derivatives. Polymers 10(2):213

    Article  PubMed Central  Google Scholar 

  • Avalos J, Limón MC (2015) Biological roles of fungal carotenoids. Curr Genet 61(3):309–324

    Article  CAS  PubMed  Google Scholar 

  • Badalyan SM (2014) Potential of mushroom bioactive molecules to develop healthcare biotech products. In: Proceedings of the 8th international conference on mushroom biology and mushroom products, New Delhi, 19–22 Nov 2014

    Google Scholar 

  • Bae JT, Sim GS, Lee DH et al (2005) Production of exopolysaccharide from mycelial culture of Grifola frondosa and its inhibitory effect on matrix metalloproteinase-1 expression in UV-irradiated human dermal fibroblasts. FEMS Microbiol Lett 251:347–354

    Article  CAS  PubMed  Google Scholar 

  • Bai YB, Gao YQ, Nie XD et al (2019) Antifungal activity of griseofulvin derivatives against phytopathogenic fungi in vitro and in vivo and three-dimensional quantitative structure–activity relationship analysis. J Agric Food Chem 67(22):6125–6132

    Article  CAS  PubMed  Google Scholar 

  • Barel AO, Paye M, Maibach HI (2014) Use of food supplements as nutricosmetics in health and fitness. In: Handbook of cosmetic science and technology, 4th edn. CRC Press, Boca Raton, pp 583–596

    Chapter  Google Scholar 

  • Baumann L (2007) Skin ageing and its treatment. J Pathol 211:241–251

    Article  CAS  PubMed  Google Scholar 

  • Bazela K, Solyga-Zurek A, Debowska R et al (2014) L-Ergothioneine protects skin cells against UV-induced damage-a preliminary study. Cosmetics 1:51–60

    Article  Google Scholar 

  • Benkeblia N (2015) Ganoderma lucidum polysaccharides and terpenoids: profile and health benefits. J Food Nutr Diet 1:1–6

    Google Scholar 

  • Bentley R (2006) From miso, sake and shoyu to cosmetics: a century of science for kojic acid. Nat Prod Rep 23:1046–1062

    Article  CAS  PubMed  Google Scholar 

  • Bisen PS, Baghel RK, Sanodiya BS et al (2010) Lentinus edodes: a macrofungus with pharmacological activities. Curr Med Chem 17:2419–2430

    Article  CAS  PubMed  Google Scholar 

  • Bondy GS, Pestka JJ (2000) Immunomodulation by fungal toxins. J Toxicol Environ Health B Crit Rev 3(2):109–143

    Article  CAS  PubMed  Google Scholar 

  • Bowe WP (2013) Cosmetic benefits of natural ingredients: mushrooms, feverfew, tea, and wheat complex. J Drugs Dermatol 12:133–136

    Google Scholar 

  • Brandalise F, Cesaroni V, Gregori A et al (2017) Dietary supplementation of Hericium erinaceus increases mossy fiber-CA3 hippocampal neurotransmission and recognition memory in wild-type mice. Evid Based Complement Alternat Med 2017:3864340

    Article  PubMed  PubMed Central  Google Scholar 

  • Buckman SY, Gresham A, Hale P et al (1998) COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer. Carcinogenesis 19(5):723–729

    Article  CAS  PubMed  Google Scholar 

  • Cao Y, Prescott SM (2002) Many actions of cyclooxygenase-2 in cellular dynamics and in cancer. J Cell Physiol 190:279–286

    Article  CAS  PubMed  Google Scholar 

  • Çetin MB, Ceylan G, Cantürk Z et al (2021) Screening of antioxidant activity of mycelia and culture liquids of fungi from Turkey. Microbiology 90(1):133–143

    Article  Google Scholar 

  • Chakraborty I, Sen IK, Mondal S et al (2019) Bioactive polysaccharides from natural sources: a review on the antitumor and immunomodulating activities. Biocatal Agric Biotechnol 22:101425

    Article  Google Scholar 

  • Chang TS (2009) An updated review of tyrosinase inhibitors. Int J Mol Sci 10:2440–2475

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chang ST, Wasser SP (2018) Current and future research trends in agricultural and biomedical applications of medicinal mushrooms and mushroom products. Int J Med Mushrooms 20(12):1521–9437

    Article  Google Scholar 

  • Chen W, Lee MK, Jefcoate C et al (2014) Fungal cytochrome p450 monooxygenases: their distribution, structure, functions, family expansion, and evolutionary origin. Genome Biol Evol 6(7):1620–1634

    Article  PubMed  PubMed Central  Google Scholar 

  • Cheung LM, Cheung PC, Ooi VE (2003) Antioxidant activity and total phenolics of edible mushroom extracts. Food Chem 81:249–255

    Article  CAS  Google Scholar 

  • Chiavaroli A, Sinan KI, Zengin G et al (2020) Identification of chemical profiles and biological properties of Rhizophora racemose G. Mey. Extracts obtained by different methods and solvents. Antioxidants 9(6):533

    Article  CAS  PubMed Central  Google Scholar 

  • Chien CC, Tsai ML, Chen CC et al (2008) Effects on tyrosinase activity by the extracts of Ganoderma lucidum and related mushrooms. Mycopathologia 166:117–120

    Article  CAS  PubMed  Google Scholar 

  • Choi CM, Berson DS (2006) Cosmeceuticals. Semin Cutan Med Surg 25:163–168

    Article  CAS  PubMed  Google Scholar 

  • Choi MH, Han HK, Lee YJ et al (2014) In vitro anti-cancer activity of hydrophobic fractions of Sparassis latifolia extract using AGS, A529, and HepG2 cell lines. J Mushroom 12:304–310

    Google Scholar 

  • Cör D, Knez Ž, Knez Hrnčič M (2018) Antitumour, antimicrobial, antioxidant and antiacetylcholinesterase effect of Ganoderma lucidum terpenoids and polysaccharides: a review. Molecules 23(3):649

    Article  PubMed Central  Google Scholar 

  • Corana F, Cesaroni V, Mannucci B et al (2019) Array of metabolites in Italian Hericium erinaceus mycelium, primordium, and sporophore. Molecules 24(19):3511

    Article  CAS  PubMed Central  Google Scholar 

  • Costa-Silva F, Marques G, Matos CC et al (2011) Selenium contents of Portuguese commercial and wild edible mushrooms. Food Chem 126(1):91–96

    Article  CAS  Google Scholar 

  • Covino S, D’Ellena E, Tirillini B et al (2019) Characterization of biological activities of methanol extract of Fuscoporia torulosa (Basidiomycetes) from Italy. Int J Med Mushrooms 21(11):1051–1063

    Article  PubMed  Google Scholar 

  • Črešnar B, Petrič Š (2011) Cytochrome P450 enzymes in the fungal kingdom. Biochimica et Biophysica Acta (BBA)-Proteins Proteomics 1814(1):29–35

    Article  Google Scholar 

  • Dai YC, Yang ZL, Cui BK et al (2009) Species diversity and utilization of medicinal mushrooms and fungi in China (review). Int J Med Mushrooms 11:287–302

    Article  Google Scholar 

  • De Melo Macoris JD, Brugnari T, Gandolfi Boer C et al (2017) Antioxidant properties and antimicrobial potential of aqueous extract of basidioma from Lentinus edodes (BerK) Sing (Shiitake). Int J Curr Microbiol Appl Sci 6(9):3757–3767

    Article  Google Scholar 

  • De Silva DD, Rapior S, Hyde KD et al (2012) Medicinal mushrooms in prevention and control of diabetes mellitus. Fungal Divers 56:1–29

    Article  Google Scholar 

  • Dini I, Laneri S (2019) Nutricosmetics: a brief overview. Phytother Res 33(12):3054–3063

    Article  PubMed  Google Scholar 

  • Dubost NJ, Beelman RB, Peterson D, Royse DJ (2006) Identification and quantification of ergothioneine in cultivated mushrooms by liquid chromatography-mass spectroscopy. Int J Med Mushrooms 8(3):215–222

    Article  CAS  Google Scholar 

  • Dubost NJ, Ou B, Beelman RB (2007) Quantification of polyphenols and ergothioneine in cultivated mushrooms and correlation to total antioxidant capacity. Food Chem 105(2):727–735

    Article  CAS  Google Scholar 

  • El Knidri H, Belaabed R, Addaou A et al (2018) Extraction, chemical modification and characterization of chitin and chitosan. Int J Biol Macromol 120:1181–1189

    Article  PubMed  Google Scholar 

  • Falandysz J (2013) On published data and methods for selenium in mushrooms. Food Chem 138(1):242–250

    Article  CAS  PubMed  Google Scholar 

  • Farage MA, Miller KW, Elsner P et al (2008) Intrinsic and extrinsic factors in skin ageing: a review. Int J Cosmet Sci 30(2):87–95

    Article  CAS  PubMed  Google Scholar 

  • Ferrante F, Angelini P, Venanzoni R et al (2020) Antimicrobial, antioxidant, and antiproliferative effects of Coronilla minima: an unexplored botanical species. Antibiotics 9:611

    Article  CAS  PubMed Central  Google Scholar 

  • Fisher GJ (2005) The pathophysiology of photoaging of the skin. Cutis 75(2):5–8

    PubMed  Google Scholar 

  • Friedman M (2015) Chemistry, nutrition, and health-promoting properties of Hericium erinaceus (Lion’s Mane) mushroom fruiting bodies and mycelia and their bioactive compounds. J Agric Food Chem 63(32):7108–7123

    Article  CAS  PubMed  Google Scholar 

  • Gao JM, Zhang AL, Chen H et al (2004) Molecular species of ceramides from the ascomycete truffle Tuber indicum. Chem Phys Lipids 131:205–213

    Article  CAS  PubMed  Google Scholar 

  • Gargano ML, van Griensven LJLD, Isikhuemhen OS et al (2017) Medicinal mushrooms: valuable biological resources of high exploitation potential. Plant Biosyst 151(3):548–565

    Article  Google Scholar 

  • Gautier S, Xhauflaire-Uhoda E, Gonry P et al (2008) Chitinglucan, a natural cell scaffold for skin moisturization and rejuvenation. Int J Cosmet Sci 30:459–469

    Article  CAS  PubMed  Google Scholar 

  • Girometta C (2019) Antimicrobial properties of Fomitopsis officinalis in the light of its bioactive metabolites: a review. Mycology 10(1):32–39

    Article  CAS  PubMed  Google Scholar 

  • Girometta CE, Bernicchia A, Baiguera RM et al (2020) An Italian research culture collection of wood decay fungi. Diversity 12(2):58

    Article  Google Scholar 

  • Gong P, Wang S, Liu M et al (2020) Extraction methods, chemical characterizations and biological activities of mushroom polysaccharides: a mini-review. Carbohydr Res 494:108037

    Article  CAS  PubMed  Google Scholar 

  • Gregori A, Švagelj M, Voglar D et al (2016) Growth characteristics and ergosterol content of Grifola frondosa in various solid-state substrates. Chem Biochem Eng Q 30(2):183–188

    Article  CAS  Google Scholar 

  • Gromkowska-Kępka KJ, Puścion-Jakubik A, Markiewicz-Żukowska R et al (2021) The impact of ultraviolet radiation on skin photoaging-review of in vitro studies. J Cosmet Dermatol 00:1–5

    Google Scholar 

  • Gründemann C, Reinhardt JK, Lindequist U (2020) European medicinal mushrooms: do they have potential for modern medicine? – an update. Phytomedicine 66:153131

    Article  PubMed  Google Scholar 

  • Gupta AK, Adam P, Dlova N et al (2001) Therapeutic options for the treatment of tinea capitis caused by Trichophyton species: griseofulvin versus the new oral antifungal agents, terbinafine, itraconazole, and fluconazole. Pediatr Dermatol 18(5):433–438

    Article  CAS  PubMed  Google Scholar 

  • Gupta SK, Gautam A, Kumar S (2014) Natural skin whitening agents: a current status. Adv Biol Res 8:257–259

    Google Scholar 

  • Heinz A (2020) Elastases and elastokines: elastin degradation and its significance in health and disease. Crit Rev Biochem Mol Biol 55(3):1–22

    Article  Google Scholar 

  • Hobbs C (2005) The chemistry, nutritional value, immunopharmacology, and safety of the traditional food of medicinal split-gill fugus Schizophyllum commune Fr: Fr (Schizophyllaceae) a literature review. Int J Med Mushrooms 7:127–140

    Article  CAS  Google Scholar 

  • Hyde KD, Bahkali AH, Moslem MA (2010) Fungi – an unusual source for cosmetics. Fungal Divers 43:1–9

    Article  Google Scholar 

  • Ikekawa T (2001) Beneficial effects of edible and medicinal mushrooms on health care. Int J Med Mushrooms 3:79–86

    Google Scholar 

  • Jianzhang D (2003) Study on enriched germanium of Ganoderma lucidum by submerged culture. J Shenzhen Polytech 1

    Google Scholar 

  • Kalaras MD, Richie JP, Calcagnotto A et al (2017) Mushrooms: a rich source of the antioxidants ergothioneine and glutathione. Food Chem 233:429–433

    Article  CAS  PubMed  Google Scholar 

  • Kawaguchi Y, Tanaka H, Okada T et al (1997) Effect of reactive oxygen species on the elastin mRNA expression in cultured human dermal fibroblasts. Free Radic Biol Med 23(1):162–165

    Article  CAS  PubMed  Google Scholar 

  • Kendall AC, Nicolaou A (2013) Bioactive lipid mediators in skin inflammationand immunity. Prog Lipid Res 52:141–164

    Article  CAS  PubMed  Google Scholar 

  • Kim D, Park J, Kim J et al (2006) Flavonoids as mushroom tyrosinase inhibitors: a fluorescence quenching study. J Agric Food Chem 54:935–941

    Article  CAS  PubMed  Google Scholar 

  • Kim MY, Seguin P, Ahn JK et al (2008) Phenolic compound concentration and antioxidant activities of edible and medicinal mushrooms from Korea. J Agric Food Chem 56:7265–7270

    Article  CAS  PubMed  Google Scholar 

  • Kim SY, Go KC, Song YS et al (2014) Extract of the mycelium of T. matsutake inhibits elastase activity and TPA-induced MMP-1 expression in human fibroblasts. Int J Mol Med 34:1613–1621

    Article  PubMed  Google Scholar 

  • Ko HJ, Kim J, Ahn M et al (2021) Ergothioneine alleviates senescence of fibroblasts induced by UVB damage of keratinocytes via activation of the Nrf2/HO-1 pathway and HSP70 in keratinocytes. Exp Cell Res 400(1):112516

    Article  CAS  PubMed  Google Scholar 

  • Lademann J, Meinke MC, Sterry W et al (2011) Carotenoids in human skin. Exp Dermatol 20(5):377–382

    Article  CAS  PubMed  Google Scholar 

  • Le Ngoc TN, Oh YK, Lee YJ et al (2018) Effects of Sparassis crispa in medical therapeutics: a systematic review and meta-analysis of randomized controlled trials. Int J Mol Sci 19(5):1487

    Article  Google Scholar 

  • Lee JS, Shin DB, Lee SM et al (2013) Melanogenesis inhibitory and antioxidant activities of Phellinus baumii methanol extract. Korean J Mycol 41:104–111

    Article  Google Scholar 

  • Liao WC, Hsueh CY, Chan CF (2014) Antioxidative activity, moisture retention, film formation, and viscosity stability of Auricularia fuscosuccinea, white strain water extract. Biosci Biotechnol Biochem 78:1029–1036

    Article  CAS  PubMed  Google Scholar 

  • Lin J, Chiang H, Lin Y et al (2008) Natural products with skin-whitening effects. J Food Drug Anal 16:1–10

    Google Scholar 

  • Liu H, He L (2012) Comparison of the moisture retention capacity of Tremella polysaccharides and hyaluronic acid. J Anhui Agric Sci 40:13093–13094

    CAS  Google Scholar 

  • Lo HC (2021) Therapeutic potentials of medicinal mushrooms for nonalcoholic fatty liver disease: a review of current evidence. Int J Med Mushrooms 23(1):59–66

    Article  Google Scholar 

  • Machado ECFA, Ambrosano L, Lage R et al (2017) Nutraceuticals for healthy skin aging. In: Watson RR (ed) Nutrition and functional foods for healthy aging. Academic Press, Cambridge, pp 273–281

    Chapter  Google Scholar 

  • Maity P, Sen IK, Chakraborty I et al (2021) Biologically active polysaccharide from edible mushrooms: a review. Int J Biol Macromol 172:408–417

    Article  CAS  PubMed  Google Scholar 

  • Markova NG, Karaman-Jurukovska N, Dong KK et al (2009) Skin cells and tissue are capable of using L-ergothioneine as an integral component of their antioxidant defense system. Free Radic Biol Med 46(8):1168–1176

    Article  CAS  PubMed  Google Scholar 

  • Matsumoto T, Ikuta N, Mori M et al (2010) Mechanics of wrinkle formation: micromechanical analysis of skin deformation during wrinkle formation in ultraviolet-irradiated mice. Skin Res Technol 16(2):179–189

    Article  PubMed  Google Scholar 

  • Meckfessel MH, Brandt S (2014) The structure, function, and importance of ceramides in skin and their use as therapeutic agents in skin-care products. J Am Acad Dermatol 71(1):177–184

    Article  CAS  PubMed  Google Scholar 

  • Meng TX, Furuta S, Fukamizu S et al (2011) Evaluation of biological activities of extracts from the fruiting body of Pleurotus citrinopileatus for skin cosmetics. J Wood Sci 57:452–458

    Article  CAS  Google Scholar 

  • Morin-Crini N, Lichtfouse E, Torri G et al (2019) Applications of chitosan in food, pharmaceuticals, medicine, cosmetics, agriculture, textiles, pulp and paper, biotechnology, and environmental chemistry. Environ Chem Lett 17(4):1667–1692

    Article  CAS  Google Scholar 

  • Muzzarelli RAA, Muzzarelli C (2005) Chitosan chemistry: relevance to the biomedical sciences. In: Heinze T (ed) Polysaccharides I. Advances in polymer science, vol 186. Springer, Berlin

    Google Scholar 

  • Nagasaka R, Ishikawa Y, Inada T et al (2015) Depigmenting effect of winter medicinal mushroom Flammulina velutipes (higher Basidiomycetes) on melanoma cells. Int J Med Mushrooms 17:511–520

    Article  PubMed  Google Scholar 

  • Nguyen TK, Shin DB, Lee KR et al (2013) Antioxidant and anti-inflammatory activities of fruiting bodies of Dyctiophora indusiata. J Mushroom 11:269–277

    Article  Google Scholar 

  • Ogra Y, Ishiwata K, Encinar JR et al (2004) Speciation of selenium in selenium-enriched shiitake mushroom, Lentinula edodes. Anal Bioanal Chem 379:861–866

    Article  CAS  PubMed  Google Scholar 

  • Oluba OM (2019) Ganoderma terpenoid extract exhibited anti-plasmodial activity by a mechanism involving reduction in erythrocyte and hepatic lipids in Plasmodium berghei infected mice. Lipids Health Dis 18:12

    Article  PubMed  PubMed Central  Google Scholar 

  • Oricha BS (2010) Cosmeceuticals: a review. Afr J Pharm Pharmacol 4:127–129

    CAS  Google Scholar 

  • Papakonstantinou E, Roth M, Karakiulakis G (2012) Hyaluronic acid: a key molecule in skin aging. Dermato-Endocrinology 4:253–258

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Papp LV, Lu J, Holmgren A, Khanna KK (2007) From selenium to selenoproteins: synthesis, identity, and their role in human health. Antioxid Redox Signal 9(7):775–806

    Article  CAS  PubMed  Google Scholar 

  • Parvez S, Kang M, Chung HS et al (2007) Naturally occurring tyrosinase inhibitors: mechanism and applications in skin health, cosmetics and agriculture industries. Phytother Res 21:805–816

    Article  CAS  PubMed  Google Scholar 

  • Paul BD, Snyder SH (2010) The unusual amino acid L-ergothioneine is a physiologic cytoprotectant. Cell Death Differ 17(7):1134–1140

    Article  CAS  PubMed  Google Scholar 

  • Perna S, Spadaccini D, Botteri L et al (2019) Efficacy of bergamot: from anti-inflammatory and anti-oxidative mechanisms to clinical applications as preventive agent for cardiovascular morbidity, skin diseases, and mood alterations. Food Sci Nutr 7(2):369–384

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Phillips TJ, Demircay Z, Sahu M (2001) Hormonal effects on skin aging. Clin Geriatr Med 17(4):661–672

    Article  CAS  PubMed  Google Scholar 

  • Prendergast PM, Shiffman MA (eds) (2011) Systemic aesthetic medicine: art and techniques. Springer, Berlin

    Google Scholar 

  • Quintero-Cabello KP, Palafox-Rivera P, Lugo-Flores MA et al (2021) Contribution of bioactive compounds to the antioxidant capacity of the edible mushroom Neolentinus lepideus. Chem Biodivers 18:e2100085

    Article  CAS  PubMed  Google Scholar 

  • Rafferty TS, Beckett GJ, Walker C et al (2003) Selenium protects primary human keratinocytes from apoptosis induced by exposure to ultraviolet radiation. Clin Exp Dermatol 28(3):294–300

    Article  CAS  PubMed  Google Scholar 

  • Ramkumar L, Ramanathan T, Johnprabagaran J (2012) Evaluation of nutrients, trace metals and antioxidant activity in Volvariella volvacea (Bull ex Fr.) Sing. Emir J Food Agric 24(2):113–119

    Google Scholar 

  • Ratto D, Corana F, Mannucci B et al (2019) Hericium erinaceus improves recognition memory and induces hippocampal and cerebellar neurogenesis in frail mice during aging. Nutrients 11(4):715

    Google Scholar 

  • Ribeiro B, Pinho PGD, Andrade PB et al (2011) Do bioactive carotenoids contribute to the color of edible mushrooms? Open Chem Biomed Methods J 4:14–18

    Article  CAS  Google Scholar 

  • Rivera-Palafox P, Silva-Espinoza BA, González-Aguilar GA et al (2021) Antioxidant properties and industrial uses of edible polyporales. J Fungi 7(3):196

    Article  Google Scholar 

  • Rossi P, Cesaroni V, Brandalise F et al (2018) Dietary supplementation of lion’s mane medicinal mushroom, Hericium erinaceus (Agaricomycetes), and spatial memory in wild-type mice. Int J Med Mushrooms 20(5):1521–9437

    Article  Google Scholar 

  • Rzymski P, Mleczek M, Niedzielski P et al (2017) Cultivation of Agaricus bisporus enriched with selenium, zinc and copper. J Sci Food Agric 97(3):923–928

    Article  CAS  PubMed  Google Scholar 

  • Sandewicz IM, Julio GR, Zhu VX (2003) Anhydrous cosmetic compositions containing mushroom extract. US Patent US6645502, 11 Nov 2003

    Google Scholar 

  • Sator PG, Schmidt JB, Hönigsmann H (2003) Comparison of epidermal hydration and skin surface lipids in healthy individuals and in patients with atopic dermatitis. J Am Acad Dermatol 48:352–358

    Article  PubMed  Google Scholar 

  • Savino E, Girometta C, Miteva-Staleva J et al (2016) Wood decay macrofungi: strain collection and studies about antioxidant properties. C R Acad Bulg Sci 69(6):747–755

    CAS  Google Scholar 

  • Scharffetter-Kochanek K, Brenneisen P, Wenk J et al (2000) Photoaging of the skin from phenotype to mechanisms. Exp Gerontol 35(3):307–316

    Article  CAS  PubMed  Google Scholar 

  • Sitotaw R, Lulekal E, Abate D (2020) Ethnomycological study of edible and medicinal mushrooms in Menge District, Asossa zone, Benshangul Gumuz region, Ethiopia. J Ethnobiol Ethnomed 16:11

    Article  PubMed  PubMed Central  Google Scholar 

  • Siwulski M, Budzyńska S, Rzymski P et al (2019) The effects of germanium and selenium on growth, metalloid accumulation and ergosterol content in mushrooms: experimental study in Pleurotus ostreatus and Ganoderma lucidum. Eur Food Res Technol 245(9):1799–1810

    Article  CAS  Google Scholar 

  • Stanikunaite R, Khan SI, Trappe JM et al (2009) Cyclooxygenase-2 inhibitory and antioxidant compounds from the truffle Elaphomyces granulatus. Phytother Res 23:575–578

    Article  CAS  PubMed  Google Scholar 

  • Synytsya A, Míčková K, Synytsya A et al (2009) Glucans from fruit bodies of cultivated mushrooms Pleurotus ostreatus and Pleurotus eryngii: structure and potential prebiotic activity. Carbohydr Polym 76:548–556

    Article  CAS  Google Scholar 

  • Tang H, Ye ZW, Liu C et al (2019) Increasing of the contain of carotenoids in Caterpillar mushroom, Cordyceps militaris (Ascomycetes) by using the fungal elicitors cultivation. Int J Med Mushrooms 21(12):1521–9437

    Article  Google Scholar 

  • Taofiq O, González-Paramás AM, Martins A et al (2016a) Mushrooms extracts and compounds in cosmetics, cosmeceuticals and nutricosmetics – a review. Ind Crop Prod 90:38–48

    Article  CAS  Google Scholar 

  • Taofiq O, Heleno SA, Calhelha RC et al (2016b) Development of mushroom-based cosmeceutical formulations with anti-inflammatory, anti-tyrosinase, antioxidant, and antibacterial properties. Molecules 21:1372

    Article  PubMed Central  Google Scholar 

  • Taofiq O, Heleno SA, Calhelha RC et al (2019) Phenolic acids, cinnamic acid, and ergosterol as cosmeceutical ingredients: stabilization by microencapsulation to ensure sustained bioactivity. Microchem J 147:469–477

    Article  CAS  Google Scholar 

  • Vahlquist A, Duvic M (2007) Retinoids and carotenoids in dermatology. CRC Press, Boca Raton

    Book  Google Scholar 

  • Valverde ME, Hernández-Pérez T, Paredes-López O (2015) Edible mushrooms: improving human health and promoting quality life. Int J Microbiol 376387:14

    Google Scholar 

  • Vázquez F, Palacios S, Alemañ N et al (1996) Changes of the basement membrane and type IV collagen in human skin during aging. Maturitas 25(3):209–215

    Article  PubMed  Google Scholar 

  • Vigna L, Morelli F, Agnelli GM et al (2019) Hericium erinaceus improves mood and sleep disorders in patients affected by overweight or obesity: could circulating pro-BDNF and BDNF be potential biomarkers? Evid Based Complement Alternat Med 2019:7861297

    Article  PubMed  PubMed Central  Google Scholar 

  • Wang X, Zhang Z, Zhao M (2015) Carboxymethylation of polysaccharides from Tremella fuciformis for antioxidant and moisture-preserving activities. Int J Biol Macromol 72:526–530

    Article  CAS  PubMed  Google Scholar 

  • Wang J, Cao B, Zhao H et al (2017) Emerging roles of Ganoderma lucidum in anti-aging. Aging Dis 8(6):691

    Article  PubMed  PubMed Central  Google Scholar 

  • Wani BA, Bodha RH, Wani AH (2010) Nutritional and medicinal importance of mushrooms. J Med Plants Res 4(24):2598–2604

    Article  Google Scholar 

  • Watson RE, Gibbs NK, Griffiths CE et al (2014) Damage to skin extracellular matrix induced by UV exposure. Antioxid Redox Signal 21(7):1063–1077

    Article  CAS  PubMed  Google Scholar 

  • Wawrzyn GT, Quin MB, Choudhary S et al (2012) Draft genome of Omphalotus olearius provides a predictive framework for sesquiterpenoid natural product biosynthesis in Basidiomycota. Chem Biol 19(6):772–783

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wei S, Van Griensven LJLD (2008) Pro- and antioxidative properties of medicinal mushroom extracts. Int J Med Mushrooms 10(4):315–324

    Article  CAS  Google Scholar 

  • Wu YJ, Wei ZX, Zhang FM et al (2019) Structure, bioactivities and applications of the polysaccharides from Tremella fuciformis mushroom: a review. Int J Biol Macromol 121:1005–1010

    Article  CAS  PubMed  Google Scholar 

  • Xu H, Liu JH, Shen ZY et al (2010) Analysis of chemical composition, structure of Grifola frondosa polysaccharides and its effect on skin TNF-α levels, lgG content, T lymphocytes rate and caspase-3 mRNA. Carbohydr Polym 82(3):687–691

    Article  CAS  Google Scholar 

  • Yang T, Sun J, Lian T et al (2014) Process optimization for extraction of carotenoids from medicinal caterpillar fungus, Cordyceps militaris (Ascomycetes). Int J Med Mushrooms 16(2):1521–9437

    Article  Google Scholar 

  • Yao N, White PJ, Alavi S (2011) Impact of β-glucan and other oat flour components on physico-chemical and sensory properties of extruded oat cereals. Int J Food Sci Technol 46:651–660

    Article  CAS  Google Scholar 

  • Yildiz O, Can Z, Laghari AQ et al (2015) Wild edible mushrooms as a natural source of phenolics and antioxidants. J Food Biochem 39:148–154

    Article  CAS  Google Scholar 

  • Zeb M, Lee CH (2021) Medicinal properties and bioactive compounds from wild mushrooms native to North America. Molecules 26(2):251

    Article  CAS  PubMed Central  Google Scholar 

  • Zengin G, Ferrante C, Estelle Gnapi D et al (2019) Comprehensive approaches on the chemical constituents and pharmacological properties of flowers and leaves of American basil (Ocimum americanum L.). Food Res Int 125:108610

    Article  CAS  PubMed  Google Scholar 

  • Zhang Y, Kong H, Fang Y et al (2013a) Schizophyllan: a review on its structure, properties, bioactivities and recent developments. Bioactive Carbohydr Diet Fibre 1(1):53–71

    Article  CAS  Google Scholar 

  • Zhang K, Meng XY, Sun Y et al (2013b) Preparation of Tremella, Speranskiae tuberculatae and Eriocaulon buergerianum extracts and their performance in cosmetics. Deterg Cosmet 36:28–32

    Google Scholar 

  • Zhao S, Gao Q, Rong C et al (2020) Immunomodulatory effects of edible and medicinal mushrooms and their bioactive immunoregulatory products. J Fungi 6:269

    Article  CAS  Google Scholar 

  • Zhou S, Liu P, Chen J et al (2016) Characterization of mutants of a tyrosine ammonia-lyase from Rhodotorula glutinis. Appl Microbiol Biotechnol 100(24):10443–10452

    Article  CAS  PubMed  Google Scholar 

  • Ziaja-Sołtys M, Radzki W, Nowak J et al (2020) Processed fruiting bodies of Lentinus edodes as a source of biologically active polysaccharides. Appl Sci 10:470

    Article  Google Scholar 

  • Zuccotti E, Oliveri M, Girometta C et al (2018) Nutritional strategies for psoriasis: current scientific evidence in clinical trials. Eur Rev Med Pharmacol Sci 22(23):8537–8551

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, Biology and Biotechnology, Università degli Studi di Perugia, Perugia, Italy

    Paola Angelini & Roberto Venanzoni

  2. Department of Earth and Environmental Sciences, Università degli Studi di Pavia, Pavia, Italy

    Carolina Elena Girometta

  3. Scuola Superiore in Medicina Estetica Sistemica (SSMES), Tivoli, Italy

    Gianluigi Bertuzzi

Authors
  1. Paola Angelini
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Carolina Elena Girometta
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Roberto Venanzoni
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gianluigi Bertuzzi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Carolina Elena Girometta .

Editor information

Editors and Affiliations

  1. Department of Environmental Studies, Maharaja Sayajirao University of Baroda, Vadodara, India

    Arun Arya

  2. Mycological Laboratory, Institute of Biology, Ss. Cyril and Methodius University, Skopje, North Macedonia

    Katerina Rusevska

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Angelini, P., Girometta, C.E., Venanzoni, R., Bertuzzi, G. (2022). Anti-Aging Properties of Medicinal Mushrooms in Systemic Aesthetic Medicine. In: Arya, A., Rusevska, K. (eds) Biology, Cultivation and Applications of Mushrooms . Springer, Singapore. https://doi.org/10.1007/978-981-16-6257-7_7

Download citation

Publish with us

Policies and ethics

Search

Navigation