Skip to main content

Biopotency of Pteridophytes: A Review

  • Chapter
  • First Online:
Ferns

Abstract

From Silurian period, pteridophytes exist in the nature and expected to harbour various useful secondary metabolites. By the presence of secondary metabolites, pteridophytes are able to survive for more than 450 million years and house various biological activities, viz. anti-bacterial, anti-cancer, anti-diabetic, anti-fungal, anti-inflammatory, anti-oxidant, hepatoprotectivity, wound healing, etc. The review intends to summarize the available biopotential of pteridophytes from 2000 to 2021. A total of 244 species are taken into account for the present review. This chapter recorded anti-oxidant potential (135), anti-bacterial and anti-fungal activities (97), cytotoxic properties (61), anti-cancer activities (39), anti-inflammatory activities (26), anti-diabetic potential (23), hepatoprotective properties (9), wound healing potential (7) and larvicidal activities (6) of pteridophytes. We made an attempt to provide an update on the biopotential of pteridophytes. This review might be useful for the pteridologist, phytochemist and pharmacist for further research.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abdul Qadir A, Cakmak YS, Zengin G (2018) Phenolic compounds, antioxidant properties and enzyme inhibition ability of Adiantum capillus-veneris L. linked to Alzheimer’s disease, diabetes mellitus and skin disorders. Curr Organic Chem 22(17):1697–1703

    Article  CAS  Google Scholar 

  • Abiola GFA, Fatoba OP, Adepoju AO et al (2018) Phytochemical analysis, antimicrobial activity and identification of phytoconstituents in Gleichenia pectinata (Willd.) C. Presl. Int J Biomed Adv Res 9(12):400–406

    Google Scholar 

  • Adnan M, Siddiqui AJ, Hamadou WS et al (2021) Phytochemistry, bioactivities, pharmacokinetics and toxicity prediction of Selaginella repanda with its anticancer potential against human lung, breast and colorectal carcinoma cell lines. Molecules 26(3):768

    Article  PubMed  PubMed Central  Google Scholar 

  • Abraham G, Yadav RK, Kaushik G (2015) Antimicrobial activity and identification of potential antimicrobial compounds from aquatic pteridophyte, AzollamicrophyllaKaulf. Indian J Exp Biol 53(4):232–235

    CAS  PubMed  Google Scholar 

  • Ali MS, Amin MR, Kamal CM et al (2013) In vitro antioxidant, cytotoxic, thrombolytic activities and phytochemical evaluation of methanol extract of the A. philippense L. leaves. Asian Pac J Trop Biomed 3(6):464–469. https://doi.org/10.1016/S2221-1691(13)60097-0

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ali R, Hossain M, Runa JF et al (2014) Evaluation of thrombolytic potential of three medicinal plants available in Bangladesh, as a potent source of thrombolytic compounds. Avicenna J Phytomed 4(6):430–436

    CAS  Google Scholar 

  • Alim A, Khan A, Rahman BM et al (2007) In vitro antimicrobial properties and cytotoxic activities of chromium complexes. Res J Agric Biol Sci 3(6):599–604

    Google Scholar 

  • Al-Shabanah OA, Alam K, Nagi MN et al (2000) Protective effect of aminoguanidine, a nitric oxide synthase inhibitor, against carbon tetrachloride induced hepatotoxicity in mice. Life Sci 66(3):265–270. https://doi.org/10.1016/s0024-3205(99)00589-5

    Article  CAS  PubMed  Google Scholar 

  • Akter S, Monir H, Ismot A et al (2014) Investigation of In vitro antioxidant, antimicrobial and cytotoxic activity of Diplazium esculentum (Retz). Sw. IJAPBC 3(3):723–733

    CAS  Google Scholar 

  • Amoroso VB, Lagumbay JD, Mendez RA et al (2014) Bioactives in three Philippine edible ferns. Asian Int J Life Sci 23(2):445–454

    Google Scholar 

  • Angalao L, Doctor JGP, Banwa T (2012) Antimicrobial activities of Azollafiliculoides Lam. (Pteridophyte) and Brachytheciumbuchananii (Hook.) Jaeg (Bryophyte). Int J Sci Clin Lab 2:71–81. https://doi.org/10.7718/iamure.ijscl.v2i1.389

    Article  Google Scholar 

  • Anitta T, Prashob PKJ, Chandramohanakumar N (2016) A profiling of anti-tumour potential of sterols in the mangrove fern Acrostichum aureum. Int J Pharmacogn Phytochem Res 8(11):1828–1832

    Google Scholar 

  • Antesa DA, Grino YA (2013) DPPH radical scavenging activity, total phenolics, and antimicrobial screening of selected pteridophytes. Open Conf Proc J 4:259

    Article  Google Scholar 

  • Arullappan S, Sakunie S, Lew AC et al (2017) Phytochemical screening and evaluation of cytotoxic effect and antioxidant activity of fractions isolated from Stenochlaena palustris (Burm.f.) Bedd. Leaves. Indian J Pharm Educ Res 51(4S):s735–s740

    Article  CAS  Google Scholar 

  • Awe S, Amobi OO (2015) Antibacterial, phytochemical and proximate analysis of pteridiumaquilinum. Int J Res Pharm Biosci 2:1–7

    Google Scholar 

  • Azam A, Bani S, Hasanpoor S et al (2015) The effect of equisetum arvense (horse tail) ointment on wound healing and pain intensity after episiotomy: a randomized placebo-controlled trial. Iran Red Crescent Med J 17(3):e25637. https://doi.org/10.5812/ircmj.25637

    Article  Google Scholar 

  • Bahadori MB, Mahmoodi F, Aliahmadi A et al (2015) Antibacterial evaluation and preliminary phytochemical screening of selected ferns from Iran. Res J Pharmacogn 2:53–59

    Google Scholar 

  • Balne D, Pallerla P, Vanapatla SR et al (2013) Hepatoprotective effect of whole plant extract fractions of Marsilea minuta Linn. Asian J Pharm Clin Res 6(3):100–107

    Google Scholar 

  • Banani D, Duttachoudhury M et al (2014) Antioxidant and anti-inflammatory activity of aqueous and methanolic extracts of rhizome part of Drynaria quercifolia (L.) J. Smith. Int J Pharm Pharm Sci 6(6):43–49

    Google Scholar 

  • Baskaran XR, Geo Vigila AV, Zhang SZ (2018) A review of the use of pteridophytes for treating human ailments. J Zhejiang Univ-Sci B (Biomed & Biotechnol) 19(2):85–119

    Article  CAS  Google Scholar 

  • Bennett RN, Wallsgrove RM (2006) Secondary metabolites in plant defense mechanisms. New Phytologist 127:617–633

    Article  Google Scholar 

  • Britto AJD, Gracelin DHS, Benjamin PJRK (2014) Study on potential biocontrol agent—Angiopteris evecta (forst) hoff. against Xanthomonas campestris. Eur J Mol Biol Biochem 1(5):192–195

    Google Scholar 

  • Brown AWA (1986) Insecticide resistance in mosquitoes: a pragmatic review. J Am Mosq Control Assoc 2(2):123–140

    CAS  PubMed  Google Scholar 

  • Brown AWA, Pal R (1971) Insecticide resistance in arthropods, World Health Organization, Monger, vol 38. Switzerland, Geneva, p 491

    Google Scholar 

  • Cao H, Chai TT, Wang X et al (2017) Phytochemicals from fern species: potential for medicine applications. Phytochem Rev 16:379–440. https://doi.org/10.1007/s11101-016-9488-7

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chai TT, Kwek MT, Ong HC et al (2015a) Water fraction of edible medicinal fern Stenochlaena palustris is a potent α-glucosidase inhibitor with concurrent antioxidant activity. Food Chem 186:26–31. https://doi.org/10.1016/j.foodchem.2014.12.099

    Article  CAS  PubMed  Google Scholar 

  • Chai TT, Yeoh LY, Ismail NIM et al (2015b) Evaluation of glucosidase inhibitory and cytotoxic potential of five selected edible and medicinal ferns. TropJ Pharm Res 14(3):449–454

    Article  Google Scholar 

  • Chand Basha M, Sreenivasulu N, Pramod (2013) Anti-diabetic activity of Actiniopteris radiata (Linn.). Asian J Res Chem Pharm Sci 1:1–6

    Google Scholar 

  • Chang HC, Huang GJ, Dinesh CA et al (2007) Antioxidant activities and polyphenol contents of six folk medicinal ferns used as “Gusuibu”. Botanical Studies 48:397–406

    CAS  Google Scholar 

  • Chen YH, Chang FR, Lin YJ et al (2008) Identification of antioxidants from rhizome of Davallia solida. Food Chem 107:684–691

    Article  CAS  Google Scholar 

  • Chen CY, Chiu FY, Lin Y et al (2015) Chemical constituents analysis and antidiabetic activity validation of four fern species from Taiwan. Int J Mol Sci 16(2):2497–2516. https://doi.org/10.3390/ijms16022497

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cheng L-H, Wu J-B, Jian J-Y, Shih C-C (2017) (−)-Epicatechin-3-O-β-D-allopyranoside from Davallia formosana prevents diabetes and dyslipidemia in streptozotocin-induced diabetic mice. PLoS One 12(3):e0173984. https://doi.org/10.1371/journal.pone.0173984

    Article  CAS  Google Scholar 

  • Choudhury J, Majumdar S, Roy S et al (2017) Antioxidant activity and phytochemical screening of two edible wetland Pteridophytes Diplazium esculentum (Retz.) Sw. and Marsilea minuta L.–A comparative study. WJPMR 53(9):195–203

    Google Scholar 

  • Chuah EL, Zakaria ZA, Suhaili Z et al (2014) Antimicrobial activities of plant extracts against methicillin-susceptible and methicillin-resistant Staphylococcus aureus. J Microbiol Res 4(1):6–13

    Google Scholar 

  • Clericuzio M, Tinello S, Burlando B, Ranzato E, Martinotti S, Cornara L, La Rocca A (2012) Flavonoid oligoglycosides from Ophioglossum vulgatum L. having wound healing properties. Planta Med 78(15):1639–1644. https://doi.org/10.1055/s-0032-1315149. Epub 2012 Aug 30

    Article  CAS  PubMed  Google Scholar 

  • Dalli AK, Saha G, Chakraborty U (2007) Characterization of antimicrobial compounds from a common fern, Pteris biaurita. Indian J Exp Biol 45(3):285–290

    CAS  PubMed  Google Scholar 

  • Daneman D (2006) Type 1 diabetes. Lancet 367(9513):847–858. https://doi.org/10.1016/S0140-6736(06)68341-4

    Article  CAS  PubMed  Google Scholar 

  • Daonian Z, Jinlan R, Yaling C et al (2010) Antioxidant and hepatoprotective activity of ethanol extract of Arachniodes exilis (Hance) Ching. J Ethnopharmacol 129(2):232–237

    Article  Google Scholar 

  • Daryono RNH, Rhomawati M (2020) An examination of medicinal potential of Pneumatopteris callosa: phytochemical screening, antibacterial, and antioxidant activity. IOP Conf Ser Earth Environ Sci 456:012068

    Article  Google Scholar 

  • Das PK, Rajagopalan PK (1981) Role of stimulated migration of mosquitoes in development and reversal of malathion resistance in Culex pipensfatigans. Indian J Med Res 73:139–143

    PubMed  Google Scholar 

  • Dash DK, Yeligar VC, Nayak SS et al (2007) Evaluation of hepatoprotective and antioxidant activity of Ichnocarpus frutescens (Linn) R.Br. on Paracetamol induced hepatotoxicity in rats. Trop J Pharm Res 6(3):755–765

    Article  Google Scholar 

  • Deepa J, Parashurama TR, Krishnappa M, Nataraja S (2013) Antimicrobial efficacy of Blechnum orientale L. Int J Pharm Biol Sci 4(2):475–479

    Google Scholar 

  • de Queiroz GM, Flavio ASP, Edvanio RR et al (2015) Phytochemical characterization, antimicrobial activity, and antioxidant potential of Equisetum hyemale L. (Equisetaceae) extracts. J Med Food 18(7):830–834

    Article  PubMed  Google Scholar 

  • Dela Cruz RY, Aileen May GA, Glenda ZD et al (2017) Phytochemical screening, antioxidant and anti-inflammatory activities of the three fern (Polypodiaceae) species in Bukidnon, Philippines. Bull Env Pharmacol Life Sci 6(3):28–33

    Google Scholar 

  • Devasagayam TPA, Tilak JC, Boloor KK et al (2004) Review: free radical and antioxidants in human health: current status and future prospects. J Assoc Physicians India 52:794–804

    CAS  PubMed  Google Scholar 

  • Devika V, Prasanna G (2016) In vitro hepatoprotective activity of Drynaria quercifilia L. rhizome. World J Pharm Pharm Sci 5(1):512–521

    CAS  Google Scholar 

  • Dion C, Haug C, Guan H et al (2015) Evaluation of the anti-inflammatory and antioxidative potential of four fern species from China intended for use as food supplements. Nat Prod Commun 10(4):597–603

    PubMed  Google Scholar 

  • Dvorakova M, Pumprova K, Antonínová Z et al (2021) Nutritional and antioxidant potential of fiddleheads from European ferns. Foods 10(2):460

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fabiana RN, Tais Adelita AB, Angélica ML et al (2009) Antiinflammatory and antinociceptive activities of Blechnum occidentale L. extract. J Ethnopharmacol 125(1):102–107

    Article  Google Scholar 

  • Faizal A, Taufik I, Anisah FR et al (2020) Antioxidant and antibacterial properties of tree fern Cyathea contaminans. Biodiversitas 21(5):2201–2205

    Google Scholar 

  • Farook MA, Muthu Mohamed HS, Santhosh Kumar G (2019) Phytochemical screening, antibacterial and antioxidant activity of Azolla pinnata. Int J Res Anal Rev 6(2):240i–247i

    Google Scholar 

  • Farràs A, López V, Maggi F et al (2021) Polypodium vulgare L.: polyphenolic profile, cytotoxicity and cytoprotective properties in different cell lines. Preprints: 2021050351 https://doi.org/10.20944/preprints202105.0351.v1

  • Fierascu I, Fierascu RC, Ungureanu C et al (2021) Application of polypodiopsida class in nanotechnology–potential towards development of more effective bioactive solutions. Antioxidants 10:748. https://doi.org/10.3390/antiox10050748

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gayathri V, Asha V, Subromaniam A (2005) Preliminary studies on the immunomodulatory and antioxidant properties of Selaginella species. Indian J Pharmacol 37:381–385

    Article  Google Scholar 

  • Geisiany Q, Souza-Moreira T, Salgado H et al (2014) Antimicrobial activity and toxicity in vitro and in vivo of Equisetum hyemale extracts. Rev Cienc Farm Basica Apl 35(4):559–563

    Google Scholar 

  • Gerard A (2013) Evaluation of antimicrobial activity of methanolic extracts of Azollamicrophylla. Vegetos Int J Palnt Res 26(1):200. https://doi.org/10.5958/j.2229-4473.26.1.029

    Article  Google Scholar 

  • Goldberg DJ, Cooper JR (1975) Effects of thiamine antagonists on nerve conduction. I. Actions of antimetabolites and fern extract on propagated action potentials. J Neurobiol 6(5):435–452. https://doi.org/10.1002/neu.480060502

    Article  CAS  PubMed  Google Scholar 

  • Gracelin DHS, Britto AJD, Kumar PBJR (2012) Antibacterial screening of a few medicinal ferns against antibiotic resistant phytopathogen. Int J Pharm Sci Res 3(3):868–873

    Google Scholar 

  • Guha P, Mukhopadhyay R, Gupta K (2005) Antifungal activity of the crude extracts and extracted phenols from gametophytes and sporophytes of two species of Adiantum. Taiwania 50(4):272–283

    Google Scholar 

  • Gupta SK, Ghosala M, Biswasb R (2014) Evaluation of in vitro antioxidant activity of methanolic extracts of some ferns from Mawsynram of Meghalaya, India. Int J Curr Sci 12:E87–E97

    Google Scholar 

  • Halder K, Chakraborty S (2018) An account of antioxidant potential in pteridophytes: a biochemical perspective. Intl J Bioinform Biological Sci 6(1):15–24

    Google Scholar 

  • Halimatussakdiah H, Amna U, Wahyuningsih P (2018) Preliminary phytochemical analysis and larvicidal activity of edible fern (Diplazium esculentum (Retz.)Sw.) extract against Culex. J Nat 18(3):141–147

    Article  Google Scholar 

  • Hammami S, Ali S, Ridha EM et al (2016) Essential oil constituents and antioxidant activity of Asplenium Ferns. J Chromatogr Sci 54(8):1341–1345

    Article  CAS  PubMed  Google Scholar 

  • Han HJ, Tan NH, Zeng GZ et al (2008) Natural inhibitors of DNA topoisomerase I with cytotoxicities. Chem Biodivers 5(7):1364–1368. https://doi.org/10.1002/cbdv.200890124

    Article  CAS  PubMed  Google Scholar 

  • Handayani S, Hermawan A, Meiyanto E et al (2013) Induction of Apoptosis on MCF-7 cells by Selaginella Fractions. J App Pharm Sci 3(4):31–34

    Google Scholar 

  • Haripriya D, Selvan N, Jeyakumar N et al (2010) The effect of extracts of Selaginella involvens and Selaginella inaequalifolia leaves on poultry pathogens. Asian Pacific J Trop Med 3(9):678–681

    Article  Google Scholar 

  • Hassan V, Ali S, Fatemeh MK, Hossein D, Mir BB (2015) Cytotoxicity, antioxidant activity and phenolic content of eight fern species from North of Iran. Pharm Sci 21:18–24

    Article  Google Scholar 

  • Helena C, Paramas AG, Maria TA et al (2005) Characterisation of polyphenols by HPLC-PADESI/MS and antioxidant activity in Equisetum telmateia. Phytochem Anal 16(5):380–387

    Article  Google Scholar 

  • Hendy PH, Deny S, Shahbudin S et al (2013) Wound healing properties of ethanolic extract of Acrostichum aureum and Acrostichum speciosum rhizome in rats. J Trop Resour Sustain Sci 1(2):42–48

    Google Scholar 

  • Hort MA, Dalbó S, Brighente IMC et al (2008) Antioxidant and hepatoprotective effects of Cyathea phalerata Mart. (Cyatheaceae). Basic Clin Pharmacol Toxicol 103(1):17–24

    Article  CAS  PubMed  Google Scholar 

  • How YL, Lim YY, Kim KH (2011) Potential dermal wound healing agent in Blechnum orientale Linn. BMC Complement Altern Med 11:62

    Article  Google Scholar 

  • How YL, Yau YL, Kah HK (2010) Blechnum Orientale Linn - a fern with potential as antioxidant, anticancer and antibacterial agent. BMC Complementary and Alternative Medicine 10:15. https://doi.org/10.1186/1472-6882-10-15

  • Hu MF, Yen MH, Liao JW et al (2004) Hepatoprotective effects of the folk medicines of “Yan-Kan-Tang No.1” and “Yan- Kan-Tang No.2” on rats. Crop Environ Bioinform 1:229–238

    Google Scholar 

  • Huanjie Y, Ping QD (2010) Targeting apoptosis pathway with natural terpenoids: implications for treatment of breast and prostate cancer. Curr Drug Targets 11(6):733–744

    Article  Google Scholar 

  • Ibrahim AY, El-Gengaihi SE, Motawe HM (2011) Phytochemical and cytotoxicity investigations of Salvadora persica bark extracts. J Arab Soc Med Res 6(2):127–133

    Google Scholar 

  • Irene Pearl J, Ismail TS, Irudayaraj V et al (2011) Pharmacognostical studies on anti-cancer spikemoss Selaginella involvens (sw.) spring. Int J Drug Dev Res 2(6):195–211

    Google Scholar 

  • Irudayaraj V, Janaky M, Johnson M, Selvan N (2010) Preliminary phytochemical and antimicrobial studies on a spike-moss selaginella inaequalifolia (Hook. & Grev.) Spring. Asian Pacific J Trop Med 3(12):957–960

    Article  Google Scholar 

  • Ishaq MS, Hussain MM, Afridi MS et al (2014) In vitro phytochemical, antibacterial, and antifungal activities of leaf, stem, and root extracts of Adiantum capillus veneris. Sci World J 2:269793. https://doi.org/10.1155/2014/269793

    Article  Google Scholar 

  • Ismail AM, Al-Khasreji TO, Maulood BK (2019) Phytochemical and antioxidant activity of Asplenium Species (spleenworts) extracts from northern districts of Iraq. Eng Technol J 37(1):248–251

    Article  Google Scholar 

  • Ismiarni KYA, Betha OS, Muliati F et al (2015) Antioxidant and Anti-inflammatory activity of the Indonesian ferns, Nephrolepis falcata and Pyrrosia lanceolata. Int J Pharm Pharm Sci 7(12):162–165

    Google Scholar 

  • Jain AK, Mehta SC, Shrivastava NM (2006) Hypoglycemic and antihyperglycemic effects of newly synthesized sulfonyloxy derivatives of Azlactone in normal and Alloxan diabetic rabbits. Indian J Pharmacol 37(6):395–396

    Article  Google Scholar 

  • Jaishee N, Chakraborty U (2014a) Evaluation of in-vitro antioxidant activities of Pteris biaurita L. Int J Pharm Pharm Sci 6(2):413–421

    Google Scholar 

  • Jaishee N, Chakraborty U (2014b) Pharmacological studies and evaluation of antioxidant properties of Drynaria quercifolia (L.) J. Smith. Wor J Pharm Pharmac Sci 3:1205–1216

    Google Scholar 

  • Janakiraman N, Johnson M (2015) In vitro antioxidant properties of natural products isolated from selected species of cyathea. J Clin Nephrol Res 2(2):1027

    Google Scholar 

  • Janakiraman N, Johnson M (2016) Ethanol extracts of selected Cyathea species decreased cell viability and Inhibited Growth in MCF 7 cell line cultures. J Acupunct Meridian Stud 9(3):151–155

    Article  PubMed  Google Scholar 

  • Janakiraman N, Johnson M (2017) Larvicidal potential of Cyathea species against Culex quinquefasciatus. Pharmaceut Biomed Res 3(1):48–51

    Article  Google Scholar 

  • Jarial R, Singh L, Thakur S et al (2016) Applications of fern dipteris conjugate in anti-bacterial and anti-lipolytic purpose. In: Proceedings of the National Conference for Postgraduate Research (NCON-PGR 2016). Universiti Malaysia Pahang (UMP), Pekan, Pahang., 24–25 September 2016, pp 775–782

    Google Scholar 

  • Jarial R, Singh L, Thakur S et al (2017) Evaluation of anti-lipolytic, anti-oxidant and anti-bacterial activities of selected ferns. J Appl Pharm Sci 7(06):150–156

    CAS  Google Scholar 

  • Jarial R, Shard A, Thakur S et al (2018a) Characterization of flavonoids from fern Cheilanthes tenuifolia and evaluation of antioxidant, antimicrobial and anticancer activities. J King Saud Univ Sci 30(4):425–432

    Article  Google Scholar 

  • Jarial R, Sveta T, Mimi S et al (2018b) Potent anticancer, antioxidant and antibacterial activities of isolated flavonoids from Asplenium nidus. J King Saud Univ Sci 30(2):185–192

    Article  Google Scholar 

  • Jenat PJ, Suresh SN (2018) Phytochemical analysis and antimicrobial activity of fern Adiantum lunulatum Burm.f. World J Pharm Res 7(3):640–648

    CAS  Google Scholar 

  • Jeetendra N, Manish B (2011) Correlation of antioxidant activity with phenolic content and isolation of antioxidant compound from Lygodium flexuosum (L.) SW. extracts. Int J Pharm Pharm Sci 3(2):48–52

    Google Scholar 

  • Jianguo C, Xian X, Xuefei C et al (2013) Characterization of flavonoids from Dryopteris erythrosora and evaluation of their antioxidant, anticancer and acetylcholinesterase inhibition activities. Food Chem Toxicol 51:242–250

    Article  Google Scholar 

  • Jing Y, Zhang G, Ma E et al (2010) Amentoflavone and the extracts from Selaginella tamariscina and their anticancer activity. Chin Herb Med 5:226–229

    CAS  Google Scholar 

  • Jinu U, Thayumanavan T, Singh TB et al (2014) In vitro antioxidant capacity of the fern, Drynaria quercifolia (L) SM, rhizome extract. Int J Pharm Pharm Sci 6(7):413–416

    Google Scholar 

  • Johnson M, Anwardeen I, Periasamy A et al (2021) Evaluation of phenolic constituents and toxicity of lycophytes and ferns of shervarayan hills aqueous extracts. Chem Africa 4:513–523. https://doi.org/10.1007/s42250-021-00240-0

    Article  CAS  Google Scholar 

  • Johnson M, Gowtham J, Sivaraman A et al (2014) Antioxidant, Larvicidal, and Cytotoxic Studies on Asplenium aethiopicum (Burm. f.) Becherer. Int Scholarly Res Notices 876170:1–6

    Article  Google Scholar 

  • Johnson M, Jeeva S, Mahesh M, Janakiraman N (2017b) Antibacterial Potentials of Adiantum Species against the UTI Pathogens. J Microbiol Experiment 4(1):104

    Google Scholar 

  • Johnson M, Madona CX, Almeida RS (2020) In Vitro toxicity, antioxidant, anti-inflammatory, and antidiabetic potential of Sphaerostephanos unitus (L.) Holttum. Antibiotics 9(6):333

    Article  CAS  PubMed Central  Google Scholar 

  • Johnson M, Ramakrishnan P, Perumal S et al (2017a) Anti inflammatory activity of selected pteridophytes from Western Ghats. Int J Complement Alt Med 9(4):00307. https://doi.org/10.15406/ijcam.2017.09.00307

    Article  Google Scholar 

  • Jung HJ, Park K, Lee IS et al (2007) S-Phase accumulation of Candida albicans by anticandidal effect of amentoflavone isolated from Selaginella tamariscina. Biol Pharm Bul l30(10):1969–1971

    Article  Google Scholar 

  • Jutarat T, Jindarat P (2011) Determination of flavonoid content and antioxidant activity from ferns by ultrasonic extraction. In: Proceedings of the TIChE International Conference, Hatyai, Songkhla Thailand, 10–11 November 2011, p 1–4

    Google Scholar 

  • Kaewsuwan S, Yuenyongsawada S, Plubrukarna A et al (2015) Bioactive interruptins A and B from Cyclosorus terminans: antibacterial, anticancer, stem cell proliferation and ROS scavenging activities. Songklanakarin J Sci Technol 37(3):309–317

    CAS  Google Scholar 

  • Kahl R, Kappus H (1993) Toxikologie der synthetischen Antioxidantien BHA und BHT im Vergleich mit dem natürlichen Antioxidans Vitamin E [Toxicology of the synthetic antioxidants BHA and BHT in comparison with the natural antioxidant vitamin E]. Z Lebensm Unters Forsch 196(4):329–338. German. https://doi.org/10.1007/BF01197931

    Article  CAS  PubMed  Google Scholar 

  • Kalpana Devi R, Vasantha S, Annamalai P et al (2016) Phytochemical analysis in vitro antioxidant potential and Gas chromatography-Mass spectrometry studies of Dicranopteris linearis. Asian J Pharm Clin Res 9(8):220–225. https://doi.org/10.22159/ajpcr.2016.v9s2.13636

    Article  CAS  Google Scholar 

  • Kar HK, Kumar B (2010) IAL textbook of leprosy. Jaypee Brothers Medical Publishers Private Limited, New Delhi

    Google Scholar 

  • Kathirvel A, Rai AK, Maurya GS et al (2014) Dryopteris cochleata rhizome: a nutritional source of essential elements, phytochemicals, antioxidants and antimicrobials. Int J Pharm Sci 6(2):179-188

    Google Scholar 

  • Kaur P, Kaur V, Kumar M et al (2014) Suppression of SOS response in Escherichia coli PQ37, antioxidant potential and antiproliferative action of methanolic extract of Pteris vittata L. on human MCF-7 breast cancer cells. Food Chem Toxicol 74:326–333

    Article  CAS  PubMed  Google Scholar 

  • Khan M, Kormin F, Iwansyah AC (2016) Microwave assisted extraction; phytochemical evaluation of Malaysian palm oil trunk epiphytes ferns. Int J Pharm Pharm Sci 8(4):174–180

    Google Scholar 

  • Kiran PM, Raju AV, Rao BG (2012) Investigation of hepatoprotective activity of Cyatheagigantea (Wall. ex. Hook.) leaves against paracetamol-induced hepatotoxicity in rats. Asian Pac J Trop Biomed 2(5):352–356. https://doi.org/10.1016/S2221-1691(12)60055-0

    Article  PubMed  PubMed Central  Google Scholar 

  • Krishnaraju AV, Tsay HS (2006) Biological screening of medicinal plants collected from Eastern Ghats of India using Artemia salina. Int J Appl Sci Eng 4(2):115–125

    Google Scholar 

  • Kumar S, Samydurai P, Ramakrishnan R et al (2013) Polyphenols, vitamin-E estimation and in vitro antioxidant activity of Adiantum capillus-veneris. Int J Innov Pharm Sci Res 4(1):258–262

    Google Scholar 

  • Kunnathupara BS, Sowmya S, Velliyur KG, Poornima K (2016) Quantitative phytochemical analysis, in vitro antioxidant potential and gas chromatography-mass spectrometry studies in ethanolic extract of Azolla microphylla. Asian J Pharm Clin Res 9(2):318–323

    Google Scholar 

  • Lai H-Y, Lim Y-Y (2011a) Antioxidant Properties of Some Malaysian Ferns. 3rd International Conference on Chemical, Biological and Environmental Engineering. IPCBEE 20:8–12. http://www.ipcbee.com/vol20/2-ICBEE2011E004.pdf

    Google Scholar 

  • Lai HY, Lim YY (2011b) Evaluation of Antioxidant Activities of the Methanolic Extracts of Selected Ferns in Malaysia. Int J Environ Sci dev 2(6):442–447

    Article  Google Scholar 

  • Lai HY, Limy YY, Shiau PT (2009) Antioxidative, tyrosinase inhibiting and antibacterial activities of leaf extracts from medicinal ferns. Biosci Biotechnol Biochem 73:1362–1366

    Article  CAS  PubMed  Google Scholar 

  • Lamichhane R, Kim S, Poudel A et al (2014) Evaluation of in vitro and in vivo Biological Activities of Cheilanthes albomarginata Clarke. BMC Complement Altern Med 14:342

    Article  PubMed  PubMed Central  Google Scholar 

  • Lamichhane R, Kim SG, Poudel A et al (2015) Identification of flavonoids from Cheilanthes albomarginata clarke and their simultaneous determination and quantification by UPLC/DAD method. J Liq Chromatogr Relat Technol l38(19):1713–1721. https://doi.org/10.1080/10826076.2015.1091011

    Article  CAS  Google Scholar 

  • Lamichhane R, Pandeya PR, Lee KH et al (2019) Angiopteris helferiana, a fern with great potential medicinal value: Antiadipogenic, anti-inflammatory, and anti-diabetic activity. Phcog Mag 15:423-432

    Google Scholar 

  • Lan K-P, Shen Y-P, Lee S-H et al (2011) Antioxidant and free radical-scavenging activities of Pteris multifida poiret aqueous extract. J Food Qual 34:252–258. https://doi.org/10.1111/j.1745-4557.2010.00356.x

    Article  CAS  Google Scholar 

  • Lee J, Choi Y, Woo ER et al (2009) Antibacterial and synergistic activity of isocryptomerin isolated from Selaginella tamariscina. J Microbiol Biotechnol 19(2):204–207

    Article  CAS  PubMed  Google Scholar 

  • Lee H, Lin JY (1988) Antimutagenic activity of extracts from anticancer drugs in Chinese medicine. Mutat Res 204(2):229–234. https://doi.org/10.1016/0165-1218(88)90093-6

    Article  CAS  PubMed  Google Scholar 

  • Lee SM, Na K, An RB et al (2003) Antioxidant activity of two phloroglucinol derivatives from Dryopteris crassirhizoma. Biol Pharm Bull 26(9):1354–1356

    Article  CAS  PubMed  Google Scholar 

  • Lee IS, Nishikawa A, Furukawa F et al (1999) Effects of Selaginella tamariscina on in vitro tumor cell growth, p53 expression, GI arrest and in vivo gastric cell proliferation. Cancer Lett 144(1):93–99

    Article  CAS  PubMed  Google Scholar 

  • Li JH, He CW, Liang NC et al (1999) Effects of antitumor compounds isolated from Pteris semipinnata L on DNA topoisomerases and cell cycle of HL-60 cells. Zhongguo Yao Li Xue Bao 20(6):541–545

    CAS  PubMed  Google Scholar 

  • Li J, Lei X, Chen K (2014) Comparison of cytotoxic activities of extracts from Selaginella species. Pharmacogn Mag 10(40):529–535

    Article  PubMed  PubMed Central  Google Scholar 

  • Li J, Liang N, Mo L et al (1998) Comparison of the cytotoxicity of five constituents from Pteris semipinnata L. in vitro and the analysis of their structure-activity relationships. Yao xue xue bao = Acta Pharmaceutica Sinica 33(9):641–644

    CAS  PubMed  Google Scholar 

  • Li S, Zhu R, Zhong M (2010) Effects of ultrasonic-assistant extraction parameters on total flavones yield of Selaginella doederleinii and its antioxidant activity. J Med Plants Res 4(17):1743–1750

    CAS  Google Scholar 

  • Liu HC, Chen RM, Jain WC et al (2001) Cytotoxic and antioxidant effects of the water extract of the traditional Chinese herb Gusuibu (Drynaria fortunei) on rat osteoblasts. J Formosan Med Assoc 100:383–388

    CAS  PubMed  Google Scholar 

  • Liu Y, Wujisguleng W, Long C (2012) Food uses of ferns in China: a review. Acta Soc Bot Poloniae 81:1–10

    Article  Google Scholar 

  • Madhu K, Vijaya R, Ganga R (2012) Investigation of hepatoprotective activity of Cyathea gigantea (Wall. ex. Hook.) leaves against paracetamol-induced hepatotoxicity in rats. Asian Pac J Trop Biomed 2(5):352–356

    Article  Google Scholar 

  • Mahfuz A, Fayad BAS, Kanij Nahar D et al (2019) Characterization of in-vitro antioxidant, cytotoxic, thrombolytic and membrane stabilizing potential of different extracts of Cheilanthes tenuifolia and Stigmasterol isolation from n-hexane extract. Clin Phytoscience 5:39. https://doi.org/10.1186/s40816-019-0135-x

    Article  CAS  Google Scholar 

  • Malviya J, Joshi V, Singh K (2012) Antimicrobial activity of some ethno-medicinal plants used by Baiga tribes from Amarkantak, India. Adv Life Sci Technol 4:19–26

    Google Scholar 

  • Mandal A, Mondal AK (2011) Studies on antimicrobial activities of some selected ferns and lycophytes in Eastern India with special emphasis on ethno-medicinal uses. Afr J Plant Sci 5(7):412–420

    Google Scholar 

  • Maneesha S, Kangna M, Chhaya S (2015) Phytochemical evaluation and antioxidant activity of different samples of Pteris Vittata in Doon Valley, Uttarakhand Region. Int J Pure App Biosci 3(4):296–304

    Google Scholar 

  • Manivannan V, Johnson M (2020) Total phenolic, tannin, triterpenoid, flavonoid and sterol contents, anti-diabetic, anti-inflammatory and cytotoxic activities of Tectaria paradoxa (Fee.) Sledge. Toxicol Rep 7:1465–1468. https://doi.org/10.1016/j.toxrep.2020.10.013

    Article  CAS  Google Scholar 

  • Manivannan V, Johnson M, Almeida R et al (2020) Phytochemical profile and bio-activity of Bolbitis appendiculata (Willd.) K. Iwats extracts. S Afr J Bot 137(12):236–241. https://doi.org/10.1016/j.sajb.2020.10.013

    Article  CAS  Google Scholar 

  • Manivannan V, Johnson M, Almeida RS et al (2021) Chemical profiling of Tectaria paradoxa (Fee.)Sledge and Bolbitis appendiculata (Willd.) K. Iwats using UHPLC. Biocatal Agric Biotechnol 34:102043

    Article  CAS  Google Scholar 

  • Manjunatha K, Vidya V, Manohara YN (2007) Wound healing activity of Lycopodium serratum. Indian J Pharm Sci 69(2):283–287

    Article  Google Scholar 

  • Maria FB, Morais-Braga T, Souza M, Karla KA et al (2013) Phenol composition, cytotoxic and anti-kinetoplastidae activities of Lygodium venustum SW. (Lygodiaceae). Exp Parasitol 134(2):178–182

    Article  Google Scholar 

  • Mary S, Mahesh MK (2015) Anti-inflammatory activity of Cyathea nilgirensis Holttum, against Carrageenan induced Paw edema. Int J Recent Sci Res 6(8):5807–5809

    Google Scholar 

  • Mathad P, Chandrakant J, Modi R et al (2015) Phytochemical and antioxidant activity of Actiniopteris radiata Linn.an important pteridophytic medicinal plant of Gulbarga region. Int J Res Appl Nat Soc Sci 3(2):27–34

    Google Scholar 

  • McCutcheon AR, Roberts TE, Gibbons E et al (1995) Antiviral screening of British Columbian medicinal plants. J Ethnopharmacol 49:101–110

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Meera G, Josekumar VS (2016) In vitro cytotoxicity screening, phytochemical profile and heavy metal analysis of different extracts of Acrostichum heterophyllum L. Indian J Nat Prod Res 7(1):19–24

    Google Scholar 

  • Meyer BN, Ferrigi NR, Putnam JE et al (1982) Brine shrimp: a convenient general bioassay for active plant constituents. Planta Med 45(5):31–34

    Article  CAS  PubMed  Google Scholar 

  • Miao N, Tao H, Tong C et al (1996) The Selaginella tamariscina (Beauv.) Spring complex in the treatment of experimental diabetes and its effect on blood rheology. China J Chinese Mater Med 21(8):493–495

    CAS  Google Scholar 

  • Middleton EJ, Kandaswami C, Theoharides TC (2000) The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease and cancer. Pharmacol Rev 52(4):673–751

    CAS  PubMed  Google Scholar 

  • Milon CM, Avijit DSM, Abdur R, Rezwana NC (2013) Evaluation of anti-oxidant, cytotoxic and anti-microbial properties of Drynaria quercifolia. Int Res J Pharm 3(2):46–48

    Google Scholar 

  • Mimica DN, Natasa S, Jelena C et al (2008) Phenolic compounds in field Horsetail (Equisetum arvense L.) as Natural Antioxidants. Molecules 13(7):1455–1464

    Article  Google Scholar 

  • Mizushina Y, Watanabe I, Ohta K et al (1998) Studies on inhibitors of mammalian DNA polymerase a and b. Biochemical Pharmacology 55:537–541

    Article  CAS  PubMed  Google Scholar 

  • Mohammad SA, Mohammad RA, Chowdhury MIK et al (2013) In vitro antioxidant, cytotoxic, thrombolytic activities and phytochemical evaluation of methanol extract of the A. philippense L. leaves. Asian Pac J Trop Biomed 3(6):464–469. https://doi.org/10.1016/S2221-1691(13)60097-0

    Article  CAS  Google Scholar 

  • Mordi Joseph C, Ewhre O, Lawrence E et al (2016) Aqueous leaf extract of Dryopteris dilatata on STZ – induced diabetic wistar rats with associated hyperlipidemic ameliorating property. IOSR J Dent Med Sci (IOSR-JDMS) 15(6):97–104

    Google Scholar 

  • Myers KA, Marshal RD, Friedin J (1980) Principles of pathology in surgery, 1st edn. Blackwell Scientific Publications, London, pp 58–82

    Google Scholar 

  • Nair AS, Shylesh BS, Gopakumar B et al (2006) Anti-diabetes and hypoglycaemic properties of Hemionitis arifolia (Burm.) Moore in rats. J Ethnopharmacol 106(2):192–197

    Article  Google Scholar 

  • Nagarajan G, Britto AJD (2014) Evaluation of antibacterial activity of different parts of medicinal fern—Marsilea minuta L. Life Sci Leafl 50:34–37

    Google Scholar 

  • Nath K, Anupam DT, Mrinal KB, Deeshikha B, Shiela C, Debarati C, Mitra A, Amitabha B (2018) Antibacterial activity of certain ferns against multi drug resistant organisms. J Nat Remedies 17(4):144–153

    Google Scholar 

  • Navarro-Yepes J, Zavala-Flores L, Anandhan A et al (2014) Antioxidant gene therapy against neuronal cell death. Pharmacol Ther 142(2):206–230. https://doi.org/10.1016/j.pharmthera.2013.12.007

    Article  CAS  PubMed  Google Scholar 

  • Nayak N, Sibanarayan R, Mishra MP et al (2013) Antibacterial activity of the terrestrial fern Lygodiumflexuosum (L.) Sw. against multidrug resistant enteric- and uro-pathogenic bacteria. J Acute Dis 2(4):270–276. https://doi.org/10.1016/S2221-6189(13)60142-0

    Article  Google Scholar 

  • Nawaz ASN, Junaid S, Dileep N et al (2014) Antioxidant activity of Azolla pinnata and Azolla rubra – a comparative study. Sch Acad J Biosci 2(10):719–723

    Google Scholar 

  • Nayak N, Padhy RN (2017) GC-MS analysis of bioactive compounds and host toxicity Studies of Azolla caroliniana symbiotic with the Cyanobacterium Anabaena azollae. Indian J Pharm Educ Res 51(2s):s24–s33

    Article  CAS  Google Scholar 

  • Newman DJ, Cragg GM (2007) Natural products as sources of new drugs over the last 25 years. J Nat Prod 70(4):461–467

    Article  CAS  PubMed  Google Scholar 

  • Nilanthi SMLD, Wijayarathna C, Hettiarachchi GHCM (2015) Investigation of an in vitro antimicrobial activity of Angiopterisevecta (Forst.) Hoffm. RRJCHEM 4(3):47–52

    CAS  Google Scholar 

  • Nithya TG, Jayanthi J, Raghunathan MG (2015) Phytochemical, Antibacterial and GC-MS analysis of a floating fern Salvinia molesta D.S.Mitchell (1972). IJPRIF 8(9):85–90

    CAS  Google Scholar 

  • Nofrizal DPP, Dayar A (2017) Antioxidant and antibacterial constituents from two sumatran ferns, Trichomanes javanicum and Oleandra pistillaris. Nat Prod Commun 12(8):1263–1264

    Google Scholar 

  • Nor Aini A, Merrina J, Stanslas S et al (2008) Cytotoxic potential on breast cancer cells using selected forest species found in Malaysia. Int J Cancer Res 4(3):103–109

    Article  Google Scholar 

  • Nyarko HD, Barku VYA, Batama J (2012) Antimicrobial examinations of Cymbopogon citratus and Adiatumcapillus veneris used in Ghanaian folkloric medicine. Int J Life Sci Pharma Res 2(2):L 115-121

    Google Scholar 

  • Padhy R, Dash SK (2015) Antibacterial evaluation of methanolic rhizome extract from an in vivo and in vitro grown pteridophyte, Drynariaquercifolia (LINN.) J Smith. Asian J Pharm Clin Res 8(4):130–138

    Google Scholar 

  • Pal SK (2013) Antimicrobial activity of ferns. IOSR J Comput Eng 12(2):01–03

    Article  Google Scholar 

  • Pal SK (2014) Study of antibacterial activity of some ethnomedicinal ferns of Darjeeling District, West Bengal. J Environ Sociobiol 11(2):285–290

    Google Scholar 

  • Panda SS, Sahoo K, Rana M, Rout NC, Dhal NK (2014) Antimicrobial activities and phytochemical investigation of some native pteridophytes. Asian J Pharm Clin Res 7(1):43–45

    Google Scholar 

  • Pandey BS, Shrivastavaa AK, Chauhan D (2014) Evaluation of in vitro antioxidant potential of methanolic extracts of the phytochemical analysis of Adiantum and Pteris ferns & its role as antioxidant. Indian J Sci Res 4(1):31–38

    Google Scholar 

  • Parihar P, Leena P, Achaleshwar B (2010) In vitro antibacterial activity of fronds (leaves) of some important pteridophytes. J Microbiol Antimicrob 2(2):19–22

    Google Scholar 

  • Pargavi B, Sivakumar T (2014) Research article phytochemical screening and antimicrobial activity of Drynariaquercifolia (L.) J. Smith. Int J Curr Res Chem Pharm Sci 1(5):68–73

    Google Scholar 

  • Patel RM, Patel SK (2011) Cytotoxic activity of methanolic extract of Artocarpus heterophyllus against A549, Hela and MCF-7 cell lines. J App Pharm Sci 1(7):167–171

    Google Scholar 

  • Patil DT, Gurav KD, Kadam AS et al (2013) Qualitative analysis of secondary metabolites from some filicales members. IJRPC 3(2):300–302

    CAS  Google Scholar 

  • Paul T, Banerjee S (2013) In vitro evaluation of α-amylase inhibitory activity & antioxidant potential of Pteris vittata L. with special reference to its HPTLC profile. Int J Pharma Bio Sci 4(2):494–503

    CAS  Google Scholar 

  • Paul T, Das B, Apte KG (2012) Evaluation of anti-hyperglycemic activity of Adiantum Philippense Linn, a pteridophyte in alloxan induced diabetic rats. Diabetes Metab J 3:226

    Article  Google Scholar 

  • Paul Raj K, Irudayaraj V, Johnson M, Patric Raja D (2011) Phytochemical and anti-bacterial activity of epidermal glands extract of Christella parasitica (L.) H. Lev. Asian Pacific J Trop Biomed 1(1):8–11

    Article  CAS  Google Scholar 

  • Pauline VC, Irudayaraj V, Johnson M (2012) Anti-bacterial efficacy of macroscopic, microscopic parts of sporophyte and in vitro cultured gametophyte of a fern Cyclosorus interruptus (Willd.) H. Ito (Thelypteridaceae - Pteridophyta). J Chem Pharmaceut Res 4(2):1167–1172

    Google Scholar 

  • Paulsamy S, Moorthy D, Nandakumar K et al (2013) Evaluation of in vitro antioxidant potential of methanolic extracts of the Ferns Actiniopteris radiata (SW) Link and Equisetum ramosissimum Desf. Int J Res Dev Pharm Life Sci 2(3):451–455

    Google Scholar 

  • Peres MTLP, Simionatto E, Hess SC, Bonani VFL et al (2009) Chemical and biological studies of Microgramma vacciniifolia (Langsd. & Fisch.) Copel (Polypodiaceae). Quimica Nova 32(4):897–901

    Article  CAS  Google Scholar 

  • Pizzino G, Irrera N, Cucinotta M et al (2017) Oxidative stress: harms and benefits for human health. Oxid Med Cell Longev 2017:8416763. https://doi.org/10.1155/2017/8416763

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Porter JR, Barrett TG (2005) Monogenic syndromes of abnormal glucose homeostasis: clinical review and relevance to the understanding of the pathology of insulin resistance and beta cell failure. J Med Genet 42(12):893–902

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Prabu D, Nappinai M, Ponnudurai K et al (2008) Evaluation of wound-healing potential of Pisonia grandis R. Br: A preclinical study in Wistar rats. Int J Low Extrem Wounds 7(1):21–27

    Article  CAS  PubMed  Google Scholar 

  • Pradeep K, Ajudhia NK (2013) Hepatoprotective effect of Drynaria quercifolia fronds hydroalcoholic extract and isolated constituent against CCl 4 -induced hepatocellular damage. Br J Pharm Res 3(4):563–578

    Article  Google Scholar 

  • Prasanna G, Chitra M, Suvitha N (2014) In vitro antimicrobial activity of Drynariaquercifolia L. rhizome. Asian J Biochem Pharm Res 4:342–9

    Google Scholar 

  • Prasanna G, Chitra M (2015) In vitro anti-inflammatory activity of Drynaria quercifolia rhizome. Res J Pharmacognosy Phytochem 7(1):06–08. https://doi.org/10.5958/0975-4385.2015.00002.3

    Article  Google Scholar 

  • Preeti K, Namdeo J (2018) Phytochemical screening and in-vitro anticancer activity of extracts of Tectariacicutaria. Int J Pharm Sci Res 9(8):3463–3468

    CAS  Google Scholar 

  • Priscilla J, Geethaa S, Sreeramanan S et al (2014) Brine shrimp lethality test and anti-proliferation test against human cancer-origin cell lines using ethanolic and water extracts of Selaginella doederleinii Hieron. J T J Biomed Pharm Res 3(4):63–69

    Google Scholar 

  • Rabiea T, Shiblur R, Shakhawat H et al (2013) Medicinal potential of pteridophytes – an antihyperglycemic and antinociceptive activity evaluation of methanolic extract of whole plants of Christella dentate. Adv Nat Appl Sci 7(1):67–73

    Google Scholar 

  • Radulović N, Stojanović G, Palić R (2006) Composition and antimicrobial activity of Equisetum arvense L. essential oil. Phytother Res 20(1):85–88. https://doi.org/10.1002/ptr.1815

    Article  CAS  PubMed  Google Scholar 

  • Samira S, Rahmatullah MD, Nandi JK et al (2014) Preliminary antihyperglycemic and analgesic activity studies with Angiopteris evecta leaves in Swiss albino mice. World J Pharm Pharm Sci 3(10):01–12

    Google Scholar 

  • Raina R, Prawez S, Verma PK et al (2008) Medicinal plants and their role in wound healing. Vet Scan 3(1):1–7

    Google Scholar 

  • Raja DP, Johnson M, Irudayaraj V et al (2012) Antimicrobial efficacy of selected ferns of Western Ghats, South India. Int J Curr Pharm Res 4(2):58–60

    Google Scholar 

  • Rajendran P, Nandakumar N, Rengarajan T et al (2014) Antioxidants and human diseases. Clin Chim Acta 436:332–347. https://doi.org/10.1016/j.cca.2014.06.004

    Article  CAS  PubMed  Google Scholar 

  • Rajimol EK, Mohammed SP, Latheef N et al (2014) Evaluation of antidiabetic and hypolipidemic potential of Drynaria quercifolia Linn rhizome in streptozotocin induced diabetic rats. Int J Pharm Sci Rev Res 25(1):118–124

    Google Scholar 

  • Rajurkar NS, Gaikwad K (2012) Evaluation of phytochemicals, antioxidant activity and elemental content of Adiantum capillus-veneris leaves. J Chem Pharmaceut Res 4(1):365–374

    CAS  Google Scholar 

  • Ramachandra S, Quereshi SAA, Viswanath Swamy AHM et al (2007) Hepatoprotective activity of Calotropis procera flowers against paracetamol-induced hepatic injury in rats. Fitoterapia 78(7-8):451–454

    Article  Google Scholar 

  • Ramesh N, Viswanathana MB, Saraswathy A et al (2001) Phytochemical and antimicrobial studies on Drynaria quercifolia. Fitoterapia 72(8):934–936

    Article  CAS  PubMed  Google Scholar 

  • Rang HP, Dale MM, Ritter JM et al (2003) The endocrine pancreas and the control of blood glucose. In: Hardman JG, Limbird LE (eds) Pharmacology, 5th edn. Churchill, Livingstone

    Google Scholar 

  • Ranjan P, Santosh KD, Sunita P et al (2014) Studies on healing activity vis-A-vis microflora of acute induced wounds against solvent extracts of rhizome of Drynaria quercifolia Linn. OSR J Pharm Biol Sci (IOSR-JPBS) 9(5):38–49

    Google Scholar 

  • Revathi M, Sara CS (2014) Preliminary phytochemical analysis and antimicrobial activity of rhizome extract of Marsileaminuta L. IJSR 3(2):46–48

    Article  Google Scholar 

  • Royal Frank P, Suresh V, Arunachalam G et al (2012) Evaluation of hepatoprotective effect of Adiantum incisum Forsk leaf extract against CCl4 induced hepatotoxicity in rats. Int Res J Pharm 3(3):230–234

    Google Scholar 

  • Sahayaraj K, Borgio JF, Raju G (2009) Antifungal activity of three fern extracts on causative. J Plant Prot Res 49:53–56

    Article  Google Scholar 

  • Sharma D, Vikesh KB, Sandip P et al (2013) Antimicrobial activity of selected cryptogams from solan region. Int J Biol Pharm Res 4(6):448–454

    Google Scholar 

  • Salehi B, Ezzat MZ, Fokou PVT et al (2019) Athyrium plants - Review on phytopharmacy properties. J Trad Complementary Med 9:201e205. https://doi.org/10.1016/j.jtcme.2018.09.001

  • Sampath Kumar KP, Bhowmik D, Srivastava S et al (2012) Diabetes epidemic in India ‘A comprehensive review of clinical features, management and remedies. Pharma Innov 1:17–33

    Google Scholar 

  • Sandy O, Ben HC (1998) The effects of glutathione glycoside in acetaminophen-induced liver cell necrosis. Exp Mol Pathol 65(1):15–24

    Article  Google Scholar 

  • Santos MG, Kelecom A, De Paiva SR (2010) Phytochemical studied in Pteridophytes Growing in Brazil: a review. Am J Plant Sci Biotech 4(1):113–125

    Google Scholar 

  • Sarker SQ, Mondol PC, Jahangir Md A, Sarwar PM, Firoz AM (2011) Comparative study on antitumor activity of three pteridophytes ethanol extracts. J Agric Technol 7(6):1661–1671

    Google Scholar 

  • Sayema K, Dewan A (2016) Comparative antimicrobial and cytotoxic activity study of N-hexane, chloroform and carbon tetra-chloride extracts of Adiantum incisum forsk. EJPMR 3(4):100–105

    Google Scholar 

  • Sekendar A, Kawsarul M, Obayed R, Khalilur R, Aslam H, Shah A (2012) Antioxidant and cytotoxic activities of methanolic extract of Dryopteris filix-mas (L.) Schott leaves. Int J Drug Dev Res 4(2):223–229

    Google Scholar 

  • Sethi P (2014) Antibacterial activity of Marsilea quadrifolia Linn. Int Res Plant Sci 4:60–62

    Google Scholar 

  • Sharma US, Kumar A (2011) Anti-diabetic effect of Rubus ellipticus fruit extracts in Alloxan induced diabetic rats. J Diabetol 2:1–6

    CAS  Google Scholar 

  • Shokeen P, Ray K, Bala M et al (2005) Preliminary studies on activity of Ocimum sanctum, Drynaria quercifolia and Annona squamosa against Neisseria gonorrhoeae. Sexually Transm Dis 32(2):106–111

    Article  Google Scholar 

  • Shrestha SS, Sut S, Serena BDM et al (2019) Phytochemical fingerprinting and in vitro bioassays of the ethnomedicinal fern Tectaria coadunata (J. Smith) C. Christensen from Central Nepal. Molecules 24(24):4457

    Article  CAS  PubMed Central  Google Scholar 

  • Sikder MAA, Sharmin T, Rahman AFMM et al (2013) Screenings of four medicinal plants of Bangladesh for bioactivities. Dhaka Univ J Pharm Sci 12(1):59–62

    Article  Google Scholar 

  • Simán SE, Povey AC, Ward TH et al (2000) Fern spore extracts can damage DNA. Br J Cancer 83(1):69–73. https://doi.org/10.1054/bjoc.2000.1204. PMID: 10883670

    Article  PubMed  PubMed Central  Google Scholar 

  • Singh M, Govindarajan R, Singh RAK (2008) Antimicrobial flavonoid rutin from Pterisvittata L. against pathogenic gastrointestinal microflora. Am Fern J 98(2):98–103

    Article  Google Scholar 

  • Singh JK, Kumari R, Obaidullah MD et al (2014) Effect of Selaginella bryopteris on diabetic swiss albino mice caused by alloxan. Int J Basic Appl Sci Res 1(1):22–27

    Google Scholar 

  • Sinha SN (2012) In vitro antibacterial activity of ethanolic extract of Equisetum arvense L. Int J Pharm Biol Res 3(1):19–21

    Google Scholar 

  • Sivagurunathan A, Innocent BX (2014) Phytochemical analysis and antimicrobial efficiency of marsileaquadrifolialinn (Aquatic Fern). Int J Pharm Res Scholars 3(2):425–431

    Google Scholar 

  • Sivaraman J, Parimelazhagan I (2013) Evaluation of antioxidant potential of ethanolic extracts of selected species of Selaginella. Indian J Nat Prod Resour 4(3):238–244

    Google Scholar 

  • Soare LC, Mariana F, Stefan S, Zapriana D, Nicolova R, Denev P, Bejan C, Păunescu A (2012) Antioxidant activity, polyphenols content and antimicrobial activity of several native pteridophytes of Romania. Not Bot Horti Agrobo 40(1):53–57

    Article  CAS  Google Scholar 

  • Soeder RW (1985) Fern constituents: including occurrence, chemotaxonomy and physiological activity. Bot Rev 51:442–536

    Article  Google Scholar 

  • Somjintana T, Nanthita K, Narumon S et al (2005) Inhibitory activities of angiopteroside for HIV-1 reverse transcriptase and lung cancer cell-line. J Sci Res Chula Univ 30(2):187–192

    Google Scholar 

  • Somvanshi R, Sharma VK (2005) Proliferative urocystica and adenoma in a guinea-pig. J Comp Pathol 133(4):277–280. https://doi.org/10.1016/j.jcpa.2005.04.001

    Article  CAS  PubMed  Google Scholar 

  • Sood S, Sharma N (2010) Insect growth regulatory activity of Adiantum Capillus-veneris against Plutella xylostella and Aphis Craccivora in ethanol and methanol. Res J Agric Biol Sci 6(6):785–790

    Google Scholar 

  • Souza TM, MFB M-B, JGM C et al (2012) Enhancement of antimicrobial activity of antibiotics and antifungals by the use of natural products from Pityrogrammacalomelanos(L.) link. Arch Biol Sci Belgrade 64(1):43–48

    Article  Google Scholar 

  • Suja SR, Latha PG, Pushpangadan P et al (2014) Evaluation of antihepatotoxic potential of Helminthostachys zeylanica (Linn.) Hook. f., A Medicinal Fern against Ethanol Induced Liver Damage: In vitro and In vivo Studies. Columbia International Publishing. Am J Exp Biol 1(1):16–30

    Google Scholar 

  • Sunil K (2014) The importance of antioxidant and their role in pharmaceutical science - a review. Asian J Res Chem Pharmaceut Sci 1(1):27–44

    Google Scholar 

  • Suvarnalatha DK, Rukmini SVSSSL, Himabindu NN et al (2015) Antibacterial activity and phytochemical screening of Salvinia auriculata Aubl. from Tirumala Hills, Tirupati. Int J Pharm Sci Rev Res 30(1):35–38

    Google Scholar 

  • Tahir MM, Ibrahim N, Yaacob A (2014) Cytotoxicity and antiviral activities of Asplenium nidus. Phaleria macrocarpa Eleusine indica 1614:549–552. https://doi.org/10.1063/1.4895259

    Article  Google Scholar 

  • Tania P, Biswadeep D, Kishori GA et al (2012) Evaluation of anti-hyperglycemic activity of Adiantum Philippense Linn, a pteridophyte in alloxan induced diabetic rats. J Diabetes Metab 3:1–8

    Google Scholar 

  • Tania P, Suchitra B (2013) In vitro evaluation of α-amylase inhibitory activity & antioxidant potential of Pteris vittata L. with special reference to its HPTLC profile. Int J Pharm Bio Sci 4(2):494–503

    Google Scholar 

  • Tantawy EM, Shams M, Afifi M (2015) Chemical composition and biological evaluation of the volatile constituents from the aerial parts of Nephrolepisexaltata (L.) and Nephrolepiscordifolia (L.) C. Presl grown in Egypt. Nat Prod Res 30(10):1–5. https://doi.org/10.1080/14786419.2015.1046070

    Article  CAS  Google Scholar 

  • Thangam TS, Kathiresan K (1990) Synergistic effect of insecticides with plant extracts on mosquito larvae. Trop Biomed 7:135–137

    Google Scholar 

  • Thiripurasundari B, Padmini E (2018) Preliminary phytochemical screening and evaluation of antimicrobial and antioxidant activity of Azolla pinnata. Int J Recent Sci Res 9(5F):26924–26930

    Google Scholar 

  • Thite SV, Chavan YR, Aparadh VT et al (2013) Preliminary phytochemical screening of some medicinal plants. IJPCBS 3(1):87–90

    CAS  Google Scholar 

  • Thomas T (2011) Preliminary antibacterial evaluation of fronds of Pteris quadriaurita Retz. towards bacteria involved in dermatological diseases. J Appl Pharm Sci 1(8):214–216

    Google Scholar 

  • Thomas T (2013) Antibacterial activity of Adiantum lunulatum Burm. F. towards bacteria implicated in cutaneous infections. J Biol Sci Opin 1(4):334–336. https://doi.org/10.7897/2321-6328.01411

    Article  Google Scholar 

  • Thomas T (2014) A study on antibacterial and phytochemical evaluation of fronds of Adiantumraddianum C. Presl. Int J Pharmacol Screen Methods 4(2):85–88

    Google Scholar 

  • Tsun TC, Fai CW (2012) Antioxidant properties of aqueous extracts of Selaginella willdenowii. J Med Plants Res 6(7):1289–1296

    Google Scholar 

  • Vasudeva SM (1999) Economic importance of Pteridophytes. Indian Fern J 16(12):130–152

    Google Scholar 

  • Venkataratnam D, Ankola DD, Bhardwaj V et al (2006) Role of antioxidants in prophylaxis and therapy: a pharmaceutical perspective. J Control Release 113(3):189–207

    Article  Google Scholar 

  • Wali A, Sharma S, Walia M et al (2016) Two edible ferns of Western Himalaya: A comparative in vitro nutritional assessment, antioxidant capacity and quantification of lutein by UPLC/DAD. Int J Food Sci Nutr 5(3):9–18

    Google Scholar 

  • Wallace RA, Sander GP, Ferl RJ (1991) Biology: the science of life. HarperCollins, New York, pp 547–555

    Google Scholar 

  • Wills PJ, Asha VV (2006) Protective effect of Lygodium flexuosum (L.) Sw. extract against carbon tetrachloride-induced acute liver injury in rats. J Ethnopharmacol 108(3):320–326

    Article  CAS  PubMed  Google Scholar 

  • Wolf PL (1999) Biochemical diagnosis of liver diseases. Indian J Clin Biochem 14(1):59–90. https://doi.org/10.1007/BF02869152

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wu JQ, Thomas RK, Zhang XY (2013) Free radicals, antioxidant defense systems, and schizophrenia. Progr Neuro-Psychopharmacol Biol Psych 46:200–206. https://doi.org/10.1016/j.pnpbp.2013.02.015

    Article  CAS  Google Scholar 

  • Wu MJ, Weng CY, Wang L et al (2005) Immunomodulatory mechanism of the aqueous extract of sword brake fern (Pteris ensiformis Burm.). J Ethnopharmacol 98(1-2):73–81. https://doi.org/10.1016/j.jep.2004.12.031. PMID: 15763366

    Article  CAS  PubMed  Google Scholar 

  • Xia X, Cao J, Zheng Y et al (2014) Flavonoid concentrations and bioactivity of flavonoid extracts from 19 species of ferns from China. Ind Crops Prod 58:91–98

    Article  CAS  Google Scholar 

  • Yang JH, Kondratyuk TP, Marler LE et al (2010) Isolation and evaluation of kaempferol glycosides from the fern Neocheiropteris palmatopedata. Phytochem 71(5-6):641–647

    Article  CAS  Google Scholar 

  • Yeou NCJ (2015) Phytochemicals and antioxidative properties of edible fern, Stenochlaena palustris (Burm. f.) Bedd. Dissertation M. Sc (Pharmacy): Universiti Sains Malaysia

    Google Scholar 

  • Zakaria ZA, Kamisan FH, Kek TL et al (2020) Hepatoprotective and antioxidant activities of Dicranopteris linearis leaf extract against paracetamol-induced liver intoxication in rats. Pharm Biol 58(1):478–489. https://doi.org/10.1080/13880209.2020.1764058

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zakaria ZA, Kamisan FH, Omar MH et al (2017) Methanol extract of Dicranopteris linearis L. leaves impedes acetaminophen-induced liver intoxication partly by enhancing the endogenous antioxidant system. BMC Complement Altern Med 17(1):271–284

    Article  PubMed  PubMed Central  Google Scholar 

  • Zakaria ZA, Mohamed AM, Jamil NS et al (2011) In vitro cytotoxic and antioxidant properties of the aqueous, chloroform and methanol extracts of Dicranopteris linearis leaves. Afr J Biotechnol 10(2):273–282

    Google Scholar 

  • Zhang Z, ElSohly HN, Jacob MR et al (2002) Natural products inhibiting Candida albicans secreted aspartic proteases from Lycopodium cernuum. J Nat Prod 5(7):979–985

    Article  Google Scholar 

  • Zhang Y, Tian HY, Tan YF et al (2016) Isolation and identification of polyphenols from Marsilea quadrifolia with antioxidant properties in vitro and in vivo. Nat Prod Res 30(12):1404–1410. https://doi.org/10.1080/14786419.2015.1062377

    Article  CAS  PubMed  Google Scholar 

  • Zhang X, Wang X, Wang M, Cao J, Xiao J, Wang Q (2019) Effects of different pretreatments on flavonoids and antioxidant activity of Dryopteris erythrosora leave. PLoS One 14(1):e0200174

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zheng XK, Zhang L, Wang WW et al (2011) Anti-diabetic activity and potential mechanism of total flavonoids of Selaginella tamariscina (Beauv.) Spring in rats induced by high fat diet and low dose STZ. J Ethnopharmacol 137(1):662–668

    Article  CAS  PubMed  Google Scholar 

  • Zuraini Z, Sasidharan S, Roopin Kaur S et al (2010) Antimicrobial and antifungal activities of local edible fern Stenochlaena Palustris (Burm. F) Bedd. Pharmacologyonline 1:233–237

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Marimuthu, J., Janakiraman, N., Chandra Saleride, J., Sivaraman, A., Shivananthini, B., Paulraj, K. (2022). Biopotency of Pteridophytes: A Review. In: Marimuthu, J., Fernández, H., Kumar, A., Thangaiah, S. (eds) Ferns. Springer, Singapore. https://doi.org/10.1007/978-981-16-6170-9_20

Download citation

Publish with us

Policies and ethics