Abstract
The emergence of nanotechnology has provided the field of medicine with an excellent platform to explore and work with novel applications that show great potential to enhance the diagnostic and therapeutic procedures in cancer treatment and research. The methodologies regarding locating specific cells of nanoparticles are highlighted, which include active and passive targeting—two techniques that differ in the way nanoparticles target, interact, and deliver therapeutics to cancer cells. Other factors that affect the targeting of cancer cells such as nanoparticle shape, tumor permeability, as well as an understanding of the biological environment is also emphasized. Various applications regarding nanoparticles are discussed in detail; both organic and inorganic. Such examples included in the report are: liposomal nanoparticles, quantum dots, and gold nanoparticles, which have shown much promise in terms of drug delivery, imaging, and cancer treatment. Furthermore, cancer imaging and the diagnostic process regarding nanoparticles are further discussed to stress the importance of imaging and screening of cancer cells. Factors involving the design and potential issues in imaging are also underlined. The challenges concerning potential cytotoxicity, unanticipated behaviours, and bio-compatibility of nanoparticles that still remain are pointed out. However, it is clear that there is a strong potential for nanotechnology to revolutionize cancer diagnosis and treatment. This report focuses on various nanotech prospects, their methodologies and significance, as well as the benefits and disadvantages in cancer detection and imaging, diagnosis, and treatment.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Admad M et al (2012) Nanometric gold in cancer nanotechnology: current status and future prospect. J Pharm Pharmacol: 634–651
Ai J, Biazar E, Jafarpor M, Montazeri M, Majdi A, Aminifard S, Mandana Z, Akbari H, Rad H (2011) Nanotoxicology and nanoparticle safety in biomedical designs. Int J Nanomed 6:1117–1127
Alexis F, Pridgen E, Molnar L, Farokhzad O (2008) Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol Pharm 5(4). http://pubs.acs.org.ezproxy.lib.ryerson.ca/doi/abs/https://doi.org/10.1021/mp800051m
Arvizo R, Bhattacharya R, Mukherjee P (2010) Expert Opin Drug Deliv 7:753
Ayub A, Nazir S, Hussain T, Rashid U, MacRobert A (2014) Nanomaterials in combating cancer: therapeutic applications and developments. Nanomed Nanotechnol Biol Med 10:19–34
Barenholz Y (2012) Doxil-the first FDA approved nano-drug: lessons learned. US National Library of Medicine National Institute of Health. http://www.ncbi.nlm.nih.gov/pubmed/22484195
Bertrand N, We J, Xu X, Kamaly N, Farokhzad O (2014) Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. Adv Drug Deliv Rev 66:2–25
Bhati W, Vishwa A (2013) Nanotechnology method comparison for early detection of Cancer. I.J. Intell Syst Appl 03:58–65. https://doi.org/10.5815/ijisa.2013.03.06
Bhati W, Vishwa A (2013) Nanotechnology method comparison for early detection of cancer. Int J Intell Syst Appl 5(3):58–65. Web
Blanco E, Shen H, Ferrari M (2015) Principles of nanoparticle design for overcoming biological barriers to drug delivery. Nat Biol 33(9). http://www.nature.com/nbt/journal/v33/n9/full/nbt.3330.html
Brannon-Peppas L, Blanchette JO (2004) Nanoparticle and targeted systems for cancer therapy. Adv Drug Deliv Rev 56:1649–1659
Brown DM, Wilson MR, MacNee W, Stone V, Donaldson K (2001) Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicol Appl Pharmacol 175:191–199
Burns A, Ow H, Wiesner U (2006) Fluorescent core-shell silica nanoparticles: towards “Lab on a Particle”, architectures for nanobiotechnology. Chem Soc Rev 35(11):1028–1042. Web
Cagdas M, Sezer A, Bucak S (2014) Liposomes as potential drug carrier systems for drug delivery. Intech. http://www.intechopen.com/books/application-of-nanotechnology-in-drug-delivery/liposomes-as-potential-drug-carrier-systems-for-drug-delivery#article-front
Chaudhari K, Ukawala M, Manjappa A, Kumar A, Mundada P, Mishra A, Mathur R, Monkkonen J, Murthy R (2012) Opsonization, biodistribution, cellular uptake and apoptosis study of PEGylated PBCA nanoparticle as potential drug delivery carrier. Pharm Res 29:53–68. http://link.springer.com.ezproxy.lib.ryerson.ca/article/10.1007%2Fs11095-011-0510-x
Chen J et al (2005) Gold nanocages: bioconjugation and their potential use as optical imaging contrast agents. Nano Lett 5:473–477
Chen Y, Liu L (2012) Modern methods for delivery of drugs across the blood-brain barrier. Adv Drug Deliv Rev 64(7):640–665
Clancy L, Goodman P, Sinclair H, Dockery DW (2002) Effect of air pollution control on death rates in Dublin, Ireland: an intervention study. Lancet 360:1210–1214
Clementi C, Miller K, Mero A, Satchi-Fainaro R, Pasut G (2011) Dendritic poly(ethylene glycol) bearing paclitaxel and alendronate for targeting bone neoplasms. Mol Pharm 8:1063–1072
Cuenca AG, Jiang H, Hochwald SN et al (2006) Emerging implications of nanotechnology on cancer diagnostics and therapeutics. Cancer 107:459–466
Daniel M, Astruc D (2004) Gold nanoparticles: Assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Chem Rev 104(1):293–346. https://doi.org/10.1021/cr030698+
Debbage P, Jaschke W (2008) Molecular imagining with nanoparticles: giant roles for dwarf actors. Histochem Cell Biol 130:845–875
Demers LM, et al (2002) Direct patterning of modified oligonucleotides on metals and insulators by dip-pen nanolithography, 296, 1836–1838
Donaldson K, Poland CA (2013) Nanotoxicity: challenging the myth of nano-specific toxicity. Curr Opin Biotechnol 24(4):724–734. https://doi.org/10.1016/j.copbio.2013.05.003
Donaldson K, Stone V, Tran CL, Kreyling W, Borm PJA (2004) Nanotoxicology. Occup Environ Med 61:727–728
Hanahan D, Robert A (2011) Weinberg, hallmarks of cancer: the next generation. Cell 144(5):646–674. ISSN 0092-8674
Dow Chemical Company (2014) Chemical companies; dow electronic materials to build first, large-scale quantum dot manufacturing operation in Korea. Nanotechnol Wkly 142.
Durr S, Janko C, Lyer S, Tripal P, Schwarz M, Zaloga R, Alexiou C (2013) Magnetic nanoparticles for cancer therapy. Nanotechnol Rev 2(4):395–409
El-Sayed IH (2010) Nanotechnology in head and neck cancer: the race is on. Curr Oncol Rep 12(2):121–128. https://doi.org/10.1007/s11912-010-0087-2
Gentile F, Ferrari M, Decuzzi P (2008) The transport of nanoparticles in blood vessels: the effect of vessel permeability and blood rheology. Ann Biomed Eng 36:254–261
Fabbro C, Ali-Boucetta H, Da Ros T, Kostarelos K, Bianco Al, Prato M (2012) Targeting carbon nanotubes against cancer. R Soc Chem 48(33):3911–3926
Fakhoury M, Takechi R, Al-Salami H (2014) Drug permeation across the blood-brain barrier: applications of nanotechnology. Br J Med Med Res: 547–556
Ferrari M (2005) Cancer nanotechnology: opportunities and challenges. Nat Rev Cancer 5:161–171
Ferrari M (2010) Frontiers in cancer nanomedicine: directing mass transport through biological barriers. Trends Biotechnol 28(4):181–188
Fritz J, et al (2000) Translating biomeolecular recognition into nanomechanics, 288, 316–318
Gao X et al (2004) In vivo cancer targeting and imaging with semiconductor quantum dots. Nature Biotechnol 22(8):969–976. Web
Ghasemi Y, Peymani P, Afifi S (2009) Quantum dot: magic nanoparticle for imaging, detection and targeting. Acta Biomed 80:156–165
Goodall S, Jones M, Mahler S (2014) Monoclonal antibody-targeted polymeric nanoparticles for cancer therapy—future prospects. J Chem Technol Biotechnol 90:1169–1176. http://journals1.scholarsportal.info.ezproxy.lib.ryerson.ca/details/02682575/v90i0007/1169_mapnfctp.xml
Grossman JH, McNeil SE (2012) Nanotechnology in cancer medicine. (Cover story). Phys Today 65(8):38–42
Gunasekera UA, Pankhurst QA, Douek M (2009) Imaging applications of nanotechnology in cancer. Target Oncol 4(3):169–181. https://doi.org/10.1007/s11523-009-0118-9
Jawaid AM, Chattopadhyay S, Wink DJ, Page LE, Snee PT (2013) “A”. ACS Nano 7(4):3190–3197. https://doi.org/10.1021/nn305697q
Jiang W, Kim BY, Rutka JT, Chan WC (2007) Advances and challenges of nanotechnology-based drug delivery systems. Expert Opin Drug Deliv 4(6):621–633. https://doi.org/10.1517/17425247.4.6.621
Johnston HJ, Hutchison G, Christensen FM, Peters S, Hankin S, Stone V (2010) (2010), A review of the in vivo and in vitro toxicity of silver and gold particulates: particle attributes and biological mechanisms responsible for the observed toxicity. Crit Rev Toxicol 40:328
Jokerst JV, Lobovkina T, Zare RN, Gambhir SS (2011) Nanoparticle PEGylation for imaging and therapy. Nanomedicine (lond) 6(4):715–728
Hamilton RF, Wu N, Porter D, Buford M, Wolfarth M, Holian A (2009) Particle length-dependent titanium dioxide nanomaterials toxicity and bioactivity. Part Fibre Toxicol 6:35
Hayashi K, Nakamura M, Miki H, Ozaki S, Abe M, Matsumoto T, Sakamoto W, Yogo T, Ishimura K (2014) Magnetically responsive smart nanoparticles for cancer treatment with a combination of magnetic hyperthermia and remote-control drug release. Theranostics 4(8)
Kang B, Mackey MA, El-Sayed MA (2010) Nuclear targeting of gold nanoparticles in cancer cells induces DNA damage, causing cytokinesis arrest and apoptosis. J Am Chem Soc 132(5):1517
Karathanasis E, Suryanarayanan S, Balusu S, McNeeley K, Sechopoulos I, Karellas A, Annapragada A, Bellamkonda R (2009) Imaging nanoprobe for prediction of outcome of nanoparticle chemotherapy by using mammography. Radiology 250:398–406
Kreyling WG, Semmler-Behnke M, Seitz J, Scymczak W, Wenk A, Mayer P, Takenaka S, Oberdorster G (2009) Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs. Inhal Toxicol 21(Suppl 1):55–60
Kroll A, Pillukat MH, Hahn D, Schnekenburger J (2009) Current in vitro methods in nanoparticle risk assessment: limitations and challenges. Eur J Pharm Biopharm 72:370–377
Lamprecht A, Yamamoto H, Takeuchi H, Kawashima Y (2005) Nanoparticles enhance therapeutic efficiency by selectively increased local drug dose in experimental colitis in rats. J Pharmacol Exp Ther 315:196–202
Leroux J-C, Allemann E, De Jaeghere F, Duelker E, Gurny R (1996) Biodegradable nanoparticles—from sustained release formulation to improved site specific drug delivery. J Control Release 30:339–350
Loo C, Lowery A, Halas N, West J, Drezek R (2005) Immunotargeted nanoshells for integrated cancer imaging and therapy. Nano Lett 5(4):709–711
Yezhelyev MV, Al-Hajj A, Morris C, et al (2007) In situ molecular profiling of breast cancer biomarkers with multicolor quantum dots. Adv Mater 19(20):3146–3151. Web
Malam Y, Loizidou M, Seifalian A (2009) Liposomes and Nanoparticles: nanosized vehicles for drug delivery in cancer. Trends Pharmacol Sci 30(11). http://www.sciencedirect.com.ezproxy.lib.ryerson.ca/science/article/pii/S0165614709001370
Marega R, Karmani L, Flamant L, Nageswaran PG, Valembois V, Masereel B, Bonifazi D (2012) Antibody-functionalized polymer-coated gold nanoparticles targeting cancer cells: an in vitro and in vivo study. J Mater Chem 22(39):2135–21312. https://doi.org/10.1039/c2jm33482h
Matsumura Y, Maeda H (1986) A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Can Res 46:6387–6392
Mühlfeld C, Gehr P, Rothen-Rutishauser B (2008) Translocation and cellular entering mechanisms of nanoparticles in the respiratory tract. Swiss Med Wkly 138:387–391
Nie S, Xing Y, Kim GJ, Simons JW (2007) Nanotechnology applications in cancer. Annu Rev Biomed Eng 9:257–288
Nima Z, Mahmood M, Karmakar A, Mustafa T, Bourdo S, Xu Y, Biris A (2013) Single-walled carbon nanotubes as specific targeting and Raman spectroscopic agents for detection and discrimination of single human breast cancer cells. J Biomed Opt. https://doi.org/10.1117/1.JBO.18.5.055003
Oerlemans C, Bult W, Bos M, Storm G, Nijsen J, Hennick W (2010) Polymeric micelles in anticancer therapy: targeting, imaging and triggered release. Pharm Res 27(12):2569–2589. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982955/
Osaka T, Nakanishi T, Shanmugan S, Takahama S, Zhang H (2009) Effect of surface charge of magnetite nanoparticles on their internalization into breast cancer and umbilical vein endothelial cells. Elsevier Coll Surf B 71(2):325–330
Pagano A, Honore S, Esteve M, Braguer D (2012) Nanodrug potential in cancer therapy: efficacy/toxicity studies in cancer cells. Int J Nanotechnol 9(3/4/5/6/7):502
Pan Y, Neuss S, Leifert A, Fischler M, Wen F, Simon U, Schmid G, Brandau W, Jahnen-Dechent W (2007) Size-dependent cytotoxicity of gold nanoparticles. Small 3(11):1941–1949
Peng, C-W, Li Y (2010) Application of quantum dots-based biotechnology in cancer diagnosis: current status and future perspectives. J Nanomater 2010(2010):1–11. Web
Poland CA, Byrne F, Cho WS, Prina-Mello A, Murphy FA, Davies GL, Coey JM, Gounko Y, Duffin R, Volkov Y et al (2012) Length dependent pathogenic effects of nickel nanowires in the lungs and the peritoneal cavity. Nanotoxicology 6:899–911
Prajapati PM, Shah Y, Sen DJ (2010) Gold nanoparticles: a new approach for cancer detection. J Chem Pharm Res 2(1):30–37
Jain RK (1999) Transport of molecules, particles, and cells in solid tumors. Annu Rev Biomed Eng 1:241–263
Reynolds AR, Moein Moghimi S, Hodivala-Dilke K (2003) Nanoparticle-mediated gene delivery to tumour neovasculature. Trends Mol Med 9:2–4
Rhyner MN, Smith AM, Gao X, Mao H, Yang L, Nie S (2006) Quantum dots and multifunctional nanoparticles: new contrast agents for tumor imaging. Nanomed 1(2):209–217
Roberts MJ, Bentley MD, Harris JM (2012) Chemistry for peptide and protein PEGylation. Adv Drug Deliv Rev 64:116–127
Roux E, Francis MF, Winnik FM, Leroux JC (2004) Stimuli responsive liposome-polymer complexes: towards the design of intelligent drug carriers. In: Svenson S (ed) Carrier based drug delivery systems. CS Symposium Series 879, American Chemical Society, Washington, DC, pp 26–39
Rutishauser R, Mühlfeld C, Blank F, Musso C, Gehr P (2007) Translocation of particles and inflammatory responses after exposure to ine particles and nanoparticles in an epithelial air-way model. Part Fibre Toxicol 4:9–15
Salmaso S, Caliceti P (2013) Stealth properties to improve therapeutic efficacy of drug nanocarriers. J Drug Deliv 2013
Sanvicens N, Marco MP (2008) Multifunctional nanoparticles—properties and prospects for their use in human medicine. Trends Biotechnol 26(8):425–433
Sawant R, Torchilin V (2010) Liposomes as ‘smart’ pharmaceutical nanocarriers. Soft Matter 6:4026–4044
Sengupta S, Sasisekharan R (2007) Exploiting nanotechnology to target cancer. Br J Cancer 96:1315–1319
Shi C, et al (2008, 2009) Quantum dots-based multiplexed immunohistochemistry of protein expression in human prostate cancer cells. Eur J Histochem EJH 52.2:127–34. Web
Sinha R, Kim GJ, Nie S, Shin DM (2006) Nanotechnology in cancer therapeutics: bioconjugated nanoparticles for drug delivery. Mol Cancer Ther 5(8):1909–1917. https://doi.org/10.1158/1535-7163.MCT-06-0141
Slingerland M, Guchelaar H-J, Gelderblom H (2012) Liposomal drug formulations in cancer therapy: 15 years along the road. Drug Disc Today 17:160–166
Strebhardt K, Ullrich A (2008) Paul Ehrlich’s magical bullet concept: 100 years of progress. Nat Rev Cancer 8:473–480
Sun Y et al (2002) Template-engaged replacement reaction: a one-step approach to the large-scale synthesis of metal nanostructures with hollow interiors. Nano Lett 2:481–485
Sutradhar K, Amin M (2013) Nanotechnology in cancer drug delivery and selective targeting. ISRN Nanotechnol 2014. http://search.proquest.com.ezproxy.lib.ryerson.ca/docview/1503653656/fulltextPDF?accountid=13631
Toy R, Bauer L, Hoimes C, Ghaghada KB, Karathanasis E (2014) Targeted nanotechnology for cancer imaging. Adv Drug Deliv Rev 76:79–97. https://doi.org/10.1016/j.addr.2014.08.002
Toy R, Hayden E, Shoup C, Baskaran H, Karathanasis E (2011) The effects of particle size, density and shape on margination of nanoparticles in microcirculation. Nanotechnology 22(2011):115101. http://iopscience.iop.org.ezproxy.lib.ryerson.ca/article/10.1088/09574484/22/11/115101/meta;jsessionid=6918F0A405162504A3701210EA0BB28D.c3.iopscience.cld.iop.org
Wang X, Yang L, Chen Z, Shin DM (2008) Application of nanotechnology in cancer therapy and imaging. CA A Cancer J Clinic 58:97–110
Watson P, Jones AT, Stephens DJ (2005) Intracellular trafficking pathways and drug delivery: fluorescence imaging of living and fixed cells. Adv Drug Deliv Rev 57:43–61
Xia Y et al (2011) Gold nanocages: from synthesis to theranostic applications. Acc Chem Res 44:914–924
Yacobi NR, Phuleria HC, Demaio L, Liang CH, Peng CA, Sioutas C et al (2007) Nanoparticle effects on rat alveolar epithelial cell monolayer barrier properties. Toxicol in Vitro 21:1373–1381
Zhong Y, Meng F, Deng C, Zhong Z (2014) Ligand-directed active tumor-targeting polymeric nanoparticles for cancer chemotherapy. Biomacromolecules 15:1955–1969. http://pubs.acs.org.ezproxy.lib.ryerson.ca/doi/pdf/https://doi.org/10.1021/bm5003009
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Cappuccitti, A. et al. (2022). Nanotechnology for Biomedical Devices: Cancer Treatment. In: Mubarak, N.M., Gopi, S., Balakrishnan, P. (eds) Nanotechnology for Electronic Applications. Materials Horizons: From Nature to Nanomaterials. Springer, Singapore. https://doi.org/10.1007/978-981-16-6022-1_11
Download citation
DOI: https://doi.org/10.1007/978-981-16-6022-1_11
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-16-6021-4
Online ISBN: 978-981-16-6022-1
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)