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Spondyloarthropathies and Environmental Stresses

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Ankylosing Spondylitis - Axial Spondyloarthritis

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Abstract

Spondyloarthropathies (SpA) refer to a multifactorial disease affecting the axial and peripheral skeleton, mainly in the larger joints of the lower limbs. The exact mechanism that causes most SpAs is still vague; however, it is clear that both genetics and environmental factors are involved in the pathogenesis of the disease. Environmental factors directly implicate innate immunity, which is a vital compartment in triggering autoinflammatory disorders. To date, only a few studies specifically focused on the potential role of these factors, including mechanical, psychological, and oxidative stresses, smoking, diet, and infections. Here we discuss the contribution of named stresses and related molecular mechanisms on SpA diseases, apart from the diet and infection, which were the concept of previous chapters.

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Authors and Affiliations

  1. Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Hanieh Mojtahedi

  2. Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Narjes Soleimanifar

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  1. Hanieh Mojtahedi
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Correspondence to Narjes Soleimanifar .

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  1. Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Mohammad Hossein Nicknam

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Mojtahedi, H., Soleimanifar, N. (2022). Spondyloarthropathies and Environmental Stresses. In: Nicknam, M.H. (eds) Ankylosing Spondylitis - Axial Spondyloarthritis. Springer, Singapore. https://doi.org/10.1007/978-981-16-4733-8_8

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