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Ionic Liquids for Transdermal Drug Delivery: Choline Geranate System as a Case Study

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Application of Ionic Liquids in Drug Delivery

Abstract

Transdermal administration is of high interest for drug delivery due to its non-invasiveness and easy dosing. However, this route of drug delivery faces the challenges of low drug permeability across the skin. This chapter reviews the role of ionic liquids (ILs) for transdermal delivery of active pharmaceutical ingredients (APIs). In particular, it focuses on the case of the Choline Geranate (CAGE), including its synthesis, structural features, physical properties, and enhanced permeation across epithelial barriers as a transdermal drug carrier. Its scale-up and medical applications are also discussed. This system has potential to become a powerful excipient to improve the pharmacokinetic profiles of many pharmaceutical products in transdermal applications.

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Authors and Affiliations

  1. Chemical and Petroleum Engineering Department, University of Calgary, Calgary, AB, Canada

    Paula Berton

  2. Fiber and Biopolymer Research Institute, Department of Plant and Soil Science, Texas Tech University, Lubbock, TX, USA

    Julia L. Shamshina

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  1. Paula Berton
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  2. Julia L. Shamshina
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Correspondence to Paula Berton .

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Editors and Affiliations

  1. Department of Applied Chemistry, Kyushu University, Fukuoka, Japan

    Masahiro Goto

  2. Department of Chemical Engineering, Universiti Teknologi PETRONAS, Perak, Malaysia

    Muhammad Moniruzzaman

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Berton, P., Shamshina, J.L. (2021). Ionic Liquids for Transdermal Drug Delivery: Choline Geranate System as a Case Study. In: Goto, M., Moniruzzaman, M. (eds) Application of Ionic Liquids in Drug Delivery. Springer, Singapore. https://doi.org/10.1007/978-981-16-4365-1_3

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