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Architectures of Nucleolipid Assemblies and Their Applications

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Molecular Architectonics and Nanoarchitectonics

Part of the book series: Nanostructure Science and Technology ((NST))

Abstract

The ability of nucleobases, nucleosides, nucleotides and their derivatives to support supramolecular interactions has enabled the construction of a variety of architectures. In particular, nucleolipid hybrids have gained significant interest as they serve as excellent scaffolds for the bottom-up generation of hierarchical assemblies with wide biomedical and material applications. In this chapter, we provided a detailed discussion on the recent advances in the design and applications of nucleolipid assemblies. First, we discuss various design approaches in synthesizing nucleolipid supramolecular synthons and the various self-assembled architectures they form. In the second part, recent applications of nucleolipid assemblies are reviewed in detail. Emphasis is laid on assemblies that can be used as delivery tools, injectable gels, tissue engineering scaffolds, sensors and environment remedial systems. Easy synthesis, ability to tune the assembling process and useful applications of the nucleolipid architectures discussed in this chapter underscore the high potential of nucleolipid assemblies in the real-life applications.

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Acknowledgements

S.G.S is grateful to the past and present lab members and collaborators who have worked in the area of nucleolipids. M.B.W is grateful to CSIR, India, and Wellcome Trust-DBT India Alliance for a graduate research fellowship. Prime Minister’s Research Fellowship (PMRF) to S.D. is greatly appreciated. S.G.S thanks Wellcome Trust-DBT India Alliance (IA/S/16/1/502360) and CSIR, India (02-0086/12/EMR-II), for research grants.

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  1. Department of Chemistry, Indian Institute of Science Education and Research (IISER), Pune, India

    Manisha B. Walunj, Swagata Dutta & Seergazhi G. Srivatsan

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  1. Manisha B. Walunj
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  2. Swagata Dutta
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  3. Seergazhi G. Srivatsan
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Correspondence to Seergazhi G. Srivatsan .

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  1. Bioorganic Chemistry Laboratory, New Chemistry Unit and School of Advanced Materials (SAMat), Jawaharlal Nehru Centre for Advanced Scientific Research, Bengaluru, Karnataka, India

    Thimmaiah Govindaraju

  2. International Center for Materials, Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), Ibaraki, Tsukuba, Japan

    Katsuhiko Ariga

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Walunj, M.B., Dutta, S., Srivatsan, S.G. (2022). Architectures of Nucleolipid Assemblies and Their Applications. In: Govindaraju, T., Ariga, K. (eds) Molecular Architectonics and Nanoarchitectonics. Nanostructure Science and Technology. Springer, Singapore. https://doi.org/10.1007/978-981-16-4189-3_13

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