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Prospects of Mesenchymal Stem Cell Secretome in Veterinary Regenerative Therapy

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Stem Cells in Veterinary Science

Abstract

Regenerative medicine, a branch of translational research, comprises the generation and use of therapeutic stem cells. The mesenchymal stem cells (MSCs) used in preclinical models for tissue engineering of connective tissues have shown it as a promising agent in rebuilding damaged tissues like nerve injury, fracture, ligament and cartilage, liver, heart, etc. Paracrine mechanisms are considered the primary mode of action in adult stem cell signaling and therapy. MSCs secrete various cytokines and growth factors, including autocrine and paracrine actions. The promise of cell-free therapy has led to the development of products derived from stem cells. Microvesicles/exosomes derived from MSCs are exploited in therapeutic uses as pharmaceutical agents’ delivery. Another central area of application of extracellular vesicles (EVs) is immune therapy due to their anti-inflammatory and immunomodulatory effects. Most translational research regarding mesenchymal stem cells and their conditioned media (CM) have been conducted in human subjects, and little work has been done in livestock and pets, as livestock and pets also encounter similar ailments. Hence, there is an excellent scope of stem cell secretome in veterinary regenerative therapy, especially in treating diseases like paraplegia or spinal cord injury, diabetic wounds, ligament/tendon injury, and bone injury/fracture. It may be an essential component of veterinary pharmaceuticals shortly.

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Authors and Affiliations

  1. Division of Physiology and Climatology, ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, India

    Vikash Chandra & G. Taru Sharma

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  1. Vikash Chandra
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  2. G. Taru Sharma
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  1. Department of Bioinformatics, College of Animal Biotechnology, Ludhiana, Punjab, India

    Ratan Kumar Choudhary

  2. Department of Microbial and Environmental Biotechnology, College of Animal Biotechnology, Ludhiana, Punjab, India

    Shanti Choudhary

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Chandra, V., Sharma, G.T. (2021). Prospects of Mesenchymal Stem Cell Secretome in Veterinary Regenerative Therapy. In: Choudhary, R.K., Choudhary, S. (eds) Stem Cells in Veterinary Science. Springer, Singapore. https://doi.org/10.1007/978-981-16-3464-2_16

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