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Fungi a Potential Source of Bioactive Metabolites an Indian Prospective

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Progress in Mycology

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Abstract

Fungi are multifaceted microbes and are one of the largest groups among living organisms and have established themselves as an important source of the diverse bioactive metabolites. These metabolites are of different attributes such as antibacterial, antifungal, immunosuppressant, cholesterol-lowering, anticancer, anti-inflammatory, antidiabetic, etc. This group of microbes has been explored for producing bioactive metabolites for their pharmaceutical applications after the discovery of penicillin. Interestingly, some fungal metabolites or their derivatives have been brought to the market in the form of drugs under different categories such as penicillin G, cephalosporin C, fusidic acid, retapamulin, valnemulin, tiamulin (antibacterial), griseofulvin, micafungin, anidulafungin, caspofungin (antifungal), lovastatin (anti-hypercholesterolemic), and cyclosporine A (immunosuppressant). In earlier work in India, the bioactive metabolites were isolated from soil fungi by Hindustan Antibiotics Ltd. at Pune and Rishikesh and Hoechst Pharmaceuticals, Mumbai. Later, the emphasis was shifted to marine and endophytic fungi as interest shown by prime institutes like Hoechst Pharmaceuticals, Mumbai; Piramal Enterprises Ltd., Mumbai; Indian Institute of Integrated Medicine, Jammu; Banaras Hindu University, Varanasi; University of Jammu, Jammu; and University of Agricultural Sciences, Bangalore, to name few. This chapter highlights the bioactive metabolites from fungi isolated from various sources (soil, plants, marine, etc.) with some examples.

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Acknowledgements

One of the authors (SKD) is grateful to management of Hoechst Marion Roussel Ltd., Mumbai, and Piramal Enterprises Ltd, Mumbai, for providing facilities. RNK is grateful to the Head and Coordinator, CAS and FIST in Botany, Institute of Science, BHU, Varanasi, for providing the essential research facilities.

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Authors and Affiliations

  1. TERI-Deakin Nano Biotechnology Centre, The Energy and Resources Institute, New Delhi, India

    Sunil K. Deshmukh

  2. CAS in Botany, Institute of Science, Banaras Hindu University, Varanasi, India

    Ravindra N. Kharwar

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  1. Sunil K. Deshmukh
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  2. Ravindra N. Kharwar
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Editors and Affiliations

  1. Division of Biological Sciences and Engineering, Netaji Subhas University of Technology, New Delhi, Delhi, India

    Tulasi Satyanarayana

  2. TERI-Deakin Nano Biotechnology Centre, The Energy and Resources Institute, New Delhi, India

    Sunil Kumar Deshmukh

  3. Director, Greenvention Biotech Pvt. Ltd., Uruli Kanchan, Maharashtra, India

    Mukund V. Deshpande

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Deshmukh, S.K., Kharwar, R.N. (2021). Fungi a Potential Source of Bioactive Metabolites an Indian Prospective. In: Satyanarayana, T., Deshmukh, S.K., Deshpande, M.V. (eds) Progress in Mycology. Springer, Singapore. https://doi.org/10.1007/978-981-16-3307-2_16

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