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Microbiome in Human Health and Disease pp 123–141Cite as

Understanding the Interplay Between the Host Immune–Microbiome Interactions: A State of the Art Review

Abstract

The microbiome and immune system are effectively impacting each other to endure, characterizing the healthy individual’s dysfunctional equilibrium. The human gut has the most complex microbiota of the multitude of non-sterile cavities, with a solid effect on host homeostasis and immunostasis, making it fundamental for looking after health. Simultaneously, mammalian immunity is formed by resident bacteria. At the point when this immune system–microbiota partnership is working appropriately, it takes into account the acceptance of defensive reactions to pathogen just as the upkeep of regulatory pathways engaged with the support of resilience to harmless antigens. The investigation of the microbiome–immune system crosstalk has shown a solid association between microbial communities and the advancement of hypersensitive infections and asthma. Interruption of the microbiome affects the host’s safe reaction and can prompt infection pathogenesis. Disease and remedial medicines, then again, affect microbial populaces. A preview of the present status of the microbiome–immune system in host weakness to pathogens, extreme hypersensitivity responses, autoimmunity, chronic inflammation, and cancer research is emphasized in this review. The turn of events and use of next-generation DNA sequencing strategies have changed gut microecology, considering new experiences into the synthesis of the intestinal microbiota and it connects to an assortment of diseases. We additionally examine how we have gotten familiar with the associations between resident microbes and the immune system, just as the outcomes of these outcomes for human health.

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References

  • Alex S, Lange K, Amolo T, Grinstead JS, Haakonsson AK, Szalowska E, Koppen A, Mudde K, Haenen D, Roelofsen H, Houtman R (2013) Short-chain fatty acids stimulate angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating peroxisome proliferator-activated receptor γ. Mol Cell Biol 33(7):1303–1316

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Alexander KL, Targan SR, Elson CO III (2014) Microbiota activation and regulation of innate and adaptive immunity. Immunol Rev 260(1):206–220

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Arneson D, Shu L, Tsai B, Barrere-Cain R, Sun C, Yang X (2017) Multidimensional integrative genomics approaches to dissecting cardiovascular disease. Front Cardiovasc Med 4:8

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Balmer ML, Schürch CM, Saito Y, Geuking MB, Li H, Cuenca M, Kovtonyuk LV, McCoy KD, Hapfelmeier S, Ochsenbein AF, Manz MG (2014) Microbiota-derived compounds drive steady-state granulopoiesis via MyD88/TICAM signaling. J Immunol 193(10):5273–5283

    Article  CAS  PubMed  Google Scholar 

  • Belkaid Y, Naik S (2013) Compartmentalized and systemic control of tissue immunity by commensals. Nat Immunol 14(7):646–653

    Article  CAS  PubMed  Google Scholar 

  • Berche P (2012) Louis Pasteur, from crystals of life to vaccination. Clin Microbiol Infect 18:1–6

    Article  CAS  PubMed  Google Scholar 

  • Bergström JH, Birchenough GM, Katona G, Schroeder BO, Schütte A, Ermund A, Johansson ME, Hansson GC (2016) Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16. Proc Natl Acad Sci 113(48):13833–13838

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Brown EM, Sadarangani M, Finlay BB (2013) The role of the immune system in governing host-microbe interactions in the intestine. Nat Immunol 14(7):660–667

    Article  CAS  PubMed  Google Scholar 

  • Carvalho FA, Aitken JD, Vijay-Kumar M, Gewirtz AT (2012) Toll-like receptor–gut microbiota interactions: perturb at your own risk! Annu Rev Physiol 74:177–198

    Article  CAS  PubMed  Google Scholar 

  • Cash HL, Whitham CV, Behrendt CL, Hooper LV (2006) Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science 313(5790):1126–1130

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chaudhry A, Rudensky AY (2013 Mar 1) Control of inflammation by integration of environmental cues by regulatory T cells. J Clin Invest 123(3):939–944

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Clayton JB, Vangay P, Huang HU, Ward T, Hillmann BM, Al-Ghalith GA, Travis DA, Long HT, Van Tuan B, Van Minh V, Cabana F (2016) Captivity humanizes the primate microbiome. Proc Natl Acad Sci 113(37):10376–10381

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Clemente JC, Ursell LK, Parfrey LW, Knight R (2012) The impact of the gut microbiota on human health: an integrative view. Cell 148(6):1258–1270

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Croker BA, Lawson BR, Rutschmann S, Berger M, Eidenschenk C, Blasius AL, Moresco EM, Sovath S, Cengia L, Shultz LD, Theofilopoulos AN (2008) Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. Proc Natl Acad Sci 105(39):15028–15033

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • De Souza HS, Fiocchi C (2016) Immunopathogenesis of IBD: current state of the art. Nat Rev Gastroenterol Hepatol 13(1):13

    Article  PubMed  CAS  Google Scholar 

  • Dias LP, Luzo ÂCM, Volpe BB, Durán M, Galdames SE, Ferreira LA, Durán N, Fávaro WJ (2018) Effects of intravesical therapy with platelet-rich plasma (PRP) and Bacillus Calmette-Guérin (BCG) in non-muscle invasive bladder cancer. Tissue Cell 52:17–27

    Article  PubMed  Google Scholar 

  • Faderl M, Noti M, Corazza N, Mueller C (2015) Keeping bugs in check: the mucus layer as a critical component in maintaining intestinal homeostasis. IUBMB Life 67(4):275–285

    Article  CAS  PubMed  Google Scholar 

  • Fukata M, Abreu MT (2007) TLR4 signalling in the intestine in health and disease. Biochem Soc Trans 35(6):1473–1478

    Article  CAS  PubMed  Google Scholar 

  • Fukuda S, Toh H, Hase K, Oshima K, Nakanishi Y, Yoshimura K, Tobe T, Clarke JM, Topping DL, Suzuki T, Taylor TD (2011) Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature 469(7331):543–547

    Article  CAS  PubMed  Google Scholar 

  • Garaude J, Kent A, van Rooijen N, Blander JM (2012) Simultaneous targeting of toll-and nod-like receptors induces effective tumor-specific immune responses. Sci Transl Med 4(120):120ra16–120ra16

    Article  PubMed  CAS  Google Scholar 

  • Geuking MB, Cahenzli J, Lawson MA, Ng DC, Slack E, Hapfelmeier S, McCoy KD, Macpherson AJ (2011) Intestinal bacterial colonization induces mutualistic regulatory T cell responses. Immunity 34(5):794–806

    Article  CAS  PubMed  Google Scholar 

  • Geva-Zatorsky N, Sefik E, Kua L et al (2017) Mining the human gut microbiota for immunomodulatory organisms. Cell 168(5):928–943

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Goodman AL, Kallstrom G, Faith JJ, Reyes A, Moore A, Dantas G, Gordon JI (2011) Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice. Proc Natl Acad Sci 108(15):6252–6257

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, Taniguchi K, Yu GY, Österreicher CH, Hung KE, Datz C (2012) Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature 491(7423):254–258

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Groussin M, Mazel F, Sanders JG, Smillie CS, Lavergne S, Thuiller W, Alm EJ (2017) Unraveling the processes shaping mammalian gut microbiomes over evolutionary time. Nat Commun 8(1):1–12

    Article  CAS  Google Scholar 

  • Gupta VK, Paul S, Dutta C (2017) Geography, ethnicity or subsistence-specific variations in human microbiome composition and diversity. Front Microbiol 8:1162

    Article  PubMed  PubMed Central  Google Scholar 

  • Hajj Hussein I, Chams N, Chams S, El Sayegh S, Badran R, Raad M, Gerges-Geagea A, Leone A, Jurjus A (2015) Vaccines through centuries: major cornerstones of global health. Front Public Health 3:269

    Article  PubMed  PubMed Central  Google Scholar 

  • Halwachs B, Madhusudhan N, Krause R, Nilsson RH, Moissl-Eichinger C, Högenauer C, Thallinger GG, Gorkiewicz G (2017) Critical issues in mycobiota analysis. Front Microbiol 8:180

    Article  PubMed  PubMed Central  Google Scholar 

  • Hansson GC, Johansson ME (2010) The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Gut Microbes 1(1):51–54

    Article  PubMed  PubMed Central  Google Scholar 

  • Hapfelmeier S, Lawson MA, Slack E, Kirundi JK, Stoel M, Heikenwalder M, Cahenzli J, Velykoredko Y, Balmer ML, Endt K, Geuking MB (2010) Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses. Science 328(5986):1705–1709

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Heijtz RD, Wang S, Anuar F, Qian Y, Björkholm B, Samuelsson A, Hibberd ML, Forssberg H, Pettersson S (2011) Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci 108(7):3047–3052

    Article  CAS  PubMed Central  Google Scholar 

  • Holmes E, Li JV, Athanasiou T, Ashrafian H, Nicholson JK (2011) Understanding the role of gut microbiome–host metabolic signal disruption in health and disease. Trends Microbiol 19(7):349–359

    Article  CAS  PubMed  Google Scholar 

  • Hooper LV, Littman DR, Macpherson AJ (2012) Interactions between the microbiota and the immune system. Science 336(6086):1268–1273

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, Codelli JA, Chow J, Reisman SE, Petrosino JF, Patterson PH (2013) Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 155(7):1451–1463

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hunt PW, Sinclair E, Rodriguez B, Shive C, Clagett B, Funderburg N, Robinson J, Huang Y, Epling L, Martin JN, Deeks SG (2014) Gut epithelial barrier dysfunction and innate immune activation predict mortality in treated HIV infection. J Infect Dis 210(8):1228–1238

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Iliev ID, Funari VA, Taylor KD, Nguyen Q, Reyes CN, Strom SP, Brown J, Becker CA, Fleshner PR, Dubinsky M, Rotter JI (2012) Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis. Science 336(6086):1314–1317

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Johansson ME, Larsson JM, Hansson GC (2011) The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host–microbial interactions. Proc Natl Acad Sci 108(Suppl 1):4659–4665

    Article  CAS  PubMed  Google Scholar 

  • Kawasaki T, Kawai T (2014) Toll-like receptor signaling pathways. Front Immunol 5:461

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kendall PL, Moore DJ, Hulbert C, Hoek KL, Khan WN, Thomas JW (2009) Reduced diabetes in btk-deficient nonobese diabetic mice and restoration of diabetes with provision of an anti-insulin IgH chain transgene. J Immunol 183(10):6403–6412

    Article  CAS  PubMed  Google Scholar 

  • Khosravi A, Yáñez A, Price JG, Chow A, Merad M, Goodridge HS, Mazmanian SK (2014) Gut microbiota promote hematopoiesis to control bacterial infection. Cell Host Microbe 15(3):374–381

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kinnebrew MA, Buffie CG, Diehl GE, Zenewicz LA, Leiner I, Hohl TM, Flavell RA, Littman DR, Pamer EG (2012) Interleukin 23 production by intestinal CD103+ CD11b+ dendritic cells in response to bacterial flagellin enhances mucosal innate immune defense. Immunity 36(2):276–287

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kinnebrew MA, Ubeda C, Zenewicz LA, Smith N, Flavell RA, Pamer EG (2010) Bacterial flagellin stimulates toll-like receptor 5—dependent defense against vancomycin-resistant Enterococcus infection. J Infect Dis 201(4):534–543

    Article  CAS  PubMed  Google Scholar 

  • Korn T, Oukka M, Kuchroo V, Bettelli E (2007) Th17 cells: effector T cells with inflammatory properties. Semin Immunol 19(6):362–371

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kumar V, Abbas AK, Aster JC (2017) Robbins basic pathology e-book. Elsevier, Amsterdam

    Google Scholar 

  • Ley RE, Peterson DA, Gordon JI (2006) Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell 124(4):837–848

    Article  CAS  PubMed  Google Scholar 

  • Li Y, Kundu P, Seow SW, de Matos CT, Aronsson L, Chin KC, Kärre K, Pettersson S, Greicius G (2012) Gut microbiota accelerate tumor growth via c-Jun and STAT3 phosphorylation in APC min/+ mice. Carcinogenesis 33(6):1231–1238

    Article  CAS  PubMed  Google Scholar 

  • Littman DR, Pamer EG (2011) Role of the commensal microbiota in normal and pathogenic host immune responses. Cell Host Microbe 10(4):311–323

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lofgren JL, Whary MT, Ge Z, Muthupalani S, Taylor NS, Mobley M, Potter A, Varro A, Eibach D, Suerbaum S, Wang TC (2011) Lack of commensal flora in helicobacter pylori–infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia. Gastroenterology 140(1):210–220

    Article  PubMed  Google Scholar 

  • Lozupone CA (2018) Unraveling interactions between the microbiome and the host immune system to decipher mechanisms of disease. Msystems 3(2):e00183–e00117

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Luczynski P, McVey Neufeld KA, Oriach CS, Clarke G, Dinan TG, Cryan JF (2016) Growing up in a bubble: using germ-free animals to assess the influence of the gut microbiota on brain and behavior. Int J Neuropsychopharmacol 19(8):pyw020

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Macpherson AJ, Uhr T (2004) Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303(5664):1662–1665

    Article  CAS  PubMed  Google Scholar 

  • Mao K, Baptista AP, Tamoutounour S, Zhuang L, Bouladoux N, Martins AJ, Huang Y, Gerner MY, Belkaid Y, Germain RN (2018) Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism. Nature 554(7691):255–259

    Article  CAS  PubMed  Google Scholar 

  • Matson V, Fessler J, Bao R, Chongsuwat T, Zha Y, Alegre ML, Luke JJ, Gajewski TF (2018) The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients. Science 359(6371):104–108

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Maynard CL, Elson CO, Hatton RD, Weaver CT (2012) Reciprocal interactions of the intestinal microbiota and immune system. Nature 489(7415):231–241

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mezouar S, Chantran Y, Michel J, Fabre A, Dubus JC, Leone M, Sereme Y, Mège JL, Ranque S, Desnues B, Chanez P (2018) Microbiome and the immune system: from a healthy steady-state to allergy associated disruption. Hum Microbiom J 10:11–20

    Article  Google Scholar 

  • Momose Y, Hirayama K, Itoh K (2008) Effect of organic acids on inhibition of Escherichia coli O157: H7 colonization in gnotobiotic mice associated with infant intestinal microbiota. Antonie Van Leeuwenhoek 93(1–2):141–149

    Article  CAS  PubMed  Google Scholar 

  • Nicholson JK, Holmes E, Kinross J, Burcelin R, Gibson G, Jia W, Pettersson S (2012) Host-gut microbiota metabolic interactions. Science 336(6086):1262–1267

    Article  CAS  PubMed  Google Scholar 

  • Ochi A, Nguyen AH, Bedrosian AS, Mushlin HM, Zarbakhsh S, Barilla R, Zambirinis CP, Fallon NC, Rehman A, Pylayeva-Gupta Y, Badar S (2012) MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells. J Exp Med 209(9):1671–1687

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Peterson DA, McNulty NP, Guruge JL, Gordon JI (2007) IgA response to symbiotic bacteria as a mediator of gut homeostasis. Cell Host Microbe 2(5):328–339

    Article  CAS  PubMed  Google Scholar 

  • Peterson LW, Artis D (2014) Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat Rev Immunol 14(3):141–153

    Article  CAS  PubMed  Google Scholar 

  • Reuven EM, Fink A, Shai Y (2014) Regulation of innate immune responses by transmembrane interactions: lessons from the TLR family. Biochim Biophys Acta 1838(6):1586–1593

    Article  CAS  PubMed  Google Scholar 

  • Salzman NH, Underwood MA, Bevins CL (2007) Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa. Semin Immunol 19(2):70–83

    Article  CAS  PubMed  Google Scholar 

  • Schmidt D, Amrani A, Verdaguer J, Bou S, Santamaria P (1999) Autoantigen-independent deletion of diabetogenic CD4+ thymocytes by protective MHC class II molecules. J Immunol 162(8):4627–4636

    Article  CAS  PubMed  Google Scholar 

  • Schwabe RF, Jobin C (2013) The microbiome and cancer. Nat Rev Cancer 13(11):800–812

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sharma P, Allison JP (2015) The future of immune checkpoint therapy. Science 348(6230):56–61

    Article  CAS  PubMed  Google Scholar 

  • Sheflin AM, Whitney AK, Weir TL (2014) Cancer-promoting effects of microbial dysbiosis. Curr Oncol Rep 16(10):406

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Sheridan BS, Lefrançois L (2010) Intraepithelial lymphocytes: to serve and protect. Curr Gastroenterol Rep 12(6):513–521

    Article  PubMed  PubMed Central  Google Scholar 

  • Siebert JC, Görg C, Palmer B, Lozupone C (2019) Visualizing microbiome–immune system interplay. Immunother 11(2):63–67

    Article  CAS  Google Scholar 

  • Sivan A, Corrales L, Hubert N, Williams JB, Aquino-Michaels K, Earley ZM, Benyamin FW, Lei YM, Jabri B, Alegre ML, Chang EB (2015) Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy. Science 350(6264):1084–1089

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Slack E, Hapfelmeier S, Stecher B, Velykoredko Y, Stoel M, Lawson MA, Geuking MB, Beutler B, Tedder TF, Hardt WD, Bercik P (2009) Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. Science 325(5940):617–620

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sommer F, Bäckhed F (2013) The gut microbiota—masters of host development and physiology. Nat Rev Microbiol 11(4):227–238

    Article  CAS  PubMed  Google Scholar 

  • Taherali F, Varum F, Basit AW (2018) A slippery slope: on the origin, role and physiology of mucus. Adv Drug Deliv Rev 124:16–33

    Article  CAS  PubMed  Google Scholar 

  • Talham GL, Jiang HQ, Bos NA, Cebra JJ (1999) Segmented filamentous bacteria are potent stimuli of a physiologically normal state of the murine gut mucosal immune system. Infect Immun 67(4):1992–2000

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Trompette A, Gollwitzer ES, Yadava K, Sichelstiel AK, Sprenger N, Ngom-Bru C, Blanchard C, Junt T, Nicod LP, Harris NL, Marsland BJ (2014) Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med 20(2):159–166

    Article  CAS  PubMed  Google Scholar 

  • Vaishnava S, Yamamoto M, Severson KM, Ruhn KA, Yu X, Koren O, Ley R, Wakeland EK, Hooper LV (2011) The antibacterial lectin RegIIIγ promotes the spatial segregation of microbiota and host in the intestine. Science 334(6053):255–258

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yong Z, Chang L, Mei YX, Yi L (2007) Role and mechanisms of CD4+ CD25+ regulatory T cells in the induction and maintenance of transplantation tolerance. Transpl Immunol 17(2):120–129

    Article  CAS  PubMed  Google Scholar 

  • Yoshikawa T, Saijo M, Morikawa S (2014) Emergence of zoonotic orthopox virus infections. In: Viral infections and global change, vol 377. Wiley

    Google Scholar 

  • Yu LX, Yan HX, Liu Q, Yang W, Wu HP, Dong W, Tang L, Lin Y, He YQ, Zou SS, Wang C (2010) Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents. Hepatology 52(4):1322–1333

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

Kuraganti Gunaswetha, Edla Sujatha, Pallaval Veera Bramhachari are grateful to Kakatiya University, Warangal and Krishna University, Machilipatnam for the support extended.

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The authors declare that they have no competing interests.

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Author notes

  1. Kuraganti Gunaswetha, Edla Sujatha and Pallaval Veera Bramhachari contributed equally with all other contributors.

Authors and Affiliations

  1. Department of Microbiology, Kakatiya University, Warangal, Telangana, India

    Kuraganti Gunaswetha & Edla Sujatha

  2. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    Pallaval Veera Bramhachari

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  1. Kuraganti Gunaswetha
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  2. Edla Sujatha
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Correspondence to Edla Sujatha .

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  1. Department of Biotechnology, Krishna University, Machilipatnam, Andhra Pradesh, India

    Pallaval Veera Bramhachari

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Gunaswetha, K., Sujatha, E., Bramhachari, P.V. (2021). Understanding the Interplay Between the Host Immune–Microbiome Interactions: A State of the Art Review. In: Bramhachari, P.V. (eds) Microbiome in Human Health and Disease. Springer, Singapore. https://doi.org/10.1007/978-981-16-3156-6_8

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