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Protein-Based Nanotubes

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Smart Soft-Matter Nanotubes

Part of the book series: Nanostructure Science and Technology ((NST))

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Abstract

One of the practical methodologies for the fabrication of soft-matter nanotubes involves a template technique. Potent template methods to prepare polymer nanotubes including synthetic and natural macromolecules like proteins can be divided into two approaches, i.e., endo-templating and exo-templating. This chapter describes the preparation, functions, and applications of protein-based nanotubes. Protein nanotubes are mainly fabricated by using endo-templating with the use of polycarbonate membrane or microporous alumina. First, a typical procedure of wetting layer-by-layer template synthesis with a track-etched nanoporous polycarbonate membrane is introduced as reliable and facile technique to fabricate the structure-guided protein-based nanotubes. For example, the combination of two protein building blocks, positively charged poly-l-arginine (PLAR) and a negatively charged human serum albumin (HSA), can produce homogeneous (PLAR/HSA)3 nanotubes. Various kinds of protein-based nanotubes with rational combination of functional proteins and enzymes are discussed in succession from the perspective of structural characteristics and unique functions. Finally, the author addresses the elaborated assembly of GroEL-based nanotubes into protein nanotubes with high axial ratios.

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Authors and Affiliations

  1. Nanomaterials Research Institute (NMRI), Department of Materials and Chemistry, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 5, 1-1-1 Higashi, 305-8565, Tsukuba, Ibaraki, Japan

    Toshimi Shimizu

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Correspondence to Toshimi Shimizu .

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Shimizu, T. (2021). Protein-Based Nanotubes. In: Smart Soft-Matter Nanotubes. Nanostructure Science and Technology. Springer, Singapore. https://doi.org/10.1007/978-981-16-2685-2_7

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