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Di-phenylalanine-Based Nanotubes

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Smart Soft-Matter Nanotubes

Part of the book series: Nanostructure Science and Technology ((NST))

Abstract

Suitable combinations and sequences of amino acids result in the construction of rational three-dimensional structures, thereby exhibiting a variety of vital functions including mechanical, structural, enzymatic, chaperone, immune, storage, and transport actions. Notably, dipeptides represented by di-l-phenylalanine, although the structure is the shortest and simple as a peptide, can play a talented role in the self-assembly into nanostructures. For example, Gazit’s group has carried out pioneering work on self-assembled tubular structures from the di-phenylalanine peptide. This chapter describes the preparation, functions, and applications of the di-phenylalanine- or its analogues-based nanotubes. Self-assembly of the di-phenylalanine by diluting the 1,1,1,3,3,3-hexafluoro-2-propanol solution with water gives tough and discrete nanotube structures with high-axial ratios. First, a systematic study on molecular packing of hydrophobic dipeptides in single crystal X-ray structures by Görbitz is introduced to understand the crystal packing features for the various combinations of two hydrophobic amino acids. The author discusses many potent applications of the di-phenylalanine-based nanotubes. Representative properties and functions are turn-on fluorescence, recognition and sensing, ferroelectrics and piezoelectrics, nonlinear optical effect, quantum confinement, light harvesting, supercapacitor, mechanical reinforcement, and detection of cancer cell and neurotoxin.

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Authors and Affiliations

  1. Nanomaterials Research Institute (NMRI), Department of Materials and Chemistry, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan

    Toshimi Shimizu

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Correspondence to Toshimi Shimizu .

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Shimizu, T. (2021). Di-phenylalanine-Based Nanotubes. In: Smart Soft-Matter Nanotubes. Nanostructure Science and Technology. Springer, Singapore. https://doi.org/10.1007/978-981-16-2685-2_4

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