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Development of Novel Anti-infective Formulations for Wound Disinfection

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Wound Healing Research

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Abstract

Wound infection and disinfection mainly rely on the type of wounds and the development of a novel and effective way of wound repairing or healing materials. Development of novel anti-infective formulations depends on the type of wounds and mechanism of healing the wound. Nowadays, wound healing and management is quite a challenging area of research, whereas development of anti-infective formulations needs an extensive information on the pathogenesis of wound infection and its healing. This seems to be a much more complicated process which is controlled by different exogenous and endogenous factors. In the elderly, systemic disorders like diabetes, immunosuppression, venous disease, and metabolic deficiencies also affect the healing of wounds. Apart from this, accumulation of some pathogenic bacteria in skin wounds occurs where they are aggregated and immobilized in an adhesive matrix of extracellular polymeric substances which leads to the weak penetration of antibiotics and subsequently makes it difficult to eradicate the bacteria completely. This happens due to the host clearance mechanisms, i.e., antibodies and phagocytes through the microbial biofilm. In addition, toxins produced from bacteria lead to an excessive, detrimental inflammatory response such as development of antibiotic resistance and delayed wound healing followed by prolonged hospitalization. Therefore, wound infections and its healing have emerged as a big cause of death and burden toward the healthcare system. Based on the above scenario, different anti-infective therapies and formulations were suggested which will be described in this chapter. Several antimicrobial therapies as well as antimicrobials are used for wound healing which is discussed in this chapter. Besides this, some naturally derived antimicrobials such as essential oil and honey also play a key role in curing wounds. In addition, nanoparticles also help in wound healing by an excellent approach to speeding up the recovery of acute and chronic wounds, by energizing proper movement through the different phases of healing.

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Authors and Affiliations

  1. School of Biotechnology, KIIT University, Bhubaneswar, Odisha, India

    Regalin Rout

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  1. Regalin Rout
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  1. Department of Chemical Engineering, Chungbuk National University, Cheongju, Korea (Republic of)

    Prasun Kumar

  2. Institute of Science, Nirma University, Ahmedabad, India

    Vijay Kothari

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Rout, R. (2021). Development of Novel Anti-infective Formulations for Wound Disinfection. In: Kumar, P., Kothari, V. (eds) Wound Healing Research. Springer, Singapore. https://doi.org/10.1007/978-981-16-2677-7_11

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