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Development and Integration of New Green Reactions

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Middle Molecular Strategy

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Abstract

Over the last few decades, the quest for environmentally benign chemical transformations has become an important topic in both industrial and academic research. An integrated synthesis that combines multiple reactions in a single operation in a one-pot or a flow system without isolating intermediates has recently drawn much attention as a replacement for conventional step-by-step synthesis. Because in the reaction integration process the reaction mixtures are directly used to the next reaction without purification and the generated co- and by-products may have negative effects on the next reaction, integrating highly atom-economical reactions is quite important. To this end, we developed several highly atom-economical direct catalytic reactions. In this review, we focused on the developments of synthesis and reactions of N-unprotected ketimines and their applications for time integration (one-pot sequential process through N-unprotected ketimine synthesis).

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Authors and Affiliations

  1. Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan

    Takashi Ohshima, Hiroyuki Morimoto & Tetsuya Kadota

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  1. Takashi Ohshima
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  2. Hiroyuki Morimoto
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  3. Tetsuya Kadota
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Correspondence to Takashi Ohshima .

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Editors and Affiliations

  1. Graduate School of Science, Osaka University, Toyanaka, Osaka, Japan

    Koichi Fukase

  2. Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan

    Takayuki Doi

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Ohshima, T., Morimoto, H., Kadota, T. (2021). Development and Integration of New Green Reactions. In: Fukase, K., Doi, T. (eds) Middle Molecular Strategy. Springer, Singapore. https://doi.org/10.1007/978-981-16-2458-2_15

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