Abstract
MicroRNAs are small non-coding RNAs that regulate the expression of many genes. Alteration of microRNA expressions is associated with the occurrence of diseases including cancer, obesity, and obesity-related cancer. miRNAs are also known to regulate different cancer-related gene expressions indicating microRNAs could function as tumor suppressors and oncogenes. Obesity and cancer are the two critical diseases affecting millions of people all over the world. Obesity has been associated with incidence and a major risk factor for the occurrence of diseases like diabetes, cardiovascular disease, and various cancers. Synthesis of miRNAs-based therapeutics like miRNA mimics, anti-miR oligonucleotides is going on to cure obesity, cancer, and obesity-associated cancer. miRNAs emerged as a potential biomarker and being considered as a diagnostic, prognostic, and therapeutic target for the treatment of obesity, cancer, and obesity-associated cancer.
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Acknowledgments
KSP acknowledges financial support from DBT-India, in the form of a Senior Research fellowship. PPK and MS acknowledge financial support from Indian Council of Medical Research (ICMR), India in the form of Senior Research fellowships. AKS acknowledges CSIR-India for providing Senior Research Fellowships. SK thanks the University Grants Commission, India, and Department of Science and Technology, India, for providing financial support in the form of UGC-BSR Research Start-Up-Grant (No. F.30–372/2017 (BSR)) and DST-SERB Grant (EEQ/2016/000350), respectively. SK is grateful to the Central University of Punjab, Bathinda, India, for providing a Research Seed Money Grant (GP-25).
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Prajapati, K.S., Shuaib, M., Kushwaha, P.P., Singh, A.K., Sharma, R., Kumar, S. (2021). miRNAs as Therapeutic Target in Obesity and Cancer. In: Kumar, S., Gupta, S. (eds) Obesity and Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-16-1846-8_12
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