Abstract
For many years, protein–protein interactions have been determined solely by virtue of experiments. The experimental techniques employed to elucidate these interactions, however, have faced many inherent limitations. The experimental techniques are time-consuming and not well-suited for creating protein networks that comprise a voluminous amount of data. Consequently, researchers have looked forward to utilize computational techniques to determine such interactions. This chapter will discuss the currently employed computational methods and other web resources like databases and analysis tools. It will also describe how protein interactions are mapped into a network to provide better insight into various pathways that operate at the cellular level. Furthermore, the chapter also throws light on the computational techniques of protein–protein docking and states its implications in further experimental research design.
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Poluri, K.M., Gulati, K., Sarkar, S. (2021). Prediction, Analysis, Visualization, and Storage of Protein–Protein Interactions Using Computational Approaches. In: Protein-Protein Interactions. Springer, Singapore. https://doi.org/10.1007/978-981-16-1594-8_6
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