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Energetic Aspects of Protein–Protein Interactions (PPIs)

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Protein-Protein Interactions

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Abstract

The increasing demand to build holistic models of protein–protein interactions in the cell requires understanding them at the structural level. Structure in turn is elucidated by furnishing biophysical information, that is, thermodynamic and kinetic parameters of the interaction. The thermodynamic parameters that are usually calculated to understand association between proteins are the variations in free energy, entropy, heat capacity, and enthalpy. Similarly, rates of association are also determined under kinetics in order to gain better insight into these interactions. This chapter also highlights the high selectivity of PPIs and outlines basic principles of energetics and some mutagenesis studies that have been performed to get insights into the high affinity protein interactions.

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  1. Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India

    Krishna Mohan Poluri, Khushboo Gulati & Sharanya Sarkar

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Poluri, K.M., Gulati, K., Sarkar, S. (2021). Energetic Aspects of Protein–Protein Interactions (PPIs). In: Protein-Protein Interactions. Springer, Singapore. https://doi.org/10.1007/978-981-16-1594-8_3

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