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High Level of Inflammation

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Coal-burning Type of Endemic Fluorosis

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Abstract

In low concentration, fluoride is considered a necessary compound for human health. Long-term exposure to excessive content of fluoride is the reason for a disease called fluorosis. In more than 25 countries and regions in the world, the excessive fluoride content in the environment has led to the occurrence of chronic endemic fluorosis. Fluorosis not only damages bones and teeth, but also causes extensive pathological damage to human organs/systems. The pathogenesis of endemic fluorosis has not been fully elucidated. Many studies have shown that the mechanism of chronic fluorosis causing extensive pathological damage in the body may be oxidative stress induced by accumulation of fluoride. As an essential intermediate process that causes inflammation, it is such oxidative stress causes extensive damage to the body’s tissues. At present, there are few reports about the pathological role of inflammation in the pathogenesis of endemic fluorosis. Therefore, this section outlines the pathological role of inflammation in the pathogenesis of endemic fluorosis and focuses on the effects of inflammation on organs/systems (such as kidney, thyroid, cardiovascular, brain, and reproductive system) during fluoride exposure, together with its possible mechanism of injury.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China

    Wen-Feng Yu

  2. The Key Laboratory of Endemic and Ethnic Diseases (Guizhou Medical University) of the Ministry of Education, Guiyang, Guizhou, People’s Republic of China

    Wen-Feng Yu

  3. The Provincial Key Laboratory of Medical Molecular Biology, Guiyang, Guizhou, People’s Republic of China

    Wen-Feng Yu

  4. Department of Interventional Medicine at the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China

    Zhi Huang

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  1. Wen-Feng Yu
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  2. Zhi Huang
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Correspondence to Wen-Feng Yu .

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Editors and Affiliations

  1. Department of Pathology, Affiliated Hospital and Key Laboratory of Endemic and Ethnic Diseases of the Ministry of Education, Guizhou Medical University, Guiyang, China

    Zhi-Zhong Guan

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Yu, WF., Huang, Z. (2021). High Level of Inflammation. In: Guan, ZZ. (eds) Coal-burning Type of Endemic Fluorosis. Springer, Singapore. https://doi.org/10.1007/978-981-16-1498-9_13

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