Abstract
In this chapter, the detection principle based on particle levitation in a coupled acoustic-gravitational (CAG) field is theoretically described. A detection concept based on particle levitation is described in Sect. 3.1. The dependence of the levitation coordinate on the density and size of the particle is simulated in Sect. 3.2. Moreover, the effect of the thickness of a gold layer on the microparticle on the levitation coordinate is investigated in Sect. 3.3. In addition, the effect of gold nanoparticle (AuNP) binding on the levitation of a microparticle is discussed in Sect. 3.4. Because a device-dependent parameter is important for the evaluation of the actual binding number of AuNPs, its determination is described in Sect. 3.5.
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References
Masudo T, Okada T (2001) Particle characterization and separation by a coupled acoustic-gravity field. Anal Chem 73:3467–3471
Masudo T, Okada T (2001) Ultrasonic radiation—novel principle for microparticle separation. Anal Sci 17:i1341–i1344
Masudo T, Okada T (2006) Particle separation with ultrasound radiation force. Curr Anal Chem 2:213–227
Masudo T, Okada T (2004) Elution control of microparticles with a coupled acoustic-gravity field and orthogonal laminar flow. Anal Sci 20:753–755
Kanazaki T, Hirawa S, Harada M, Okada T (2010) Coupled acoustic-gravity field for dynamic evaluation of ion exchange with a single resin bead. Anal Chem 82:4472–4478
Green NM (1963) Avidin 3. The Nature of the biotin-binding Site. Biochem J 89:599–609
Lin A, Lee ASY, Lin CC, Lee CK (2006) Determination of binding constant and stoichiometry for antibody-antigen interaction with surface plasmon resonance. Curr Proteomics 3:271–282
Stevens PW, Henry MR, Kelso DM (1999) DNA hybridization on microparticles: determining capture-probe density and equilibrium dissociation constants. Nucleic Acid Res 27:1719–1727
Kagakubinran (Chemical Index) (2004). Maruzen, Tokyo
Takei H, Okamoto T (2016) Morphology effects of cap-shaped silver nanoparticle films as a SERS platform. Anal Sci 32:287–293
Miyagawa A, Okada Y, Okada T (2020) Aptamer-based sensing of small organic molecules by measuring levitation coordinate of single microsphere in combined acoustic-gravitational field. ACS Omega 5:3542–3549
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Miyagawa, A. (2021). Principle of Detection Based on Particle Levitation in Coupled Acoustic-Gravitational Field. In: Acoustic Levitation-Based Trace-Level Biosensing. Springer Theses. Springer, Singapore. https://doi.org/10.1007/978-981-16-1425-5_3
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DOI: https://doi.org/10.1007/978-981-16-1425-5_3
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