Abstract
Lipid droplets (LDs) are intracellular organelles dedicated for fat storage and play critical roles in cellular homeostasis. Recently, LD biology has moved to the forefront of biomedical research due to their involvement in a variety of diseases that are affected by lipid imbalance, such as obesity, type 2 diabetes, fatty liver, cardiovascular diseases, Alzheimer’s disease, and cancer. Growing evidence suggests that majority of intracellular pathogens, be they viral, bacterial, or protozoan, rely on host LDs for completing some steps of their life cycle, thus emphasizing the importance of LDs in host-pathogen interactions. Host and pathogen lipids play vital role in the ability of the pathogen to evade host immune system. Therefore, droplet homeostasis and pathogen replication are intricately linked, the mechanisms of which are largely unknown. This chapter summarizes our current understanding of how unique aspect of LD biology is exploited by pathogens for their replication and propagation in the host. Advancement in the field of lipidomics for performing lipid-profiling of host-pathogen interactions will shed light on many novel and unanticipated findings in disease pathogenesis aimed at discovery of novel biomarkers and identification of therapeutic interventions.
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Acknowledgments
This work was supported by the Early Career Intramural Project of the All India Institute of Medical Sciences (AIIMS), New Delhi. A. Bhattacharyya is supported by Ramanujan Fellowship of Science & Engineering Research Board (SERB), Department of Science and Technology (DST), Govt. of India (grant: RJF/2019/000040).
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Bhattacharyya, A., Choudhary, V. (2021). Lipidomics to Study the Role of Lipid Droplets in Host-Pathogen Interactions. In: Hameed, S., Fatima, Z. (eds) Integrated Omics Approaches to Infectious Diseases. Springer, Singapore. https://doi.org/10.1007/978-981-16-0691-5_23
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DOI: https://doi.org/10.1007/978-981-16-0691-5_23
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