Abstract
Striatum, the main entrance of cortical afferents to the basal ganglia, plays an important role in the Parkinson’s disease, and it is often overlooked in the study of Parkinson’s disease. In this paper, we add globus pallidus externus (GPe), globus pallidus internus (GPi), and subthalamic nucleus (STN) nuclei on the basis of the striatum-inhibiting microcirculation and build a striatum-GP-STN model. Numerical analysis results show that increasing the synaptic connections of medium spiny neurons (MSNs) to GPe and GPi neurons results in a pathological synchronization of GPe and GPi neurons, and the power spectral density indicates a significant increase in beta-band energy. This is likely to be a potential source of beta-band in the Parkinson’s disease. The expansion of the striatum-GP-STN model also provides new ideas for studying Parkinson’s disease in the future.
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Acknowledgements
This research was supported by the National Science Foundation of China (Grants 11572015, 11772019).
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Yu, Y., Liang, K., Wang, Q. (2021). Synchronization and Beta Oscillations in Globus Pallidus: Role of the Striatum. In: Lintas, A., Enrico, P., Pan, X., Wang, R., Villa, A. (eds) Advances in Cognitive Neurodynamics (VII). ICCN2019 2019. Advances in Cognitive Neurodynamics. Springer, Singapore. https://doi.org/10.1007/978-981-16-0317-4_19
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DOI: https://doi.org/10.1007/978-981-16-0317-4_19
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