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Sleep Disorders in Multiple Sclerosis

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Sleep and Neuropsychiatric Disorders
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Abstract

Multiple sclerosis (MS) is the most common chronic inflammatory demyelinating disease of the central nervous system. Along with a variety of motor features, MS patients may develop several non-motor features including fatigue, sleep disturbances and pain. Multiple factors such as pain, nocturia, depression, muscle weakness, effect of multiple drugs and disease severity all contribute to sleep disruption in cases of MS. Lack of sound sleep in MS patients often leads to increased fatigue, excessive daytime somnolence, metabolic disturbances such as diabetes and obesity as well as increased risk of cardiovascular disorders. Roughly 2–21% of MS patients suffer from obstructive sleep apnoea (OSA) and 40% from insomnia, resulting in increased fatigue, impaired cognition, poor sleep quality, excessive daytime sleepiness and overall poor quality of life. This chapter focuses on the prevalence, pathogenesis and management of sleep disorders in patients with MS.

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Madhaw, G., Kumar, N. (2022). Sleep Disorders in Multiple Sclerosis. In: Gupta, R., Neubauer, D.N., Pandi-Perumal, S.R. (eds) Sleep and Neuropsychiatric Disorders. Springer, Singapore. https://doi.org/10.1007/978-981-16-0123-1_34

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