Abstract
Oral route of administration is the most accepted delivery route due to easy painless administration. Oral route is more suitable for chronic therapy and sustained delivery. In recent years oral approach has been used for delivery of various anticancer drugs like Zytiga, Capecitabine, Topotecan. The number of oral administrations of anti-tumour agents has been increased with respect to all other available cancer therapies. Preferable for patients as it reduces the efforts of regular visit to clinic or venepuncture. The most limiting factor for oral delivery is gastrointestinal barrier where epithelial membrane leads to poor permeability of drug and chemicals and enzymes in gastrointestinal tract causes degradation of bioactive compounds. In addition to this pH varies drastically across the GI tract, ranges from 1 to 2 pH in stomach reaching 7 to 8 in colon and rectum. To conquer this limitations nanocarriers are been developed to encapsulate and protect the drugs eventually increasing their pharmacokinetics. The most attractive method includes pH responsive soluble coatings, mucoadhesive nanocarriers, enzyme inhibitor and microbial control system. The present review discusses natural products in cancer treatment, obstacles in their oral delivery and nanotechnology approach to deal with the challenges.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Agarwal, T., Narayana, S. N., Pal, K., Pramanik, K., Giri, S., & Banerjee, I. (2015). Calcium alginate-carboxymethyl cellulose beads for colon-targeted drug delivery. International Journal of Biological Macromolecules, 75, 409–417. https://doi.org/10.1016/j.ijbiomac.2014.12.052
Artursson, P., Lindmark, T., Davis, S. S., & Illum, L. (1994). Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2). Pharmaceutical Research, 11(9), 1358–1361. https://doi.org/10.1023/a:1018967116988
Augustin, E., Czubek, B., Nowicka, A. M., Kowalczyk, A., Stojek, Z., & Mazerska, Z. (2016). Improved cytotoxicity and preserved level of cell death induced in colon cancer cells by doxorubicin after its conjugation with iron-oxide magnetic nanoparticles. Toxicology In Vitro, 33, 45–53. https://doi.org/10.1016/j.tiv.2016.02.009
Aungst, B. J. (2012). Absorption enhancers: Applications and advances. The AAPS Journal, 14(1), 10–18. https://doi.org/10.1208/s12248-011-9307-4
Baas, T. C., & Thacker, P. A. (1996). Impact of gastric pH on dietary enzyme activity and survivability in swine fed β-glucanase supplemented diets. Canadian Journal of Animal Science, 76(2), 245–252. https://doi.org/10.4141/cjas96-036
Bakry, A. M., Abbas, S., Ali, B., Majeed, H., Abouelwafa, M. Y., Mousa, A., et al. (2016). Microencapsulation of oils: A comprehensive review of benefits, techniques, and applications. Comprehensive Reviews in Food Science and Food Safety, 15(1), 143–182. https://doi.org/10.1111/1541-4337.12179
Balboa, E. M. (2014). Potential of antioxidant extracts produced by aqueous processing of renewable resources for the formulation of cosmetics. Industrial Crop Production, 58, 104–110. https://doi.org/10.1016/j.indcrop.2014.03.041
Bernal, J., Mendiola, J. A., Ibanez, E., & Cifuentes, A. (2011). Advanced analysis of nutraceuticals. Journal of Pharmaceutical and Biomedical Analysis, 55(4), 758–774. https://doi.org/10.1016/j.jpba.2010.11.033
Bernkop-Schnurch, A. (1998). The use of inhibitory agents to overcome the enzymatic barrier to perorally administered therapeutic peptides and proteins. Journal of Controlled Release, 52(1–2), 1–16. https://doi.org/10.1016/s0168-3659(97)00204-6
Bhatia, M., Ahuja, M., & Mehta, H. (2015). Thiol derivatization of Xanthan gum and its evaluation as a mucoadhesive polymer. Carbohydrate Polymers, 131, 119–124. https://doi.org/10.1016/j.carbpol.2015.05.049
Bhattacharya, R., Mukherjee, P., Xiong, Z., Atala, A., Soker, S., & Mukhopadhyay, D. (2004). Gold nanoparticles inhibit VEGF165-induced proliferation of HUVEC cells. Nano Letters, 4(12), 2479–2481. https://doi.org/10.1021/nl0483789
Bhattacharya, S., Mondal, L., Mukherjee, B., Dutta, L., Ehsan, I., Debnath, M. C., et al. (2018). Apigenin loaded nanoparticle delayed development of hepatocellular carcinoma in rats. Nanomedicine, 14(6), 1905–1917. https://doi.org/10.1016/j.nano.2018.05.011
Bianco, A., Kostarelos, K., & Prato, M. (2005). Applications of carbon nanotubes in drug delivery. Current Opinion in Chemical Biology, 9(6), 674–679. https://doi.org/10.1016/j.cbpa.2005.10.005
Bilia, A. R., Guccione, C., Isacchi, B., Righeschi, C., Firenzuoli, F., & Bergonzi, M. C. (2014). Essential oils loaded in nanosystems: A developing strategy for a successful therapeutic approach. Evidence-Based Complementary and Alternative Medicine, 2014, 651593. https://doi.org/10.1155/2014/651593
Bisht, S., Feldmann, G., Soni, S., Ravi, R., Karikar, C., Maitra, A., et al. (2007). Polymeric nanoparticle-encapsulated curcumin (“nanocurcumin”): A novel strategy for human cancer therapy. Journal of Nanbiotechnology, 5, 3. https://doi.org/10.1186/1477-3155-5-3
Bobo, D., Robinson, K. J., Islam, J., Thurecht, K. J., & Corrie, S. R. (2016). Nanoparticle-based medicines: A review of FDA-approved materials and clinical trials to date. Pharmaceutical Research, 33(10), 2373–2387. https://doi.org/10.1007/s11095-016-1958-5
Byrne, J. D., Betancourt, T., & Brannon-Peppas, L. (2008). Active targeting schemes for nanoparticle systems in cancer therapeutics. Advanced Drug Delivery Reviews, 60(15), 1615–1626. https://doi.org/10.1016/j.addr.2008.08.005
Carvalho, F. C., Bruschi, M. L., Evangelista, R. C., & Gremião, M. P. D. (2010). Mucoadhesive drug delivery systems. Brazilian Journal of Pharmaceutical Sciences, 46, 1–17.
Chemtob, C., Chaumeil, J. C., & N'Dongo, M. (1986). Tablets of metronidazole microcapsules: Release characteristics. International Journal of Pharmaceutics, 29(1), 83–92. https://doi.org/10.1016/0378-5173(86)90202-4
Chen, J. L., & Cyr, G. N. (1970). Compositions producing adhesion through hydration. In R. S. Manly (Ed.), Adhesion in biological systems (pp. 163–181). London: Academic Press.
Chen, L., Remondetto, G. E., & Subirade, M. (2006). Food protein-based materials as nutraceutical delivery systems. Trends in Food Science and Technology, 17(5), 272–283. https://doi.org/10.1016/j.tifs.2005.12.011
Chen, Y., Tezcan, O., Li, D., Beztsinna, N., Lou, B., Etrych, T., et al. (2017). Overcoming multidrug resistance using folate receptor-targeted and pH-responsive polymeric nanogels containing covalently entrapped doxorubicin. Nanoscale, 9(29), 10404–10419. https://doi.org/10.1039/C7NR03592F
Colomer, R., Alba, E., González-Martin, A., Paz-Ares, L., Martín, M., Llombart, A., et al. (2010). Treatment of cancer with oral drugs: A position statement by the Spanish Society of Medical Oncology (SEOM). Annals of Oncology, 21(2), 195–198. https://doi.org/10.1093/annonc/mdp595
de Barros, J. M., Lechner, T., Charalampopoulos, D., Khutoryanskiy, V. V., & Edwards, A. D. (2015). Enteric coated spheres produced by extrusion/spheronization provide effective gastric protection and efficient release of live therapeutic bacteria. International Journal of Pharmaceutics, 493(1–2), 483–494. https://doi.org/10.1016/j.ijpharm.2015.06.051
Deshpande, A. A., Shah, N. H., Rhodes, C. T., & Malick, W. (1997). Development of a novel controlled-release system for gastric retention. Pharmaceutical Research, 14(6), 815–819. https://doi.org/10.1023/a:1012171010492
Dhillon, N., Aggarwal, B. B., Newman, R. A., Wolff, R. A., Kunnumakkara, A. B., Abbruzzese, J. L., et al. (2008). Phase II trial of curcumin in patients with advanced pancreatic cancer. Clinical Cancer Research, 14(14), 4491–4499. https://doi.org/10.1158/1078-0432.ccr-08-0024
Din, F. U., Aman, W., Ullah, I., Qureshi, O. S., Mustapha, O., Shafique, S., et al. (2017). Effective use of nanocarriers as drug delivery systems for the treatment of selected tumors. International Journal of Nanomedicine, 12, 7291–7309. https://doi.org/10.2147/IJN.S146315
Duncan, R., & Izzo, L. (2005). Dendrimer biocompatibility and toxicity. Advanced Drug Delivery Reviews, 57(15), 2215–2237. https://doi.org/10.1016/j.addr.2005.09.019
Ensign, L. M., Cone, R., & Hanes, J. (2012). Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers. Advanced Drug Delivery Reviews, 64(6), 557–570. https://doi.org/10.1016/j.addr.2011.12.009
Fang, Z., & Bhandari, B. (2010). Encapsulation of polyphenols—a review. Trends in Food Science & Technology, 21(10), 510–523. https://doi.org/10.1016/j.tifs.2010.08.003
Faridi Esfanjani, A., & Jafari, S. M. (2016). Biopolymer nano-particles and natural nano-carriers for nano-encapsulation of phenolic compounds. Colloids and Surfaces. B, Biointerfaces, 146, 532–543. https://doi.org/10.1016/j.colsurfb.2016.06.053
Fernández-López, J., & Viuda-Martos, M. (2018). Introduction to the special issue: Application of essential oils in food systems. Food, 7(4), 56. https://doi.org/10.3390/foods7040056
Fernandez-Urrusuno, R., Calvo, P., Remunan-Lopez, C., Vila-Jato, J. L., & Alonso, M. J. (1999). Enhancement of nasal absorption of insulin using chitosan nanoparticles. Pharmaceutical Research, 16(10), 1576–1581. https://doi.org/10.1023/a:1018908705446
Figueiro, F., Bernardi, A., Frozza, R. L., Terroso, T., Zanotto-Filho, A., Jandrey, E. H., et al. (2013). Resveratrol-loaded lipid-core nanocapsules treatment reduces in vitro and in vivo glioma growth. Journal of Biomedical Nanotechnology, 9(3), 516–526. https://doi.org/10.1166/jbn.2013.1547
Findlay, M., von Minckwitz, G., & Wardley, A. (2008). Effective oral chemotherapy for breast cancer: Pillars of strength. Annals of Oncology, 19(2), 212–222. https://doi.org/10.1093/annonc/mdm285
Föger, F., Hoyer, H., Kafedjiiski, K., Thaurer, M., & Bernkop-Schnürch, A. (2006). In vivo comparison of various polymeric and low molecular mass inhibitors of intestinal P-glycoprotein. Biomaterials, 27(34), 5855–5860. https://doi.org/10.1016/j.biomaterials.2006.08.004
Fukushima, S., Kishimoto, S., Takeuchi, Y., & Fukushima, M. (2000). Preparation and evaluation of o/w type emulsions containing antitumor prostaglandin. Advanced Drug Delivery Reviews, 45(1), 65–75. https://doi.org/10.1016/s0169-409x(00)00101-0
Goldberg, M., & Gomez-Orellana, I. (2003a). Challenges for the oral delivery of macromolecules. Nature Reviews Drug Discovery, 2(4), 289–295. https://doi.org/10.1038/nrd1067
Goldberg, M., & Gomez-Orellana, I. (2003b). Challenges for the oral delivery of macromolecules. Nature Reviews. Drug Discovery, 2(4), 289–295. https://doi.org/10.1038/nrd1067
Gunasekaran, T., Haile, T., Nigusse, T., & Dhanaraju, M. D. (2014). Nanotechnology: An effective tool for enhancing bioavailability and bioactivity of phytomedicine. Asian Pacific Journal of Tropical Biomedicine, 4(Suppl 1), S1-7. https://doi.org/10.12980/apjtb.4.2014c980
Han, M. R., Kwon, M. C., Lee, H. Y., Kim, J. C., Kim, J. D., Yoo, S. K., et al. (2007). pH-dependent release property of alginate beads containing calcium carbonate particles. lJournal of Microencapsulation, 24(8), 787–796. https://doi.org/10.1080/02652040701657820
Han, M., Fang, Q. L., Zhan, H. W., Luo, T., Liang, W. Q., & Gao, J. Q. (2009). In vitro and in vivo evaluation of a novel capsule for colon-specific drug delivery. Journal of Pharmaceutical Sciences, 98(8), 2626–2635. https://doi.org/10.1002/jps.21627
Homayun, B., Lin, X., & Choi, H. J. (2019). Challenges and recent progress in oral drug delivery systems for biopharmaceuticals. Pharmaceutics, 11(3), 129. https://doi.org/10.3390/pharmaceutics11030129
Kagan, L., & Hoffman, A. (2008). Systems for region selective drug delivery in the gastrointestinal tract: Biopharmaceutical considerations. Expert Opinion on Drug Delivery, 5(6), 681–692. https://doi.org/10.1517/17425247.5.6.681
Kang, M. J., Kim, H. G., Kim, J. S., Oh, D. G., Um, Y. J., Seo, C. S., et al. (2013). The effect of gut microbiota on drug metabolism. Expert Opinion on Drug Metabolism & Toxicology, 9(10), 1295–1308. https://doi.org/10.1517/17425255.2013.807798
Kashyap, D., Tuli, H. S., Sharma, A., Sak, K., Srivastava, S., Pandey, A., et al. (2019). Natural product-based nanoformulations for cancer therapy: Opportunities and challenges. Seminars in Cancer Biology, 14, 31421264. https://doi.org/10.1016/j.semcancer.2019.08.014
Khoshnoudi-Nia, S., Sharif, N., & Jafari, S. M. (2020). Loading of phenolic compounds into electrospun nanofibers and electrosprayed nanoparticles. Trends in Food Science & Technology, 95, 59–74. https://doi.org/10.1016/j.tifs.2019.11.013
Klausner, E. A., Eyal, S., Lavy, E., Friedman, M., & Hoffman, A. (2003a). Novel levodopa gastroretentive dosage form: In-vivo evaluation in dogs. Journal of Controlled Release, 88(1), 117–126. https://doi.org/10.1016/s0168-3659(02)00487-x
Klausner, E. A., Lavy, E., Friedman, M., & Hoffman, A. (2003b). Expandable gastroretentive dosage forms. Journal of Controlled Release, 90(2), 143–162. https://doi.org/10.1016/s0168-3659(03)00203-7
Knarreborg, A., Jensen, S. K., & Engberg, R. M. (2003). Pancreatic lipase activity as influenced by unconjugated bile acids and pH, measured in vitro and in vivo. The Journal of Nutritional Biochemistry, 14(5), 259–265. https://doi.org/10.1016/s0955-2863(03)00008-1
Kojima, M., & Nakagami, H. (2002). Development of controlled release matrix pellets by annealing with micronized water-insoluble or enteric polymers. Journal of Controlled Release, 82(2–3), 335–343. https://doi.org/10.1016/s0168-3659(02)00143-8
Kumari, A., Yadav, S. K., & Yadav, S. C. (2010). Biodegradable polymeric nanoparticles based drug delivery systems. Colloids and Surfaces. B, Biointerfaces, 75(1), 1–18. https://doi.org/10.1016/j.colsurfb.2009.09.001
Laffleur, F., & Michalek, M. (2017). Modified xanthan gum for buccal delivery-A promising approach in treating sialorrhea. International Journal of Biological Macromolecules, 102, 1250–1256. https://doi.org/10.1016/j.ijbiomac.2017.04.123
Lai, S. K., Wang, Y. Y., & Hanes, J. (2009). Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. Advanced Drug Delivery Reviews, 61(2), 158–171. https://doi.org/10.1016/j.addr.2008.11.002
Leal, J., Dong, T., Taylor, A., Siegrist, E., Gao, F., Smyth, H. D. C., et al. (2018). Mucus-penetrating phage-displayed peptides for improved transport across a mucus-like model. International Journal of Pharmaceutics, 553(1–2), 57–64. https://doi.org/10.1016/j.ijpharm.2018.09.055
Lee, H. J., Kim, S. E., Kwon, I. K., Park, C., Kim, C., Yang, J., et al. (2010). Spatially mineralized self-assembled polymeric nanocarriers with enhanced robustness and controlled drug-releasing property. Chemical Communications, 46(3), 377–379. https://doi.org/10.1039/B913732G
Li, J., Wang, Y., Yang, C., Wang, P., Oelschlager, D. K., Zheng, Y., et al. (2009a). Polyethylene glycosylated curcumin conjugate inhibits pancreatic cancer cell growth through inactivation of Jab1. Molecular Pharmacology, 76(1), 81–90. https://doi.org/10.1124/mol.109.054551
Li, H., Zhao, X., Ma, Y., Zhai, G., Li, L., & Lou, H. (2009b). Enhancement of gastrointestinal absorption of quercetin by solid lipid nanoparticles. Journal of Controlled Release, 133(3), 238–244. https://doi.org/10.1016/j.jconrel.2008.10.002
Li, Z., Wu, X., Li, J., Yao, L., Sun, L., Shi, Y., et al. (2012). Antitumor activity of celastrol nanoparticles in a xenograft retinoblastoma tumor model. International Journal of Nanomedicine, 7, 2389–2398. https://doi.org/10.2147/IJN.S29945
Li, C., Zhou, K., Chen, D., Xu, W., Tao, Y., Pan, Y., et al. (2019). Solid lipid nanoparticles with enteric coating for improving stability, palatability, and oral bioavailability of enrofloxacin. International Journal of Nanomedicine, 14, 1619–1631. https://doi.org/10.2147/IJN.S183479
Lin, T.-H., Hsu, W.-H., Tsai, P.-H., Huang, Y.-T., Lin, C.-W., Chen, K.-C., et al. (2017). Dietary flavonoids, luteolin and quercetin, inhibit invasion of cervical cancer by reduction of UBE2S through epithelial–mesenchymal transition signaling. tFood & Function, 8(4), 1558–1568. https://doi.org/10.1039/C6FO00551A
Liu, H., Tang, R., Pan, W. S., Zhang, Y., & Liu, H. (2003). Potential utility of various protease inhibitors for improving the intestinal absorption of insulin in rats. The Journal of Pharmacy and Pharmacology, 55(11), 1523–1529. https://doi.org/10.1211/0022357022052
Liu, F., Ye, M., Wang, C., Hu, Z., Zhang, Y., Qin, H., et al. (2013). Polyacrylamide gel with switchable trypsin activity for analysis of proteins. Analytical Chemistry, 85(15), 7024–7028. https://doi.org/10.1021/ac4017693
Liu, C., Ma, F., Wang, T., Wang, S., Chen, W., Xiao, J., et al. (2018). Preparation of defatted walnut meal hydrolysate-loaded enteric-coated pellets with enhanced oral absorption efficiency. Journal of Drug Delivery Science and Technology, 46, 207–214. https://doi.org/10.1016/j.jddst.2018.05.011
MacAdam, A. (1993). The effect of gastro-intestinal mucus on drug absorption. Advanced Drug Delivery Reviews, 11(3), 201–220. https://doi.org/10.1016/0169-409X(93)90010-2
Mahato, R. I., Narang, A. S., Thoma, L., & Miller, D. D. (2003). Emerging trends in oral delivery of peptide and protein drugs. Critical Reviews in Therapeutic Drug Carrier Systems, 20(2–3), 153–214. https://doi.org/10.1615/critrevtherdrugcarriersyst.v20.i23.30
Mahdavi, S. A., Jafari, S. M., Ghorbani, M., & Assadpoor, E. (2014). Spray-drying microencapsulation of anthocyanins by natural biopolymers: A review. Drying Technology, 32(5), 509–518. https://doi.org/10.1080/07373937.2013.839562
Majumdar, D., Jung, K. H., Zhang, H., Nannapaneni, S., Wang, X., Amin, A. R., et al. (2014). Luteolin nanoparticle in chemoprevention: In vitro and in vivo anticancer activity. Cancer Prevention Research (Philadelphia, Pa.), 7(1), 65–73. https://doi.org/10.1158/1940-6207.capr-13-0230
Mallery, S. R., Stoner, G. D., Larsen, P. E., Fields, H. W., Rodrigo, K. A., Schwartz, S. J., et al. (2007). Formulation and in-vitro and in-vivo evaluation of a mucoadhesive gel containing freeze dried black raspberries: Implications for oral cancer chemoprevention. Pharmaceutical Research, 24(4), 728–737. https://doi.org/10.1007/s11095-006-9192-1
Marcato, P. D., & Durán, N. (2008). New aspects of nanopharmaceutical delivery systems. lJournal of Nanoscience and Nanotechnology, 8(5), 2216–2229. https://doi.org/10.1166/jnn.2008.274
Minaei, A., Sabzichi, M., Ramezani, F., Hamishehkar, H., & Samadi, N. (2016). Co-delivery with nano-quercetin enhances doxorubicin-mediated cytotoxicity against MCF-7 cells. Molecular Biology Reports, 43(2), 99–105. https://doi.org/10.1007/s11033-016-3942-x
Moroz, E., Matoori, S., & Leroux, J.-C. (2016). Oral delivery of macromolecular drugs: Where we are after almost 100 years of attempts. Advanced Drug Delivery Reviews, 101, 108–121. https://doi.org/10.1016/j.addr.2016.01.010
Mukerjee, A., & Vishwanatha, J. K. (2009). Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy. Anticancer Research, 29(10), 3867–3875.
Mukherjee, P., Bhattacharya, R., Wang, P., Wang, L., Basu, S., Nagy, J. A., et al. (2005). Antiangiogenic properties of gold nanoparticles. Clinical Cancer Research, 11(9), 3530–3534. https://doi.org/10.1158/1078-0432.ccr-04-2482
Munin, A., & Edwards-Lévy, F. (2011). Encapsulation of natural polyphenolic compounds; a review. Pharmaceutics, 3(4), 793–829. https://doi.org/10.3390/pharmaceutics3040793
Nam, S., Lee, S. Y., Kang, W. S., & Cho, H. J. (2018). Development of resveratrol-loaded herbal extract-based nanocomposites and their application to the therapy of ovarian cancer. Nanomaterials, 8(6), 384. https://doi.org/10.3390/nano8060384
Narayanan, N. K., Nargi, D., Randolph, C., & Narayanan, B. A. (2009). Liposome encapsulation of curcumin and resveratrol in combination reduces prostate cancer incidence in PTEN knockout mice. International Journal of Cancer, 125(1), 1–8. https://doi.org/10.1002/ijc.24336
Nayak, A., Maji, R., & Das, B. (2010). Gastroretentive drug delivery systems: A review. Asian Journal of Pharmaceutical and Clinical Research, 3, 2–10.
Neo, Y. P., Ray, S., Jin, J., Gizdavic-Nikolaidis, M., Nieuwoudt, M. K., Liu, D., et al. (2013). Encapsulation of food grade antioxidant in natural biopolymer by electrospinning technique: A physicochemical study based on zein-gallic acid system. Food Chemistry, 136(2), 1013–1021. https://doi.org/10.1016/j.foodchem.2012.09.010
Ni, R., Zhao, J., Liu, Q., Liang, Z., Muenster, U., & Mao, S. (2017). Nanocrystals embedded in chitosan-based respirable swellable microparticles as dry powder for sustained pulmonary drug delivery. European Journal of Pharmaceutical Sciences, 99, 137–146. https://doi.org/10.1016/j.ejps.2016.12.013
Noh, K., Kang, Y. R., Nepal, M. R., Shakya, R., Kang, M. J., Kang, W., et al. (2017). Impact of gut microbiota on drug metabolism: An update for safe and effective use of drugs. Archives of Pharmacal Research, 40(12), 1345–1355. https://doi.org/10.1007/s12272-017-0986-y
Ochi, M. M., Amoabediny, G., Rezayat, S. M., Akbarzadeh, A., & Ebrahimi, B. (2016). In vitro co-delivery evaluation of novel pegylated nano-liposomal herbal drugs of silibinin and glycyrrhizic acid (nano-phytosome) to hepatocellular carcinoma cells. Cell Journal, 18(2), 135–148. https://doi.org/10.22074/cellj.2016.4308
Okuda, Y., Okamoto, Y., Irisawa, Y., Okimoto, K., Osawa, T., & Yamashita, S. (2014). Formulation design for orally disintegrating tablets containing enteric-coated particles. Chemical and Pharmaceutical Bulletin, 62(5), 407–414. https://doi.org/10.1248/cpb.c13-00752
Orive, G., Gascón, A. R., Hernández, R. M., Domínguez-Gil, A., & Pedraz, J. L. (2004). Techniques: New approaches to the delivery of biopharmaceuticals. Trends in Pharmacological Sciences, 25(7), 382–387. https://doi.org/10.1016/j.tips.2004.05.006
Park, J. B. (1983). Acrylic bone cement: In vitro and in vivo property-structure relationship—a selective review. Annals of Biomedical Engineering, 11(3–4), 297–312. https://doi.org/10.1007/bf02363289
Patel, S., Jani, P., & Manseta, P. (2011). Pharmaceutical approaches related to systemic delivery of protein and peptide drugs: An overview. International Journal of Pharmaceutical Sciences Review and Research, 12, 42–52.
Perona, J. S., & Botham, K. M. (2013). Olive oil as a functional food: Nutritional and health benefits. In R. Aparicio & J. Harwood (Eds.), Handbook of olive oil: Analysis and properties (pp. 677–714). Boston, MA: Springer.
Peters, S. A., Jones, C. R., Ungell, A. L., & Hatley, O. J. (2016). Predicting drug extraction in the human gut wall: Assessing contributions from drug metabolizing enzymes and transporter proteins using preclinical models. Clinical Pharmacokinetics, 55(6), 673–696. https://doi.org/10.1007/s40262-015-0351-6
Portero, A., Remuñán-López, C., Criado, M. T., & Alonso, M. J. (2002). Reacetylated chitosan microspheres for controlled delivery of anti-microbial agents to the gastric mucosa. lJournal of Microencapsulation, 19(6), 797–809. https://doi.org/10.1080/0265204021000022761
Rajendran, I., Dhandapani, H., Anantanarayanan, R., & Rajaram, R. (2015). Apigenin mediated gold nanoparticle synthesis and their anti-cancer effect on human epidermoid carcinoma (A431) cells. RSC Advances, 5(63), 51055–51066. https://doi.org/10.1039/C5RA04303D
Rao, G., Mandapalli, P., Manthri, R., & Veerareddy, P. (2013). Development and in vivo evaluation of gastroretentive delivery systems for cefuroxime axetil. Saudi Pharmaceutical Journal, 21, 53–59. https://doi.org/10.1016/j.jsps.2012.01.003
Richard, J. (2017). Challenges in oral peptide delivery: Lessons learnt from the clinic and future prospects. Therapeutic Delivery, 8(8), 663–684. https://doi.org/10.4155/tde-2017-0024
Roccia, P. (2014). Influence of spray-drying operating conditions on sunflower oil powder qualities. Powder Technology, 254, 7–313. https://doi.org/10.1016/j.powtec.2014.01.044
Roy, S., Pal, K., Anis, A., Pramanik, K., & Prabhakar, B. (2009). Polymers in mucoadhesive drug-delivery systems: A brief note. Designed Monomers and Polymers, 12(6), 483–495. https://doi.org/10.1163/138577209X12478283327236
Sanna, V., Chamcheu, J. C., Pala, N., Mukhtar, H., Sechi, M., & Siddiqui, I. A. (2015). Nanoencapsulation of natural triterpenoid celastrol for prostate cancer treatment. International Journal of Nanomedicine, 10, 6835–6846. https://doi.org/10.2147/ijn.s93752
Sha, X., Yan, G., Wu, Y., Li, J., & Fang, X. (2005). Effect of self-microemulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cells. European Journal of Pharmaceutical Sciences, 24(5), 477–486. https://doi.org/10.1016/j.ejps.2005.01.001
Sharma, R. A., Euden, S. A., Platton, S. L., Cooke, D. N., Shafayat, A., Hewitt, H. R., et al. (2004). Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance. Clinical Cancer Research, 10(20), 6847–6854. https://doi.org/10.1158/1078-0432.ccr-04-0744
Sharma, A., Kashyap, D., Sak, K., Tuli, H. S., & Sharma, A. K. (2018). Therapeutic charm of quercetin and its derivatives: A review of research and patents. Pharmaceutical Patent Analyst, 7(1), 15–32. https://doi.org/10.4155/ppa-2017-0030
Shi, Y., Sun, X., Zhang, L., Sun, K., Li, K., Li, Y., et al. (2018). Fc-modified exenatide-loaded nanoparticles for oral delivery to improve hypoglycemic effects in mice. Scientific Reports, 8(1), 726. https://doi.org/10.1038/s41598-018-19170-y
Singh, M. N., Hemant, K. S. Y., Ram, M., & Shivakumar, H. G. (2010). Microencapsulation: A promising technique for controlled drug delivery. Research in Pharmaceutical Sciences, 5(2), 65–77.
Smart, J. D., Kellaway, I. W., & Worthington, H. E. (1984). An in-vitro investigation of mucosa-adhesive materials for use in controlled drug delivery. The Journal of Pharmacy and Pharmacology, 36(5), 295–299. https://doi.org/10.1111/j.2042-7158.1984.tb04377.x
Sonaje, K., Chen, Y. J., Chen, H. L., Wey, S. P., Juang, J. H., Nguyen, H. N., et al. (2010). Enteric-coated capsules filled with freeze-dried chitosan/poly(gamma-glutamic acid) nanoparticles for oral insulin delivery. Biomaterials, 31(12), 3384–3394. https://doi.org/10.1016/j.biomaterials.2010.01.042
Sou, K., Oyajobi, B., Goins, B., Phillips, W. T., & Tsuchida, E. (2009). Characterization and cytotoxicity of self-organized assemblies of curcumin and amphiphatic poly(ethylene glycol). Journal of Biomedical Nanotechnology, 5(2), 202–208. https://doi.org/10.1166/jbn.2009.1025
Stone, R. C., Fellows, B. D., Qi, B., Trebatoski, D., Jenkins, B., Raval, Y., et al. (2015). Highly stable multi-anchored magnetic nanoparticles for optical imaging within biofilms. Journal of Colloid and Interface Science, 459, 175–182. https://doi.org/10.1016/j.jcis.2015.08.012
Sudhakar, Y., Kuotsu, K., & Bandyopadhyay, A. K. (2006). Buccal bioadhesive drug delivery—a promising option for orally less efficient drugs. Journal of Controlled Release, 114, 15–40. https://doi.org/10.1016/j.jconrel.2006.04.012
Suresh, D., & Srinivasan, K. (2010). Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats. The Indian Journal of Medical Research, 131, 682–691.
Survay, N. S., Upadhyaya, C. P., Kumar, B., Young, K. E., Yoon, D.-Y., & Park, S.-W. (2011). New genera of flavonols and flavonol derivatives as therapeutic molecules. Journal of Korean Society for Applied Biological Chemistry, 54(1), 1–18. https://doi.org/10.3839/jksabc.2011.001
Tahmasebi Mirgani, M., Isacchi, B., Sadeghizadeh, M., Marra, F., Bilia, A. R., Mowla, S. J., et al. (2014). Dendrosomal curcumin nanoformulation downregulates pluripotency genes via miR-145 activation in U87MG glioblastoma cells. International Journal of Nanomedicine, 9, 403–417. https://doi.org/10.2147/ijn.s48136
Takenaka, H., Kawashima, Y., & Lin, S. Y. (1980). Preparation of enteric-coated microcapsules for tableting by spray-drying technique and in vitro simulation of drug release from the tablet in GI tract. Journal of Pharmaceutical Sciences, 69(12), 1388–1392. https://doi.org/10.1002/jps.2600691209
Truong-Le, V., Lovalenti, P. M., & Abdul-Fattah, A. M. (2015). Stabilization challenges and formulation strategies associated with oral biologic drug delivery systems. Advanced Drug Delivery Reviews, 93, 95–108. https://doi.org/10.1016/j.addr.2015.08.001
Tsui, K. H., Chung, L. C., Feng, T. H., Chang, P. L., & Juang, H. H. (2012). Upregulation of prostate-derived Ets factor by luteolin causes inhibition of cell proliferation and cell invasion in prostate carcinoma cells. International Journal of Cancer, 130(12), 2812–2823. https://doi.org/10.1002/ijc.26284
Tummala, S., Satish Kumar, M. N., & Prakash, A. (2015). Formulation and characterization of 5-Fluorouracil enteric coated nanoparticles for sustained and localized release in treating colorectal cancer. Saudi Pharmaceutical Journal, 23(3), 308–314. https://doi.org/10.1016/j.jsps.2014.11.010
Ueno, Y., Ohmi, T., Yamamoto, M., Kato, N., Moriguchi, Y., Kojima, M., et al. (2007). Orally-administered caspase inhibitor PF-03491390 is retained in the liver for prolonged periods with low systemic exposure, exerting a hepatoprotective effect against alpha-fas-induced liver injury in a mouse model. Journal of Pharmacological Sciences, 105(2), 201–205. https://doi.org/10.1254/jphs.sc0070207
Varma, M. V., Ashokraj, Y., Dey, C. S., & Panchagnula, R. (2003). P-glycoprotein inhibitors and their screening: A perspective from bioavailability enhancement. Pharmacological Research, 48(4), 347–359. https://doi.org/10.1016/s1043-6618(03)00158-0
Verhoef, J. C., Boddé, H. E., de Boer, A. G., Bouwstra, J. A., Junginger, H. E., Merkus, F. W. H. M., et al. (1990). Transport of peptide and protein drugs across biological membranes. European Journal of Drug Metabolism and Pharmacokinetics, 15(2), 83–93. https://doi.org/10.1007/BF03190191
Ways, T. M. M., Lau, W. M., & Khutoryanskiy, V. V. (2018). Chitosan and its derivatives for application in mucoadhesive drug delivery systems. Polymers, 10(3), 267. https://doi.org/10.3390/polym10030267
Werle, M., & Hoffer, M. (2006). Glutathione and thiolated chitosan inhibit multidrug resistance P-glycoprotein activity in excised small intestine. Journal of Controlled Release, 111(1–2), 41–46. https://doi.org/10.1016/j.jconrel.2005.11.011
Wu, C., Wu, Y., Jin, Y., Zhu, P., Shi, W., Li, J., et al. (2019). Endosomal/lysosomal location of organically modified silica nanoparticles following caveolae-mediated endocytosis. RSC Advances, 9(24), 13855–13862. https://doi.org/10.1039/C9RA00404A
Yagi, T., Ishizaki, K., & Takebe, H. (1980). Cytotoxic effects of protease inhibitors on human cells. 2. Effect of elastatinal. Cancer Letters, 10(4), 301–307. https://doi.org/10.1016/0304-3835(80)90046-4
Yang, Q., Wang, S., Fan, P., Wang, L., Di, Y., Lin, K., et al. (2005). pH-responsive carrier system based on carboxylic acid modified mesoporous silica and polyelectrolyte for drug delivery. Chemistry of Materials, 17(24), 5999–6003. https://doi.org/10.1021/cm051198v
Zaman, M. S., Chauhan, N., Yallapu, M. M., Gara, R. K., Maher, D. M., Kumari, S., et al. (2016). Curcumin nanoformulation for cervical cancer treatment. Scientific Reports, 6, 20051. https://doi.org/10.1038/srep20051
Zhang, J., Zhang, J., & Wang, R. (2018). Gut microbiota modulates drug pharmacokinetics. Drug Metabolism Reviews, 50(3), 357–368. https://doi.org/10.1080/03602532.2018.1497647
Zhao, N., & Augsburger, L. L. (2005). The influence of swelling capacity of superdisintegrants in different pH media on the dissolution of hydrochlorothiazide from directly compressed tablets. AAPS PharmSciTech, 6(1), E120–E126. https://doi.org/10.1208/pt060119
Zhao, Q. S., Hu, L. L., Wang, Z. D., Li, Z. P., Wang, A. W., & Liu, J. (2017). Resveratrol-loaded folic acid-grafted dextran stearate submicron particles exhibits enhanced antitumor efficacy in non-small cell lung cancers. The Korean Journal of Counseling and Psychotherapy, 72, 185–191. https://doi.org/10.1016/j.msec.2016.10.077
Zhou, J., Zhou, M., Yang, F. F., Liu, C. Y., Pan, R. L., Chang, Q., et al. (2015). Involvement of the inhibition of intestinal glucuronidation in enhancing the oral bioavailability of resveratrol by labrasol containing nanoemulsions. Molecular Pharmaceutics, 12(4), 1084–1095. https://doi.org/10.1021/mp5005838
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Shinde, P., Badgujar, H.F., Kumar, U. (2021). Strategies to Improve Oral Delivery of Natural Anticancer Molecules. In: Singh, S. (eds) Emerging Trends in Nanomedicine. Springer, Singapore. https://doi.org/10.1007/978-981-15-9920-0_2
Download citation
DOI: https://doi.org/10.1007/978-981-15-9920-0_2
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-15-9919-4
Online ISBN: 978-981-15-9920-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)