Abstract
Nephrosclerosis is now a major cause of ESRD, along with diabetic kidney disease, in developed countries. Despite attracting more attention recently, nephrosclerosis remains poorly understood, especially with regard to its pathological features and their association with progression of CKD. This chapter provides a summary of our latest published data on nephrosclerosis dealing with its pathological aspects. Additionally, similarities and differences of pathological features between nephrosclerosis and diabetic kidney disease are discussed, comparing our biopsy-based cohorts of nephrosclerosis and diabetic nephropathy.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, Saran R, Wang AY, Yang CW. Chronic kidney disease: global dimension and perspectives. Lancet. 2013;382(9888):260–72. https://doi.org/10.1016/S0140-6736(13)60687-X. Erratum in: Lancet. 2013;382(9888):208.
United States Renal Data System. 2016 USRDS annual data report: epidemiology of kidney disease in the United States. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2016.
ERA-EDTA Registry. ERA-EDTA Registry annual report 2015. Amsterdam: Academic Medical Center, Department of Medical Informatics; 2017.
Japanese Society for Dialysis Therapy Renal Data Registry. Annual report 2014, JSDT Renal Data Registry (JRDR). Ren Replace Ther 2014;3:18. https://doi.org/10.1186/s41100-017-0097-8.
Takebayashi S, Kiyoshi Y, Hisano S, Uesugi N, Sasatomi Y, Meng J, Sakata N. Benign nephrosclerosis: incidence, morphology and prognosis. Clin Nephrol. 2001;55(5):349–56.
Liang S, Le W, Liang D, Chen H, Xu F, Chen H, Liu Z, Zeng C. Clinico-pathological characteristics and outcomes of patients with biopsy-proven hypertensive nephrosclerosis: a retrospective cohort study. BMC Nephrol. 2016;17:42. https://doi.org/10.1186/s12882-016-0254-2.
Haruhara K, Tsuboi N, Kanzaki G, Koike K, Suyama M, Shimizu A, Miyazaki Y, Kawamura T, Ogura M, Yokoo T. Glomerular density in biopsy-proven hypertensive nephrosclerosis. Am J Hypertens. 2015;28(9):1164–71. https://doi.org/10.1093/ajh/hpu267.
Olson JL. Renal disease caused by hypertension. In: Jenette JC, Olson JL, Schwartz MM, Silva FG, editors. Heptinstall’s pathology of the kidney. 7th ed. Philadelphia: Wolters Kluwer; 2015. p. 849–96.
Morduchowicz G, Boner G, Ben-Bassat M, Rosenfeld JB. Proteinuria in benign nephrosclerosis. Arch Intern Med. 1986;146(8):1513–6.
Narvarte J, Privé M, Saba SR, Ramirez G. Proteinuria in hypertension. Am J Kidney Dis. 1987;10(6):408–16.
Toto RD. Proteinuria and hypertensive nephrosclerosis in African Americans. Kidney Int Suppl. 2004;92:S102–4.
Dasgupta I, Porter C, Innes A, Burden R. “Benign” hypertensive nephrosclerosis. QJM. 2007;100(2):113–9.
Vikse BE, Aasarød K, Bostad L, Iversen BM. Clinical prognostic factors in biopsy-proven benign nephrosclerosis. Nephrol Dial Transplant. 2003;18(3):517–23.
Sumida K, Hoshino J, Ueno T, Mise K, Hayami N, Suwabe T, Kawada M, Imafuku A, Hiramatsu R, Hasegawa E, Yamanouchi M, Sawa N, Fujii T, Ohashi K, Takaichi K, Ubara Y. Effect of proteinuria and glomerular filtration rate on renal outcome in patients with biopsy-proven benign nephrosclerosis. PLoS One. 2016;11(1):e0147690. https://doi.org/10.1371/journal.pone.0147690.
Momoki K, Kataoka H, Moriyama T, Mochizuki T, Nitta K. Hyperuricemia as a predictive marker for progression of nephrosclerosis: clinical assessment of prognostic factors in biopsy-proven arterial/arteriolar nephrosclerosis. J Atheroscler Thromb. 2017;24(6):630–42. https://doi.org/10.5551/jat.37523.
Furuichi K, Shimizu M, Yuzawa Y, Hara A, Toyama T, Kitamura H, Suzuki Y, Sato H, Uesugi N, Ubara Y, Hoshino J, Hisano S, Ueda Y, Nishi S, Yokoyama H, Nishino T, Kohagura K, Ogawa D, Mise K, Shibagaki Y, Kimura K, Haneda M, Makino H, Matsuo S, Wada T, Research Group of Diabetic Nephropathy and Nephrosclerosis, Ministry of Health, Labour and Welfare of Japan, and Japan Agency for Medical Research and Development. Nationwide multicenter kidney biopsy study of Japanese patients with hypertensive nephrosclerosis. Clin Exp Nephrol. 2017;22(3):629–37. https://doi.org/10.1007/s10157-017-1496-4.
Levin A, Stevens PE. Summary of KDIGO 2012 CKD Guideline: behind the scenes, need for guidance, and a framework for moving forward. Kidney Int. 2014;85(1):49–61. https://doi.org/10.1038/ki.2013.444.
Glassock RJ, Rule AD. The implications of anatomical and functional changes of the aging kidney: with an emphasis on the glomeruli. Kidney Int. 2012;82(3):270–7. https://doi.org/10.1038/ki.2012.65.
O’Sullivan ED, Hughes J, Ferenbach DA. Renal aging: causes and consequences. J Am Soc Nephrol. 2017;28(2):407–20. https://doi.org/10.1681/ASN.2015121308.
Hommos MS, Glassock RJ, Rule AD. Structural and functional changes in human kidneys with healthy aging. J Am Soc Nephrol. 2017;28(10):2838–44. https://doi.org/10.1681/ASN.2017040421.
Olson JL, Laszik ZG. Diabetic nephropathy. In: Jenette JC, Olson JL, Schwartz MM, Silva FG, editors. Heptinstall’s pathology of the kidney. 7th ed. Philadelphia: Wolters Kluwer; 2015. p. 897–949.
Tervaert TW, Mooyaart AL, Amann K, Cohen AH, Cook HT, Drachenberg CB, Ferrario F, Fogo AB, Haas M, de Heer E, Joh K, Noël LH, Radhakrishnan J, Seshan SV, Bajema IM, Bruijn JA. Renal pathology society. Pathologic classification of diabetic nephropathy. J Am Soc Nephrol. 2010;21(4):556–63. https://doi.org/10.1681/ASN.2010010010.
Furuichi K, Yuzawa Y, Shimizu M, Hara A, Toyama T, Kitamura H, Suzuki Y, Sato H, Uesugi N, Ubara Y, Hisano S, Ueda Y, Nishi S, Yokoyama H, Nishino T, Kohagura K, Ogawa D, Mise K, Shibagaki Y, Kimura K, Haneda M, Makino H, Matsuo S, Wada T. Nationwide multicentre kidney biopsy study of Japanese patients with type 2 diabetes. Nephrol Dial Transplant. 2017;33(1) https://doi.org/10.1093/ndt/gfw417.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Yamanouchi, M., Furuichi, K., Wada, T. (2021). Nephrosclerosis and Diabetic Kidney Disease. In: Wada, T., Furuichi, K., Kashihara, N. (eds) Diabetic Kidney Disease. Springer, Singapore. https://doi.org/10.1007/978-981-15-9301-7_11
Download citation
DOI: https://doi.org/10.1007/978-981-15-9301-7_11
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-15-9300-0
Online ISBN: 978-981-15-9301-7
eBook Packages: MedicineMedicine (R0)