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Nephrosclerosis and Diabetic Kidney Disease

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Diabetic Kidney Disease

Abstract

Nephrosclerosis is now a major cause of ESRD, along with diabetic kidney disease, in developed countries. Despite attracting more attention recently, nephrosclerosis remains poorly understood, especially with regard to its pathological features and their association with progression of CKD. This chapter provides a summary of our latest published data on nephrosclerosis dealing with its pathological aspects. Additionally, similarities and differences of pathological features between nephrosclerosis and diabetic kidney disease are discussed, comparing our biopsy-based cohorts of nephrosclerosis and diabetic nephropathy.

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References

  1. Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, Saran R, Wang AY, Yang CW. Chronic kidney disease: global dimension and perspectives. Lancet. 2013;382(9888):260–72. https://doi.org/10.1016/S0140-6736(13)60687-X. Erratum in: Lancet. 2013;382(9888):208.

  2. United States Renal Data System. 2016 USRDS annual data report: epidemiology of kidney disease in the United States. Bethesda, MD: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2016.

    Google Scholar 

  3. ERA-EDTA Registry. ERA-EDTA Registry annual report 2015. Amsterdam: Academic Medical Center, Department of Medical Informatics; 2017.

    Google Scholar 

  4. Japanese Society for Dialysis Therapy Renal Data Registry. Annual report 2014, JSDT Renal Data Registry (JRDR). Ren Replace Ther 2014;3:18. https://doi.org/10.1186/s41100-017-0097-8.

  5. Takebayashi S, Kiyoshi Y, Hisano S, Uesugi N, Sasatomi Y, Meng J, Sakata N. Benign nephrosclerosis: incidence, morphology and prognosis. Clin Nephrol. 2001;55(5):349–56.

    CAS  PubMed  Google Scholar 

  6. Liang S, Le W, Liang D, Chen H, Xu F, Chen H, Liu Z, Zeng C. Clinico-pathological characteristics and outcomes of patients with biopsy-proven hypertensive nephrosclerosis: a retrospective cohort study. BMC Nephrol. 2016;17:42. https://doi.org/10.1186/s12882-016-0254-2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Haruhara K, Tsuboi N, Kanzaki G, Koike K, Suyama M, Shimizu A, Miyazaki Y, Kawamura T, Ogura M, Yokoo T. Glomerular density in biopsy-proven hypertensive nephrosclerosis. Am J Hypertens. 2015;28(9):1164–71. https://doi.org/10.1093/ajh/hpu267.

    Article  CAS  PubMed  Google Scholar 

  8. Olson JL. Renal disease caused by hypertension. In: Jenette JC, Olson JL, Schwartz MM, Silva FG, editors. Heptinstall’s pathology of the kidney. 7th ed. Philadelphia: Wolters Kluwer; 2015. p. 849–96.

    Google Scholar 

  9. Morduchowicz G, Boner G, Ben-Bassat M, Rosenfeld JB. Proteinuria in benign nephrosclerosis. Arch Intern Med. 1986;146(8):1513–6.

    Article  CAS  Google Scholar 

  10. Narvarte J, Privé M, Saba SR, Ramirez G. Proteinuria in hypertension. Am J Kidney Dis. 1987;10(6):408–16.

    Article  CAS  Google Scholar 

  11. Toto RD. Proteinuria and hypertensive nephrosclerosis in African Americans. Kidney Int Suppl. 2004;92:S102–4.

    Article  CAS  Google Scholar 

  12. Dasgupta I, Porter C, Innes A, Burden R. “Benign” hypertensive nephrosclerosis. QJM. 2007;100(2):113–9.

    Article  CAS  Google Scholar 

  13. Vikse BE, Aasarød K, Bostad L, Iversen BM. Clinical prognostic factors in biopsy-proven benign nephrosclerosis. Nephrol Dial Transplant. 2003;18(3):517–23.

    Article  CAS  Google Scholar 

  14. Sumida K, Hoshino J, Ueno T, Mise K, Hayami N, Suwabe T, Kawada M, Imafuku A, Hiramatsu R, Hasegawa E, Yamanouchi M, Sawa N, Fujii T, Ohashi K, Takaichi K, Ubara Y. Effect of proteinuria and glomerular filtration rate on renal outcome in patients with biopsy-proven benign nephrosclerosis. PLoS One. 2016;11(1):e0147690. https://doi.org/10.1371/journal.pone.0147690.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Momoki K, Kataoka H, Moriyama T, Mochizuki T, Nitta K. Hyperuricemia as a predictive marker for progression of nephrosclerosis: clinical assessment of prognostic factors in biopsy-proven arterial/arteriolar nephrosclerosis. J Atheroscler Thromb. 2017;24(6):630–42. https://doi.org/10.5551/jat.37523.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Furuichi K, Shimizu M, Yuzawa Y, Hara A, Toyama T, Kitamura H, Suzuki Y, Sato H, Uesugi N, Ubara Y, Hoshino J, Hisano S, Ueda Y, Nishi S, Yokoyama H, Nishino T, Kohagura K, Ogawa D, Mise K, Shibagaki Y, Kimura K, Haneda M, Makino H, Matsuo S, Wada T, Research Group of Diabetic Nephropathy and Nephrosclerosis, Ministry of Health, Labour and Welfare of Japan, and Japan Agency for Medical Research and Development. Nationwide multicenter kidney biopsy study of Japanese patients with hypertensive nephrosclerosis. Clin Exp Nephrol. 2017;22(3):629–37. https://doi.org/10.1007/s10157-017-1496-4.

    Article  PubMed  Google Scholar 

  17. Levin A, Stevens PE. Summary of KDIGO 2012 CKD Guideline: behind the scenes, need for guidance, and a framework for moving forward. Kidney Int. 2014;85(1):49–61. https://doi.org/10.1038/ki.2013.444.

    Article  PubMed  Google Scholar 

  18. Glassock RJ, Rule AD. The implications of anatomical and functional changes of the aging kidney: with an emphasis on the glomeruli. Kidney Int. 2012;82(3):270–7. https://doi.org/10.1038/ki.2012.65.

    Article  PubMed  PubMed Central  Google Scholar 

  19. O’Sullivan ED, Hughes J, Ferenbach DA. Renal aging: causes and consequences. J Am Soc Nephrol. 2017;28(2):407–20. https://doi.org/10.1681/ASN.2015121308.

    Article  PubMed  Google Scholar 

  20. Hommos MS, Glassock RJ, Rule AD. Structural and functional changes in human kidneys with healthy aging. J Am Soc Nephrol. 2017;28(10):2838–44. https://doi.org/10.1681/ASN.2017040421.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Olson JL, Laszik ZG. Diabetic nephropathy. In: Jenette JC, Olson JL, Schwartz MM, Silva FG, editors. Heptinstall’s pathology of the kidney. 7th ed. Philadelphia: Wolters Kluwer; 2015. p. 897–949.

    Google Scholar 

  22. Tervaert TW, Mooyaart AL, Amann K, Cohen AH, Cook HT, Drachenberg CB, Ferrario F, Fogo AB, Haas M, de Heer E, Joh K, Noël LH, Radhakrishnan J, Seshan SV, Bajema IM, Bruijn JA. Renal pathology society. Pathologic classification of diabetic nephropathy. J Am Soc Nephrol. 2010;21(4):556–63. https://doi.org/10.1681/ASN.2010010010.

    Article  PubMed  Google Scholar 

  23. Furuichi K, Yuzawa Y, Shimizu M, Hara A, Toyama T, Kitamura H, Suzuki Y, Sato H, Uesugi N, Ubara Y, Hisano S, Ueda Y, Nishi S, Yokoyama H, Nishino T, Kohagura K, Ogawa D, Mise K, Shibagaki Y, Kimura K, Haneda M, Makino H, Matsuo S, Wada T. Nationwide multicentre kidney biopsy study of Japanese patients with type 2 diabetes. Nephrol Dial Transplant. 2017;33(1) https://doi.org/10.1093/ndt/gfw417.

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Correspondence to Masayuki Yamanouchi .

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Yamanouchi, M., Furuichi, K., Wada, T. (2021). Nephrosclerosis and Diabetic Kidney Disease. In: Wada, T., Furuichi, K., Kashihara, N. (eds) Diabetic Kidney Disease. Springer, Singapore. https://doi.org/10.1007/978-981-15-9301-7_11

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  • DOI: https://doi.org/10.1007/978-981-15-9301-7_11

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