Abstract
Diabetes mellitus (DM) is a metabolic disorder with a rising prevalence globally. Currently about 400 million people are affected. In 2016, it was the seventh leading cause of death worldwide. Diabetes mellitus is prevalent in most countries. Its major feature is the high level of blood glucose which can be caused by insulin resistance or reduced insulin production. As the disease progresses, complications like diabetic neuropathy, nephropathy, and retinopathy occur. The use of herbs and natural products in the management of diabetes mellitus dates to the prehistoric era. Eighteen studies from about nine countries showed that between 18% and 72% use traditional and complementary medicine in the management of diabetes. In developing countries where the disease is highly prevalent natural products are very common because of ready availability, cheapness, and minimal side effects. This review highlights alkaloids, one of the most important secondary metabolites isolated from plants which have been studied to have anti-diabetes effects. Alkaloids are a group of highly diverse natural products that contain one or more basic nitrogen atoms in a heterocyclic ring. The various plants that contain them, their pharmacological actions studied thus far, mechanism of action will be extensively discussed. The aim of this review is to provide rich knowledge on research carried out thus far on plant alkaloids in the management of diabetes: their pharmacology, chemistry, and effectiveness which will serve as a platform for further research and development of novel drug molecules that can further help in the management of this disease.
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References
Aniszewski T (2015) Introduction. In: Alkaloids. Elsevier, Amsterdam, pp 1–20
Verpoorte R (2000) Alkaloids | liquid chromatography. In: Poole C, Cooke M (eds) Encyclopedia of separation science. Academic Press, Cambridge, MA, pp 1949–1956
Fan W (2017) Epidemiology in diabetes mellitus and cardiovascular disease. Cardiovasc Endocrinol 6:8–16
Mendez CE, Umpierrez GE (2014) Pharmacotherapy for hyperglycemia in noncritically ill hospitalized patients. Diabetes Spectr 27:180–188. https://doi.org/10.2337/diaspect.27.3.180
Asadi-Samani M, Kooti W, Farokhipour M et al (2016) The role of medicinal plants in the treatment of diabetes: a systematic review. Electron Physician 8(1):1832–1842. https://doi.org/10.19082/1832
Fernando IPS, Ryu BM, Ahn G et al (2020) Therapeutic potential of algal natural products against metabolic syndrome: a review of recent developments. Trends Food Sci Technol 97:286–299
Dowarah J, Singh VP (2020) Anti-diabetic drugs recent approaches and advancements. Bioorganic Med Chem 28:115263
Debnath B, Singh S, Das M et al (2018) Role of plant alkaloids on human health: a review of biological activities. Mater Today 9:56–72. https://doi.org/10.1016/j.mtchem.2018.05.001
Tiong SH, Looi CY, Hazni H et al (2013) Antidiabetic and antioxidant properties of alkaloids from Catharanthus roseus (L.) G. Don. Molecules 18:9770–9784. https://doi.org/10.3390/molecules18089770
Ullah Jan N, Ali A, Ahmad B et al (2018) Evaluation of antidiabetic potential of steroidal alkaloid of Sarcococca saligna. Biomed Pharmacother 100:461–466. https://doi.org/10.1016/j.biopha.2018.01.008
Sah SP, Sah ML, Juyal V, Pandey S (2010) Hypoglycemic activity of aqueous extract of Urtica parviflora roxb. in normoglycemic rats. Int J Phytomed 2:47–51
Uzor PF, Osadebe PO (2016) Antidiabetic activity of the chemical constituents of Combretum dolichopetalum root in mice. EXCLI J 15:290–296. https://doi.org/10.17179/excli2016-252
Li CJ, Chen PN, Li HJ et al (2020) Potential antidiabetic fumiquinazoline alkaloids from the marine-derived fungus scedosporium apiospermum F41-1. J Nat Prod 83(4):1082–1091. https://doi.org/10.1021/acs.jnatprod.9b01096
Tabussum A, Riaz N, Saleem M et al (2013) α-Glucosidase inhibitory constituents from Chrozophora plicata. Phytochem Lett 6:614–619. https://doi.org/10.1016/j.phytol.2013.08.005
Yang H, Liu DQ, Liang TJ et al (2014) Racemosin C, a novel minor bisindole alkaloid with protein tyrosine phosphatase-1B inhibitory activity from the green alga Caulerpa racemosa. J Asian Nat Prod Res 16:1158–1165. https://doi.org/10.1080/10286020.2014.965162
Dong H, Wang N, Zhao L, Lu F (2012) Berberine in the treatment of type 2 Diabetes mellitus: a systemic review and meta-analysis. Evid Based Complement Alternat Med 2012:591654. https://doi.org/10.1155/2012/591654
Paul M, Hemshekhar M, Kemparaju K, Girish KS (2019) Berberine mitigates high glucose-potentiated platelet aggregation and apoptosis by modulating aldose reductase and NADPH oxidase activity. Free Radic Biol Med 130:196–205. https://doi.org/10.1016/j.freeradbiomed.2018.10.453
Liu L, Du X, Zhang Z, Zhou J (2018) Trigonelline inhibits caspase 3 to protect β cells apoptosis in streptozotocin-induced type 1 diabetic mice. Eur J Pharmacol 836:115–121. https://doi.org/10.1016/j.ejphar.2018.08.025
Costantino L, Laura R, Renato P, Tiziana B, Pompeo P, Fabio G (2003) Isolation and pharmacological activities of the Tecoma stans alkaloids. Il Farmaco 9:781–785
Luo J, Fort DM, Carlson TJ, Noamesi BK, Nii-Amon-Kotei D, King SR, Tsai J, Quan J, Hobensack C, Lapresca P, Waldeck N, Mendez CD, Jolad SD, Bierer DE, Reaven GM (1998) Cryptolepis sanguinolenta: an ethnobotanical approach to drug discovery and the isolation of a potentially useful new antihyperglycaemic agent. Diabet Med 15(5):367–374
Nadkarni KM (1992) Dr. K. M. Nadkarni’s Indian materia medica, with Ayurvedic, Unani-Tibbi, Siddha, Allopathic, Homeopathic, Naturopathic & home remedies, appendices & indexes. In: Nadkarni KM (ed) The Indian plants and drugs. Indian materia medica, vol 2. Popular Prakashan, Bombay
Cooper EJ, Hudson AL, Parker CA, Morgan NG (2003) Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans. Eur J Pharmacol 482:189–196
Nandkarni AK (1992) Indian Materia Medica, vol 1. Popular Prakashan, Bombay
Ayyanar M, Subash-Babu P (2012) Syzygium cumini (L.) Skeels: a review of its phytochemical constituents and traditional uses. Asian Pac J Trop Biomed 2(3):240–246. https://doi.org/10.1016/S2221-1691(12)60050-1
Shukla AK, Bigoniya P, Srivastava B (2012) Hypoglycemic activity of Lepidium sativum Linn seed total alkaloid on alloxan induced diabetic rats. Res J Med Plant 6(8):587–596
Wiedemann M, Gurrola-DÃaz CM, Vargas-Guerrero B, Wink M, GarcÃa-López PM, Lupanine MD (2015) Improves glucose homeostasis by influencing KATP channels and insulin gene expression. Molecules 20(10):19085–19100. https://doi.org/10.3390/molecules201019085
Shibano M, Tsukamoto D, Masuda A, Tanaka Y, Kusano G (2001) Two new pyrrolidine alkaloids, radicamines A and B, as inhibitors of alpha-glucosidase from Lobelia chinensis Lour. Chem Pharm Bull 49(10):1362
Tabopda TK, Ngoupayo J, Liu J, Mitaine-Offer AC, Tanoli SA, Khan SN, Ali MS, Ngadjui BT, Tsamo E, Lacaille-Dubois MA, Luu B (2008) Bioactive aristolactams from Piper umbellatum. Phytochemistry 69(8):1726–1731
Gao H, Huang YN, Gao B, Li P, Inagaki C, Kawabata J (2008) Inhibitory effect on α-glucosidase by Adhatoda vasica Nees. Food Chem 108(3):965–972
Brahmachari G (2012) Bioactive natural products: opportunities and challenges in medicinal chemistry. World Scientific Publishing, Singapore
Oku T, Yamada M, Nakamura M, Sadamori N, Nakamura S (2006) Inhibitory effects of extractives from leaves of Morus alba on human and rat small intestinal disaccharidase activity. Br J Nutr 95:933–938
Asano N, Yamashita T, Yasuda K, Ikeda K, Kizu H, Kameda Y, kato A, Nash R-J, Lee HS, Ryu KS (2001) Polyhydroxylated alkaloids isolated from mulberry trees (Morusalba L.) and silkworms (Bombyx mori L.). J Agric Food Chem 49:4208–4213
Patel MB, Mishra S (2011) Hypoglycemic activity of alkaloidal fraction of Tinospora cordifolia. Phytomedicine 18(12):1045–1052
Shimoda H, Nishida N, Ninomiya K, Matsuda H, Yoshikawa M (2001) Javaberine A, new TNF-alpha and nitric oxide production inhibitor, from the roots of Talinum paniculatum. Heterocycles 55(11):2043–2050
Catthareeya T, Papirom P, Chanlun S, Kupittayanant S (2013) Talinum paniculatum (jacq.) GERTN: a medicinal plant with potential estrogenic activity in ovariectomized rats. Int J Pharm Pharm Sci 5(2):478–485
Lee H-S (2002) Rat lens aldose reductase inhibitory activities of Coptis japonica root-derived isoquinoline alkaloids. J Agric Food Chem 50:7013–7016
Takada K, Uehara T, Nakao Y, Matsunaga S, van Soest WM, Fusetani N (2004) Schulzeines A-C, new alpha-glucosidase inhibitors from the marine sponge Penares schulzei. J Am Chem Soc 126:187–193
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Aloko, S., Bello, M.O. (2021). The Role of Alkaloids in the Management of Diabetes Mellitus. In: Chen, H., Zhang, M. (eds) Structure and Health Effects of Natural Products on Diabetes Mellitus. Springer, Singapore. https://doi.org/10.1007/978-981-15-8791-7_15
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