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Total Synthesis of Dictyodendrins by the Gold-Catalyzed Cascade Cyclization of Conjugated Diynes with Pyrroles

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Total Synthesis of Indole Alkaloids

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Abstract

Total synthesis of dictyodendrins A–E was achieved on the basis of a novel gold-catalyzed cascade reaction for the construction of pyrrolo[2,3-c]carbazole scaffold. The synthetic strategy features functionalization of pyrrole pyrrolo[2,3-c]carbazole scaffold at the C1 (arylation), C2 (acylation), N3 (alkylation), and C5 (oxidation) positions. This synthetic method could be used for the diversity-oriented synthesis of dictyodendrin derivatives for medicinal applications.

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Authors and Affiliations

  1. Faculty of Pharmaceutical Sciences, Doshisha Women’s College of Liberal Arts, Kyotanabe, Japan

    Dr. Junpei Matsuoka

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  1. Dr. Junpei Matsuoka
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Correspondence to Junpei Matsuoka .

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Matsuoka, J. (2020). Total Synthesis of Dictyodendrins by the Gold-Catalyzed Cascade Cyclization of Conjugated Diynes with Pyrroles. In: Total Synthesis of Indole Alkaloids. Springer Theses. Springer, Singapore. https://doi.org/10.1007/978-981-15-8652-1_2

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