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Summa of Erasers of Histone Acetylation with Special Emphasis on Classical Histone Deacetylases (HDACs)

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Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy

Abstract

The human genome in order to get accommodated within the constrained nuclear space requires remarkably high level of condensation (Tseng and Yang 2013). This condensation results in the formation of chromatin, a supremely organized nucleoprotein structure (Olins and Olins 1974). Nucleosome forms the fundamental unit of this structural polymer (chromatin). Each nucleosome has a nucleosome core formed from an octameric complex made of polycationic core histones around which 145–147 bp of DNA are wrapped (Davey et al. 2002; Korolev et al. 2018; Luger et al. 1997; McGinty and Tan 2015). Adjacent nucleosome cores of two nucleosomes are connected by linker DNA which is frequently in contact with linker histone H1 (or H5 in birds) (Andreeva et al. 1978; Simpson 1978). Apart from the significant role in genomic compaction, nucleosomes serve as signalling focal points for chromatin-templated processes (McGinty and Tan 2015).

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  1. Division of Basic Sciences and Humanities, Faculty of Agriculture, Wadura Sopore, SKUAST-Kashmir, India

    Shabir Ahmad Ganai

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Ganai, S.A. (2020). Summa of Erasers of Histone Acetylation with Special Emphasis on Classical Histone Deacetylases (HDACs). In: Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy. Springer, Singapore. https://doi.org/10.1007/978-981-15-8179-3_3

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