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A Wonder Plant Withania: Pharmacological and Chemical Perspectives

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Evidence Based Validation of Traditional Medicines

Abstract

Plants belonging to Withania genus are well-known medicinal plants and are commonly used as herbal medicine in the Ayurvedic health system. These plants belong to the family Solanaceae and comprise of 23 known species distributed in North Africa, the Middle East, Asia, the Mediterranean, and the Canary Islands. However, only six species, namely, Withania somnifera (L.) Dunal, Withania coagulans (Stocks) Dunal, Withania adpressa Coss, Withania aristata (Aiton) Pauquy, Withania frutescens (L.) Pauquy, and Withania obtusifolia Täckh, are extensively investigated with regard to their pharmacological properties and bioactive constituents. Therefore, in this chapter, the traditional uses of the six Withania species and the pharmacological validations of the plants and plant-derived constituents are discussed. Applications of the bioactive constituents in drug discovery are explained by discussing the semisynthetic modifications and structure-activity relationships.

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Authors and Affiliations

  1. Department of Plant and Soil Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, South Africa

    Surjeet Verma & Namrita Lall

  2. School of Natural Resources, College of Agriculture, Food and Natural Resources, University of Missouri, Columbia, MO, USA

    Namrita Lall

  3. College of Pharmacy, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India

    Namrita Lall

  4. Department of Biochemistry, Office of the Executive Dean, Faculty of Science, University of Johannesburg, Johannesburg, South Africa

    Debra Meyer

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  1. Surjeet Verma
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  2. Namrita Lall
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Correspondence to Namrita Lall .

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Editors and Affiliations

  1. Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India

    Subhash C. Mandal

  2. NEF College of Pharmacy, Guwahati, Assam, India

    Raja Chakraborty

  3. Faculty of Pharmaceutical Science, Assam down town University, Guwahati, Assam, India

    Saikat Sen

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Verma, S., Lall, N., Meyer, D. (2021). A Wonder Plant Withania: Pharmacological and Chemical Perspectives. In: Mandal, S.C., Chakraborty, R., Sen, S. (eds) Evidence Based Validation of Traditional Medicines. Springer, Singapore. https://doi.org/10.1007/978-981-15-8127-4_41

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