Prospects of Cell Immobilization in Cancer Research and Immunotherapy

Komeri, Remya; Syama, H. P.; Preethi, G. U.; Unnikrishnan, B. S.; Shiji, R.; Archana, M. G.; Mohan, Deepa; Tripathi, Anuj; Sreelekha, T. T.

doi:10.1007/978-981-15-7998-1_4

Remya Komeri⁴,
H. P. Syama⁴,
G. U. Preethi⁴,
B. S. Unnikrishnan⁴,
R. Shiji⁴,
M. G. Archana⁴,
Deepa Mohan⁴,
Anuj Tripathi^5,6 &
…
T. T. Sreelekha⁴

Part of the book series: Gels Horizons: From Science to Smart Materials ((GHFSSM))

638 Accesses

Abstract

Cell immobilization is upgraded from a status of fundamental technique to an advanced approach for therapeutic applications. Thinking beyond the conventional surgical, radiation and chemotherapy for cancer management, the advent of immunotherapy via transplanting tumor antigens or engineered cancer cells has a promising role. Highlighting the significance of transplanting cellular vaccines and genetically engineered cells, creating a dynamic barrier through immobilization technique appreciates the physical isolation of cells from the systemic factors, continuous delivery of therapeutic molecules and formation of a local immune stimulatory environment. Transplantation of potential stem cells encapsulated in suitable matrices is also explored for cancer therapy. Irrespective of the therapeutic applications, cell immobilization approaches have prospects in generating reconstructive tumor models for cancer drug screening. In this chapter, the methods of cell immobilization, potential matrices for cell encapsulation, relevance in advanced cancer immunotherapy, and applications in reconstructive tumor models are discussed.

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Abbreviations

Ca:: Calcium
PVA:: Polyvinyl alcohol
IgG:: Immunoglobulin G
PSS:: Polystyrene sulfonic acid
PEI:: Polyethylene imine
PEG:: Polyethylene glycol
PVA:: Polyvinyl alcohol
PLGA:: Polylactic-co-glycolic acid
DNA:: Deoxyribonucleic acid
mAbs:: Monoclonal antibodies
FDA:: Food and drug administration
PD-1:: Programmed death 1
PDL-1:: Programmed death ligand 1
CTLA:: Cytotoxic t‑lymphocyte antigen
HBV:: Hepatitis B virus
HPV:: Human papillomavirus
RNA:: Ribonucleic acid
APC:: Atigen-presenting cells
DC:: Dendritic cell
GM-CSF:: Granulocyte-macrophage colony-stimulating factor
IL-2:: Interleukin 2
PAP:: Prostatic acid phosphates
MART-1:: Melanoma associated antigen recognized by T cells
EVA:: Ethyl vinyl acetate
MIP:: Macrophage inflammatory protein
CD:: Cluster of differentiation
HER:: Human epidermal growth factor receptor
MSR:: Mesoporous silica rods
OVA:: Ovalbumin
ECM:: Extracellular matrix
TME:: Tumor microenvironment
CNC:: Cellulose nanocrystals

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Acknowledgements

Authors would like to acknowledge Board of Research in Nuclear Sciences, Department of Atomic Energy, Government of India for the financial support.

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Authors and Affiliations

Laboratory of Biopharmaceuticals and Nanomedicine, Division of Cancer Research, Regional Cancer Centre (Research Centre, University of Kerala), Thiruvananthapuram, Kerala, India
Remya Komeri, H. P. Syama, G. U. Preethi, B. S. Unnikrishnan, R. Shiji, M. G. Archana, Deepa Mohan & T. T. Sreelekha
Nuclear Agriculture and Biotechnology Division, Bhabha Atomic Research Centre, Mumbai, India
Anuj Tripathi
Homi Bhabha National Institute, Mumbai, India
Anuj Tripathi

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Remya Komeri
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H. P. Syama
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G. U. Preethi
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B. S. Unnikrishnan
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R. Shiji
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M. G. Archana
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Deepa Mohan
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Anuj Tripathi
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T. T. Sreelekha
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Correspondence to T. T. Sreelekha .

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Nuclear Agriculture and Biotechnology Division, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India
Anuj Tripathi
Nuclear Agriculture and Biotechnology Division, Bhabha Atomic Research Centre, Mumbai, Maharashtra, India
Jose Savio Melo

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Komeri, R. et al. (2021). Prospects of Cell Immobilization in Cancer Research and Immunotherapy. In: Tripathi, A., Melo, J.S. (eds) Immobilization Strategies . Gels Horizons: From Science to Smart Materials. Springer, Singapore. https://doi.org/10.1007/978-981-15-7998-1_4

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DOI: https://doi.org/10.1007/978-981-15-7998-1_4
Published: 29 October 2020
Publisher Name: Springer, Singapore
Print ISBN: 978-981-15-7997-4
Online ISBN: 978-981-15-7998-1
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