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Where Does HIPEC Stand: An Evidence Based Review

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Multidisciplinary Approach to Surgical Oncology Patients

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Abstract

Traditionally, peritoneal surface malignancies (PSM) were considered as terminal diseases because of their advanced nature, therefore, systemic chemotherapy was given with palliative intent only. As a result, very poor survival outcomes were observed. But with the introduction of complete cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), the scenario has been changed dramatically. Since the disease is confined to the abdominal cavity, CRS and HIPEC have become the effective treatment modality for selected cases of PSM. HIPEC has been used in upfront, interval, recurrent, and palliative settings. The most common malignancies treated by CRS and HIPEC worldwide are Pseudomyxoma Peritonei (PMP), Malignant Peritoneal Mesothelioma (MPM), ovarian cancers, colorectal and gastric cancers, and selected cases of peritoneal sarcomatosis. This scientific review will highlight the rationale of HIPEC, the important clinical data, and correct applications of HIPEC in selected patients of various PSM. Ongoing trials and future directions will prove to be an indispensable arm in the oncological armamentarium.

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  1. Department of Surgical Oncology, All India Institute of Medical Sciences, New Delhi, India

    M. D. Ray & Kunal Dhall

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    M. D. Ray

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Ray, M.D., Dhall, K. (2021). Where Does HIPEC Stand: An Evidence Based Review. In: Ray, M.D. (eds) Multidisciplinary Approach to Surgical Oncology Patients. Springer, Singapore. https://doi.org/10.1007/978-981-15-7699-7_44

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