Abstract
In this chapter, we describe the development of a protocol using the combination of Ni(II) salt, bisphosphine ligand, and a catalytic amount of acid anhydride, to achieve the hydrocarboxylation of various alkynes with formic acid with high selectivity and remarkable functional group compatibility, affording α, β-unsaturated carboxylic acids regio- and stereoselectively. Both terminal and internal alkynes are amenable substrates. A mechanism proceeding through carbon monoxide recycling in catalytic amount is demonstrated to be crucial for the success of this transformation.
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Fu, MC. (2020). Nickel-Catalyzed Hydrocarboxylation of Alkynes with Formic Acid Through Catalytic CO Recycling. In: Studies on Green Synthetic Reactions Based on Formic Acid from Biomass. Springer Theses. Springer, Singapore. https://doi.org/10.1007/978-981-15-7623-2_3
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DOI: https://doi.org/10.1007/978-981-15-7623-2_3
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Online ISBN: 978-981-15-7623-2
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