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Sleep: Evolution and Functions pp 61–78Cite as

Sleep Loss: What Does It Do to Our Brain and Body?

Abstract

It is nowadays a common practice to “work without sleep and catch up later.” It is not a good idea to keep up with sleep deficit. In recent years, several reports have shown that the consequences of chronic sleep loss are not reversible. It may cause impairment in neuronal functions and neurodegeneration. The energy expenditure, risk of hypertension, cardiovascular disease increases, and the immune system diffuses into a compromised state during sleep deprivation. Sleep deprivation may cause the deposition of toxic metabolites usually produced during long hours of wakefulness. It may impair neurological functions and cause the death of brain cells. Sleep loss is affecting the health of children, adults, and elderly people. The brain shrinks, and the body becomes vulnerable to diseases. It affects the brain and neural development in children too. It is an irony that though its implications are gradually becoming clear, still it is turning out to be an epidemic in our modern society. Sleep loss can become a liability for the people having unusual lifestyles, working for long hours, in the night shift, and the subjects suffering from chronic sleep disorders. Here, we review some evidence to appraise the understanding of the known changes in our brain and body after prolonged sleep deprivation.

Keywords

  • Brain maturation
  • Cardiovascular disease
  • Immunity
  • Metabolic disorders
  • Obesity
  • Sleep deprivation

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Acknowledgments

Funding to SKJ from DBT, DST, DST-PURSE, UGC-DRS, and UPOE-II is highly acknowledged.

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  1. School of Life Sciences, Jawaharlal Nehru University, New Delhi, Delhi, India

    Vibha M. Jha & Sushil K. Jha

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Jha, V.M., Jha, S.K. (2020). Sleep Loss: What Does It Do to Our Brain and Body?. In: Sleep: Evolution and Functions. Springer, Singapore. https://doi.org/10.1007/978-981-15-7175-6_4

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