Skip to main content
SpringerLink
Log in

Sudden Noncardiac Deaths Caused by Poisoning

  • Chapter
  • First Online:
Sudden Death

  • 646 Accesses

Abstract

Toxic diseases are currently on the rise, especially among adolescents and youth groups. Poisoning-induced death also constitutes the main cause of death. We mainly discuss the causes of toxic sudden noncardiac death. As can be seen, injuries to multiple systems such as the respiratory system, nervous system, digestive system, endocrine system, and immune system and electrolyte imbalance caused by poisoning can lead to sudden death. If a toxic disease is discovered in time, diagnosed, and given proper disposition, sudden death can be avoided. It is important that clinicians caring for poisoning patients need to be familiar with the characteristics of toxic diseases for accurate diagnosis and centralized management.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Gallagher LM, Kappatos D, Tisch C, et al. Suicide by poisoning in New Zealand—a toxicological analysis. N Z Med J. 2012;125:15.

    PubMed  Google Scholar 

  2. Gjersing L, Jonassen KV, Biong S, et al. Diversity in causes and characteristics of drug-induced deaths in an urban setting. Scand J Public Health. 2013;41:119.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Sinyor M, Howlett A, Cheung AH, et al. Substances used in completed suicide by overdose in Toronto: an observational study of coroner’s data. Can J Psychiatr. 2012;57:184.

    Article  Google Scholar 

  4. Manchikanti L, Helm S, Fellows B, et al. Opioid epidemic in the United States. Pain Physician. 2012;15:ES9–ES38.

    Article  PubMed  Google Scholar 

  5. Khan SQ, Berrington de Gonzalez A, Best AF, et al. Infant and youth mortality trends by race/ethnicity and cause of death in the United States. JAMA Pediatr. 2018;172(12):e183317.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Curtin SC, Tejada-Vera B, Warmer M. Drug overdose deaths among adolescents aged 15-19 in the United States: 1999-2015. NCHS Data Brief. 2017;(282):1–8.

    Google Scholar 

  7. Ren Y, Zhang M, Luo X, et al. Secular trend of the leading causes of death in China from 2003 to 2013. Afr Health Sci. 2017;17(2):532–7.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Wang SY, Li YH, Chi GB, et al. Injury-related fatalities in China: an under-recognised public-health problem. Lancet. 2008;372(9651):1765–73.

    Article  CAS  PubMed  Google Scholar 

  9. Kim KS, Kim SD, Lee SH. Trend of mortality rate and injury burden of transport accidents, suicides, and falls. J Prev Med Public Health. 2012;45(1):8–13.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Manini AF, Nelson LS, Olsen D, et al. Medical examiner and medical toxicologist agreement on cause of death. Forensic Sci Int. 2011;206(1–3):71–6.

    Article  PubMed  Google Scholar 

  11. World Health Organisation. International classification of diseases (ICD-10). version 2016. 2010. https://icd.who.int/browse10/2016/en. Accessed Jan 2019.

  12. Jouven XDM, Guerot C, Ducimetière P. Predicting sudden death in the population, the Paris prospective study I. Circulation. 1999;99:1978–93.

    Article  CAS  PubMed  Google Scholar 

  13. Zipes DP, Wellens HJ. Sudden cardiac death. Circulation. 1998;98(21):2334–51.

    Article  CAS  PubMed  Google Scholar 

  14. Knight B. Simpson’s forensic medicine, vol. 14. 11th ed. London: Hodder Headline Group; 1997. p. 105–12.

    Google Scholar 

  15. Marelsson S, Thornorgeirsson G. Sudden noncardiac arrest out-of-hospital in the Reykjavík area 1987-1999. Laeknabladid. 2001;87(12):973–8.

    CAS  PubMed  Google Scholar 

  16. Gurger M, Turkoglu A, Atescelik M, et al. Sudden suspected death in emergency department: autopsy results. Turk J Emerg Med. 2014;14(3):115–20.

    Article  PubMed  Google Scholar 

  17. Hampson NB. U.S. mortality due to carbon monoxide poisoning, 1999-2014. Accidental and intentional deaths. Ann Am Thorac Soc. 2016;13:1768.

    PubMed  Google Scholar 

  18. Hampson NB, Hauff NM. Risk factors for short-term mortality from carbon monoxide poisoning treated with hyperbaric oxygen. Crit Care Med. 2008;36:2523.

    Article  CAS  PubMed  Google Scholar 

  19. Blaas V, Manhart J, Port A, Keil W, Büttner A. An autopsy approach on bolus deaths. J Forensic Legal Med. 2016;42:82–7.

    Article  Google Scholar 

  20. Brinkmann B. Ersticken. In: Brinkmann B, Madea B, editors. Handbuch gerichtliche Medizin. Band 1. 1st ed. Berlin: Springer; 2003. p. 785–6.

    Google Scholar 

  21. Dettmeyer R, Schütz H, Verhoff M. Rechtsmedizin. 2nd ed. Heidelberg: Springer; 2014.

    Google Scholar 

  22. Penning R. Rechtsmedizin systematisch. 2nd ed. UniMed Verlag: Bremen; 2006.

    Google Scholar 

  23. Wang Y, Gao D, Zuojun G, et al. Radiomics nomogram analyses for differentiating pneumonia and acute paraquat lung injury. Sci Rep. 2019;9(1):15029.

    Article  Google Scholar 

  24. Hendrickson RG, Horowitz BZ, Norton RL, Notenboom H. “Parachuting” meth: a novel delivery method for methamphetamine and delayed-onset toxicity from “body stuffing”. Clin Toxicol (Phila). 2006;44:379.

    Article  Google Scholar 

  25. Cantrell FL, Breckenridge HM, Jost P. Transrectal methamphetamine use: a novel route of exposure. Ann Intern Med. 2006;145:78.

    Article  PubMed  Google Scholar 

  26. Kashani J, Ruha AM. Methamphetamine toxicity secondary to intravaginal body stuffing. J Toxicol Clin Toxicol. 2004;42:987.

    Article  PubMed  Google Scholar 

  27. Nestor TA, Tamamoto WI, Kam TH, et al. Crystal methamphetamine-induced acute pulmonary edema: a case report. Hawaii Med J. 1989;48:457.

    CAS  PubMed  Google Scholar 

  28. Schaiberger PH, Kennedy TC, Miller FC, et al. Pulmonary hypertension associated with long-term inhalation of “crank” methamphetamine. Chest. 1993;104:614.

    Article  CAS  PubMed  Google Scholar 

  29. Chin KM, Channick RN, Rubin LJ. Is methamphetamine use associated with idiopathic pulmonary arterial hypertension? Chest. 2006;130:1657.

    Article  CAS  PubMed  Google Scholar 

  30. Gotway MB, Marder SR, Hanks DK, et al. Thoracic complications of illicit drug use: an organ system approach. Radiographics. 2002; 22 Spec no:S119.

    Google Scholar 

  31. O’Horo JC, Harper EP, El Rafei A, et al. Efficacy of antitoxin therapy in treating patients with foodborne botulism: a systematic review and meta-analysis of cases, 1923-2016. Clin Infect Dis. 2017;66:S43.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Bai L, Peng X, Liu Y, et al. Clinical analysis of 86 botulism cases caused by cosmetic injection of botulinum toxin (BoNT). Medicine. 2018;97(34):e10659.

    Article  PubMed  PubMed Central  Google Scholar 

  33. McDonough JH Jr, Zoeffel LD, McMonagle J, et al. Anticonvulsant treatment of nerve agent seizures: anticholinergics versus diazepam in soman-intoxicated guinea pigs. Epilepsy Res. 2000;38:1.

    Article  CAS  PubMed  Google Scholar 

  34. Marrs TC. Diazepam in the treatment of organophosphorus ester pesticide poisoning. Toxicol Rev. 2003;22:75–81.

    Article  CAS  PubMed  Google Scholar 

  35. Puranik R, Chow CK, Duflou JA, et al. Sudden death in the young. Heart Rhythm. 2005;2(12):1277–82. Accessed 10 Mar 2019.

    Article  PubMed  Google Scholar 

  36. Pereska Z, Chaparoska D, Bekarovski N, et al. Pulmonary thrombosis in acute organophosphate poisoning—case report and literature overview of prothrombotic preconditioning in organophosphate toxicity. Toxicol Rep. 2019;6:550–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Lim Y-P, Lin C-L, Hung D-Z, et al. Increased risk of deep vein thrombosis and pulmonary thromboembolism in patients with organophosphate intoxication. Medicine. 2015;94:e341.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Naik M, Bhat T, Mir M, et al. Organophosphorus poisoning: a rare case of upper extremity deep vein thrombosis. Indian J Health Sci Care. 2016;9:339.

    Article  Google Scholar 

  39. Anand S, Singh S, Saikia UN, et al. Cardiac abnormalities in acute organophosphate poisoning. Clin Toxicol. 2009;47:230–5.

    Article  CAS  Google Scholar 

  40. Buckley NA, Dawson AH, Whyte IM. Organophosphate poisoning: peripheral vascular resistance–a measure of adequate atropinization. J Toxicol Clin Toxicol. 1994;32:61–8. Accessed 10 Mar 2019

    Article  CAS  PubMed  Google Scholar 

  41. Fritts HW, Harris P, Clauss RH, et al. The effect of acetylcholine on the human pulmonary circulation under normal and hypoxic conditions. J Clin Invest. 1958;37:99–110.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Dawson A, Garthwaite D. Rodenticide usage by local authorities in Great Britain. In: Department for Environment, Food & Rural Affairs, editor. Pesticide usage survey report 185. York: Department for Environment, Food & Rural Affairs; 2001.

    Google Scholar 

  43. Long J, Peng X, Luo Y, et al. Treatment of a long-acting anticoagulant rodenticide poisoning cohort with vitamin K1 during the maintenance period. Medicine. 2016;95(51):e5461.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  44. Lucena J, Blanco M, Jurado C, et al. Cocaine-related sudden death: a prospective investigation in south-west Spain. Eur Heart J. 2010;31:318–29.

    Article  CAS  PubMed  Google Scholar 

  45. Takayama M, Waters B, Fujii H, et al. Subarachnoid hemorrhage in a Japanese cocaine abuser: cocaine-related sudden death. Legal Med. 2018;32:43–7.

    Article  CAS  PubMed  Google Scholar 

  46. Conway JE, Tamargo RJ. Cocaine use is an independent risk factor for cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Stroke. 2001;32:2338–43.

    Article  CAS  PubMed  Google Scholar 

  47. Chang Y, Liu YP, Liu CF. The effect on serotonin and MDA levels in depressed patients with insomnia when far-infrared rays are applied to acupoints. Am J Chin Med. 2009;37:837–42.

    Article  CAS  PubMed  Google Scholar 

  48. Lange RA, Cigarroa RG, Yancy CW, et al. Cocaine-induced coronary-artery vasoconstriction. N Engl J Med. 1989;321:1557–62.

    Article  CAS  PubMed  Google Scholar 

  49. Whitlow KS, Belson M, Barrueto F, et al. Tetramethylenedisulfotetramine: old agent and new terror. Ann Emerg Med. 2005;45:609.

    Article  PubMed  Google Scholar 

  50. Deng X, Li G, Mei R, et al. Long term effects of tetramine poisoning: an observational study. Clin Toxicol (Phila). 2012;50:172.

    Article  CAS  Google Scholar 

  51. Proudfoot AT, Bradberry SM, Vale JA. Sodium fluoroacetate poisoning. Toxicol Rev. 2006;25:213.

    Article  CAS  PubMed  Google Scholar 

  52. Tezer FI, Rémi J, Noachtar S. Ictal apnea of epileptic origin. Neurology. 2009;72:855.

    Article  PubMed  Google Scholar 

  53. Blum AS, Ives JR, Goldberger AL, et al. Oxygen desaturations triggered by partial seizures: implications for cardiopulmonary instability in epilepsy. Epilepsia. 2000;41:536.

    Article  CAS  PubMed  Google Scholar 

  54. Bateman LM, Li CS, Seyal M. Ictal hypoxemia in localization-related epilepsy: analysis of incidence, severity and risk factors. Brain. 2008;131:3239.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Plescia CJ, Manu P. Hypoglycemia and sudden death during treatment with methadone for opiate detoxification. Am J Ther. 2018;25(2):e267–9.

    Article  PubMed  Google Scholar 

  56. Faskowitz AJ, Kramskiy VN, Pasternak GW. Methadone-induced hypoglycemia. Cell Mol Neurobiol. 2013;33:537–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Snell-Bergeon JK, Wadwa RP. Hypoglycemia, diabetes, and cardiovascular disease. Diabetes Technol Ther. 2012;14(suppl 1):S51–8.

    Article  CAS  PubMed  Google Scholar 

  58. Lang JE, Pflaumer A, Davis AM. Causes of sudden death in the young—cardiac and non-cardiac. Prog Pediatric Cardiol. 2017;45:2–13.

    Article  Google Scholar 

  59. Pumphrey RSH. Lessons for management of anaphylaxis from a study of fatal reactions. Clin Exp Allergy. 2000;30:1144–50.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Poisoning Treatment Department, The Fifth Medical Center of Chinese PLA General Hospital, Beijing, China

    Xiaobo Peng & Zewu Qiu

Authors
  1. Xiaobo Peng
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Zewu Qiu
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Emergency Department, The First Medical Center of Chinese PLA General Hospital, Beijing, China

    Haiyan Zhu

Rights and permissions

Reprints and permissions

Copyright information

© 2021 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Peng, X., Qiu, Z. (2021). Sudden Noncardiac Deaths Caused by Poisoning. In: Zhu, H. (eds) Sudden Death. Springer, Singapore. https://doi.org/10.1007/978-981-15-7002-5_22

Download citation

  • DOI: https://doi.org/10.1007/978-981-15-7002-5_22

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-7001-8

  • Online ISBN: 978-981-15-7002-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation