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Implantable CMOS Fluorescent Imaging Devices

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Functional Brain Mapping: Methods and Aims

Part of the book series: Brain Informatics and Health ((BIH))

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Abstract

Optical techniques are one of the most useful methods for elucidating how the brain works. In particular, by using a potential-sensitive dye [1] or a calcium probe, potential changes in cell membrane or Ca2+ ion concentration associated with neural activities can be converted to fluorescence intensity. Visualizing neural activity by combining these and microscopic techniques is widely used in recent neurosciences.

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References

  1. Blasdel GG, Salama G (1986) Nature 321:579–585

    Article  CAS  Google Scholar 

  2. Nakai J, Ohkura M, Imoto K (2001) Nat Biotechnol 19:137–141

    Article  CAS  Google Scholar 

  3. Dombeck DA, Graziano MS, Tank DW (2009) J Neurosci 29:13751–13760

    Article  CAS  Google Scholar 

  4. Ferezou I, Bolea S, Petersen CCH (2006) Neuron 50:617–629. Sawinski J, Wallace DJ, Greenberg DS, Grossmann S, Denk W, Kerr JN (2009) Proc Natl Acad Sci USA 106:19557–19562

    Google Scholar 

  5. Ghosh KK, Burns LD, Cocker ED, Nimmerjahn A, Ziv Y, El Gamal A, Schnitzer MJ (2011) Nat Methods 8:871–878

    Google Scholar 

  6. UCLA miniscope project. https://miniscope.org

  7. Ohta J, Higuchi A, Tagawa A, Sasagawa K, Tokuda T, Hatanaka Y, Ishikawa Y Shiosaka S (2008) An implantable CMOS image sensor for monitoring deep brain activities of a freely moving mouse. In: 2008 IEEE biomedical circuits and systems conference. IEEE, pp 269–272

    Google Scholar 

  8. Ohta J, Tokuda T, Sasagawa K, Noda T (2009) Sensors 9, 9073–9093

    Google Scholar 

  9. Ohta J, Ohta Y, Takehara H, Noda T, Sasagawa K, Tokuda T, Haruta M, Kobayashi T, Akay YM, Akay M (2017) Proc IEEE 105:158–166

    Google Scholar 

  10. Takehara H, Katsuragi Y, Ohta Y, Motoyama M, Takehara H, Noda T, Sasagawa K, Tokuda T, Ohta J (2016) Appl Phys Express 9:047001

    Article  Google Scholar 

  11. Kobayashi T, Motoyama M, Masuda H, Ohta Y, Haruta M, Noda T, Sasagawa K, Tokuda T, Tamura H, Ishikawa Y, Shiosaka S, Ohta J (2012) Biosens Bioelectron 38:321–330

    Article  CAS  Google Scholar 

  12. Haruta M, Sunaga Y, Yamaguchi T, Takehara H, Noda T, Sasagawa K, Tokuda T, Ohta J (2015) Jpn J Appl Phys 54:04DL10. Sunaga Y, Yamaura H, Haruta M, Yamaguchi T, Motoyama M, Ohta Y, Takehara H, Noda T, Sasagawa K, Tokuda T, Yoshimura Y (2016) Implantable imaging device for brain functional imaging system using flavoprotein fluorescence. Jpn J Appl Phys 55(3S2):03DF02

    Google Scholar 

  13. Wong WS, Sands T, Cheung NW, Kneissl M, Bour DP, Mei P, Romano LT, Johnson NM (1999) Appl Phys Lett 75:1360–1362

    Google Scholar 

  14. Sasagawa K, Haruta M, Fujimoto K, Ohta Y, Noda T, Tokuda T, Ohta J (2017) The 13th IEEE BioCAS (BioCAS2017)

    Google Scholar 

  15. Sasagawa K, Yamaguchi T, Haruta M, Sunaga Y, Ohta Y, Takehara H, Takehara H, Noda T, Tokuda T, Ohta J (2016) Ext. Abstr. Solid state devices and materials, H-4-05

    Google Scholar 

  16. Sasagawa K, Kimura A, Haruta M, Noda T, Tokuda T, Ohta J (2018) Biomed Opt Express 9:4329–4344

    Google Scholar 

  17. Sasagawa K, Ohta Y, Kawahara M, Haruta M, Noda T, Tokuda T, Ohta J (2019) AIP Adv 9:035108

    Google Scholar 

  18. Hee WS, Sasagawa K, Kameyama A, Kimura A, Haruta M, Tokuda T, Ohta J (2019) Lens-free dual-color fluorescent CMOS image sensor for Förster resonance energy transfer imaging. Sens Mater 31(8):2579–2594

    Google Scholar 

  19. Sasagawa K, Ohta Y, Haruta M, Noda T, Tokuda T, Ohta J (2018) IEEE BioCAS 2018. Cleveland, OH, USA

    Google Scholar 

  20. Rustami E, Sasagawa K, Ohta Y, Haruta M, Noda T, Tokuda T, Ohta J (2019) A thin composite emission filter and fiber coupled laser excitation for implantable fluorescence imager application. In: 2019 IEEE international symposium on circuits and systems (ISCAS) A2L-I-2, Sapporo, Japan

    Google Scholar 

  21. Rustami E, Sasagawa K, Sugie K, Ohta Y, Haruta M, Noda T, Tokuda T, Ohta J, Needle-type image sensor with band-pass composite emission filter and parallel fiber-coupled laser excitation. IEEE Trans Circ Syst I (to be published)

    Google Scholar 

  22. Wang A, Molnar A (2012) A light-field image sensor in 180 nm CMOS. J Solid-State Circ 47(1):257–271. https://doi.org/10.1109/JSSC.2011.2164669

  23. Adams JK, Boominathan V, Avants BW, Vercosa DG, Ye F, Baraniuk RG, Robinson JT, Veeraraghavan A (2017) Sci Adv 3:e1701548

    Article  Google Scholar 

  24. Sugie K, Sasagawa K, Guinto MC, Haruta M, Tokuda T, Ohta J (2019) Electron Lett 55(13):729–731

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, Nara, Japan

    Kiyotaka Sasagawa, Makito Haruta, Yasumi Ohta, Hironari Takehara, Takashi Tokuda & Jun Ohta

  2. Future Interdisciplinary Research of Science and Technology (FIRST), Tokyo Institute of Technology, Tokyo, Japan

    Takashi Tokuda

Authors
  1. Kiyotaka Sasagawa
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  2. Makito Haruta
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  3. Yasumi Ohta
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  4. Hironari Takehara
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  5. Takashi Tokuda
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  6. Jun Ohta
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Corresponding author

Correspondence to Kiyotaka Sasagawa .

Editor information

Editors and Affiliations

  1. University of Maryland, Baltimore, MD, USA

    Vassiliy Tsytsarev

  2. University of Southern California, West Hollywood, USA

    Vicky Yamamoto

  3. Department of Information Engineering, Maebashi Institute of Technology, Maebashi, Japan

    Ning Zhong

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© 2020 The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

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Sasagawa, K., Haruta, M., Ohta, Y., Takehara, H., Tokuda, T., Ohta, J. (2020). Implantable CMOS Fluorescent Imaging Devices. In: Tsytsarev, V., Yamamoto, V., Zhong, N. (eds) Functional Brain Mapping: Methods and Aims. Brain Informatics and Health. Springer, Singapore. https://doi.org/10.1007/978-981-15-6883-1_6

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  • DOI: https://doi.org/10.1007/978-981-15-6883-1_6

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-6882-4

  • Online ISBN: 978-981-15-6883-1

  • eBook Packages: Computer ScienceComputer Science (R0)

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