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Transcranial Dynamic Fluorescence Imaging for the Study of the Epileptic Seizures

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Functional Brain Mapping: Methods and Aims

Part of the book series: Brain Informatics and Health ((BIH))

Abstract

In last decade functional brain mapping has made significant strides through development of advanced methods, culminating into revolutionary diagnostic imaging and therapeutic applications of neurophotonics. Imaging technologies include intrinsic optical imaging, voltage-sensitive dye, photoacoustic, optical coherence tomography, multi-spectral imaging, UV, yellow light, thermal and near-infrared spectroscopy. Some of these technologies are not only used in animal studies of the model of epileptic seizures but also been in clinical trials. However, translation of such basic science application of brain mapping technologies into clinical setting remains challenging. In this paper we review current advances in the field, along with one clear focus on laser speckle contrast imaging and its application in epilepsy. Our conclusion is that functional brain optical imaging could play a key role in bridging between morphology and functional activity of the brain, and thus contribute to more accurate diagnostics and improved efficacy of the therapy. Coupling brain optical imaging with measurements of disease biomarkers and adding as well as other neuroscience techniques is making early diagnosis more effective and applicable for variable clinical tasks.

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Acknowledgement

The images used in the Figs. 1, 2 and 3 are obtained by Dr. Vyacheslav Kalchenko, Weizmann Institute of Science

Author information

Authors and Affiliations

  1. Department of Veterinary Resources, Weizmann Institute of Science, 234 Herzl St., Rehovot, 7610001, Israel

    Vyacheslav Kalchenko

  2. Vice President for Administration and Finance, Weizmann Institute of Science, 234 Herzl St., Rehovot, 7610001, Israel

    Alon Harmelin

  3. Psychiatric Array, Kaplan Hospital, The Hebrew University of Jerusalem, Jerusalem, Israel

    David Israeli

  4. Founding Chairman of the Board of Directors, CEO and Scientific Director, President & Scientific Director, Society for Brain Mapping & Therapeutics (SBMT), Brain Mapping Foundation, 860 Via De La Paz, Suite E-1 Pacific Palisades, Pacific Palisades, 90272-3668, CA, USA

    Babak Kateb

  5. School of Engineering and Applied Science, Aston University, Birmingham, B4 7ET, United Kingdom

    Igor Meglinski

  6. Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, 73019, USA

    Qinggong Tang

  7. Department of Biomedical Engineering, John Hopkins University, Baltimore, USA

    Nitish V. Thakor

  8. Saint Petersburg State University, Translational Research Institute, Saint Petersburg, Russia

    Alla Ignashchenkova & Anna Volnova

  9. Department of Anatomy and Neurobiology, University of Maryland, 20 Penn st, HSF-2, Baltimore, 21201, MD, USA

    Vassiliy Tsytsarev

  10. Society of Brain Mapping and Therapeutics, Santa Monica, CA, USA

    Babak Kateb

  11. Brain Mapping Foundation, West Hollywood, CA, USA

    Babak Kateb

  12. National Center for NanoBioElectronics, Los Angeles, CA, USA

    Babak Kateb

  13. Brain technology and Innovation Park, Los Angeles, CA, USA

    Babak Kateb

Authors
  1. Vyacheslav Kalchenko
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  2. Alon Harmelin
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  3. David Israeli
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  4. Babak Kateb
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  5. Igor Meglinski
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  6. Qinggong Tang
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  7. Nitish V. Thakor
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  8. Alla Ignashchenkova
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  9. Anna Volnova
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  10. Vassiliy Tsytsarev
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Corresponding author

Correspondence to Vyacheslav Kalchenko .

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Editors and Affiliations

  1. University of Maryland, Baltimore, MD, USA

    Vassiliy Tsytsarev

  2. University of Southern California, West Hollywood, USA

    Vicky Yamamoto

  3. Department of Information Engineering, Maebashi Institute of Technology, Maebashi, Japan

    Ning Zhong

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Kalchenko, V. et al. (2020). Transcranial Dynamic Fluorescence Imaging for the Study of the Epileptic Seizures. In: Tsytsarev, V., Yamamoto, V., Zhong, N. (eds) Functional Brain Mapping: Methods and Aims. Brain Informatics and Health. Springer, Singapore. https://doi.org/10.1007/978-981-15-6883-1_3

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  • DOI: https://doi.org/10.1007/978-981-15-6883-1_3

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