Abstract
Honey is one of the most nutritional natural products that not only provides us healthy nutrition but also has a potential to be an alternative treatment option for different pathologies from microbial infection to metabolic disease. Honey is a byproduct of flower syrup produced by honeybees and possesses an intricate chemical composition that varies with botanical sources and geographical locations. This chapter is aimed to provide readers an understanding of complex composition, biological activities, adverse effect, and therapeutic benefits of honey. Honey possesses many biological activities, such as antioxidant, anti-microbial, anti-inflammatory, anti-proliferative, anti-cancer, and anti-metastatic effects, suggesting potential therapeutic roles in many human pathologies. Flavonoids and polyphenols in honey are the two active ingredients, which are of therapeutic importance in many diseases. In conclusion, honey may be developed as a natural therapeutic agent for many pathologies, and extensive studies are therefore recommended.
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References
Abdulrhman M, El-Hefnawy M, Ali R, El-Goud A (2011) Type 1 diabetes-complications, pathogenesis, and alternative treatments. InTech, Croatia, pp 228–233
Abuharfeil N, Al-Oran R, Abo-Shehada M (1999) The effect of bee honey on the proliferative activity of human B-and T-lymphocytes and the activity of phagocytes. Food Agric Immunol 11(2):169–177
Adebolu TJAJB (2005) Effect of natural honey on local isolates of diarrhea-causing bacteria in southwestern Nigeria. Afr J Biotechnol 4(10):1172–1174
Ahmad A, Khan RA, Mesaik MA (2009) Anti inflammatory effect of natural honey on bovine thrombin-induced oxidative burst in phagocytes. Phytother Res 23(6):801–808. https://doi.org/10.1002/ptr.2648
Ahmed S, Othman NH (2013) Honey as a potential natural anticancer agent: a review of its mechanisms. Evid Based Complement Alternat Med 2013:829070. https://doi.org/10.1155/2013/829070
Ahmed AKJ, Hoekstra MJ, Hage JJ, Karim RB (2003) Honey-medicated dressing: transformation of an ancient remedy into modern therapy. Ann Plast Surg 50(2):143–148
Ajibola A, Chamunorwa JP, Erlwanger KH (2012) Nutraceutical values of natural honey and its contribution to human health and wealth. Nutr Metab (Lond) 9:61–61. https://doi.org/10.1186/1743-7075-9-61
Akanmu MA, Olowookere TA, Atunwa SA, Ibrahim BO, Lamidi OF, Adams PA, Ajimuda BO, Adeyemo LE (2011) Neuropharmacological effects of Nigerian honey in mice. Afr J Tradit Complement Altern Med 8(3):230–249. https://doi.org/10.4314/ajtcam.v8i3.65285
Al Somal N, Coley KE, Molan PC, Hancock BM (1994) Susceptibility of Helicobacter pylori to the antibacterial activity of manuka honey. J R Soc Med 87(1):9–12
Ali A (1995) Natural honey accelerates healing of indomethacin-induced antral ulcers in rats. Saudi Med J 16(2):161–166
Ali AT, Chowdhury MN, Al Humayyd MS (1991) Inhibitory effect of natural honey on Helicobacter pylori. Trop Gastroenterol 12(3):139–143
Aliyu M, Odunola OA, Farooq AD, Rasheed H, Mesaik AM, Choudhary MI, Channa IS, Khan SA, Erukainure OL (2013) Molecular mechanism of antiproliferation potential of Acacia honey on NCI-H460 cell line. Nutr Cancer 65(2):296–304. https://doi.org/10.1080/01635581.2013.756920
Al-Jabri AA (2005) Honey, milk and antibiotics. Afr J Biotechnol 4(13):1580–1587
Al-Mamary M, Al-Meeri A, Al-Habori M (2002) Antioxidant activities and total phenolics of different types of honey. Nutr Res 22(9):1041–1047
Alnaqdy A, Al-Jabri A, Al Mahrooqi Z, Nzeako B, Nsanze H (2005) Inhibition effect of honey on the adherence of Salmonella to intestinal epithelial cells in vitro. Int J Food Microbiol 103(3):347–351. https://doi.org/10.1016/j.ijfoodmicro.2004.11.042
Alvarez-Suarez JM, Tulipani S, Romandini S, Bertoli E, Battino M (2010) Contribution of honey in nutrition and human health: a review. Mediterr J Nutr Metab 3(1):15–23
Al-Waili NS (2001) Therapeutic and prophylactic effects of crude honey on chronic seborrheic dermatitis and dandruff. Eur J Med Res 6(7):306–308
Al-Waili NS (2003) Effects of daily consumption of honey solution on hematological indices and blood levels of minerals and enzymes in normal individuals. J Med Food 6(2):135–140. https://doi.org/10.1089/109662003322233549
Al-Waili NS (2004a) Investigating the antimicrobial activity of natural honey and its effects on the pathogenic bacterial infections of surgical wounds and conjunctiva. J Med Food 7(2):210–222. https://doi.org/10.1089/1096620041224139
Al-Waili NS (2004b) Natural honey lowers plasma glucose, C-reactive protein, homocysteine, and blood lipids in healthy, diabetic, and hyperlipidemic subjects: comparison with dextrose and sucrose. J Med Food 7(1):100–107. https://doi.org/10.1089/109662004322984789
Al-Waili NS (2005) Mixture of honey, beeswax and olive oil inhibits growth of Staphylococcus aureus and Candida albicans. Arch Med Res 36(1):10–13. https://doi.org/10.1016/j.arcmed.2004.10.002
Al-Waili NS, Boni NS (2003a) Natural honey lowers plasma prostaglandin concentrations in normal individuals. J Med Food 6(2):129–133. https://doi.org/10.1089/109662003322233530
Al-Waili NS, Boni NS (2003b) Natural honey lowers plasma prostaglandin concentrations in normal individuals. J Med Food 6(2):129–133. https://doi.org/10.1089/109662003322233530
Al-Waili NS, Haq A (2004a) Effect of honey on antibody production against thymus-dependent and thymus-independent antigens in primary and secondary immune responses. J Med Food 7(4):491–494. https://doi.org/10.1089/jmf.2004.7.491
Al-Waili NS, Haq A (2004b) Effect of honey on antibody production against thymus-dependent and thymus-independent antigens in primary and secondary immune responses. J Med Food 7(4):491–494. https://doi.org/10.1089/jmf.2004.7.491
Araujo JR, Goncalves P, Martel F (2011) Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines. Nutr Res 31(2):77–87. https://doi.org/10.1016/j.nutres.2011.01.006
Asadi-Pooya AA, Pnjehshahin MR, Beheshti S (2003) The antimycobacterial effect of honey: an in vitro study. Riv Biol 96(3):491–495
Ashrafi S, Mastronikolas S, Wu C (2005) Use of honey in treatment of aphthous ulcers. In: Abstract, pp 9–12
Attia WY, Gabry MS, El-Shaikh KA, Othman GA (2008) The anti-tumor effect of bee honey in Ehrlich ascite tumor model of mice is coincided with stimulation of the immune cells. Egypt J Immunol 15(2):169–183
Babacan S, Rand AG (2007) Characterization of honey amylase. J Food Sci 72(1):C050–C055. https://doi.org/10.1111/j.1750-3841.2006.00215.x
Bâcvarov VI (1970) Treatment of chronic bronchitis and bronchial asthma with honey (Zur Bienenhonigbehandlung der chronischen Bronchitis und des Bronchialasthmas). Ther Ggw 109(2):260–268
Badawy OF, Shafii SS, Tharwat EE, Kamal AM (2004) Antibacterial activity of bee honey and its therapeutic usefulness against Escherichia coli O157:H7 and Salmonella typhimurium infection. Rev Sci Tech 23(3):1011–1022. https://doi.org/10.20506/rst.23.3.1543
Bahrami M, ATAIE JA, Hosseini S (2008) Effects of natural honey consumption in diabetic patients: an 8-week randomized clinical trial. Int J Food Sci Nutr 60(7):618–626
Baiomy A, Rady HM, Amer MA, Kiwan HS (2009) Effect of some honey bee extracts on the proliferation, proteolytic and gelatinolytic activities of the hepatocellular carcinoma Hepg2 cell line. Aust J Basic Appl Sci 3:2754–2769
Bansal V, Medhi B, Pandhi P (2005) Honey—a remedy rediscovered and its therapeutic utility. Kathmandu Univ Med J 3(3):305–309
Barra MPG, Ponce-Díaz MC, Venegas-Gallegos C (2010) Volatile compounds in honey produced in the central valley of Ñuble province, Chile. Chile J Agric Res 70(1):75–84
Basualdo C, Sgroy V, Finola MS, Marioli JM (2007) Comparison of the antibacterial activity of honey from different provenance against bacteria usually isolated from skin wounds. Vet Microbiol 124(3-4):375–381. https://doi.org/10.1016/j.vetmic.2007.04.039
Bell SG (2007) The therapeutic use of honey. Neonatal Netw 26(4):247–251. https://doi.org/10.1891/0730-0832.26.4.247
Beretta G, Granata P, Ferrero M, Orioli M, Facino RMJACA (2005) Standardization of antioxidant properties of honey by a combination of spectrophotometric/fluorimetric assays and chemometrics. Anal Chim Acta 533(2):185–191
Beretta G, Orioli M, Facino RM (2007) Antioxidant and radical scavenging activity of honey in endothelial cell cultures (EA.hy926). Planta Med 73(11):1182–1189. https://doi.org/10.1055/s-2007-981598
Bergman A, Yanai J, Weiss J, Bell D, David MP (1983) Acceleration of wound healing by topical application of honey. An animal model. Am J Surg 145(3):374–376. https://doi.org/10.1016/0002-9610(83)90204-0
Bertoncelj J, Doberšek U, Jamnik M, Golob TJFC (2007) Evaluation of the phenolic content, antioxidant activity and colour of Slovenian honey. Food Chem 105(2):822–828
Betts J (2008) The clinical application of honey in wound care. Nurs Times 104(14):43–44
Bilsel Y, Bugra D, Yamaner S, Bulut T, Cevikbas U, Turkoglu U (2002a) Could honey have a place in colitis therapy? Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation. Dig Surg 19(4):306–312. https://doi.org/10.1159/000064580
Bilsel Y, Bugra D, Yamaner S, Bulut T, Cevikbas U, Turkoglu U (2002b) Could honey have a place in colitis therapy? Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation. Dig Surg 19(4):306–311.; discussion 311-302. https://doi.org/10.1159/000064580
Blasa M, Candiracci M, Accorsi A, Piacentini MP, Piatti EJFC (2007) Honey flavonoids as protection agents against oxidative damage to human red blood cells. Food Chem 104(4):1635–1640
Bogdanov S, Jurendic T, Sieber R, Gallmann P (2008) Honey for nutrition and health: a review. J Am Coll Nutr 27(6):677–689. https://doi.org/10.1080/07315724.2008.10719745
Brady N, Molan P, Harfoot C (1996) The sensitivity of dermatophytes to the antimicrobial activity of manuka honey and other honey. Pharm Pharmacol Commun 2(10):471–473
Bravo L (1998) Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev 56(11):317–333. https://doi.org/10.1111/j.1753-4887.1998.tb01670.x
Candiracci M, Piatti E, Dominguez-Barragan M, Garcia-Antras D, Morgado B, Ruano D, Gutierrez JF, Parrado J, Castano A (2012) Anti-inflammatory activity of a honey flavonoid extract on lipopolysaccharide-activated N13 microglial cells. J Agric Food Chem 60(50):12304–12311. https://doi.org/10.1021/jf302468h
Carlos A, David H, Carmen G (2011) Role of honey polyphenols in health. J ApiProd ApiMed Sci 3(4):141–159
Cavanagh D, Beazley J, Ostapowicz F (1970) Radical operation for carcinoma of the vulva. A new approach to wound healing. J Obstet Gynaecol Br Commonw 77(11):1037–1040. https://doi.org/10.1111/j.1471-0528.1970.tb03455.x
Cerchier P, Dabalà M, Brunelli K (2017) Green synthesis of copper nanoparticles with ultrasound assistance. Green Process Synthesis 6. https://doi.org/10.1515/gps-2016-0192
Chambers J (2006) Topical manuka honey for MRSA-contaminated skin ulcers. Palliat Med 20(5):557. https://doi.org/10.1191/0269216306pm1160xx
Chen L, Mehta A, Berenbaum M, Zangerl AR, Engeseth NJ (2000) Honeys from different floral sources as inhibitors of enzymatic browning in fruit and vegetable homogenates. J Agric Food Chem 48(10):4997–5000. https://doi.org/10.1021/jf000373j
Chepulis L (2007) The effect of honey compared to sucrose, mixed sugars, and a sugar-free diet on weight gain in young rats. J Food Sci 72(3):S224–S229
Cho H, Yun CW, Park WK, Kong JY, Kim KS, Park Y, Lee S, Kim BK (2004) Modulation of the activity of pro-inflammatory enzymes, COX-2 and iNOS, by chrysin derivatives. Pharmacol Res 49(1):37–43. https://doi.org/10.1016/s1043-6618(03)00248-2
Chow J (2002) Probiotics and prebiotics: a brief overview. J Ren Nutr 12(2):76–86. https://doi.org/10.1053/jren.2002.31759
Chowdhury MM (1999) Honey: is it worth rubbing it in? J R Soc Med 92(12):663–663. https://doi.org/10.1177/014107689909201227
Cianciosi D, Forbes-Hernández TY, Afrin S, Gasparrini M, Reboredo-Rodriguez P, Manna PP, Zhang J, Bravo Lamas L, Martínez Flórez S, Agudo Toyos P, Quiles JL, Giampieri F, Battino M (2018) Phenolic compounds in honey and their associated health benefits: a review. Molecules 23(9):2322. https://doi.org/10.3390/molecules23092322
Clarke AM, Ndip N (2011) Identification of volatile compounds in solvent extracts of honeys produced in South Africa. Afr J Agric Res 6(18):4327–4334
Cushnie TP, Lamb AJ (2005) Antimicrobial activity of flavonoids. Int J Antimicrob Agents 26(5):343–356. https://doi.org/10.1016/j.ijantimicag.2005.09.002
Dashora N, Sodde V, Bhagat J, Prabhu KS, Lobo RJPC (2011) Antitumor activity of Dendrophthoe falcata against ehrlich ascites carcinoma in swiss albino mice. Pharmaceut Crops 2:1–7
Dunford C, Cooper R, Molan P (2000) Using honey as a dressing for infected skin lesions. Nurs Times 96(14 Suppl):7–9
Dustmann JHJA (1979) Antibacterial effect of honey. Apiacta 14(1):7–11
Dutta RC (2002) Peptide immunomodulators versus infection; an analysis. Immunol Lett 83(3):153–161. https://doi.org/10.1016/S0165-2478(02)00066-4
Earnshaw WC (1995) Nuclear changes in apoptosis. Curr Opin Cell Biol 7(3):337–343. https://doi.org/10.1016/0955-0674(95)80088-3
Eddy JJ, Gideonsen MD, Mack GP (2008) Practical considerations of using topical honey for neuropathic diabetic foot ulcers: a review. WMJ 107(4):187–190
Edebo L, Kihlstrom E, Magnusson K, Stendahl O (1980) In: Curtis ASG, Pitts JD (eds) Cell adhesion and motility. Cambridge University Press, Cambridge
Efem SE (1988) Clinical observations on the wound healing properties of honey. Br J Surg 75(7):679–681. https://doi.org/10.1002/bjs.1800750718
El-Soud NHA (2012) Honey between traditional uses and recent medicine. Macedonian J Med Sci 5(2):205–214
Emsen IM (2007) A different and safe method of split thickness skin graft fixation: medical honey application. Burns 33(6):782–787. https://doi.org/10.1016/j.burns.2006.12.005
English HK, Pack AR, Molan PC (2004) The effects of manuka honey on plaque and gingivitis: a pilot study. J Int Acad Periodontol 6(2):63–67
Erejuwa OO (2014) Effect of honey in diabetes mellitus: matters arising. J Diabetes Metab Disord 13(1):23–23. https://doi.org/10.1186/2251-6581-13-23
Erejuwa OO, Sulaiman SA, Wahab MSA (2014) Effects of honey and its mechanisms of action on the development and progression of cancer. Molecules 19(2):2497–2522. https://doi.org/10.3390/molecules19022497
Estevinho L, Pereira AP, Moreira L, Dias LG, Pereira E (2008) Antioxidant and antimicrobial effects of phenolic compounds extracts of Northeast Portugal honey. Food Chem Toxicol 46(12):3774–3779. https://doi.org/10.1016/j.fct.2008.09.062
Eteraf-Oskouei T, Najafi M (2013) Traditional and modern uses of natural honey in human diseases: a review. Iran J Basic Med Sci 16(6):731–742
Ezz El-Arab AM, Girgis SM, Hegazy EM, Abd El-Khalek AB (2006) Effect of dietary honey on intestinal microflora and toxicity of mycotoxins in mice. BMC Complement Altern Med 6:6–6. https://doi.org/10.1186/1472-6882-6-6
Fakhrildin M-BMR, Alsaadi RAR (2014) Honey supplementation to semen-freezing medium improves human sperm parameters post-thawing. J Fam Reprod Health 8(1):27–31
Fauzi AN, Norazmi MN, Yaacob NSJF (2011) Tualang honey induces apoptosis and disrupts the mitochondrial membrane potential of human breast and cervical cancer cell lines. Food Chem Toxicol 49(4):871–878
Fernandez-Cabezudo MJ, El-Kharrag R, Torab F, Bashir G, George JA, El-Taji H, Al-Ramadi BK (2013) Intravenous administration of manuka honey inhibits tumor growth and improves host survival when used in combination with chemotherapy in a melanoma mouse model. PLoS One 8(2):e55993. https://doi.org/10.1371/journal.pone.0055993
Food Data Central (FDC) (2019) Honey. https://fdc.nal.usda.gov/fdc-app.html#/food-details/169640/nutrients. Accessed 5 Jan 2020
Frankel S, Robinson G, Berenbaum MJJAR (1998) Antioxidant capacity and correlated characteristics of 14 unifloral honeys. J Api Res 37(1):27–31
French VM, Cooper RA, Molan PC (2005) The antibacterial activity of honey against coagulase-negative staphylococci. J Antimicrob Chemother 56(1):228–231. https://doi.org/10.1093/jac/dki193
Gannabathula S, Skinner MA, Rosendale D, Greenwood JM, Mutukumira AN, Steinhorn G, Stephens J, Krissansen GW, Schlothauer RC (2012) Arabinogalactan proteins contribute to the immunostimulatory properties of New Zealand honeys. Immunopharmacol Immunotoxicol 34(4):598–607. https://doi.org/10.3109/08923973.2011.641974
Gharzouli K, Amira S, Gharzouli A, Khennouf S (2002) Gastroprotective effects of honey and glucose-fructose-sucrose-maltose mixture against ethanol-, indomethacin-, and acidified aspirin-induced lesions in the rat. Exp Toxicol Pathol 54(3):217–221. https://doi.org/10.1078/0940-2993-00255
Ghashm AA, Othman NH, Khattak MN, Ismail NM, Saini R (2010) Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines. BMC Complement Altern Med 10:49–49. https://doi.org/10.1186/1472-6882-10-49
Gheldof N, Engeseth NJ (2002) Antioxidant capacity of honeys from various floral sources based on the determination of oxygen radical absorbance capacity and inhibition of in vitro lipoprotein oxidation in human serum samples. J Agric Food Chem 50(10):3050–3055. https://doi.org/10.1021/jf0114637
Gheldof N, Wang XH, Engeseth NJ (2002) Identification and quantification of antioxidant components of honeys from various floral sources. J Agric Food Chem 50(21):5870–5877. https://doi.org/10.1021/jf0256135
Gheldof N, Wang XH, Engeseth NJ (2003) Buckwheat honey increases serum antioxidant capacity in humans. J Agric Food Chem 51(5):1500–1505. https://doi.org/10.1021/jf025897t
Ghosh S, Playford RJ (2003) Bioactive natural compounds for the treatment of gastrointestinal disorders. Clin Sci 104(6):547–556. https://doi.org/10.1042/cs20030067
Grass G, Rensing C, Solioz M (2011) Metallic copper as an antimicrobial surface. Appl Environ Microbiol 77(5):1541. https://doi.org/10.1128/AEM.02766-10
Guerrini A, Bruni R, Maietti S, Poli F, Rossi D, Paganetto G, Muzzoli M, Scalvenzi L, Sacchetti G (2009) Ecuadorian stingless bee (Meliponinae) honey: a chemical and functional profile of an ancient health product. Food Chem 114(4):1413–1420. https://doi.org/10.1016/j.foodchem.2008.11.023
Gürdal M, Yücebas E, Tekin A, Beysel M, Aslan R, Sengör F (2003) Predisposing factors and treatment outcome in Fournier’s gangrene. Analysis of 28 cases. Urol Int 70(4):286–290. https://doi.org/10.1159/000070137
Haffejee IE, Moosa A (1985) Honey in the treatment of infantile gastroenteritis. Br Med J (Clin Res Ed) 290(6485):1866–1867. https://doi.org/10.1136/bmj.290.6485.1866
Hassapidou M, Fotiadou E, Maglara E, Papadopoulou SK (2006) Energy intake, diet composition, energy expenditure, and body fatness of adolescents in northern Greece. Obesity 14(5):855–862. https://doi.org/10.1038/oby.2006.99
Hegazi AG, Abd El-Hady FK (2009) Influence of honey on the suppression of human low density lipoprotein (LDL) peroxidation (in vitro). Evid Based Complement Alternat Med 6(1):113–121. https://doi.org/10.1093/ecam/nem071
Herrick JR, Wang C, Machaty Z (2016) The effects of permeating cryoprotectants on intracellular free-calcium concentrations and developmental potential of in vitro-matured feline oocytes. Reprod Fertil Dev 28(5):599–607. https://doi.org/10.1071/RD14233
Hussein SZ, Mohd Yusoff K, Makpol S, Mohd Yusof YA (2012) Gelam honey inhibits the production of proinflammatory, mediators NO, PGE(2), TNF-alpha, and IL-6 in Carrageenan-induced acute paw edema in rats. Evid Based Complement Alternat Med 2012:109636. https://doi.org/10.1155/2012/109636
Iglesias MT, De Lorenzo C, Del Carmen PM, Martín-Alvarez PJ, Pueyo E (2004) Usefulness of amino acid composition to discriminate between honeydew and floral honeys. Application to honeys from a small geographic area. J Agric Food Chem 52(1):84–89. https://doi.org/10.1021/jf030454q
Inglett GE (1976) A history of sweeteners—natural and synthetic. J Toxicol Environ Health 2(1):207–214. https://doi.org/10.1080/15287397609529427
Islam A, Khalil I, Islam N, Moniruzzaman M, Mottalib A, Sulaiman SA, Gan SH (2012) Physicochemical and antioxidant properties of Bangladeshi honeys stored for more than one year. BMC Complement Altern Med 12:177–177. https://doi.org/10.1186/1472-6882-12-177
Jaganathan SK, Mandal MJJA (2009) Honey constituents and their apoptotic effect in colon cancer cells. J ApiProd ApiMed Sci 1(2):29–36
Jagdish T, Joseph I (2004) Quantification of saccharides in multiple floral honeys using fourier transform infrared microattenuated total reflectance spectroscopy. J Agric Food Chem 52:3237–3243
James HJCUCP (1906) Breasted, Ancient Records of Egypt, vol 2. University of Chicago Press, Chicago, p 80
Jeffrey AE, Echazarreta CM (1996) Medical uses of honey. Rev Biomed 7(1):43–49
Jerez-Ebensperger RA, Luño V, Olaciregui M, González N, de Blas I, Gil L (2015) Effect of pasteurized egg yolk and rosemary honey supplementation on quality of cryopreserved ram semen. Small Ruminant Res 130:153–156. https://doi.org/10.1016/j.smallrumres.2015.07.010
Johnston JE, Sepe HA, Miano CL, Brannan RG, Alderton AL (2005) Honey inhibits lipid oxidation in ready-to-eat ground beef patties. Meat Sci 70(4):627–631. https://doi.org/10.1016/j.meatsci.2005.02.011
Kamaruzaman NA, Sulaiman SA, Kaur G, Yahaya B (2014) Inhalation of honey reduces airway inflammation and histopathological changes in a rabbit model of ovalbumin-induced chronic asthma. BMC Complement Altern Med 14:176–176. https://doi.org/10.1186/1472-6882-14-176
Khalil MI, Sulaiman SA (2010) The potential role of honey and its polyphenols in preventing heart diseases: a review. Afr J Tradit Complement Altern Med 7(4):315–321. https://doi.org/10.4314/ajtcam.v7i4.56693
Khalil MI, Alam N, Moniruzzaman M, Sulaiman SA, Gan SH (2011) Phenolic acid composition and antioxidant properties of Malaysian honeys. J Food Sci 76(6):C921–C928. https://doi.org/10.1111/j.1750-3841.2011.02282.x
Khalil I, Moniruzzaman M, Boukraa L, Benhanifia M, Islam A, Islam N, Sulaiman SA, Gan SH (2012) Physicochemical and antioxidant properties of Algerian honey. Molecules 17(9):11199–11215. https://doi.org/10.3390/molecules170911199
Khan FR, Ul Abadin Z, Rauf N (2007) Honey: nutritional and medicinal value. Int J Clin Pract 61(10):1705–1707. https://doi.org/10.1111/j.1742-1241.2007.01417.x
Khan SU, Anjum SI, Rahman K, Ansari MJ, Khan WU, Kamal S, Khattak B, Muhammad A, Khan HU (2018) Honey: Single food stuff comprises many drugs. Saudi J Biol Sci 25(2):320–325. https://doi.org/10.1016/j.sjbs.2017.08.004
Kilicoglu B, Gencay C, Kismet K, Serin Kilicoglu S, Erguder I, Erel S, Sunay AE, Erdemli E, Durak I, Akkus MA (2008) The ultrastructural research of liver in experimental obstructive jaundice and effect of honey. Am J Surg 195(2):249–256. https://doi.org/10.1016/j.amjsurg.2007.04.011
Korkmaz A, Kolankaya D (2009) Anzer honey prevents N-ethylmaleimide-induced liver damage in rats. Exp Toxicol Pathol 61(4):333–337. https://doi.org/10.1016/j.etp.2008.07.005
Küçük M, Kolaylı S, Karaoğlu Ş, Ulusoy E, Baltacı C, Candan FJFC (2007) Biological activities and chemical composition of three honeys of different types from Anatolia. Food Chem 100(2):526–534
Kumar KS, Bhowmik D, Biswajit C, Chandira M (2010) Medicinal uses and health benefits of honey: an overview. J Chem Pharm Res 2(1):385–395
Kumar PPNV, Shameem U, Kollu P, Kalyani RL, Pammi SVN (2015) Green synthesis of copper oxide nanoparticles using aloe vera leaf extract and its antibacterial activity against fish bacterial pathogens. BioNanoScience 5(3):135–139. https://doi.org/10.1007/s12668-015-0171-z
Kyselova Z (2011) Toxicological aspects of the use of phenolic compounds in disease prevention. Interdiscip Toxicol 4(4):173–183. https://doi.org/10.2478/v10102-011-0027-5
Lachman J, Kolihova D, Miholova D, Košata J, Titěra D, Kult K (2007) Analysis of minority honey components: Possible use for the evaluation of honey quality. Food Chem 101(3):973–979
Lay-flurrie K (2008) Honey in wound care: effects, clinical application and patient benefit. Br J Nurs 17(11):S30–S36. https://doi.org/10.12968/bjon.2008.17.Sup5.29649
Lazarević KB, Andrić F, Trifković J, Tešić Ž, Milojković-Opsenica D (2012) Characterisation of Serbian unifloral honeys according to their physicochemical parameters. Food Chem 132(4):2060–2064. https://doi.org/10.1016/j.foodchem.2011.12.048
Lee D-C, Lee S-Y, Cha S-H, Choi Y-S, Rhee H-I (1998) Discrimination of native bee-honey and foreign bee-honey by SDS-PAGE. Kor J Food Sci Technol 30(1):1–5
Leekumjorn S, Sum AK (2008) Molecular dynamics study on the stabilization of dehydrated lipid bilayers with glucose and trehalose. J Phys Chem B 112(34):10732–10740. https://doi.org/10.1021/jp8025489
Leong AG, Herst PM, Harper JL (2012) Indigenous New Zealand honeys exhibit multiple anti-inflammatory activities. Innate Immun 18(3):459–466
Li Y, Shi W, Li Y, Zhou Y, Hu X, Song C, Ma H, Wang C, Li Y (2008) Neuroprotective effects of chlorogenic acid against apoptosis of PC12 cells induced by methylmercury. Environ Toxicol Pharmacol 26(1):13–21. https://doi.org/10.1016/j.etap.2007.12.008
Lusby PE, Coombes AL, Wilkinson JM (2005) Bactericidal activity of different honeys against pathogenic bacteria. Arch Med Res 36(5):464–467. https://doi.org/10.1016/j.arcmed.2005.03.038
Maeda Y, Loughrey A, Earle JA, Millar BC, Rao JR, Kearns A, McConville O, Goldsmith CE, Rooney PJ, Dooley JS, Lowery CJ, Snelling WJ, McMahon A, McDowell D, Moore JE (2008) Antibacterial activity of honey against community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA). Complement Ther Clin Pract 14(2):77–82. https://doi.org/10.1016/j.ctcp.2007.11.004
Majtán J, Kováčová E, Bíliková K, Šimúth J (2006) The immunostimulatory effect of the recombinant apalbumin 1–major honeybee royal jelly protein–on TNFα release. Int Immunopharmacol 6(2):269–278. https://doi.org/10.1016/j.intimp.2005.08.014
Mandal MD, Mandal S (2011) Honey: its medicinal property and antibacterial activity. Asian Pac J Trop Biomed 1(2):154–160. https://doi.org/10.1016/s2221-1691(11)60016-6
Manyi-Loh CE, Ndip RN, Clarke AM (2011) Volatile compounds in honey: a review on their involvement in aroma, botanical origin determination and potential biomedical activities. Int J Mol Sci 12(12):9514–9532. https://doi.org/10.3390/ijms12129514
Markelov V, Trushin MJNJN (2006) Bee venom therapy and low dose naltrexone for treatment of multiple sclerosis. Nepal J Neurosci 3(2):71–77
Mato I, Huidobro JF, Simal-Lozano J, Sancho MT (2003) Significance of nonaromatic organic acids in honey. J Food Prot 66(12):2371–2376. https://doi.org/10.4315/0362-028x-66.12.2371
McGovern DP, Abbas SZ, Vivian G, Dalton HR (1999) Manuka honey against Helicobacter pylori. J R Soc Med 92(8):439–439. https://doi.org/10.1177/014107689909200832
Meda A, Lamien CE, Millogo J, Romito M, Nacoulma OG (2004) Therapeutic uses of honey and honeybee larvae in central Burkina Faso. J Ethnopharmacol 95(1):103–107. https://doi.org/10.1016/j.jep.2004.06.016
Medhi B, Puri A, Upadhyay S, Kaman L (2008) Topical application of honey in the treatment of wound healing: a metaanalysis. JK Sci 10(4):166–169
Mijanur Rahman M, Gan SH, Khalil MI (2014) Neurological effects of honey: current and future prospects. Evid Based Complement Alternat Med 2014:13. https://doi.org/10.1155/2014/958721
Mitchell EAD, Mulhauser B, Mulot M, Mutabazi A, Glauser G, Aebi A (2017) A worldwide survey of neonicotinoids in honey. Science 358(6359):109–111. https://doi.org/10.1126/science.aan3684
Molan PC (1999) Why honey is effective as a medicine. 1. Its use in modern medicine. Bee World 80(2):80–92
Molan PC (2001a) Potential of honey in the treatment of wounds and burns. Am J Clin Dermatol 2(1):13–19. https://doi.org/10.2165/00128071-200102010-00003
Molan PC (2001b) The potential of honey to promote oral wellness. Gen Dent 49(6):584–589
Molan PJBW (2001c) Why honey is effective as a medicine: 2. The scientific explanation of its effects. Bee World 82(1):22–40
Molan PJBETRS (2002) Not all honeys are the same for wound healing. Bull Eur Tissue Rep Soc 9:5–6
Molan PC, Allen KL (1996) The effect of gamma-irradiation on the antibacterial activity of honey. J Pharm Pharmacol 48(11):1206–1209. https://doi.org/10.1111/j.2042-7158.1996.tb03922.x
Motallebnejad M, Akram S, Moghadamnia A, Moulana Z, Omidi S (2008) The effect of topical application of pure honey on radiation-induced mucositis: a randomized clinical trial. J Contemp Dent Pract 9(3):40–47
Moundoi M, Padila-Zakour O, Worobo R (2001) Antimicrobial activity of honey against food pathogens and food spoilage microorganisms. NYSAES 1:61–71
Mullin CA, Frazier M, Frazier JL, Ashcraft S, Simonds R, Vanengelsdorp D, Pettis JS (2010) High levels of miticides and agrochemicals in North American apiaries: implications for honey bee health. PLoS One 5(3):e9754. https://doi.org/10.1371/journal.pone.0009754
Murosak S, Muroyama K, Yamamoto Y, Liu T, Yoshikai Y (2002) Nigerooligosaccharides augments natural killer activity of hepatic mononuclear cells in mice. Int Immunopharmacol 2(1):151–159. https://doi.org/10.1016/s1567-5769(01)00152-7
Najafi M, Mahdizadeh AE, Rafiei F, Eteraf OT (2008) Effects of pharmacologic preconditioning by natural honey on arrhythmias and infarct size in isolated heart. Pharmaceut Sci 4:1–11
Najafi M, Shaseb E, Ghaffary S, Fakhrju A, Eteraf Oskouei T (2011) Effects of chronic oral administration of natural honey on ischemia/reperfusion-induced arrhythmias in isolated rat heart. Iran J Basic Med Sci 14(1):75–81
Nasuti C, Gabbianelli R, Falcioni G, Cantalamessa F (2006) Antioxidative and gastroprotective activities of anti-inflammatory formulations derived from chestnut honey in rats. Nutr Res 26(3):130–137
Natarajan S, Williamson D, Grey J, Harding KG, Cooper RA (2001) Healing of an MRSA-colonized, hydroxyurea-induced leg ulcer with honey. J Dermatolog Treat 12(1):33–36. https://doi.org/10.1080/095466301750163563
Newman T (1983) Honey Almanac, vol 1. Newman, Chicago, IL, p 983
Nicholson DWJN (2000) From bench to clinic with apoptosis-based therapeutic agents. Nature 407(6805):810
Nurul Syazana MS, Gan SH, Halim AS, Shah NSM, Gan SH, Sukari HA (2012) Analysis of volatile compounds of Malaysian Tualang (Koompassia excelsa) honey using gas chromatography mass spectrometry. Afr J Tradit Complement Altern Med 10(2):180–188. https://doi.org/10.4314/ajtcam.v10i2.2
Obaseiki-Ebor EE, Afonya TC (1984) In-vitro evaluation of the anticandidiasis activity of honey distillate (HY-1) compared with that of some antimycotic agents. J Pharm Pharmacol 36(4):283–284. https://doi.org/10.1111/j.2042-7158.1984.tb04373.x
Obi CL, Ugoji EO, Edun SA, Lawal SF, Anyiwo CE (1994) The antibacterial effect of honey on diarrhoea causing bacterial agents isolated in Lagos, Nigeria. Afr J Med Med Sci 23(3):257–260
Olaitan PB, Adeleke OE, Ola IO (2007) Honey: a reservoir for microorganisms and an inhibitory agent for microbes. Afr Health Sci 7(3):159–165. https://doi.org/10.5555/afhs.2007.7.3.159
Oskuee RK, Banikamali A, Bazzaz BSF, Hosseini HA, Darroudi M (2016) Honey-based and ultrasonic-assisted synthesis of silver nanoparticles and their antibacterial activities. J Nanosci Nanotechnol 16(8):7989–7993. https://doi.org/10.1166/jnn.2016.13031
Oyefuga O, Ajani E, Salau B, Agboola F, Adebawo O (2012) Honey consumption and its anti-ageing potency in white Wister albino rats. Sch J Biol Sci 1(2):15–19
Pasupuleti VR, Sammugam L, Ramesh N, Gan SH (2017) Honey, propolis, and royal jelly: a comprehensive review of their biological actions and health benefits. Oxid Med Cell Longev 2017:1259510–1259510. https://doi.org/10.1155/2017/1259510
Pataca LC, Borges Neto W, Marcucci MC, Poppi RJ (2007) Determination of apparent reducing sugars, moisture and acidity in honey by attenuated total reflectance-Fourier transform infrared spectrometry. Talanta 71(5):1926–1931. https://doi.org/10.1016/j.talanta.2006.08.028
Patton T, Barrett J, Brennan J, Moran N (2006) Use of a spectrophotometric bioassay for determination of microbial sensitivity to manuka honey. J Microbiol Methods 64(1):84–95. https://doi.org/10.1016/j.mimet.2005.04.007
Petrus K, Schwartz H, Sontag G (2011) Analysis of flavonoids in honey by HPLC coupled with coulometric electrode array detection and electrospray ionization mass spectrometry. Anal Bioanal Chem 400(8):2555–2563. https://doi.org/10.1007/s00216-010-4614-7
Rakha MK, Nabil ZI, Hussein AA (2008) Cardioactive and vasoactive effects of natural wild honey against cardiac malperformance induced by hyperadrenergic activity. J Med Food 11(1):91–98. https://doi.org/10.1089/jmf.2006.172
Rashed M, Soltan M (2004) Major and trace elements in different types of Egyptian mono-floral and non-floral bee honeys. J Food Compos Anal 17(6):725–735
Sakai DK (1987) Adhesion of Aeromonas salmonicida strains associated with net electrostatic charges of host tissue cells. Infect Immun 55(3):704–710
Salata OV (2004) Applications of nanoparticles in biology and medicine. J Nanobiotechnol 2(1):3. https://doi.org/10.1186/1477-3155-2-3
Samanta A, Burden AC, Jones GR (1985) Plasma glucose responses to glucose, sucrose, and honey in patients with diabetes mellitus: an analysis of glycaemic and peak incremental indices. Diabet Med 2(5):371–373. https://doi.org/10.1111/j.1464-5491.1985.tb00654.x
Samarghandian S, Afshari JT, Davoodi S (2010) Modulation of programmed cell death by honey bee in human prostate adenocarcinoma. J Med Plant Res 4(23):2551–2556
Samarghandian S, Afshari JT, Davoodi S (2011a) Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3. Clinics (Sao Paulo) 66(6):1073–1079. https://doi.org/10.1590/s1807-59322011000600026
Samarghandian S, Afshari JT, Davoodi S (2011b) Honey induces apoptosis in renal cell carcinoma. Pharmacogn Mag 7(25):46–52. https://doi.org/10.4103/0973-1296.75901
Samarghandian S, Nezhad MA, Mohammadi G (2014a) Role of caspases, Bax and Bcl-2 in chrysin-induced apoptosis in the A549 human lung adenocarcinoma epithelial cells. Anticancer Agents Med Chem 14(6):901–909. https://doi.org/10.2174/1871520614666140209144042
Samarghandian S, Samini F, Taghavi M (2014b) Antiproliferative and cytotoxic properties of honey in human prostate cancer cell line (PC-3): possible mechanism of cell growth inhibition and apoptosis induction African. J Pharm Pharmacol 8(1):9–15
Samarghandian S, Farkhondeh T, Samini F (2017) Honey and health: a review of recent clinical research. Pharm Res 9(2):121–127. https://doi.org/10.4103/0974-8490.204647
Sanz ML, Polemis N, Morales V, Corzo N, Drakoularakou A, Gibson GR, Rastall RA (2005) In vitro investigation into the potential prebiotic activity of honey oligosaccharides. J Agric Food Chem 53(8):2914–2921. https://doi.org/10.1021/jf0500684
Sarmadi F, Kazemi P, Tirgar P, Fayazi S, Esfandiari S, Sotoodeh L, Molaeian S, Dashtizad M (2019) Using natural honey as an anti-oxidant and thermodynamically efficient cryoprotectant in embryo vitrification. Cryobiology 91:30–39. https://doi.org/10.1016/j.cryobiol.2019.11.001
Sato T, Miyata G (2000) The nutraceutical benefit, part iii: honey. Nutrition 16(6):468–469. https://doi.org/10.1016/s0899-9007(00)00271-9
Schmitt-Schillig S, Schaffer S, Weber CC, Eckert GP, Müller WE (2005) Flavonoids and the aging brain. J Physiol Pharmacol 56(Suppl 1):23–36
Schramm DD, Karim M, Schrader HR, Holt RR, Cardetti M, Keen CL (2003) Honey with high levels of antioxidants can provide protection to healthy human subjects. J Agric Food Chem 51(6):1732–1735
Sela MO, Shapira L, Grizim I, Lewinstein I, Steinberg D, Gedalia I, Grobler SR (1998) Effects of honey consumption on enamel microhardness in normal versus xerostomic patients. J Oral Rehabil 25(8):630–634. https://doi.org/10.1046/j.1365-2842.1998.00274.x
Shenoy R, Bialasiewicz A, Khandekar R, Al Barwani B, Al Belushi H (2009) Traditional medicine in oman: its role in ophthalmology. Middle East Afr J Ophthalmol 16(2):92–96. https://doi.org/10.4103/0974-9233.53869
Shimazawa M, Chikamatsu S, Morimoto N, Mishima S, Nagai H, Hara H (2005) Neuroprotection by Brazilian Green Propolis against in vitro and in vivo ischemic neuronal damage. Evid Based Complement Alternat Med 2(2):201–207. https://doi.org/10.1093/ecam/neh078
Shin H-S, Ustunol ZJ (2005) Carbohydrate composition of honey from different floral sources and their influence on growth of selected intestinal bacteria: an in vitro comparison. Food Res Int 38(6):721–728
Siddiqui I, Furgala B (1967) Isolation and characterization of oligosaccharides from honey. Part I. Disaccharides. J Apicult Res 6(3):139–145
Sierra-Ávila R, Pérez-Alvarez M, Cadenas-Pliego G, Padilla VC, Orta CA, Pérez Camacho O, Jiménez-Regalado E et al (2015) Synthesis of copper nanoparticles using mixture of allylamine and polyallylamine. J Nanomater 2015:9. https://doi.org/10.1155/2015/367341
Simon A, Traynor K, Santos K, Blaser G, Bode U, Molan P (2009) Medical honey for wound care—still the ‘latest resort’? Evid Based Complement Altern Med 6(2):165–173. https://doi.org/10.1093/ecam/nem175
Snowdon JA, Cliver DO (1996) Microorganisms in honey. Int J Food Microbiol 31(1-3):1–26. https://doi.org/10.1016/0168-1605(96)00970-1
Souza Tette PA, Rocha Guidi L, de Abreu Glória MB, Fernandes C (2016) Pesticides in honey: a review on chromatographic analytical methods. Talanta 149:124–141. https://doi.org/10.1016/j.talanta.2015.11.045
Subrahmanyam M (1991) Topical application of honey in treatment of burns. Br J Surg 78(4):497–498. https://doi.org/10.1002/bjs.1800780435
Subrahmanyam M (1993) Storage of skin grafts in honey. Lancet 341(8836):63–64. https://doi.org/10.1016/0140-6736(93)92547-7
Swellam T, Miyanaga N, Onozawa M, Hattori K, Kawai K, Shimazui T, Akaza H (2003) Antineoplastic activity of honey in an experimental bladder cancer implantation model: in vivo and in vitro studies. Int J Urol 10(4):213–219. https://doi.org/10.1046/j.0919-8172.2003.00602.x
Tallett S, MacKenzie C, Middleton P, Kerzner B, Hamilton R (1977) Clinical, laboratory, and epidemiologic features of a viral gastroenteritis in infants and children. Pediatrics 60(2):217–222
Telles S, Puthige R, Kalkuni Visweswaraiah N (2007) An ayurvedic basis for using honey to treat herpes. Med Sci Monit 13(11):LE17–LE17
Timm M, Bartelt S, Hansen EW (2008a) Immunomodulatory effects of honey cannot be distinguished from endotoxin. Cytokine 42(1):113–120. https://doi.org/10.1016/j.cyto.2008.01.005
Timm M, Bartelt S, Hansen EW (2008b) Immunomodulatory effects of honey cannot be distinguished from endotoxin. Cytokine 42(1):113–120. https://doi.org/10.1016/j.cyto.2008.01.005
Tomasin R, Gomes-Marcondes MC (2011) Oral administration of Aloe vera and honey reduces Walker tumour growth by decreasing cell proliferation and increasing apoptosis in tumour tissue. Phytother Res 25(4):619–623. https://doi.org/10.1002/ptr.3293
Tonks A, Cooper RA, Price AJ, Molan PC, Jones KP (2001a) Stimulation of TNF-alpha release in monocytes by honey. Cytokine 14(4):240–242. https://doi.org/10.1006/cyto.2001.0868
Tonks A, Cooper RA, Price AJ, Molan PC, Jones KP (2001b) Stimulation of TNF-α release in monocytes by honey. Cytokine 14(4):240–242. https://doi.org/10.1006/cyto.2001.0868
Tonks AJ, Cooper RA, Jones KP, Blair S, Parton J, Tonks A (2003) Honey stimulates inflammatory cytokine production from monocytes. Cytokine 21(5):242–247. https://doi.org/10.1016/s1043-4666(03)00092-9
Topham J (2002) Why do some cavity wounds treated with honey or sugar paste heal without scarring? J Wound Care 11(2):53–55. https://doi.org/10.12968/jowc.2002.11.2.26372
Turkmen N, Sari F, Poyrazoglu ES, Velioglu YS (2006) Effects of prolonged heating on antioxidant activity and colour of honey. Food Chem 95(4):653–657
Van der Weyden EA (2003) The use of honey for the treatment of two patients with pressure ulcers. Br J Community Nurs 8(12):S14–S20. https://doi.org/10.12968/bjcn.2003.8.Sup6.12553
van der Weyden EA (2005) Treatment of a venous leg ulcer with a honey alginate dressing. Br J Community Nurs Suppl:S21–S27. https://doi.org/10.12968/bjcn.2005.10.sup2.18175
Venu R, Ramulu TS, Anandakumar S, Rani VS, Kim CG (2011) Bio-directed synthesis of platinum nanoparticles using aqueous honey solutions and their catalytic applications. Colloids Surf A Physicochem Eng Asp 384(1):733–738. https://doi.org/10.1016/j.colsurfa.2011.05.045
Vinson JA, Hao Y, Su X, Zubik LJ (1998) Phenol antioxidant quantity and quality in foods: vegetables. J Agric Food Chem 46(9):3630–3634
Viuda-Martos M, Ruiz-Navajas Y, Fernandez-Lopez J, Perez-Alvarez JA (2008) Functional properties of honey, propolis, and royal jelly. J Food Sci 73(9):R117–R124. https://doi.org/10.1111/j.1750-3841.2008.00966.x
Vorlova L, Pridal A (2002) Invertase and diastase activity in honeys of Czech provenience. Acta univ agric et silvic Mendel Brun 5:57–66
Wang P, Wang X, Wang L, Hou X, Liu W, Chen C (2015) Interaction of gold nanoparticles with proteins and cells. Sci Technol Adv Mater 16(3):034610. https://doi.org/10.1088/1468-6996/16/3/034610
White J, Crane E (1975) Honey a comprehensive survey. by Eva Crane, Morrison and Gibb: 194-206
White JW Jr (1962) Composition of American Honeys, vol 1261. US Department of Agriculture, Washington, DC
White JW Jr (1980) Detection of honey adulteration by carbohydrage analysis. J Assoc Off Anal Chem 63(1):11–18
Wilkinson JM, Cavanagh HM (2005) Antibacterial activity of 13 honeys against Escherichia coli and Pseudomonas aeruginosa. J Med Food 8(1):100–103. https://doi.org/10.1089/jmf.2005.8.100
Won S-R, Li C-Y, Kim J-W, Rhee H-I (2009) Immunological characterization of honey major protein and its application. Food Chem 113(4):1334–1338
Yaacob NS, Nengsih A, Norazmi MN (2013) Tualang honey promotes apoptotic cell death induced by tamoxifen in breast cancer cell lines. Evid Based Complement Alternat Med 2013:989841–989841. https://doi.org/10.1155/2013/989841
Yaghoobi N, Al-Waili N, Ghayour-Mobarhan M, Parizadeh S, Abasalti Z, Yaghoobi Z, Yaghoobi F, Esmaeili H, Kazemi-Bajestani S, Aghasizadeh R (2008) Natural honey and cardiovascular risk factors; effects on blood glucose, cholesterol, triacylglycerole, CRP, and body weight compared with sucrose. Scientific World Journal 8:463–469
Yao L, Datta N, Tomás-Barberán FA, Ferreres F, Martos I, Singanusong RJFC (2003) Flavonoids, phenolic acids and abscisic acid in Australian and New Zealand Leptospermum honeys. Food Chem 81(2):159–168
Yapucu Güneş U, Eşer I (2007) Effectiveness of a honey dressing for healing pressure ulcers. J Wound Ostomy Continence Nurs 34(2):184–190. https://doi.org/10.1097/01.WON.0000264833.11108.35
Zaid SS, Sulaiman SA, Sirajudeen KN, Othman NH (2010) The effects of Tualang honey on female reproductive organs, tibia bone and hormonal profile in ovariectomised rats--animal model for menopause. BMC Complement Altern Med 10:82. https://doi.org/10.1186/1472-6882-10-82
Zalibera M, Staško A, Šlebodová A, Jančovičová V, Čermáková T, Brezová V (2008) Antioxidant and radical-scavenging activities of Slovak honeys—an electron paramagnetic resonance study. Food Chem 110(2):512–521. https://doi.org/10.1016/j.foodchem.2008.02.015
Zand RS, Jenkins DJ, Diamandis EP (2000) Steroid hormone activity of flavonoids and related compounds. Breast Cancer Res Treat 62(1):35–49. https://doi.org/10.1023/a:1006422302173
Zumla A, Lulat A (1989) Honey—a remedy rediscovered. J R Soc Med 82(7):384–385
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Ahluwalia, M., Ahluwalia, P., Dhandapani, K.M., Vaibhav, K. (2020). Honey: A Sweet Way to Health. In: Rehman, M.U., Majid, S. (eds) Therapeutic Applications of Honey and its Phytochemicals . Springer, Singapore. https://doi.org/10.1007/978-981-15-6799-5_4
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