SNP in Forensic DNA Testing
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Single nucleotide polymorphisms (SNPs) are the most common mutations found in humans and are special molecular signatures providing intricate information pertaining to human migration patterns, ancestral history, and predisposition to diseases. In present modern forensic era, SNPs in the human populations are being used by investigative agencies across the world as productive and sometimes definitive evidence in solving cases especially pertaining to suspect/victim identification or establishing relatedness. In the present book chapter, we have provided a comprehensive account of the use of SNPs in forensic sciences. We have explained the various conventional and most modern cutting edge strategies and approaches of typing SNPs. Most importantly we have detailed the numerous applications of SNP genotyping in DNA forensics including disaster victim identification, suspect identification at the crime scene, and establishing precisely the disputes related to paternity. We have also included a few landmark case-studies which used SNP typing to reach conclusive verdict.
KeywordsSNP Genotyping NGS Kinship-analysis
- Dixon LA, Dobbins AE, Pulker HK, Butler JM, Vallone PM, Coble MD, Parson W, Berger B, Grubwieser P, Mogensen HS, Morling N, Nielsen K, Sanchez JJ, Petkovski E, Carracedo A, Sanchez-Diz P, Ramos-Luis E, Briōn M, Irwin JA, Just RS, Loreille O, Parsons TJ, Syndercombe-Court D, Schmitter H, Stradmann-Bellinghausen B, Bender K, Gill P (2006) Analysis of artificially degraded DNA using STRs and SNPs—results of a collaborative European (EDNAP) exercise. Forensic Sci Int 164:33–44CrossRefGoogle Scholar
- Nassir R, Kosoy R, Tian C, White PA, Butler LM, Silva G, Kittles R, Alarcon-Riquelme ME, Gregersen PK, Belmont JW, De La Vega FM, Seldin MF (2009) An ancestry informative marker set for determining continental origin: validation and extension using human genome diversity panels. BMC Genet 10:39CrossRefGoogle Scholar