Abstract
Biological chemiluminescence or biochemiluminescence (BL-CL) is one of the most sensitive strategies for improving the analytical performance of bioassays, allowing measurements of target analyte in 10−18 to 10−21 molar range. BL-CL is produced through enzymatic reaction via the conversion of chemical energy into light inside a living organism without the need for an excitation source. In a normal BL-CL reaction, luciferase catalyzes the oxidation of the substrate. Expectedly, the combination of BL-CL with bio-microelectromechanical systems (BioMEMS) would grant a compact, sensitive, and portable device that operates on very small sample volumes. This chapter provides a thorough review of the latest advancements of BioMEMS that operate based on the principle of BL-CL detection. A detailed comparison between the fabrication and operation of these devices along with the advantages and disadvantages of each technique are also included in this chapter.
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References
Davies R, Bartholomeusz DA, Andrade J (2003) Personal sensors for the diagnosis and management of metabolic disorders. IEEE Eng Med Biol Mag 22(1):32–42. https://doi.org/10.1109/MEMB.2003.1191447
Measuring method, cartridge for measurement, and measuring device, July 2013
Microfluidic chip for biological chemiluminescence detection and detection method thereof, May 2012
Roda A, Pasini P, Mirasoli M, Michelini E, Guardigli M (2004) Biotechnological applications of bioluminescence and chemiluminescence. Trends Biotechnol 22(6):295–303. https://doi.org/10.1016/J.TIBTECH.2004.03.011
Roda A, Michelini E, Cevenini L, Calabria D, Calabretta MM, Simoni P (2014) Integrating biochemiluminescence detection on smartphones: Mobile chemistry platform for point-of-need analysis. Anal Chem 86(15):7299–7304. https://doi.org/10.1021/ac502137s
Shahvar A, Saraji M, Shamsaei D (2018) Smartphone-based chemiluminescence sensing for TLC imaging. Sens Actuat B Chem 255:891–894. https://doi.org/10.1016/j.snb.2017.08.144
Wild D (2013) The immunoassay handbook: theory and applications of ligand binding. ELISA—Google Libros
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Cerda-Kipper, A.S., Hosseini, S. (2021). Bio-microelectromechanical Systems (BioMEMS) in Bio-sensing Applications-Biochemiluminescence Detection Strategies . In: BioMEMS. Lecture Notes in Bioengineering. Springer, Singapore. https://doi.org/10.1007/978-981-15-6382-9_7
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DOI: https://doi.org/10.1007/978-981-15-6382-9_7
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