Skip to main content

Improving Human Health: Challenges and Methodology for Controlling Thermal Doses During Cancer Therapeutic Treatment

  • 550 Accesses

Part of the Lecture Notes in Electrical Engineering book series (LNEE,volume 681)


Controlled thermal ablation in order to maximize the therapy and minimize the side effects poses a challenge during the heating of the biological tissue. Traditionally, these processes are modelled by the bio heat equation introduced by Pennes, who used the Fourier’s theory of heat conduction. During my talk I will present our automated thermal dose control and prediction system for cancer tumors therapy by using Implantable Bio-chip solution. The proposed system is able to control thermal ablation doses deposition during a laser surgery/cancer treatment. A system would help physicians to predict thermal diffusion to organize the treatment as well as maximize therapeutic effects while minimizing side effects. An innovative approach is proposed to improve the quality of thermal treatments in oncology. A biochip platform will be investigated, designed, and prototyped on an FPGA board. The destruction of tumors using a heating source has been widely used as an efficient approach for cancer treatment, where the oncologists use a heating source to destroy the targeted tumoral tissue. A case study of the Laser Interstitial Thermal Therapy (LITT) will demonstrate his feasibility as Cancer therapeutic treatment. Furthermore, our Dosimetry Framework of the Bio-heat Transfer for Laser/Cancer Treatment will be introduced. This would provide a precise idea of the predicted reaction depending on selected doses, tissue geometry, and the laser source prior to the treatment; so new treatment strategies can be proposed and evaluated.


  • Real-time monitoring
  • Thermal ablation
  • Cancer tumor
  • FPGA
  • FDM
  • Laser Interstitial Thermal Therapy
  • Thermal damage
  • Brain cancer
  • Bio heat transfer simulation
  • Thermal sensor
  • Minimally invasive surgery
  • Robotic surgical assistants
  • Robotic arm
  • Raspberry Pi B+

This is a preview of subscription content, access via your institution.

Buying options

USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-981-15-6259-4_2
  • Chapter length: 17 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
USD   229.00
Price excludes VAT (USA)
  • ISBN: 978-981-15-6259-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   299.99
Price excludes VAT (USA)
Hardcover Book
USD   299.99
Price excludes VAT (USA)
Fig. 1.
Fig. 2.
Fig. 3.
Fig. 4.
Fig. 5.
Fig. 6.
Fig. 7.
Fig. 8.
Fig. 9.
Fig. 10.
Fig. 11.
Fig. 12.


  1. Singh S, Melnik R (2020) Thermal ablation of biological tissues in disease treatment: a review of computational models and future directions. Electromagn Biol Med 39:1–40

    Google Scholar 

  2. Andreozzi A, Brunese L, Iasiello M, Tucci C, Vanoli GP (2019) Modeling heat transfer in tumors: a review of thermal therapies. Ann Biomed Eng 47(3):676–693

    CrossRef  Google Scholar 

  3. Gas P, Wyszkowska J (2019) Influence of multi-tine electrode configuration in realistic hepatic RF ablative heating. Arch Electr Eng 68(3):521–533

    Google Scholar 

  4. Huang H-W, Liauh C-T (2012) Review: Therapeutical applications of heat in cancer therapy. J Med Biol Eng 32(1):1–10

    CrossRef  Google Scholar 

  5. Mellal I, Oukaira A, Kengene E, Lakhssassi A (2017) Thermal therapy modalities for cancer treatment: a review and future perspectives. Int J Appl Sci Res Rev 4(2):14

    Google Scholar 

  6. Dewhirst MW, Viglianti BL, Lora-Michiels M, Hanson M, Hoopes PJ (2003) Basic principles of thermal dosimetry and thermal thresholds for tissue damage from hyperthermia. Int J Hyperth Off J Eur Soc Hyperth Oncol North Am Hyperth Group 19(3):267–294

    CrossRef  Google Scholar 

  7. Habash RW, Bansal R, Krewski D, Alhafid HT (2006) Thermal therapy, part 2: hyperthermia techniques. Critical Rev Biomed Eng 34(6):491–542

    Google Scholar 

  8. Kabil J, Belguerras L, Trattnig S, Pasquier C, Felblinger J, Missoffe A (2016) A review of numerical simulation and analytical modeling for medical devices safety in MRI. IMIA Yearbook:152–158

    Google Scholar 

  9. Rhoon GCV, Paulides MM, Holthe JMLV, Franckena M (2016) Hyperthermia by electromagnetic fields to enhanced clinical results in oncology. In: 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 16–20 August 2016, pp 359–362.

  10. Pennes HH (1948) Analysis of tissue and arterial blood temperatures in the resting human forearm. J Appl Physiol 1(2):93–122

    CrossRef  Google Scholar 

  11. Lakhssassi A, Kengne E, Semmaoui H (2010) Modifed pennes’ equation modelling bio-heat transfer in living tissues: analytical and numerical analysis. Natural Sci 2(12):1375

    CrossRef  Google Scholar 

  12. Wissler EH (1998) Pennes’ 1948 paper revisited. J Appl Physiol 85(1):35–41

    CrossRef  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Ahmed Lakhssassi .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 2021 Springer Nature Singapore Pte Ltd.

About this paper

Verify currency and authenticity via CrossMark

Cite this paper

Lakhssassi, A., Mellal, I., Nour, M., Fouzar, Y., Bougataya, M., Kengne, E. (2021). Improving Human Health: Challenges and Methodology for Controlling Thermal Doses During Cancer Therapeutic Treatment. In: Hajji, B., Mellit, A., Marco Tina, G., Rabhi, A., Launay, J., Naimi, S. (eds) Proceedings of the 2nd International Conference on Electronic Engineering and Renewable Energy Systems. ICEERE 2020. Lecture Notes in Electrical Engineering, vol 681. Springer, Singapore.

Download citation

  • DOI:

  • Published:

  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-15-6258-7

  • Online ISBN: 978-981-15-6259-4

  • eBook Packages: EnergyEnergy (R0)