Abstract
There has been a major shift in how multidimensional LC is perceived in the last few years. Many more analysts are aware of 2DLC, but it is still not a routine technique. More attention to robustness and method development strategies is still required, but 2D-LC is no longer a technique that suffers from solvent-compatibility, cumbersome method development, and reduced detection sensitivity. Instead, it is a rapidly maturing technique with clear applications in academia and industry. But how can we move it forward and what might the future hold? In this chapter we will discuss some of the answers to these questions.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Eeltink S, Dolman S, Detobel F, Desmet G, Swart R, Ursem M (2009) 1 mm ID poly(styrene-co-divinylbenzene) monolithic columns for high-peak capacity one- and two-dimensional liquid chromatographic separations of intact proteins. J Sep Sci 32(15–16):2504–2509
Jones OAH, Spencer MJS (2018) A simplified method for the 3D printing of molecular models for chemical education. J Chem Educ 95(1):88–96
Kimura H, Tanigawa T, Morisaka H, Ikegami T, Hosoya K, Ishizuka N, Minakuchi H, Nakanishi K, Ueda M, Cabrera K, Tanaka N (2004) Simple 2D-HPLC using a monolithic silica column for peptide separation. J Sep Sci 27(10–11):897–904
Pirok BWJ, Gargano AFG, Schoenmakers PJ (2018) Optimizing separations in online comprehensive two-dimensional liquid chromatography. J Sep Sci 41(1):68–98
Wouters B, Davydova E, Wouters S, Vivo-Truyols G, Schoenmakers PJ, Eeltink S (2015) Towards ultra-high peak capacities and peak-production rates using spatial three-dimensional liquid chromatography. Lab Chip 15(23):4415–4422
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2020 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Jones, O. (2020). Conclusions and Future Developments. In: Two-Dimensional Liquid Chromatography. SpringerBriefs in Molecular Science. Springer, Singapore. https://doi.org/10.1007/978-981-15-6190-0_7
Download citation
DOI: https://doi.org/10.1007/978-981-15-6190-0_7
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-15-6189-4
Online ISBN: 978-981-15-6190-0
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)