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Lipopolysaccharide-Binding Protein and Bactericidal/Permeability-Increasing Protein in Lipid Metabolism and Cardiovascular Diseases

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Lipid Transfer in Lipoprotein Metabolism and Cardiovascular Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1276))

Abstract

Lipopolysaccharide-binding protein (LBP) and bactericidal/permeability-increasing protein (BPI) are the main members of BPI-like family based on the similar protein structure and conserved gene homology. Both LBP and BPI participate in lipid metabolism and thereby involve in pathogenesis of certain cardiovascular diseases. This chapter describes four aspects: (1) the loci of BPI and LBP in genome, (2) the characteristics of the cDNAs and expression patterns of LBP and BPI, (3) the structures and functions of LBP and BPI, and (4) the LBP and BPI in lipid metabolism and cardiovascular research.

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Abbreviations

BPI:

Bactericidal/permeability-increasing protein

CAD:

Coronary artery disease

CETP:

Cholesteryl ester transfer protein

LBP:

Lipopolysaccharide-binding protein

PLTP:

Phospholipid transfer protein

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Authors and Affiliations

  1. Institute of Atherosclerosis, Shandong First Medical University, Shandong, China

    Yang Yu & Guohua Song

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  1. Yang Yu
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  2. Guohua Song
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  1. Department of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA

    Xian-Cheng Jiang

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Yu, Y., Song, G. (2020). Lipopolysaccharide-Binding Protein and Bactericidal/Permeability-Increasing Protein in Lipid Metabolism and Cardiovascular Diseases. In: Jiang, XC. (eds) Lipid Transfer in Lipoprotein Metabolism and Cardiovascular Disease. Advances in Experimental Medicine and Biology, vol 1276. Springer, Singapore. https://doi.org/10.1007/978-981-15-6082-8_3

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