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Effect of Natural Products on Improvement of Blood Pathophysiology for Management of Sickle Cell Anemia

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Botanical Leads for Drug Discovery

Abstract

Sickle cell anemia (SCA) is an inherited disorder in the β-globin chain of hemoglobin that affects millions of people around the world, especially children. This disease prevalently occurs in some Mediterranean and Saharan Africa. For the treatment of SCA patients, a wide range of drugs have been explored by targeting antisickling activity, γ-globulin induction, antiplatelet effect, etc., but hardly a few drugs have shown potential to combat with this complex disease phenomenon. In spite of unprecedented advances in modern system of medicine, people in the disease-prone area have been taking traditional medicinal plants or plant-derived products to increase the life span of patients. Moreover, numerous clinical trials have been going on for the use of natural products under the purview of symptomatic management of SCA. This chapter is focused on the effect of natural products in pure form or characterized phytoconstituents on particularly inhibition of hemoglobin polymerization. This summarized information will be beneficial for further exploration of new therapeutics in the treatment arena of SCA.

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Abbreviations

SCA:

Sickle cell anemia

SCD:

Sickle cell disease

WHO:

World Health Organization

HbS:

Sickle hemoglobin

RBC:

Red blood cell

HbF:

Fetal hemoglobin

USFDA:

United States Food and Drug Administration

P-selectin:

Pan selectin

NO:

Nitric oxide

NAD:

Nicotinamide adenine dinucleotide

MDA:

Malondialdehyde

References

  • Abdulmalik O, Ghatge MS, Musayev FN, Parikh A, Chen Q, Yang J, Nnamani I, Eseonu RDDN, Asakura T, Abraham DJ, Venitzc J, Safo K (2011) Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin. Acta Crystallogr 67:920–928

    CAS  Google Scholar 

  • Abraham DJ, Mehanna AS, Wireko FC, Whitney J, Thomas RP, Orringer EP (1991) Vanillin, a potential agent for the treatment of sickle cell anemia. Blood 77:1334–1341

    Article  CAS  PubMed  Google Scholar 

  • Akojie FO, Fung LW (1992) Antisickling activity of hydroxybenzoic acids in Cajanus cajan. Planta Med 58:317–320

    Article  CAS  PubMed  Google Scholar 

  • Ameh SJ, Tarfa FD, Ebeshi BU (2012) Traditional herbal management of sickle cell anemia: lessons from Nigeria. Anemia 2012:1–9

    Article  Google Scholar 

  • Ataga KI, Stocker J (2009) Senicapoc (ICA-17043): a potential therapy for the prevention and treatment of hemolysis-associated complications in sickle cell anemia. Expert Opin Investig Drugs 18:231–239

    Article  CAS  PubMed  Google Scholar 

  • Ataga KI, Kutlar A, Kanter J, Liles D, Cancado R, Friedrisch J, Guthrie TH, Madden JK, Alvarez OA, Gordeuk VR, Gualandro S, Colella MP (2017) Crizanlizumab for the prevention of pain crises in sickle cell disease. N Engl J Med 376:429–439

    Article  CAS  PubMed  Google Scholar 

  • Badawy SM (2016) Prasugrel for sickle cell vaso-occlusive events. N Engl J Med 375:185

    Article  PubMed  Google Scholar 

  • Badria FA, Ibrahim AS, Badria AF, Elmarakby AA (2015) Curcumin attenuates iron accumulation and oxidative stress in the liver and spleen of chronic iron-overloaded rats. PLoS One 10:1–13

    Article  CAS  Google Scholar 

  • Basonbul AA (2016) Approaches to reverse red cell sickling. D. phil. thesis, University of Alberta

    Google Scholar 

  • Brousseau DC, Scott JP, Badaki-Makun O, Darbari DS, Chumpitazi CE, Airewele GE, Ellison AM, Smith-Whitley K, Mahajan P, Sarnaik SA, Casper TC, Cook LJ, Dean JM, Leonard J, Hulbert ML, Powell EC, Liem RI, Hickey R, Krishnamurti L, Hillery CA, Nimmer M, Panepinto JA (2015) A multicenter randomized controlled trial of intravenous magnesium for sickle cell pain crisis in children. Blood 126:1651–1657

    Google Scholar 

  • Chang J, Patton JT, Sarkar A, Ernst B, Magnani JL, Frenette PS (2010) GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice. Blood 116:1779–1786

    Article  PubMed  PubMed Central  Google Scholar 

  • Chirico EN, Pialoux V (2012) Role of oxidative stress in the pathogenesis of sickle cell disease. Int Union Biochem Mol Biol 64:72–80

    CAS  Google Scholar 

  • Clarke DT, Jones GR, Martin MM (1986) The antisickling drug Lawsone (2-oh-i,4-naphthoquinone) protects sickled cells against membrane damage. Biochem Biophys Res Commun 139:780–786

    Article  CAS  PubMed  Google Scholar 

  • De Castro LM, Zennadi R, Jonassaint JC, Batchvarova M, Telen MJ (2012) Effect of propranolol as antiadhesive therapy in sickle cell disease. Clin Transl Sci 5:437–444

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Desimone J, Koshy M, Dorn L, Lavelle D, Bressler L, Molokie R, Talischy N (2002) Maintenance of elevated fetal hemoglobin levels by decitabine during dose interval treatment of sickle cell anemia. Blood 99:3905–3908

    Article  CAS  PubMed  Google Scholar 

  • Ekeke GI, Shode FO (1990) Phenylalanine is the predominant antisickling agent in Cajanus cajan seed extract. Planta Med 56:41–43

    Article  CAS  PubMed  Google Scholar 

  • Elusiyan CA, Ayoade O, Adeloye AO, Olorunmola FO, Agbedahunsi JM, Ogundaini AO (2018) Antisickling and radical scavenging activities of selected medicinal plants and compounds from Mitracarpus villosus (Sw.) DC. Cham. Eur J Med Plant 24:1–10

    Article  Google Scholar 

  • Fall AB, Vanhaelen-Fastré R, Vanhaelen M, Lo I, Toppet M, Ferster A, Fondu P (1999) In vitro antisickling activity of a rearranged limonoid isolated from Khaya senegalensis. Planta Med 65:209–212

    Article  CAS  PubMed  Google Scholar 

  • Frenrtte PS, Atweh GF (2007) Sickle cell disease: old discoveries, new concepts and future promise. J Clin Invest 117:850–858

    Article  CAS  Google Scholar 

  • Guerrini A, Lampronti I, Bianchi N, Zuccato C, Breveglieri G, Salvatori F, Mancini I, Rossi D, Potenza R, Chiavilli F, Sacchetti G, Gambari R, Borgatti M (2009) Bergamot (Citrus bergamia Risso) fruit extracts as γ-globin gene expression inducers: phytochemical and functional perspectives. J Agric Food Chem 57:4103–4111

    Article  CAS  PubMed  Google Scholar 

  • Haynes J Jr, Baliga BS, Obiako B, Ofori-Acquah S, Pace B (2004) Zileuton induces hemoglobin Fsynthesis in erythroid progenitors: role of the L-arginine-nitric oxide signaling pathway. Blood 103:3945–3950

    Article  CAS  PubMed  Google Scholar 

  • Hoppe C, Kuypers F, Larkin S, Hagar W, Vichinsky E, Styles L (2011) A pilot study of the short-term use of simvastatin in sickle cell disease: effects on markers of vascular dysfunction. Br J Haematol 153:655–663

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hsu LL, Sarnaik S, Williams S, Amilon C, Wissmar J, Berggren A (2018) A dose-ranging study of ticagrelor in children aged 3–17 years with sickle cell disease: a two-part phase 2 study. Am J Hematol 9:1493–1500

    Article  CAS  Google Scholar 

  • Iwu MM, Igboko AO, Onwubikob H, Ndu UE (1988) Effect of cajaminose from Cajanus cajan on gelation and oxygen affinity of sickle cell haemoglobin. J Ethnopharmacol 23:99–104

    Article  CAS  PubMed  Google Scholar 

  • Iyamu EW, Turner EA, Asakura T (2002) In vitro effects of NIPRISAN (Nix-0699): a naturally occurring, potent antisickling agent. Br J Haematol 118:337–343

    Article  CAS  PubMed  Google Scholar 

  • Kaddam L, Fadl-Elmula I, Eisawi OA, Abdelrazig HA, Salih MA, Lang F, Saeed AM (2017) Gum arabic as novel anti-oxidant agent in sickle cell anemia, phase II trial. BMC Hematol 17:1–6

    Article  CAS  Google Scholar 

  • Kapoor S, Little JA, Pecker LH (2018) Advances in the treatment of sickle cell disease. Mayo Clin Proc nn:1–15

    Google Scholar 

  • Kato GJ, Gladwin MT (2008) Evolution of novel small-molecule therapeutics targeting sickle cell vasculopathy. J Am Med Assoc 300:2638–2646

    Article  CAS  Google Scholar 

  • Kato GJ, Piel FB, Reid CD, Gaston MH, Ohene-Frempong K, Krishnamurti L, Smith WR, Panepinto JA, Weatherall DJ, Costa FF, Vichinsky EP (2018) Sickle cell disease. Nat Rev Dis Primers 4:18010

    Article  PubMed  Google Scholar 

  • Lal A, Atamna W, Killilea DW, Suh JH, Ames BN (2008) Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts. Redox Rep 13:2–10

    Article  CAS  PubMed  Google Scholar 

  • Lampronti I, Bianchi N, Borgatti M, Fibach E, Prus E, Gambari R (2003) Accumulation of γ-globin mRNA in human erythroid cells treated with angelicin. Eur J Haematol 71:189–198

    Article  CAS  PubMed  Google Scholar 

  • Lee SP, Ataga KI, Zayed M, Manganello JM, Orringer EP, Phillips DR, Parise LV (2007) Phase I study of eptifibatide in patients with sickle cell anaemia. Br J Haematol 139:612–620

    Article  CAS  PubMed  Google Scholar 

  • Lehrer-Graiwer J, Howard J, Hemmaway CJ, Awogbade M, Telfer P, Layton M, Mant T, Dufu K, Hutchaleelaha A, Koller T, Oksenberg D, Patel M, Ramoset E (2018) GBT440, a potent antisickling hemoglobin modifier reduces hemolysis improves anemia and nearly eliminates sickle cells in peripheral blood of patients with sickle cell disease. Blood 126:542

    Article  Google Scholar 

  • Lew VL, Hockaday AR, Sepulveda M, Somlyo AP, Somlyo AV, Ortiz OE, Bookchin RM (1985) Compartmentalization of sickle-cell calcium in endocytic inside-out vesicles. Nature 315:586–589

    Article  CAS  PubMed  Google Scholar 

  • Lew VL, Etzion Z, Bookchin RM (2002) Dehydration response of sickle cells to sickling-induced Ca(++) permeabilization. Blood 99:2578–2585

    Article  CAS  PubMed  Google Scholar 

  • Liu K, Xing H, Zhang S, Liu SM, Fung MC (2010) Cucurbitacin D induces fetal hemoglobin synthesis in K562 cells and human hematopoietic progenitors through activation of p38 pathway and stabilization of the γ-globin mRNA. Blood Cell Mol Dis 45:269–275

    Article  CAS  Google Scholar 

  • Machado RF, Barst RJ, Yovetich NA, Hassell KL, Kato GJ, Gordeuk VR, Gibbs JS, Little JA, Schraufnagel DE, Krishnamurti L, Girgis RE, Morris CR, Rosenzweig EB, Badesch DB, Lanzkron S, Onyekwere O, Castro OL, Sachdev V, Waclawiw MA, Woolson R, Goldsmith JC, Gladwin MT, walk-PHaSST Investigators and Patients (2011) Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity. Blood 118:855–864

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Manwani D, Frenette PS (2013) Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies. Blood 122:3892–3898

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Matsui NM, Borsig L, Rosen SD, Yaghmai M, Varki A, Embury SH (2001) P-selectin mediates the adhesion of sickle erythrocytes to the endothelium. Blood 98:1955–1962

    Article  CAS  PubMed  Google Scholar 

  • Mehanna AS, Abdullah O (2018) Aromatic aldehydes and carboxylic acids as inhibitors for sickle hemoglobin polymerization. Biomed J Sci Tech Res 3:3217–3224

    Google Scholar 

  • Morris CR, Suh JH, Hagar W, Larkin S, Bland DA, Steinberg MH, Vichinsky EP, Shigenaga M, Ames B, Kuypers FA, Klings ES (2008) Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease. Blood 111:402–410

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Morris CR, Kuypers FA, Lavrisha L, Ansari M, Sweeters N, Stewart M, Gildengorin G, Neumayr L, Vichinsky EP (2013) A randomized, placebo-controlled trial of arginine therapy for the treatment of children with sickle cell disease hospitalized with vaso-occlusive pain episodes. Haematologica 98:1375–1382

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Moutouh-de Parseval LA, Verhelle D, Glezer E, Jensen-Pergakes K, Ferguson GD, Corral LG, Morris CL, Muller G, Brady H, Chan K (2008) Pomalidomide and lenalidomide regulate erythropoiesis and fetal hemoglobin production in human CD34+ cells. J Clin Investig 118:248–258

    Article  CAS  PubMed  Google Scholar 

  • Mozzarelli A, Hofrichter J, Eaton WA (1987) Delay time of hemoglobin S polymerization prevents most cells from sickling in vivo. Science 237:500–506

    Article  CAS  PubMed  Google Scholar 

  • Mpiana PT, Mudogo V, Ngbolua KN, Tshibangu DS, Atibu EK, Kitwa EK, Kanangila AB (2009) In vitro antisickling activity of anthocyanins extracts of Vigna unguiculata (L.) walp. In: Recent Progress in medicinal plants: chemistry and medicinal value. Studium Press LLC, New Delhi, pp 91–98

    Google Scholar 

  • Mpiana PT, Mudogo V, Ngbolua KN, Tshibangu DS, Atibul EK (2010a) In vitro antisickling activity of anthocyanins extracts from Morinda lucida benth (Rubiaceae). In: Medicinal plants: phytochemistry, pharmacology and therapeutics. Daya Publishing House, New Delhi, pp 330–337

    Google Scholar 

  • Mpiana PT, Ngbolua KN, Bokota MT, Kasonga TK, Atibu EK, Tshibangu DS, Mudogo V (2010b) In vitro effects of anthocyanin extracts from Justicia secunda Vahl on the solubility of haemoglobin S and membrane stability of sickle erythrocytes. Blood Transfus 8:248–254

    PubMed  PubMed Central  Google Scholar 

  • Nelson RM, Cecconi O, Roberts WG, Aruffo A, Linhardt RJ, Bevilacqua MP (1993) Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation. Blood 82:3253–3258

    Article  CAS  PubMed  Google Scholar 

  • Ngbolua KN, Herintsoa R, Hajatiana R, Mudogo V, Tshilanda DD, Tshibangu DS, Mpiana PT (2015) In vitro anti-erythrocyte sickling effect of lunularic acid of natural origin. Int Blood Res Rev 4:1–6

    Article  Google Scholar 

  • Niihara Y, Koh H, Tran L, Razon R, Macan H, Stark C, Wun T, Adams-Graves P (2014) A phase 3 study of L-glutamine therapy for sickle cell anemia and sickle β0-thalassemia. Blood 124:86

    Article  Google Scholar 

  • Niihara Y, Miller ST, Kanter J, Lanzkron S, Smith WR, Hsu LL, Gordeuk VR, Viswanathan K, Sarnaik S, Osunkwo I, Guillaume E, Sadanandan S, Sieger L, Lasky JL, Panosyan EH, Blake OA, New TN, Bellevue R, Tran LT, Razon RL, Stark CW, Neumayr LD, Vichinsky EP (2018) A phase 3 trial of l-glutamine in sickle cell disease. N Engl J Med 379:226–235

    Article  CAS  PubMed  Google Scholar 

  • Noguchi CT, Schechter AN (1977) Inhibition of sickle hemoglobin gelation by amino acids and related compounds. Biochemistry 17:5455–5459

    Article  Google Scholar 

  • Oduola T, Idowu TO, Bello IS, Adeniyi FA, Ogunyemi EO (2012) Haematological response to intake of unripe Carica papaya fruit extract and the isolation and characterization of caricapinoside: a new antisickling agent from the extract. Asian J Pharm Clin Res 5:3–9

    Google Scholar 

  • Ohnishi ST, Ohnishi T, Ogunmola GB (2001) Green tea extract and aged garlic extract inhibit anion transport and sickle cell dehydration in vitro. Blood Cell Mol Dis 27:148–157

    Article  CAS  Google Scholar 

  • Oksenberg D, Dufu K, Patel MP, Chuang C, Li Z, Xu Q, Silva-Garcia A, Zhou C, Hutchaleelaha A, Patskovska L, Patskovsky Y, Almo SC, Sinha U, Metcalf BW, Archer DR (2016) GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease. Br J Haematol 175:141–153

    Article  CAS  PubMed  Google Scholar 

  • Ouattara B, Jansen O, Angenot L, Guissou IP, Frédérich M, Fondu P, Tits M (2009) Antisickling properties of divanilloylquinic acids isolated from Fagara zanthoxyloides Lam. (Rutaceae). Phytomedicine 16:125–129

    Article  CAS  PubMed  Google Scholar 

  • Pace BS, Shartava A, Pack-Mabien A, Mulekar M, Ardia A, Goodman SR (2003) Effects of N-acetylcysteine on dense cell formation in sickle cell disease. Am J Hematol 73:26–32

    Article  CAS  PubMed  Google Scholar 

  • Pauling L, Itano HA, Singer SJ, Wells IC (1949) Sickle cell anemia, a molecular disease. Science 110:543–548

    Article  CAS  PubMed  Google Scholar 

  • Piel FB, Hay SI, Gupta S, Weatherall DJ, Williams TN (2013) Global burden of sickle cell Anaemia in children under five, 2010–2050: modelling based on demographics, excess mortality, and interventions. PLoS Med 10:e1001484

    Article  PubMed  PubMed Central  Google Scholar 

  • Piel FB, Steinberg MH, Rees DC (2017) Sickle cell disease. N Engl J Med 376:1561–1573

    Article  CAS  PubMed  Google Scholar 

  • Qari MH, Aljaouni SK, Alardawi MS, Fatani H, Alsayes FA, Zografos P, Alsaigh M, Alalfi A, Alamin M, Gadi A, Mousa SA (2007) Reduction of painful vaso-occlusive crisis of sickle cell anaemia by tinzaparin in a double-blind randomized trial. Thromb Haemost 98:392–396

    Article  CAS  PubMed  Google Scholar 

  • Quinn CT (2018) L-glutamine for sickle cell anemia: more questions than answers. Blood 132:689–693

    Article  CAS  PubMed  Google Scholar 

  • Reid M, Badaloo A, Forrester T, Jahoor F (2006) In vivo rates of erythrocyte glutathione synthesis in adults with sickle cell disease. Am J Physiol Endocrinol Metabol 291:E73–E79

    Article  CAS  Google Scholar 

  • Rodrigue CM, Arous N, Bachir D, Smith-Ravin J, Romeo PH, Galacteros F (2001) Resveratrol, a natural dietary phytoalexin, possesses similar properties to hydroxyurea towards erythroid differentiation. Br J Haematol 113:500–507

    Article  CAS  PubMed  Google Scholar 

  • Ruiz-Nunez B, De Rooij SA, Offringa PJ, Schuitemaker GE, Teerlink T, Booi HSM, Dijck-Brouwer JDA, Muskiet FAJ (2013) Supplementation of patients with sickle cell disease with astaxanthin increases plasma- and erythrocyte-astaxanthin and may improve the hemolytic component of the disease. Free Radicals Antioxid 3:S22–S29

    CAS  Google Scholar 

  • Safo MK, Abdulmalik O, Danso-Danquah R, Burnett JC, Nokuri S, Joshi GS, Musayev FN, Asakura T, Abraham DJ (2004) Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds. J Med Chem 47:4665–4676

    Article  CAS  PubMed  Google Scholar 

  • Sato T, Ohnishi ST (1982) In vitro antisickling effect of Cepharanthine. Eur J Pharmacol 83:91–95

    Article  CAS  PubMed  Google Scholar 

  • Segal JB, Strouse JJ, Beach MC, Haywood C, Witkop C, Park H, Wilson RF, Bass EB, Lanzkron S (2008) Hydroxyurea for the treatment of sickle cell disease. Evid Rep Technol Assess 165:1–95

    Google Scholar 

  • Sickle cell disease: Data & statistics (2011) Centers for Disease Control and Prevention

    Google Scholar 

  • Steinberg MH (1999) Management of sickle cell disease. N Engl J Med 340:1021–1030

    Article  CAS  PubMed  Google Scholar 

  • Swift R, Abdulmalik O, Chen Q, Asakura T, Gustafson K, Simon JE, Zaman V, Quiusky KA, Hassell KL, Shapira I, Sidhu G, James-Goulbourne T, Carrington K, Muthu J, Gillette PN (2016) SCD-101: a new antisickling drug reduces pain and fatigue and improves red blood cell shape in peripheral blood of patients with sickle cell disease. Blood 128:121

    Article  Google Scholar 

  • Tshilanda DD, Mpiana PT, Onyamboko DN, Mbala BM, Ngbolua K, Tshibangu DS, Bokolo MK, Taba KM, Kasonga TK (2014) Antisickling activity of butyl stearate isolated from Ocimum basilicum (Lamiaceae). Asian Pac J Trop Biomed 4:393–398

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tshilanda DD, Onyamboko DNV, Babady-Bila P, Ngbolua K, Tshibangu DS, Dibwe EDF, Mpiana PT (2015) Antisickling activity of ursolic acid isolated from the leaves of Ocimum gratissimum L. (Lamiaceae). Nat Prod Biopro 5:215–221

    Article  CAS  Google Scholar 

  • Verma HK, Lakkakula S, Lakkakula BVKS (2018) Retrospection of the effect of hydroxyurea treatment in patients with sickle cell disease. Acta Haematol Pol 49:1–8

    Article  Google Scholar 

  • Wambebe C, Khamofu H, Momoh JAF, Ekpeyong M, Audu BS, Njoku OS, Bamgboye EA, Nasipuri RN, Kunle OO, Okogun JI, Enwerem MN, Audam JG, Gamaniel KS, Obodozie OO, Samuel B, Fojule G, Ogunyale O (2001) Double-blind, placebo-controlled, randomised cross-over clinical trial of NIPRISAN in patients with sickle cell disorder. Phytomedicine 8:252–261

    Article  CAS  PubMed  Google Scholar 

  • Wandersee NJ, Maciaszek JL, Giger KM, Hanson MS, Zheng S, Guo YH, Mickelson B, Hillery CA, Lykotrafitis G, Low PS, Hogg N (2015) Dietary supplementation with docosahexanoic acid (DHA) increases red blood cell membrane flexibility in mice with sickle cell disease. Blood Cell Mol Dis 54:183–188

    Article  CAS  Google Scholar 

  • Weatherall DJ (2010) The inherited diseases of hemoglobin are an emerging global health burden. Blood 115:4331

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • World Health Organisation (2006) Sickle-cell anaemia. Report by the Secretariat. Fiftyninth World Health Assembly. A59/9 Provisional Agenda Item 11(4):1–5

    Google Scholar 

  • Zhang C, Li X, Lian L, Chen Q, Abdulmalik O, Vassilev V, Lai CS, Asakura T (2004) Antisickling effect of MX-1520, a prodrug of vanillin: an in vivo study using rodents. Br J Haematol 125:788–795

    Article  CAS  PubMed  Google Scholar 

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Acknowledgment

AG, SB, and AD are thankful to DST, CSIR, and UGC (New Delhi, India), respectively, for providing fellowship to carry out research support.

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Authors have no competing interest.

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Authors and Affiliations

  1. PK-PD, Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Jammu, Jammu and Kashmir, India

    Abhishek Gour, Ashish Dogra, Shipra Bhatt & Utpal Nandi

  2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India

    Utpal Nandi

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  1. Abhishek Gour
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  2. Ashish Dogra
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  1. Plant Sciences (Biodiversity and Applied Botany Division), CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research (AcSIR) Ghaziabad, Uttar Pradesh, India, Jammu, Jammu and Kashmir, India

    Bikarma Singh

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Gour, A., Dogra, A., Bhatt, S., Nandi, U. (2020). Effect of Natural Products on Improvement of Blood Pathophysiology for Management of Sickle Cell Anemia. In: Singh, B. (eds) Botanical Leads for Drug Discovery. Springer, Singapore. https://doi.org/10.1007/978-981-15-5917-4_3

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